S136. Is Ketamine Metabolism to Norketamine and (2R,6R)-HNK Necessary for its Sustained Antidepressant-Like Activity and Cortical Neurotransmitter Release in Mice?

Name: Work Video:
Duration: 3 min 30 s
Thi Mai Loan Nguyen; Céline Defaix; Indira Mendez‐David; Thu Ha Pham; Jean‐Philippe Guilloux; Isabelle Etting; Jean‐Claude Alvarez; Josephine C. McGowan; Denis J. David; Christine A. Denny; Alain M. Gardier
{'id': 'https://openalex.org/W2945135914', 'doi': 'https://doi.org/10.1016/j.biopsych.2019.03.887', 'title': 'S136. Is Ketamine Metabolism to Norketamine and (2R,6R)-HNK Necessary for its Sustained Antidepressant-Like Activity and Cortical Neurotransmitter Release in Mice?', 'display_name': 'S136. Is Ketamine Metabolism to Norketamine and (2R,6R)-HNK Necessary for its Sustained Antidepressant-Like Activity and Cortical Neurotransmitter Release in Mice?', 'publication_year': 2019, 'publication_date': '2019-05-01', 'ids': {'openalex': 'https://openalex.org/W2945135914', 'doi': 'https://doi.org/10.1016/j.biopsych.2019.03.887', 'mag': '2945135914'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biopsych.2019.03.887', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205482884', 'display_name': 'Biological Psychiatry', 'issn_l': '0006-3223', 'issn': ['0006-3223', '1873-2402'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084562500', 'display_name': 'Thi Mai Loan Nguyen', 'orcid': 'https://orcid.org/0009-0002-9397-3364'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thi Mai Loan Nguyen', 'raw_affiliation_strings': ['Univ Paris-Sud'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067458824', 'display_name': 'Céline Defaix', 'orcid': 'https://orcid.org/0000-0002-2354-855X'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Celine Defaix', 'raw_affiliation_strings': ['Univ Paris-Sud'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050500376', 'display_name': 'Indira Mendez‐David', 'orcid': 'https://orcid.org/0000-0001-9759-0833'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Indira Mendez-David', 'raw_affiliation_strings': ['Univ Paris-Sud'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073022707', 'display_name': 'Thu Ha Pham', 'orcid': 'https://orcid.org/0000-0002-7974-7881'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thu Ha Pham', 'raw_affiliation_strings': ['Univ Paris-Sud'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063839083', 'display_name': 'Jean‐Philippe Guilloux', 'orcid': 'https://orcid.org/0000-0003-0982-3751'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210096930', 'display_name': 'Cooperativa de Ensino Superior Politécnico e Universitário', 'ror': 'https://ror.org/00w7bj245', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I4210096930']}, {'id': 'https://openalex.org/I4210103698', 'display_name': 'Centre de recherche en Epidémiologie et Santé des Populations', 'ror': 'https://ror.org/01ed4t417', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I195731000', 'https://openalex.org/I277688954', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210103698', 'https://openalex.org/I4210164847']}], 'countries': ['FR', 'PT'], 'is_corresponding': False, 'raw_author_name': 'Jean-Philippe Guilloux', 'raw_affiliation_strings': ['Université Paris Sud - CESP - UMRS1178'], 'affiliations': [{'raw_affiliation_string': 'Université Paris Sud - CESP - UMRS1178', 'institution_ids': ['https://openalex.org/I102197404', 'https://openalex.org/I4210096930', 'https://openalex.org/I4210103698']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089266507', 'display_name': 'Isabelle Etting', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134648', 'display_name': 'Hôpital Raymond-Poincaré', 'ror': 'https://ror.org/03pef0w96', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210134648']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Isabelle Etting', 'raw_affiliation_strings': ['Centre Hospitalier Univ R. Poincaré, Garches'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Univ R. Poincaré, Garches', 'institution_ids': ['https://openalex.org/I4210134648']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040351790', 'display_name': 'Jean‐Claude Alvarez', 'orcid': 'https://orcid.org/0000-0001-5344-9475'}, 'institutions': [{'id': 'https://openalex.org/I4210134648', 'display_name': 'Hôpital Raymond-Poincaré', 'ror': 'https://ror.org/03pef0w96', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210134648']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Claude Alvarez', 'raw_affiliation_strings': ['Centre Hospitalier Univ R. Poincaré, Garches'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Univ R. Poincaré, Garches', 'institution_ids': ['https://openalex.org/I4210134648']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054492364', 'display_name': 'Josephine C. McGowan', 'orcid': 'https://orcid.org/0000-0001-5132-3377'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Josephine C. McGowan', 'raw_affiliation_strings': ['Columbia University'], 'affiliations': [{'raw_affiliation_string': 'Columbia University', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062468145', 'display_name': 'Denis J. David', 'orcid': 'https://orcid.org/0000-0002-0506-6688'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Denis J. David', 'raw_affiliation_strings': ['Univ Paris-Sud'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud', 'institution_ids': ['https://openalex.org/I102197404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027515817', 'display_name': 'Christine A. Denny', 'orcid': 'https://orcid.org/0000-0002-6926-2020'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine A. Denny', 'raw_affiliation_strings': ['Columbia University'], 'affiliations': [{'raw_affiliation_string': 'Columbia University', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064219832', 'display_name': 'Alain M. Gardier', 'orcid': 'https://orcid.org/0000-0002-0320-4880'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alain Gardier', 'raw_affiliation_strings': ['Univ Paris-Sud'], 'affiliations': [{'raw_affiliation_string': 'Univ Paris-Sud', 'institution_ids': ['https://openalex.org/I102197404']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4990, 'currency': 'USD', 'value_usd': 4990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '85', 'issue': '10', 'first_page': 'S349', 'last_page': 'S349'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11071', 'display_name': 'Treatment of Major Depression', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11071', 'display_name': 'Treatment of Major Depression', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9694, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9222, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurochemical', 'display_name': 'Neurochemical', 'score': 0.9278297}], 'concepts': [{'id': 'https://openalex.org/C25876315', 'wikidata': 'https://www.wikidata.org/wiki/Q15197465', 'display_name': 'Neurochemical', 'level': 2, 'score': 0.9278297}, {'id': 'https://openalex.org/C2779177272', 'wikidata': 'https://www.wikidata.org/wiki/Q76560', 'display_name': 'Antidepressant', 'level': 3, 'score': 0.7347653}, {'id': 'https://openalex.org/C2781195155', 'wikidata': 'https://www.wikidata.org/wiki/Q18680', 'display_name': 'Prefrontal cortex', 'level': 3, 'score': 0.6776794}, {'id': 'https://openalex.org/C2780795376', 'wikidata': 'https://www.wikidata.org/wiki/Q243547', 'display_name': 'Ketamine', 'level': 2, 'score': 0.67206544}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.58826536}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.5807303}, {'id': 'https://openalex.org/C2776219046', 'wikidata': 'https://www.wikidata.org/wiki/Q162657', 'display_name': 'Neurotransmitter', 'level': 3, 'score': 0.5062317}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.46995473}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.4314003}, {'id': 'https://openalex.org/C67018056', 'wikidata': 'https://www.wikidata.org/wiki/Q414896', 'display_name': 'NMDA receptor', 'level': 3, 'score': 0.4249013}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.40344566}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37316442}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3684312}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33700407}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32665372}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28675228}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.24072352}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.17385605}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.12182066}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biopsych.2019.03.887', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205482884', 'display_name': 'Biological Psychiatry', 'issn_l': '0006-3223', 'issn': ['0006-3223', '1873-2402'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.77, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4225015657', 'https://openalex.org/W3041749296', 'https://openalex.org/W3030480099', 'https://openalex.org/W2607926272', 'https://openalex.org/W2479939550', 'https://openalex.org/W2389728407', 'https://openalex.org/W2090843049', 'https://openalex.org/W2033257871', 'https://openalex.org/W2020080842', 'https://openalex.org/W158621816'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2945135914', 'counts_by_year': [], 'updated_date': '2024-12-22T21:54:33.271736', 'created_date': '2019-05-29'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
