Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2966246125', 'doi': 'https://doi.org/10.1038/s41598-019-47680-w', 'title': 'Gene-environment interaction counterbalances social impairment in mouse models of autism', 'display_name': 'Gene-environment interaction counterbalances social impairment in mouse models of autism', 'publication_year': 2019, 'publication_date': '2019-08-07', 'ids': {'openalex': 'https://openalex.org/W2966246125', 'doi': 'https://doi.org/10.1038/s41598-019-47680-w', 'mag': '2966246125', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31391512', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6686010'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-47680-w', 'pdf_url': 'https://www.nature.com/articles/s41598-019-47680-w.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41598-019-47680-w.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080526456', 'display_name': 'Ji‐Woon Kim', 'orcid': 'https://orcid.org/0000-0003-3890-0592'}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ji-Woon Kim', 'raw_affiliation_strings': ['Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008638076', 'display_name': 'Kwanghoon Park', 'orcid': 'https://orcid.org/0000-0002-3279-4373'}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kwanghoon Park', 'raw_affiliation_strings': ['Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050858661', 'display_name': 'Ri Jin Kang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ri Jin Kang', 'raw_affiliation_strings': ['Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003077097', 'display_name': 'Edson Luck Gonzales', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Edson Luck Gonzales', 'raw_affiliation_strings': ['Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102032652', 'display_name': 'Hyun Ah Oh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyun Ah Oh', 'raw_affiliation_strings': ['Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022048539', 'display_name': 'Hana Seung', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hana Seung', 'raw_affiliation_strings': ['Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005876041', 'display_name': 'Mee Jung Ko', 'orcid': 'https://orcid.org/0000-0003-0169-1387'}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Mee Jung Ko', 'raw_affiliation_strings': ['Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076094908', 'display_name': 'Jae Hoon Cheong', 'orcid': 'https://orcid.org/0000-0001-5654-5868'}, 'institutions': [{'id': 'https://openalex.org/I27941296', 'display_name': 'Sahmyook University', 'ror': 'https://ror.org/04vxr4k74', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I27941296']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jae Hoon Cheong', 'raw_affiliation_strings': ['Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarangro, Nowon-gu, Seoul, 01795, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarangro, Nowon-gu, Seoul, 01795, South Korea', 'institution_ids': ['https://openalex.org/I27941296']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068404643', 'display_name': 'ChiHye Chung', 'orcid': 'https://orcid.org/0000-0002-3104-2399'}, 'institutions': [{'id': 'https://openalex.org/I24062138', 'display_name': 'Konkuk University', 'ror': 'https://ror.org/025h1m602', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I24062138']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'ChiHye Chung', 'raw_affiliation_strings': ['Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': ['https://openalex.org/I24062138']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064106844', 'display_name': 'Chan Young Shin', 'orcid': 'https://orcid.org/0000-0003-1764-6740'}, 'institutions': [], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Chan Young Shin', 'raw_affiliation_strings': ['NeuroVenti, Inc. and TriNeuro Inc., 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea'], 'affiliations': [{'raw_affiliation_string': 'NeuroVenti, Inc. and TriNeuro Inc., 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5064106844'], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 1.316, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.611255, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '9', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Molecular Basis of Rett Syndrome and Related Disorders', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Adult Neurogenesis and Brain Development', 'score': 0.973, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/autism', 'display_name': 'Autism', 'score': 0.540706}], 'concepts': [{'id': 'https://openalex.org/C2778538070', 'wikidata': 'https://www.wikidata.org/wiki/Q1436063', 'display_name': 'Autism spectrum disorder', 'level': 3, 'score': 0.6886109}, {'id': 'https://openalex.org/C205778803', 'wikidata': 'https://www.wikidata.org/wiki/Q38404', 'display_name': 'Autism', 'level': 2, 'score': 0.6525202}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.6206746}, {'id': 'https://openalex.org/C2781195155', 'wikidata': 'https://www.wikidata.org/wiki/Q18680', 'display_name': 'Prefrontal cortex', 'level': 3, 'score': 0.60521674}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.5124898}, {'id': 'https://openalex.org/C112592302', 'wikidata': 'https://www.wikidata.org/wiki/Q1207387', 'display_name': 'Excitatory postsynaptic potential', 'level': 3, 'score': 0.47124913}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.44736317}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.36454225}, {'id': 'https://openalex.org/C138496976', 'wikidata': 'https://www.wikidata.org/wiki/Q175002', 'display_name': 'Developmental psychology', 'level': 1, 'score': 0.31752545}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29577154}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28462067}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.27811068}, {'id': 'https://openalex.org/C17077164', 'wikidata': 'https://www.wikidata.org/wiki/Q1185869', 'display_name': 'Inhibitory postsynaptic potential', 'level': 2, 'score': 0.19376388}], 'mesh': [{'descriptor_ui': 'D000067877', 'descriptor_name': 'Autism Spectrum Disorder', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D059647', 'descriptor_name': 'Gene-Environment Interaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018811', 'descriptor_name': 'Maternal Exposure', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000067877', 'descriptor_name': 'Autism Spectrum Disorder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000067877', 'descriptor_name': 'Autism Spectrum Disorder', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019706', 'descriptor_name': 'Excitatory Postsynaptic Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019706', 'descriptor_name': 'Excitatory Postsynaptic Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019706', 'descriptor_name': 'Excitatory Postsynaptic Potentials', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019706', 'descriptor_name': 'Excitatory Postsynaptic Potentials', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006120', 'descriptor_name': 'Grooming', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006120', 'descriptor_name': 'Grooming', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018811', 'descriptor_name': 'Maternal Exposure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017966', 'descriptor_name': 'Pyramidal Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017966', 'descriptor_name': 'Pyramidal Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017966', 'descriptor_name': 'Pyramidal Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013239', 'descriptor_name': 'Stereotyped Behavior', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013239', 'descriptor_name': 'Stereotyped Behavior', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-47680-w', 'pdf_url': 'https://www.nature.com/articles/s41598-019-47680-w.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6686010', 'pdf_url': 'https://europepmc.org/articles/pmc6686010?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31391512', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-47680-w', 'pdf_url': 'https://www.nature.com/articles/s41598-019-47680-w.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'display_name': 'Reduced inequalities', 'id': 'https://metadata.un.org/sdg/10'}], 'grants': [{'funder': 'https://openalex.org/F4320322091', 'funder_display_name': 'Korea Institute of Science and Technology', 'award_id': '2E28412-18-119'}, {'funder': 'https://openalex.org/F4320322120', 'funder_display_name': 'National Research Foundation of Korea', 'award_id': 'NRF-2017M3A9G2077568'}, {'funder': 'https://openalex.org/F4320322120', 'funder_display_name': 'National Research Foundation of Korea', 'award_id': 'NRF-2016R1A5A2012284'}], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1482174726', 'https://openalex.org/W1500891748', 'https://openalex.org/W1541267199', 'https://openalex.org/W1613369435', 'https://openalex.org/W1972793642', 'https://openalex.org/W1981079086', 'https://openalex.org/W1984368478', 'https://openalex.org/W2001532157', 'https://openalex.org/W2009082639', 'https://openalex.org/W2010765482', 'https://openalex.org/W2011450194', 'https://openalex.org/W2027917639', 'https://openalex.org/W2029500632', 'https://openalex.org/W2038599400', 'https://openalex.org/W2048169382', 'https://openalex.org/W2053022831', 'https://openalex.org/W2057801246', 'https://openalex.org/W2071797996', 'https://openalex.org/W2072652550', 'https://openalex.org/W2073317062', 'https://openalex.org/W2081425755', 'https://openalex.org/W2098249941', 'https://openalex.org/W2098277878', 'https://openalex.org/W2099169745', 'https://openalex.org/W2099756187', 'https://openalex.org/W2113126716', 'https://openalex.org/W2122345676', 'https://openalex.org/W2127753140', 'https://openalex.org/W2129867386', 'https://openalex.org/W2141154555', 'https://openalex.org/W2142680666', 'https://openalex.org/W2158438953', 'https://openalex.org/W2167118090', 'https://openalex.org/W2168950294', 'https://openalex.org/W2176282258', 'https://openalex.org/W2316811866', 'https://openalex.org/W2334244908', 'https://openalex.org/W233953933', 'https://openalex.org/W2474221784', 'https://openalex.org/W2515862236', 'https://openalex.org/W2519436935', 'https://openalex.org/W2551912255', 'https://openalex.org/W2580344553', 'https://openalex.org/W2596453284', 'https://openalex.org/W2625169251', 'https://openalex.org/W2740920123', 'https://openalex.org/W2803940603', 'https://openalex.org/W2950040155', 'https://openalex.org/W2953112424'], 'related_works': ['https://openalex.org/W620566831', 'https://openalex.org/W4378085486', 'https://openalex.org/W4366602711', 'https://openalex.org/W4310092953', 'https://openalex.org/W4280602684', 'https://openalex.org/W3133980636', 'https://openalex.org/W2227393071', 'https://openalex.org/W2166141227', 'https://openalex.org/W2082102603', 'https://openalex.org/W1995350144'], 'abstract_inverted_index': {'Abstract': [0], 'Autism': [1], 'spectrum': [2], 'disorder': [3, 8], '(ASD)': [4], 'is': [5, 28], 'a': [6, 66], 'neurodevelopmental': [7], 'characterized': [9], 'by': [10], 'social': [11, 75], 'communication': [12], 'deficits': [13, 76], 'and': [14, 39, 82, 111, 116, 144, 190], 'repetitive/restricted': [15], 'behaviors.': [16], 'Although': [17], 'gene-environment': [18, 34, 67], 'interactions': [19], 'may': [20, 180], 'explain': [21], 'the': [22, 33, 74, 79, 88, 94, 102, 109, 122, 138, 147, 155, 162], 'heterogeneous': [23], 'etiology': [24], 'of': [25, 127, 137, 164], 'ASD,': [26], 'it': [27], 'still': [29], 'largely': [30], 'unknown': [31], 'how': [32], 'interaction': [35, 68, 163], 'affects': [36], 'behavioral': [37, 188], 'symptoms': [38, 173], 'pathophysiology': [40], 'in': [41, 78, 87, 101, 108, 132, 146, 187], 'ASD.': [42], 'To': [43], 'address': [44], 'these': [45], 'questions,': [46], 'we': [47], 'used': [48], 'Cntnap2': [49], 'knockout': [50], 'mice': [51], '(genetic': [52], 'factor,': [53, 63], 'G)': [54], 'exposed': [55], 'to': [56, 154, 183], 'valproic': [57], 'acid': [58], 'during': [59], 'embryonic': [60], 'development': [61], '(environmental': [62], 'E)': [64, 71], 'as': [65], '(G': [69], '×': [70, 90, 104, 149], 'model.': [72], 'Paradoxically,': [73], 'observed': [77], 'respective': [80], 'G': [81, 89, 103, 110, 148], 'E': [83, 91, 105, 112, 150], 'models': [84], 'were': [85, 142], 'improved': [86], 'model;': [92], 'however,': [93], 'high': [95], 'seizure': [96], 'susceptibility': [97], 'was': [98], 'more': [99], 'severe': [100], '-model': [106], 'than': [107], 'models.': [113, 124], 'Repetitive': [114], 'self-grooming': [115], 'hyperactivity': [117], 'did': [118], 'not': [119, 169], 'differ': [120], 'among': [121], 'three': [123], 'The': [125], 'amplitudes': [126], 'miniature': [128], 'excitatory': [129], 'postsynaptic': [130], 'currents': [131], 'layer': [133], '2/3': [134], 'pyramidal': [135], 'neurons': [136], 'medial': [139], 'prefrontal': [140], 'cortex': [141], 'aberrant': [143], 'similar': [145], 'model': [151], 'when': [152], 'compared': [153], 'control': [156], 'group.': [157], 'Our': [158], 'findings': [159], 'suggest': [160], 'that': [161], 'two': [165], 'risk': [166], 'factors': [167], 'does': [168], 'always': [170], 'aggravate': [171], 'ASD': [172], 'but': [174], 'can': [175], 'also': [176], 'alleviate': [177], 'them,': [178], 'which': [179], 'be': [181], 'key': [182], 'understanding': [184], 'individual': [185], 'differences': [186], 'phenotypes': [189], 'symptom': [191], 'intensity.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2966246125', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}], 'updated_date': '2024-09-13T14:35:47.492114', 'created_date': '2019-08-13'}