Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2007369689', 'doi': 'https://doi.org/10.1042/bj20080413', 'title': 'Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining', 'display_name': 'Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining', 'publication_year': 2009, 'publication_date': '2009-01-16', 'ids': {'openalex': 'https://openalex.org/W2007369689', 'doi': 'https://doi.org/10.1042/bj20080413', 'mag': '2007369689', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19133841', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2975036'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20080413', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2975036?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051408001', 'display_name': 'Brandi L. Mahaney', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Brandi\xa0L. Mahaney', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.', 'institution_ids': ['https://openalex.org/I168635309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035430209', 'display_name': 'Katheryn Meek', 'orcid': 'https://orcid.org/0000-0002-0454-4414'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katheryn Meek', 'raw_affiliation_strings': ['College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, U.S.A.', 'institution_ids': ['https://openalex.org/I87216513']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035453779', 'display_name': 'Susan P. Lees‐Miller', 'orcid': 'https://orcid.org/0000-0001-5809-2516'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Susan\xa0P. Lees-Miller', 'raw_affiliation_strings': ['College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, U.S.A.', 'Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1'], 'affiliations': [{'raw_affiliation_string': 'College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, U.S.A.', 'institution_ids': ['https://openalex.org/I87216513']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1', 'institution_ids': ['https://openalex.org/I168635309']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.742, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 659, 'citation_normalized_percentile': {'value': 0.999702, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '417', 'issue': '3', 'first_page': '639', 'last_page': '650'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10433', 'display_name': 'Genotoxicity and Carcinogenesis Mechanisms', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Epidemiology and Treatment of Childhood Leukemia', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ku80', 'display_name': 'Ku80', 'score': 0.7994412}, {'id': 'https://openalex.org/keywords/non-homologous-end-joining', 'display_name': 'Non-homologous end joining', 'score': 0.7716395}, {'id': 'https://openalex.org/keywords/ku70', 'display_name': 'Ku70', 'score': 0.7385945}, {'id': 'https://openalex.org/keywords/dna-damage', 'display_name': 'DNA Damage', 'score': 0.580298}, {'id': 'https://openalex.org/keywords/dna-pkcs', 'display_name': 'DNA-PKcs', 'score': 0.54004085}], 'concepts': [{'id': 'https://openalex.org/C145803527', 'wikidata': 'https://www.wikidata.org/wiki/Q18032396', 'display_name': 'DNA repair protein XRCC4', 'level': 5, 'score': 0.8649434}, {'id': 'https://openalex.org/C193104389', 'wikidata': 'https://www.wikidata.org/wiki/Q18032397', 'display_name': 'Ku80', 'level': 5, 'score': 0.7994412}, {'id': 'https://openalex.org/C122917832', 'wikidata': 'https://www.wikidata.org/wiki/Q2065945', 'display_name': 'Non-homologous end joining', 'level': 4, 'score': 0.7716395}, {'id': 'https://openalex.org/C2780919815', 'wikidata': 'https://www.wikidata.org/wiki/Q6440930', 'display_name': 'Ku70', 'level': 4, 'score': 0.7385945}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.67489284}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.6266973}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.5825731}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5725666}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5572334}, {'id': 'https://openalex.org/C68748289', 'wikidata': 'https://www.wikidata.org/wiki/Q18030783', 'display_name': 'DNA-PKcs', 'level': 4, 'score': 0.54004085}, {'id': 'https://openalex.org/C102744134', 'wikidata': 'https://www.wikidata.org/wiki/Q22280388', 'display_name': 'Homologous recombination', 'level': 3, 'score': 0.51816165}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.47949082}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.40487576}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38816452}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.2881961}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28150612}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20877725}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.17857453}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.07526451}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053903', 'descriptor_name': 'DNA Breaks, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045643', 'descriptor_name': 'DNA Repair Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011839', 'descriptor_name': 'Radiation, Ionizing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20080413', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2975036', 'pdf_url': 'https://europepmc.org/articles/pmc2975036?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975036', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19133841', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2975036', 'pdf_url': 'https://europepmc.org/articles/pmc2975036?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.57, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 181, 'referenced_works': ['https://openalex.org/W104404459', 'https://openalex.org/W1491876634', 'https://openalex.org/W1513105954', 'https://openalex.org/W1532833901', 'https://openalex.org/W1861478519', 'https://openalex.org/W1889579009', 'https://openalex.org/W1897299346', 'https://openalex.org/W1940074648', 'https://openalex.org/W1950737868', 'https://openalex.org/W1963613246', 'https://openalex.org/W1964940495', 'https://openalex.org/W1965239527', 'https://openalex.org/W1965531809', 'https://openalex.org/W1968813490', 'https://openalex.org/W1969331397', 'https://openalex.org/W1972222169', 'https://openalex.org/W1972313386', 'https://openalex.org/W1972603998', 'https://openalex.org/W1972725000', 'https://openalex.org/W1974446138', 'https://openalex.org/W1977106716', 'https://openalex.org/W1977145510', 'https://openalex.org/W1979303367', 'https://openalex.org/W1979568780', 'https://openalex.org/W1979583222', 'https://openalex.org/W1983218764', 'https://openalex.org/W1983947591', 'https://openalex.org/W1984124996', 'https://openalex.org/W1985363523', 'https://openalex.org/W1985643620', 'https://openalex.org/W1986262530', 'https://openalex.org/W1986448084', 'https://openalex.org/W1987369963', 'https://openalex.org/W1987577420', 'https://openalex.org/W1987705460', 'https://openalex.org/W1993916591', 'https://openalex.org/W1996271528', 'https://openalex.org/W1997576768', 'https://openalex.org/W1999940496', 'https://openalex.org/W2000572584', 'https://openalex.org/W2001784394', 'https://openalex.org/W2002231685', 'https://openalex.org/W2002420019', 'https://openalex.org/W2004575615', 'https://openalex.org/W2004864721', 'https://openalex.org/W2007784993', 'https://openalex.org/W2008181290', 'https://openalex.org/W2008415057', 'https://openalex.org/W2009639920', 'https://openalex.org/W2010711320', 'https://openalex.org/W2011522975', 'https://openalex.org/W2013580891', 'https://openalex.org/W2013694269', 'https://openalex.org/W2013767951', 'https://openalex.org/W2015414930', 'https://openalex.org/W2015925058', 'https://openalex.org/W2016949180', 'https://openalex.org/W2017253520', 'https://openalex.org/W2019571003', 'https://openalex.org/W2020151423', 'https://openalex.org/W2022685241', 'https://openalex.org/W2023324317', 'https://openalex.org/W2026233878', 'https://openalex.org/W2027379868', 'https://openalex.org/W2028128317', 'https://openalex.org/W2028957578', 'https://openalex.org/W2029896618', 'https://openalex.org/W2031365072', 'https://openalex.org/W2038596673', 'https://openalex.org/W2038875604', 'https://openalex.org/W2040234559', 'https://openalex.org/W2043776284', 'https://openalex.org/W2043990544', 'https://openalex.org/W2044963929', 'https://openalex.org/W2045164156', 'https://openalex.org/W2046592596', 'https://openalex.org/W2046723353', 'https://openalex.org/W2049018115', 'https://openalex.org/W2049123604', 'https://openalex.org/W2050639142', 'https://openalex.org/W2051148032', 'https://openalex.org/W2051550009', 'https://openalex.org/W2053016947', 'https://openalex.org/W2053399194', 'https://openalex.org/W2053528405', 'https://openalex.org/W2059493608', 'https://openalex.org/W2060734146', 'https://openalex.org/W2061060103', 'https://openalex.org/W2061889131', 'https://openalex.org/W2061907379', 'https://openalex.org/W2062445688', 'https://openalex.org/W2062520229', 'https://openalex.org/W2064605123', 'https://openalex.org/W2064642458', 'https://openalex.org/W2065872558', 'https://openalex.org/W2066865996', 'https://openalex.org/W2067618383', 'https://openalex.org/W2067982379', 'https://openalex.org/W2068359474', 'https://openalex.org/W2069651213', 'https://openalex.org/W2069964111', 'https://openalex.org/W2070395126', 'https://openalex.org/W2071206740', 'https://openalex.org/W2071809333', 'https://openalex.org/W2072209077', 'https://openalex.org/W2074779681', 'https://openalex.org/W2075351905', 'https://openalex.org/W2075490767', 'https://openalex.org/W2076768032', 'https://openalex.org/W2077300582', 'https://openalex.org/W2077892030', 'https://openalex.org/W2078994441', 'https://openalex.org/W2080404967', 'https://openalex.org/W2080666790', 'https://openalex.org/W2084919692', 'https://openalex.org/W2085422820', 'https://openalex.org/W2086997734', 'https://openalex.org/W2087470609', 'https://openalex.org/W2088474558', 'https://openalex.org/W2088698677', 'https://openalex.org/W2089138444', 'https://openalex.org/W2092503176', 'https://openalex.org/W2092863175', 'https://openalex.org/W2093624810', 'https://openalex.org/W2093814864', 'https://openalex.org/W2096136751', 'https://openalex.org/W2096649909', 'https://openalex.org/W2096753300', 'https://openalex.org/W2096764359', 'https://openalex.org/W2096782300', 'https://openalex.org/W2097517187', 'https://openalex.org/W2099627146', 'https://openalex.org/W2100340678', 'https://openalex.org/W2100518470', 'https://openalex.org/W2102757030', 'https://openalex.org/W2103007290', 'https://openalex.org/W2103874933', 'https://openalex.org/W2104726963', 'https://openalex.org/W2106225536', 'https://openalex.org/W2110817748', 'https://openalex.org/W2111802021', 'https://openalex.org/W2112678851', 'https://openalex.org/W2113650741', 'https://openalex.org/W2114280096', 'https://openalex.org/W2116050965', 'https://openalex.org/W2116343025', 'https://openalex.org/W2116718924', 'https://openalex.org/W2117195020', 'https://openalex.org/W2117529453', 'https://openalex.org/W2121070277', 'https://openalex.org/W2121432854', 'https://openalex.org/W2124677401', 'https://openalex.org/W2124995142', 'https://openalex.org/W2125057960', 'https://openalex.org/W2127173305', 'https://openalex.org/W2127720624', 'https://openalex.org/W2129777487', 'https://openalex.org/W2130266193', 'https://openalex.org/W2135735491', 'https://openalex.org/W2136399386', 'https://openalex.org/W2137239016', 'https://openalex.org/W2138201502', 'https://openalex.org/W2143254803', 'https://openalex.org/W2143629217', 'https://openalex.org/W2144290097', 'https://openalex.org/W2144512576', 'https://openalex.org/W2146176862', 'https://openalex.org/W2148760839', 'https://openalex.org/W2149047619', 'https://openalex.org/W2149912948', 'https://openalex.org/W2152440925', 'https://openalex.org/W2153039677', 'https://openalex.org/W2156063202', 'https://openalex.org/W2158279161', 'https://openalex.org/W2160505835', 'https://openalex.org/W2162412306', 'https://openalex.org/W2168924996', 'https://openalex.org/W2169009248', 'https://openalex.org/W2171672464', 'https://openalex.org/W2187759803', 'https://openalex.org/W2477626371'], 'related_works': ['https://openalex.org/W2947679604', 'https://openalex.org/W2552954439', 'https://openalex.org/W2169008015', 'https://openalex.org/W2094532656', 'https://openalex.org/W2047804529', 'https://openalex.org/W2046572356', 'https://openalex.org/W2041529030', 'https://openalex.org/W2025951531', 'https://openalex.org/W2007369689', 'https://openalex.org/W1873396772'], 'abstract_inverted_index': {'DNA': [0, 11, 109, 122], 'DSBs': [1, 44, 51, 70], '(double-strand': [2], 'breaks)': [3], 'are': [4, 87], 'considered': [5], 'the': [6, 62, 66, 88, 141, 151, 160], 'most': [7], 'cytotoxic': [8], 'type': [9], 'of': [10, 61, 68, 97, 150, 153, 162], 'lesion.': [12], 'They': [13], 'can': [14, 45], 'be': [15], 'introduced': [16], 'by': [17, 25, 33], 'external': [18], 'sources': [19], 'such': [20, 28, 37], 'as': [21, 29, 38], 'IR': [22], '(ionizing': [23], 'radiation),': [24], 'chemotherapeutic': [26], 'drugs': [27], 'topoisomerase': [30], 'poisons': [31], 'and': [32, 57, 112, 125, 130, 158, 164], 'normal': [34], 'biological': [35], 'processes': [36], 'V(D)J': [39], 'recombination.': [40], 'If': [41, 49], 'left': [42], 'unrepaired,': [43], 'cause': [46], 'cell': [47], 'death.': [48], 'misrepaired,': [50], 'may': [52, 135], 'lead': [53], 'to': [54], 'chromosomal': [55], 'translocations': [56], 'genomic': [58], 'instability.': [59], 'One': [60], 'major': [63], 'pathways': [64], 'for': [65, 82], 'repair': [67], 'IR-induced': [69], 'in': [71, 84, 155, 167], 'mammalian': [72, 85, 156], 'cells': [73, 86, 157], 'is': [74], 'NHEJ': [75, 83, 154], '(non-homologous': [76], 'end-joining).': [77], 'The': [78], 'main': [79], 'proteins': [80], 'required': [81], 'Ku': [89], 'heterodimer': [90], '(Ku70/80': [91], 'heterodimer),': [92], 'DNA-PKcs': [93, 163], '[the': [94], 'catalytic': [95], 'subunit': [96], 'DNA-PK': [98], '(DNA-dependent': [99], 'protein': [100], 'kinase)],': [101], 'Artemis,': [102], 'XRCC4': [103], '(X-ray-complementing': [104], 'Chinese': [105], 'hamster': [106], 'gene': [107], '4),': [108], 'ligase': [110], 'IV': [111], 'XLF': [113], '(XRCC4-like': [114], 'factor;': [115], 'also': [116, 136], 'called': [117], 'Cernunnos).': [118], 'Additional': [119], 'proteins,': [120], 'including': [121], 'polymerases': [123], 'μ': [124], 'λ,': [126], 'PNK': [127], '(polynucleotide': [128], 'kinase)': [129], 'WRN': [131], "(Werner's": [132], 'Syndrome': [133], 'helicase),': [134], 'play': [137], 'a': [138], 'role.': [139], 'In': [140], 'present': [142], 'review,': [143], 'we': [144], 'will': [145], 'discuss': [146, 159], 'our': [147], 'current': [148], 'understanding': [149], 'mechanism': [152], 'roles': [161], 'DNA-PK-mediated': [165], 'phosphorylation': [166], 'NHEJ.': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2007369689', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 25}, {'year': 2021, 'cited_by_count': 43}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 38}, {'year': 2017, 'cited_by_count': 37}, {'year': 2016, 'cited_by_count': 33}, {'year': 2015, 'cited_by_count': 47}, {'year': 2014, 'cited_by_count': 55}, {'year': 2013, 'cited_by_count': 60}, {'year': 2012, 'cited_by_count': 70}], 'updated_date': '2024-09-09T01:22:46.593951', 'created_date': '2016-06-24'}