Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2952378194', 'doi': 'https://doi.org/10.1016/s0960-894x(01)00280-3', 'title': 'Synthesis of a novel C-10 spiro-epoxide of paclitaxel', 'display_name': 'Synthesis of a novel C-10 spiro-epoxide of paclitaxel', 'publication_year': 2001, 'publication_date': '2001-07-01', 'ids': {'openalex': 'https://openalex.org/W2952378194', 'doi': 'https://doi.org/10.1016/s0960-894x(01)00280-3', 'mag': '2952378194', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11425537'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0960-894x(01)00280-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30970080', 'display_name': 'Bioorganic & Medicinal Chemistry Letters', 'issn_l': '0960-894X', 'issn': ['0960-894X', '1464-3405'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022584491', 'display_name': 'Michael Walker', 'orcid': 'https://orcid.org/0000-0001-5422-821X'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Michael A. Walker', 'raw_affiliation_strings': ['Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA'], 'affiliations': [{'raw_affiliation_string': 'Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004852507', 'display_name': 'Timothy D. Johnson', 'orcid': 'https://orcid.org/0000-0002-7676-5347'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy D. Johnson', 'raw_affiliation_strings': ['Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA'], 'affiliations': [{'raw_affiliation_string': 'Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112443850', 'display_name': 'Stella Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stella Huang', 'raw_affiliation_strings': ['Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA'], 'affiliations': [{'raw_affiliation_string': 'Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112447701', 'display_name': 'D. M. VYAS', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dolatorai M. Vyas', 'raw_affiliation_strings': ['Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA'], 'affiliations': [{'raw_affiliation_string': 'Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050915947', 'display_name': 'John F. Kadow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John F. Kadow', 'raw_affiliation_strings': ['Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA'], 'affiliations': [{'raw_affiliation_string': 'Bristol-Myers Squibb, Pharmaceutical Research Institute, Richard L. Gelb Center for Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA', 'institution_ids': ['https://openalex.org/I4210091812']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5022584491'], 'corresponding_institution_ids': ['https://openalex.org/I4210091812'], 'apc_list': {'value': 3660, 'currency': 'USD', 'value_usd': 3660, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.432, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.540455, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 75, 'max': 77}, 'biblio': {'volume': '11', 'issue': '13', 'first_page': '1683', 'last_page': '1685'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11549', 'display_name': 'Synthetic Organic Chemistry Methods', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10092', 'display_name': 'Organometallic Complex Synthesis and Catalysis', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ylide', 'display_name': 'Ylide', 'score': 0.48451346}], 'concepts': [{'id': 'https://openalex.org/C2776920199', 'wikidata': 'https://www.wikidata.org/wiki/Q408028', 'display_name': 'Epoxide', 'level': 3, 'score': 0.9766776}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9124184}, {'id': 'https://openalex.org/C2777738585', 'wikidata': 'https://www.wikidata.org/wiki/Q170744', 'display_name': 'Ketone', 'level': 2, 'score': 0.7431773}, {'id': 'https://openalex.org/C2777292972', 'wikidata': 'https://www.wikidata.org/wiki/Q423762', 'display_name': 'Paclitaxel', 'level': 3, 'score': 0.64090955}, {'id': 'https://openalex.org/C2780407432', 'wikidata': 'https://www.wikidata.org/wiki/Q103230', 'display_name': 'Ether', 'level': 2, 'score': 0.5907605}, {'id': 'https://openalex.org/C134121241', 'wikidata': 'https://www.wikidata.org/wiki/Q899301', 'display_name': 'Yield (engineering)', 'level': 2, 'score': 0.5644305}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.50835437}, {'id': 'https://openalex.org/C2779167645', 'wikidata': 'https://www.wikidata.org/wiki/Q420686', 'display_name': 'Ylide', 'level': 2, 'score': 0.48451346}, {'id': 'https://openalex.org/C114373084', 'wikidata': 'https://www.wikidata.org/wiki/Q273499', 'display_name': 'Chemical synthesis', 'level': 3, 'score': 0.4491319}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.34947833}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.16226399}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08554658}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.08190644}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C191897082', 'wikidata': 'https://www.wikidata.org/wiki/Q11467', 'display_name': 'Metallurgy', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004852', 'descriptor_name': 'Epoxy Compounds', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004852', 'descriptor_name': 'Epoxy Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0960-894x(01)00280-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30970080', 'display_name': 'Bioorganic & Medicinal Chemistry Letters', 'issn_l': '0960-894X', 'issn': ['0960-894X', '1464-3405'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11425537', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.59, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 11, 'referenced_works': ['https://openalex.org/W1964210649', 'https://openalex.org/W1975533327', 'https://openalex.org/W2020645617', 'https://openalex.org/W2024235006', 'https://openalex.org/W2027648702', 'https://openalex.org/W2091356084', 'https://openalex.org/W2094066101', 'https://openalex.org/W2108923495', 'https://openalex.org/W2125724543', 'https://openalex.org/W2950626215', 'https://openalex.org/W4233445595'], 'related_works': ['https://openalex.org/W4285806762', 'https://openalex.org/W4236208931', 'https://openalex.org/W2952450011', 'https://openalex.org/W2091420511', 'https://openalex.org/W2063691549', 'https://openalex.org/W2050728908', 'https://openalex.org/W2050423903', 'https://openalex.org/W2038894414', 'https://openalex.org/W2015592083', 'https://openalex.org/W2006429373'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2952378194', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-16T17:14:41.653630', 'created_date': '2019-06-27'}