Publication Information

{'id': 'https://openalex.org/W2971584098', 'doi': 'https://doi.org/10.1038/s41598-019-49231-9', 'title': 'Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy', 'display_name': 'Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy', 'publication_year': 2019, 'publication_date': '2019-09-04', 'ids': {'openalex': 'https://openalex.org/W2971584098', 'doi': 'https://doi.org/10.1038/s41598-019-49231-9', 'mag': '2971584098', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31484989', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6726756'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-49231-9', 'pdf_url': 'https://www.nature.com/articles/s41598-019-49231-9.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41598-019-49231-9.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068032969', 'display_name': 'Praveen K. Dhandapani', 'orcid': 'https://orcid.org/0000-0002-3486-4355'}, 'institutions': [{'id': 'https://openalex.org/I166825849', 'display_name': 'Tampere University', 'ror': 'https://ror.org/033003e23', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I166825849']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Praveen K. Dhandapani', 'raw_affiliation_strings': ['Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland', 'institution_ids': ['https://openalex.org/I166825849']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040335770', 'display_name': 'Isabel M. Begines-Moreno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Isabel M. Begines-Moreno', 'raw_affiliation_strings': ['Laboratorio de Fisiopatologia Celular y Bioenergética, Universidad Pablo de Olavide, 41013, Sevilla, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Fisiopatologia Celular y Bioenergética, Universidad Pablo de Olavide, 41013, Sevilla, Spain', 'institution_ids': ['https://openalex.org/I95013407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026430307', 'display_name': 'Gloria Brea‐Calvo', 'orcid': 'https://orcid.org/0000-0001-5536-6868'}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Gloria Brea-Calvo', 'raw_affiliation_strings': ['Centro Andaluz de Biologia de Desarrollo and CIBERER, ISCIII, Universidad Pablo de Olavide-CSIC-JA, 41013, Sevilla, Spain'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biologia de Desarrollo and CIBERER, ISCIII, Universidad Pablo de Olavide-CSIC-JA, 41013, Sevilla, Spain', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112977846', 'display_name': 'Ulrich Gärtner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200763008', 'display_name': 'University of Giessen', 'ror': 'https://ror.org/033eqas34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I200763008']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Gärtner', 'raw_affiliation_strings': ['Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany', 'institution_ids': ['https://openalex.org/I200763008']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022247782', 'display_name': 'Thomas G. Graeber', 'orcid': 'https://orcid.org/0000-0001-8574-9181'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas G. Graeber', 'raw_affiliation_strings': ['Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101977538', 'display_name': 'Gerardo Javier Sanchez', 'orcid': 'https://orcid.org/0000-0002-4674-406X'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerardo Javier Sanchez', 'raw_affiliation_strings': ['Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019184753', 'display_name': 'Rory E. Morty', 'orcid': 'https://orcid.org/0000-0003-0833-9749'}, 'institutions': [{'id': 'https://openalex.org/I4210102801', 'display_name': 'Max Planck Institute for Heart and Lung Research', 'ror': 'https://ror.org/0165r2y73', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210102801']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rory E. Morty', 'raw_affiliation_strings': ['Max-Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany', 'institution_ids': ['https://openalex.org/I4210102801']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102304524', 'display_name': 'Kai Schönig', 'orcid': 'https://orcid.org/0000-0003-3754-408X'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I4210105615', 'display_name': 'Central Institute of Mental Health', 'ror': 'https://ror.org/01hynnt93', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105615']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kai Schönig', 'raw_affiliation_strings': ['Central Institute for Mental Health, University of Heidelberg, 68159, Mannheim, Germany'], 'affiliations': [{'raw_affiliation_string': 'Central Institute for Mental Health, University of Heidelberg, 68159, Mannheim, Germany', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I4210105615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038837721', 'display_name': 'Johanna ten Hoeve', 'orcid': 'https://orcid.org/0000-0003-0226-749X'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Johanna ten Hoeve', 'raw_affiliation_strings': ['Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084652924', 'display_name': 'Astrid Wietelmann', 'orcid': 'https://orcid.org/0000-0003-1626-1961'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Astrid Wietelmann', 'raw_affiliation_strings': ['Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030368112', 'display_name': 'Thomas Braun', 'orcid': 'https://orcid.org/0000-0002-6165-4804'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Braun', 'raw_affiliation_strings': ['Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging and UCLA Metabolomics Center, 90095, Los Angeles, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066630834', 'display_name': 'Howard T. Jacobs', 'orcid': 'https://orcid.org/0000-0003-1895-6003'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Howard T. Jacobs', 'raw_affiliation_strings': ['Institute of Biotechnology, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biotechnology, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022557991', 'display_name': 'Marten Szibor', 'orcid': 'https://orcid.org/0000-0003-4029-160X'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Marten Szibor', 'raw_affiliation_strings': ['Institute of Biotechnology, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biotechnology, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1490, 'currency': 'EUR', 'value_usd': 1606, 'provenance': 'openapc'}, 'fwci': 0.493, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.622287, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '9', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11597', 'display_name': 'Neutrophil, Myeloperoxidase and Oxidative Mechanisms', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11112', 'display_name': 'Viral Infections and Immunology Research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperoxia', 'display_name': 'Hyperoxia', 'score': 0.5318275}, {'id': 'https://openalex.org/keywords/ventricular-remodeling', 'display_name': 'Ventricular remodeling', 'score': 0.5314105}, {'id': 'https://openalex.org/keywords/alternative-oxidase', 'display_name': 'Alternative oxidase', 'score': 0.48507658}, {'id': 'https://openalex.org/keywords/bioenergetics', 'display_name': 'Bioenergetics', 'score': 0.4399055}], 'concepts': [{'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.6478193}, {'id': 'https://openalex.org/C2778797674', 'wikidata': 'https://www.wikidata.org/wiki/Q847583', 'display_name': 'Cardiomyopathy', 'level': 3, 'score': 0.6193478}, {'id': 'https://openalex.org/C2780672939', 'wikidata': 'https://www.wikidata.org/wiki/Q5958429', 'display_name': 'Hyperoxia', 'level': 3, 'score': 0.5318275}, {'id': 'https://openalex.org/C2779537366', 'wikidata': 'https://www.wikidata.org/wiki/Q7920323', 'display_name': 'Ventricular remodeling', 'level': 3, 'score': 0.5314105}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.51091665}, {'id': 'https://openalex.org/C2778858093', 'wikidata': 'https://www.wikidata.org/wiki/Q24721080', 'display_name': 'Alternative oxidase', 'level': 3, 'score': 0.48507658}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.4752502}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.4720391}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.46701935}, {'id': 'https://openalex.org/C100206155', 'wikidata': 'https://www.wikidata.org/wiki/Q570714', 'display_name': 'Bioenergetics', 'level': 3, 'score': 0.4399055}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42726603}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.4162221}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.395776}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38633922}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3775956}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34537196}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3344368}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.13095644}], 'mesh': [{'descriptor_ui': 'D009202', 'descriptor_name': 'Cardiomyopathies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018496', 'descriptor_name': 'Hyperoxia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009202', 'descriptor_name': 'Cardiomyopathies', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009202', 'descriptor_name': 'Cardiomyopathies', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009202', 'descriptor_name': 'Cardiomyopathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077262', 'descriptor_name': 'Ciona', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D000077262', 'descriptor_name': 'Ciona', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018496', 'descriptor_name': 'Hyperoxia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018496', 'descriptor_name': 'Hyperoxia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D018496', 'descriptor_name': 'Hyperoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010085', 'descriptor_name': 'Oxidative Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020257', 'descriptor_name': 'Ventricular Remodeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-49231-9', 'pdf_url': 'https://www.nature.com/articles/s41598-019-49231-9.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726756', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31484989', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-49231-9', 'pdf_url': 'https://www.nature.com/articles/s41598-019-49231-9.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1268677953', 'https://openalex.org/W1746326979', 'https://openalex.org/W1965323386', 'https://openalex.org/W1968356216', 'https://openalex.org/W1972779782', 'https://openalex.org/W1981383750', 'https://openalex.org/W1986582839', 'https://openalex.org/W1995618419', 'https://openalex.org/W1996300552', 'https://openalex.org/W1996745492', 'https://openalex.org/W2013092232', 'https://openalex.org/W2014122199', 'https://openalex.org/W2019876490', 'https://openalex.org/W2026381977', 'https://openalex.org/W2030211016', 'https://openalex.org/W2034940836', 'https://openalex.org/W2046208657', 'https://openalex.org/W2050297059', 'https://openalex.org/W2050744280', 'https://openalex.org/W2056717322', 'https://openalex.org/W2063932784', 'https://openalex.org/W2072934793', 'https://openalex.org/W2098813681', 'https://openalex.org/W2105330144', 'https://openalex.org/W2140725738', 'https://openalex.org/W2149323802', 'https://openalex.org/W2152461224', 'https://openalex.org/W2188271172', 'https://openalex.org/W2315914190', 'https://openalex.org/W2415515169', 'https://openalex.org/W2522038806', 'https://openalex.org/W2568457021', 'https://openalex.org/W2592128576', 'https://openalex.org/W2701541202', 'https://openalex.org/W2805029975', 'https://openalex.org/W2886044379', 'https://openalex.org/W2905405688'], 'related_works': ['https://openalex.org/W3177319688', 'https://openalex.org/W3095514660', 'https://openalex.org/W3012086122', 'https://openalex.org/W2414628879', 'https://openalex.org/W2382385774', 'https://openalex.org/W2369920498', 'https://openalex.org/W2102775341', 'https://openalex.org/W2090100319', 'https://openalex.org/W2042804612', 'https://openalex.org/W1996018541'], 'abstract_inverted_index': {'Abstract': [0], 'Constitutive': [1], 'expression': [2, 106, 131, 163], 'of': [3, 13, 65, 83, 107, 147, 149, 157, 167, 182, 193], 'the': [4, 47, 60, 72, 81, 101, 108, 145, 158, 191], 'chemokine': [5], 'Mcp1': [6, 77, 102], 'in': [7, 165, 190], 'mouse': [8], 'cardiomyocytes': [9], 'creates': [10], 'a': [11, 114, 134, 155, 175], 'model': [12, 103, 178], 'inflammatory': [14, 194], 'cardiomyopathy,': [15], 'with': [16, 104], 'death': [17], 'from': [18, 119], 'heart': [19, 66, 169], 'failure': [20], 'at': [21], 'age': [22], '7–8': [23], 'months.': [24], 'A': [25], 'critical': [26], 'pathogenic': [27], 'role': [28], 'has': [29], 'previously': [30], 'been': [31], 'proposed': [32], 'for': [33, 87, 116], 'induced': [34], 'oxidative': [35], 'stress,': [36], 'involving': [37, 180], 'NADPH': [38], 'oxidase': [39, 110], 'activation.': [40], 'To': [41, 95], 'test': [42], 'this': [43, 55, 97], 'idea,': [44], 'we': [45, 99], 'exposed': [46], 'mice': [48], 'to': [49, 80, 121, 137, 173], 'elevated': [50], 'oxygen': [51, 85, 122], 'levels.': [52], 'Against': [53], 'expectation,': [54], 'prevented,': [56], 'rather': [57], 'than': [58], 'accelerated,': [59], 'ultrastructural': [61], 'and': [62, 127, 141, 151, 171, 198], 'functional': [63, 139], 'signs': [64], 'failure.': [67], 'This': [68], 'result': [69], 'suggests': [70], 'that': [71, 187], 'immune': [73], 'signaling': [74], 'initiated': [75], 'by': [76], 'leads': [78], 'instead': [79], 'inhibition': [82], 'cellular': [84], 'usage,': [86], 'which': [88, 112], 'mitochondrial': [89, 188], 'respiration': [90], 'is': [91, 196], 'an': [92], 'obvious': [93], 'target.': [94], 'address': [96], 'hypothesis,': [98], 'combined': [100], 'xenotopic': [105], 'alternative': [109], '(AOX),': [111], 'provides': [113], 'sink': [115], 'electrons': [117], 'blocked': [118], 'passage': [120], 'via': [123], 'respiratory': [124], 'complexes': [125], 'III': [126], 'IV.': [128], 'Ubiquitous': [129], 'AOX': [130, 162], 'provided': [132], 'only': [133], 'minor': [135], 'delay': [136], 'cardiac': [138, 150], 'deterioration': [140], 'did': [142], 'not': [143], 'prevent': [144], 'induction': [146], 'markers': [148], 'metabolic': [152], 'remodeling': [153], 'considered': [154], 'hallmark': [156], 'model.': [159], 'Moreover,': [160], 'cardiomyocyte-specific': [161], 'resulted': [164], 'exacerbation': [166], 'Mcp1-induced': [168], 'failure,': [170], 'failed': [172], 'rescue': [174], 'second': [176], 'cardiomyopathy': [177, 195], 'directly': [179], 'loss': [181], 'cIV.': [183], 'Our': [184], 'findings': [185], 'imply': [186], 'involvement': [189], 'pathology': [192], 'multifaceted': [197], 'complex.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2971584098', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-11T17:52:58.093112', 'created_date': '2019-09-12'}