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'either': [6], 'directly': [7], 'in': [8, 30, 42, 58, 119, 132, 143, 149, 161, 165, 189, 208, 260, 338, 348, 397, 411, 414, 419, 428, 454, 500, 528, 531, 546, 569, 579, 600, 611, 685, 726, 742, 774, 791, 799, 829], 'an': [9, 376], 'unchanged': [10], 'form': [11], 'or': [12, 22, 52, 115, 148], 'partially': [13], 'metabolized.': [14], 'The': [15, 27, 177, 297, 316, 401, 465, 508, 592, 632, 648, 713, 738, 755, 769, 824], 'discharge': [16], 'is': [17, 196], 'usually': [18], 'through': [19, 23, 34, 50, 71, 451], 'untreated': [20, 412], 'waste': [21, 60, 128], 'wastewater': [24, 36, 77, 190, 262, 305, 344, 413, 416], 'treatment': [25, 37, 78, 263, 417, 425, 651, 672], 'effluents.': [26], 'stable': [28], 'antibiotics': [29, 87, 156, 204, 237, 313, 337, 408, 444, 494, 511, 566, 593, 689, 696, 746, 752, 764, 773, 828], 'reduced': [31], 'amounts': [32], 'persist': [33], 'processes': [38], 'and': [39, 61, 68, 108, 151, 164, 172, 192, 217, 224, 248, 290, 375, 394, 403, 427, 431, 453, 463, 470, 483, 495, 575, 626, 662, 734, 783], 'end': [40], 'up': [41], 'receiving': [43, 602], 'waters,': [44], 'where': [45, 690], 'they': [46], 'may': [47, 64, 89, 124, 135], 'impact': [48, 66, 701, 819], 'crops': [49, 67], 'irrigation': [51], 'affect': [53], 'drinking': [54], 'water': [55, 102, 145, 434, 603], 'intakes.': [56], 'sludge': [62, 660], 'fractions': [63], 'similarly': [65], 'arable': [69], 'land': [70], 'their': [72, 95, 839], 'use': [73, 111, 229], 'as': [74, 116, 205, 342, 718], 'fertilizers.': [75], 'Conventional': [76], 'plants': [79, 264, 418], 'not': [81, 526], 'designed': [82], 'for': [83, 112, 137, 235, 292, 300, 311, 462, 490, 550, 605, 637, 707], 'removal': [85, 635], 'of': [86, 110, 185, 199, 230, 252, 269, 273, 281, 314, 318, 331, 334, 336, 373, 405, 442, 457, 467, 473, 503, 510, 534, 544, 572, 582, 607, 688, 694, 702, 710, 715, 721, 740, 745, 749, 751, 758, 772, 802, 820, 826], 'but': [88, 194], 'a': [91, 197, 215, 332, 351, 719, 727, 731], 'varying': [92], 'extent': [93], 'reduce': [94], 'concentrations.': [96, 400, 841], 'Their': [97], 'quantitative': [98], 'occurrence': [99, 404], 'within': [100], 'matrices': [103], 'depends': [104], 'on': [105, 182, 227, 658, 815], 'frequency': [107, 543], 'quantities': [109], 'therapeutic': [113], 'purposes': [114], 'growth': [117], 'promoters': [118], 'animal': [120, 166], 'production.': [121], 'Additional': [122], 'inputs': [123], 'emanate': [125], 'from': [126, 322, 477, 513, 555, 642], 'individual': [127], 'discharges.': [129], 'present': [131], 'sub-inhibitory': [133], 'concentrations': [134, 597], 'predicate': [136], 'resistance': [138], 'among': [139], 'resident': [141], 'bacteria': [142, 188], 'matrix,': [146], 'biofilms': [147], 'humans': [150], 'animals.': [152], 'In': [153, 212, 436], 'South': [154, 209], 'Africa': [155, 210], 'extensively': [158], 'used': [159], 'both': [160], 'human': [162], 'therapy': [163], 'husbandry': [167], 'without': [168], 'clearly': [169], 'followed': [170], 'regulations': [171], 'sometimes': [174], 'readily': [175], 'available.': [176], 'available': [178], 'studies': [179], 'have': [180, 520], 'focused': [181], 'presence': [184, 714], 'antibiotic': [186], 'resistant': [187], 'influent': [191, 345, 438, 548, 571, 840], 'effluent': [193, 430, 709], 'there': [195], 'paucity': [198], 'information': [200], 'relating': [201], 'these': [203, 374, 677, 821], 'emerging': [206], 'contaminants': [207], 'wastewater.': [211], 'this': [213, 349], 'thesis': [214], 'rapid': [216], 'sensitive': [218], 'analytical': [219], 'methodology': [220], 'was': [221, 255, 307, 367, 409, 578, 668, 697, 705, 724, 747, 778, 797], 'initially': [222], 'assessed': [223, 410, 493, 654], 'applied,': [225], 'based': [226], 'HPLC/diode': [231], 'array': [232], 'UV': [233, 796], 'detector': [234], 'six': [236], '(ethionamide': [238], '(ETI),': [239], 'metronidazole': [240], '(MET),': [241], 'trimethoprim': [242], '(TRI),': [243], 'ciprofloxacin': [244], '(CIP),': [245], 'sulfisoxazole': 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