Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2952219023', 'doi': 'https://doi.org/10.1021/ol503288e', 'title': 'Directed Metalation of 1-Ester-Substituted Indolizines: Base/Electrophile-Controlled Regioselective Functionalization', 'display_name': 'Directed Metalation of 1-Ester-Substituted Indolizines: Base/Electrophile-Controlled Regioselective Functionalization', 'publication_year': 2014, 'publication_date': '2014-12-26', 'ids': {'openalex': 'https://openalex.org/W2952219023', 'doi': 'https://doi.org/10.1021/ol503288e', 'mag': '2952219023', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25541908'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ol503288e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201989124', 'display_name': 'Organic Letters', 'issn_l': '1523-7052', 'issn': ['1523-7052', '1523-7060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027584912', 'display_name': 'M. Amaral', 'orcid': 'https://orcid.org/0000-0001-7974-4480'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Mônica F. Z. J. Amaral', 'raw_affiliation_strings': ['Núcleo\rde Pesquisas em Produtos Naturais e Sintéticos, Faculdade de\rCiências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto - SP 14040-903, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Núcleo\rde Pesquisas em Produtos Naturais e Sintéticos, Faculdade de\rCiências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto - SP 14040-903, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047553450', 'display_name': 'Amanda A. Baumgartner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Amanda A. Baumgartner', 'raw_affiliation_strings': ['Núcleo\rde Pesquisas em Produtos Naturais e Sintéticos, Faculdade de\rCiências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto - SP 14040-903, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Núcleo\rde Pesquisas em Produtos Naturais e Sintéticos, Faculdade de\rCiências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto - SP 14040-903, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033140936', 'display_name': 'Ricardo Vessecchi', 'orcid': 'https://orcid.org/0000-0001-8472-3190'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Ricardo Vessecchi', 'raw_affiliation_strings': ['Departamento\rde Química, Faculdade de Filosofia, Ciências e Letras\rde Ribeirão Preto, Universidade de São Paulo, Av.\rBandeirantes 3900, Ribeirão Preto -\rSP 14040-901, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Departamento\rde Química, Faculdade de Filosofia, Ciências e Letras\rde Ribeirão Preto, Universidade de São Paulo, Av.\rBandeirantes 3900, Ribeirão Preto -\rSP 14040-901, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039480602', 'display_name': 'Giuliano C. Clososki', 'orcid': 'https://orcid.org/0000-0001-7605-4150'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Giuliano C. Clososki', 'raw_affiliation_strings': ['Núcleo\rde Pesquisas em Produtos Naturais e Sintéticos, Faculdade de\rCiências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto - SP 14040-903, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Núcleo\rde Pesquisas em Produtos Naturais e Sintéticos, Faculdade de\rCiências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, Ribeirão Preto - SP 14040-903, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.451, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 51, 'citation_normalized_percentile': {'value': 0.899842, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '17', 'issue': '2', 'first_page': '238', 'last_page': '241'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13230', 'display_name': 'Indolizine Synthesis and Bioactivity Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13230', 'display_name': 'Indolizine Synthesis and Bioactivity Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12228', 'display_name': 'Organometallic Chemistry and Metalation', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13105', 'display_name': 'Chemistry of Pyrrolobenzodiazepines', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/metalation', 'display_name': 'Metalation', 'score': 0.91302747}, {'id': 'https://openalex.org/keywords/surface-modification', 'display_name': 'Surface modification', 'score': 0.5696425}, {'id': 'https://openalex.org/keywords/indolizines', 'display_name': 'Indolizines', 'score': 0.546383}, {'id': 'https://openalex.org/keywords/metal-catalyzed-reactions', 'display_name': 'Metal-Catalyzed Reactions', 'score': 0.527207}, {'id': 'https://openalex.org/keywords/base', 'display_name': 'Base (topology)', 'score': 0.48219457}], 'concepts': [{'id': 'https://openalex.org/C50027330', 'wikidata': 'https://www.wikidata.org/wiki/Q908086', 'display_name': 'Electrophile', 'level': 3, 'score': 0.940798}, {'id': 'https://openalex.org/C59759590', 'wikidata': 'https://www.wikidata.org/wiki/Q2275927', 'display_name': 'Regioselectivity', 'level': 3, 'score': 0.93058634}, {'id': 'https://openalex.org/C2775855785', 'wikidata': 'https://www.wikidata.org/wiki/Q2270356', 'display_name': 'Metalation', 'level': 2, 'score': 0.91302747}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9029901}, {'id': 'https://openalex.org/C115537861', 'wikidata': 'https://www.wikidata.org/wiki/Q7645993', 'display_name': 'Surface modification', 'level': 2, 'score': 0.5696425}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.50916857}, {'id': 'https://openalex.org/C42058472', 'wikidata': 'https://www.wikidata.org/wiki/Q810214', 'display_name': 'Base (topology)', 'level': 2, 'score': 0.48219457}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.3798431}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.14571702}, {'id': 'https://openalex.org/C134306372', 'wikidata': 'https://www.wikidata.org/wiki/Q7754', 'display_name': 'Mathematical analysis', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C147789679', 'wikidata': 'https://www.wikidata.org/wiki/Q11372', 'display_name': 'Physical chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007212', 'descriptor_name': 'Indolizines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D007212', 'descriptor_name': 'Indolizines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D009942', 'descriptor_name': 'Organometallic Compounds', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010165', 'descriptor_name': 'Palladium', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004952', 'descriptor_name': 'Esters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007212', 'descriptor_name': 'Indolizines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009942', 'descriptor_name': 'Organometallic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010165', 'descriptor_name': 'Palladium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013237', 'descriptor_name': 'Stereoisomerism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ol503288e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201989124', 'display_name': 'Organic Letters', 'issn_l': '1523-7052', 'issn': ['1523-7052', '1523-7060'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25541908', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320997', 'funder_display_name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'award_id': '2011/20742-6'}, {'funder': 'https://openalex.org/F4320320997', 'funder_display_name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'award_id': '2013/04766-8'}, {'funder': 'https://openalex.org/F4320322025', 'funder_display_name': 'Conselho Nacional de Desenvolvimento Científico e Tecnológico', 'award_id': '304734/2013-6'}], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1963737263', 'https://openalex.org/W1964477673', 'https://openalex.org/W1979975037', 'https://openalex.org/W1983357954', 'https://openalex.org/W1992035893', 'https://openalex.org/W1998497459', 'https://openalex.org/W2001258368', 'https://openalex.org/W2006991085', 'https://openalex.org/W2012722206', 'https://openalex.org/W2014923873', 'https://openalex.org/W2022049607', 'https://openalex.org/W2022996984', 'https://openalex.org/W2026157050', 'https://openalex.org/W2028366716', 'https://openalex.org/W2045660810', 'https://openalex.org/W2059015432', 'https://openalex.org/W2070596499', 'https://openalex.org/W2072984000', 'https://openalex.org/W2073176780', 'https://openalex.org/W2073890312', 'https://openalex.org/W2076540524', 'https://openalex.org/W2082978010', 'https://openalex.org/W2100127935', 'https://openalex.org/W2116368252', 'https://openalex.org/W2117773040', 'https://openalex.org/W2121765510', 'https://openalex.org/W2125839426', 'https://openalex.org/W2127636935', 'https://openalex.org/W2143533796', 'https://openalex.org/W2143981217', 'https://openalex.org/W2144329841', 'https://openalex.org/W2148284063', 'https://openalex.org/W2151172493', 'https://openalex.org/W2154574808', 'https://openalex.org/W2159632037', 'https://openalex.org/W2159887065', 'https://openalex.org/W2164595616', 'https://openalex.org/W2171490962', 'https://openalex.org/W2317529105', 'https://openalex.org/W2323912502', 'https://openalex.org/W2328100302', 'https://openalex.org/W2949061994', 'https://openalex.org/W2951070460', 'https://openalex.org/W2951442251'], 'related_works': ['https://openalex.org/W4240355085', 'https://openalex.org/W2953245046', 'https://openalex.org/W2952219023', 'https://openalex.org/W2951937329', 'https://openalex.org/W2950531886', 'https://openalex.org/W2070394192', 'https://openalex.org/W2059203659', 'https://openalex.org/W2008633520', 'https://openalex.org/W1997798257', 'https://openalex.org/W1996622215'], 'abstract_inverted_index': {'A': [0], 'variety': [1], 'of': [2, 14, 36, 39, 47, 57], 'C-2': [3], 'and': [4, 60], 'C-5': [5], 'difunctionalized': [6, 40], 'indolizines': [7, 16, 41], 'have': [8], 'been': [9], 'prepared': [10], 'through': [11], 'the': [12, 34, 48, 55, 58], 'reaction': [13, 23, 49], '1-ester-substituted': [15], 'with': [17, 24], 'organometallic': [18], 'bases': [19], 'followed': [20], 'by': [21, 54], 'a': [22, 37], 'different': [25], 'electrophiles.': [26], 'Metalation': [27], 'takes': [28], 'place': [29], 'under': [30], 'mild': [31], 'conditions': [32], 'allowing': [33], 'isolation': [35], 'number': [38], 'in': [42], 'good': [43], 'yields.': [44], 'The': [45], 'regioselectivity': [46], 'appears': [50], 'to': [51], 'be': [52], 'governed': [53], 'nature': [56], 'base': [59], 'electrophile.': [61]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2952219023', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}], 'updated_date': '2024-09-01T07:51:39.168367', 'created_date': '2019-06-27'}