Title: β-Aminoenones in the regioselective synthesis of 1,3,5-trialkylpyrazoles. The influence of the substituents in the mechanism and the regioselectivity of the reaction
Abstract: β-Aminoenones react with monoalkyl hydrazines to give regioselectively 1,3,5-trisubstituted pyrazoles. The mechanism and level of regioselectivity depend on both the substitution pattern of the substrates and the reaction conditions. When the least bulky substituent is attached at the β-position of the enone, a high regioselectivity is obtained, usually higher than that from equivalent β-diketones. If the β-substituent is the bulkiest group, the regioselectivity decreases. Nevertheless, in the conditions reported in this paper, it is possible to prepare pyrazoles not obtainable from β-diketones.
Publication Year: 1998
Publication Date: 1998-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 11
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