Publication Information

{'id': 'https://openalex.org/W2414628879', 'doi': 'https://doi.org/10.1038/srep17441', 'title': 'Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia', 'display_name': 'Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia', 'publication_year': 2015, 'publication_date': '2015-11-30', 'ids': {'openalex': 'https://openalex.org/W2414628879', 'doi': 'https://doi.org/10.1038/srep17441', 'mag': '2414628879', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26616217', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4663498'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep17441', 'pdf_url': 'https://www.nature.com/articles/srep17441.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/srep17441.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085314131', 'display_name': 'Dorien Kiers', 'orcid': 'https://orcid.org/0000-0002-4829-6643'}, 'institutions': [{'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}, {'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Dorien Kiers', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I2802934949', 'https://openalex.org/I145872427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046957535', 'display_name': 'Jelle Gerretsen', 'orcid': 'https://orcid.org/0000-0002-8935-7350'}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jelle Gerretsen', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113846211', 'display_name': 'Emmy Janssen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Emmy Janssen', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004921383', 'display_name': 'A. Todd John', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Aaron John', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005505737', 'display_name': 'Rianne Groeneveld', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'R. Groeneveld', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019221575', 'display_name': 'Johannes G. van der Hoeven', 'orcid': 'https://orcid.org/0000-0001-5362-0244'}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Johannes G. van der Hoeven', 'raw_affiliation_strings': ['Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Medicine, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112729526', 'display_name': 'Gert‐Jan Scheffer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}, {'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gert-Jan Scheffer', 'raw_affiliation_strings': ['Department of Anesthesiology, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I2802934949', 'https://openalex.org/I145872427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025445136', 'display_name': 'Peter Pickkers', 'orcid': 'https://orcid.org/0000-0002-1104-4303'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Peter Pickkers', 'raw_affiliation_strings': ['Radboud Centre for Infectious Diseases (RCI) Geert Grooteplein, Zuid 10, PO Box 9101, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Radboud Centre for Infectious Diseases (RCI) Geert Grooteplein, Zuid 10, PO Box 9101, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064342139', 'display_name': 'Matthijs Kox', 'orcid': 'https://orcid.org/0000-0001-6537-6971'}, 'institutions': [{'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}, {'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Matthijs Kox', 'raw_affiliation_strings': ['Department of Anesthesiology, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Radboud university medical center, Geert Grooteplein Zuid 10, Nijmegen, 6500 HB, The Netherlands', 'institution_ids': ['https://openalex.org/I2802934949', 'https://openalex.org/I145872427']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 1.939, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.879959, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '5', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10322', 'display_name': 'Respiratory Support and Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10322', 'display_name': 'Respiratory Support and Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10218', 'display_name': 'Sepsis Diagnosis and Treatment', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperoxia', 'display_name': 'Hyperoxia', 'score': 0.99447346}, {'id': 'https://openalex.org/keywords/oxygen-toxicity', 'display_name': 'Oxygen toxicity', 'score': 0.44613838}, {'id': 'https://openalex.org/keywords/systemic-administration', 'display_name': 'Systemic administration', 'score': 0.4132623}], 'concepts': [{'id': 'https://openalex.org/C2780672939', 'wikidata': 'https://www.wikidata.org/wiki/Q5958429', 'display_name': 'Hyperoxia', 'level': 3, 'score': 0.99447346}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.67168576}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5977042}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.56473434}, {'id': 'https://openalex.org/C2776252253', 'wikidata': 'https://www.wikidata.org/wiki/Q7663815', 'display_name': 'Systemic inflammation', 'level': 3, 'score': 0.5407169}, {'id': 'https://openalex.org/C160448771', 'wikidata': 'https://www.wikidata.org/wiki/Q184726', 'display_name': 'Phagocytosis', 'level': 2, 'score': 0.5343259}, {'id': 'https://openalex.org/C2777590204', 'wikidata': 'https://www.wikidata.org/wiki/Q125223', 'display_name': 'Oxygen toxicity', 'level': 3, 'score': 0.44613838}, {'id': 'https://openalex.org/C70289976', 'wikidata': 'https://www.wikidata.org/wiki/Q17143603', 'display_name': 'Oxygenation', 'level': 2, 'score': 0.4377641}, {'id': 'https://openalex.org/C25938499', 'wikidata': 'https://www.wikidata.org/wiki/Q7663812', 'display_name': 'Systemic administration', 'level': 3, 'score': 0.4132623}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26332295}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.19526446}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.17454365}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.15765008}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12220809}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019446', 'descriptor_name': 'Endotoxemia', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018496', 'descriptor_name': 'Hyperoxia', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001784', 'descriptor_name': 'Blood Gas Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001831', 'descriptor_name': 'Body Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006439', 'descriptor_name': 'Hemodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010587', 'descriptor_name': 'Phagocytosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep17441', 'pdf_url': 'https://www.nature.com/articles/srep17441.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4663498', 'pdf_url': 'https://europepmc.org/articles/pmc4663498?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2066/152722', 'pdf_url': 'https://repository.ubn.ru.nl/bitstream/handle/2066/152722/1/152722.pdf', 'source': {'id': 'https://openalex.org/S4306401067', 'display_name': 'Radboud Repository (Radboud University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I145872427', 'host_organization_name': 'Radboud University Nijmegen', 'host_organization_lineage': ['https://openalex.org/I145872427'], 'host_organization_lineage_names': ['Radboud University Nijmegen'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26616217', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep17441', 'pdf_url': 'https://www.nature.com/articles/srep17441.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1574330564', 'https://openalex.org/W1575883964', 'https://openalex.org/W1941901208', 'https://openalex.org/W1981181666', 'https://openalex.org/W1986463646', 'https://openalex.org/W1992036948', 'https://openalex.org/W1992105679', 'https://openalex.org/W1998904773', 'https://openalex.org/W1999848515', 'https://openalex.org/W2001418709', 'https://openalex.org/W2009381713', 'https://openalex.org/W2016806492', 'https://openalex.org/W2024981885', 'https://openalex.org/W2025009173', 'https://openalex.org/W2027518539', 'https://openalex.org/W2037265282', 'https://openalex.org/W2043385084', 'https://openalex.org/W2055487408', 'https://openalex.org/W2062726952', 'https://openalex.org/W2067700440', 'https://openalex.org/W2081376304', 'https://openalex.org/W2096446736', 'https://openalex.org/W2097672306', 'https://openalex.org/W2098562755', 'https://openalex.org/W2098749705', 'https://openalex.org/W2104595095', 'https://openalex.org/W2105095232', 'https://openalex.org/W2107466285', 'https://openalex.org/W2113489746', 'https://openalex.org/W2130065192', 'https://openalex.org/W2138667236', 'https://openalex.org/W2144073119', 'https://openalex.org/W2147934896', 'https://openalex.org/W2149423296', 'https://openalex.org/W2152780883', 'https://openalex.org/W2157434906', 'https://openalex.org/W2161771297', 'https://openalex.org/W2162275013', 'https://openalex.org/W2163104804', 'https://openalex.org/W2163212901', 'https://openalex.org/W2166514281', 'https://openalex.org/W2319750682'], 'related_works': ['https://openalex.org/W4200543832', 'https://openalex.org/W3177319688', 'https://openalex.org/W2412548458', 'https://openalex.org/W2080237291', 'https://openalex.org/W2079904502', 'https://openalex.org/W2066382330', 'https://openalex.org/W1992717802', 'https://openalex.org/W1977812519', 'https://openalex.org/W181707362', 'https://openalex.org/W1804324355'], 'abstract_inverted_index': {'Abstract': [0], 'Oxygen': [1], 'therapy': [2], 'to': [3, 46, 65, 72, 78], 'maintain': [4], 'tissue': [5, 74], 'oxygenation': [6], 'is': [7, 17], 'one': [8], 'of': [9, 12, 69, 105, 129, 157, 189], 'the': [10, 103, 150], 'cornerstones': [11], 'critical': [13], 'care.': [14], 'Therefore,': [15], 'hyperoxia': [16, 29, 43, 70, 83, 109, 146, 179], 'often': [18], 'encountered': [19], 'in': [20, 52, 92, 102, 116, 121, 126, 132, 160], 'critically': [21], 'ill': [22], 'patients.': [23], 'Epidemiologic': [24], 'studies': [25], 'have': [26], 'demonstrated': [27], 'that': [28, 178], 'may': [30, 84], 'affect': [31, 149], 'outcome,': [32], 'although': [33], 'mechanisms': [34], 'are': [35, 170], 'unclear.': [36], 'Immunologic': [37], 'effects': [38, 68, 185], 'might': [39], 'be': [40, 63], 'involved,': [41], 'as': [42, 95, 192], 'was': [44], 'shown': [45], 'attenuate': [47], 'inflammation': [48], 'and': [49, 89, 118, 135, 162, 167, 186], 'organ': [50, 90], 'damage': [51, 91], 'preclinical': [53], 'models.': [54], 'However,': [55], 'it': [56, 191], 'remains': [57], 'unclear': [58], 'whether': [59], 'these': [60, 79], 'observations': [61], 'can': [62], 'ascribed': [64], 'direct': [66, 183], 'immunosuppressive': [67], 'or': [71], 'preserved': [73], 'oxygenation.': [75], 'In': [76], 'contrast': [77], 'putative': [80], 'anti-inflammatory': [81, 184], 'effects,': [82], 'elicit': [85], 'an': [86, 193], 'inflammatory': [87, 130, 152], 'response': [88, 153], 'itself,': [93], 'known': [94], 'oxygen': [96], 'toxicity.': [97], 'Here,': [98], 'we': [99, 139], 'demonstrate': [100], 'that,': [101, 141], 'absence': [104], 'systemic': [106, 151], 'inflammation,': [107], 'short-term': [108, 173], '(100%': [110], 'O': [111], '2': [112], 'for': [113], '2.5': [114], 'hours': [115, 120], 'mice': [117, 134, 161], '3.5': [119], 'humans)': [122], 'does': [123, 147, 180], 'not': [124, 148, 181], 'result': [125], 'increased': [127], 'levels': [128], 'cytokines': [131], 'both': [133], 'healthy': [136], 'volunteers.': [137], 'Furthermore,': [138], 'show': [140], 'compared': [142], 'with': [143], 'room': [144], 'air,': [145], 'elicited': [154], 'by': [155, 172], 'administration': [156], 'bacterial': [158], 'endotoxin': [159], 'man.': [163], 'Finally,': [164], 'neutrophil': [165], 'phagocytosis': [166], 'ROS': [168], 'generation': [169], 'unaffected': [171], 'hyperoxia.': [174], 'Our': [175], 'results': [176], 'indicate': [177], 'exert': [182], 'temper': [187], 'expectations': [188], 'using': [190], 'immunomodulatory': [194], 'treatment': [195], 'strategy.': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2414628879', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-09T19:56:44.649055', 'created_date': '2016-06-24'}