Publication Information

{'id': 'https://openalex.org/W2924714478', 'doi': 'https://doi.org/10.1111/acel.12927', 'title': 'Systemic clearance of <i>p16<sup>INK4a</sup></i>‐positive senescent cells mitigates age‐associated intervertebral disc degeneration', 'display_name': 'Systemic clearance of <i>p16<sup>INK4a</sup></i>‐positive senescent cells mitigates age‐associated intervertebral disc degeneration', 'publication_year': 2019, 'publication_date': '2019-03-21', 'ids': {'openalex': 'https://openalex.org/W2924714478', 'doi': 'https://doi.org/10.1111/acel.12927', 'mag': '2924714478', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30900385', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6516165'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/acel.12927', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12927', 'source': {'id': 'https://openalex.org/S174672550', 'display_name': 'Aging Cell', 'issn_l': '1474-9718', 'issn': ['1474-9718', '1474-9728', '1474-9726'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12927', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053802073', 'display_name': 'Prashanti Patil', 'orcid': 'https://orcid.org/0000-0002-2447-8258'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Prashanti Patil', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040552450', 'display_name': 'Qing Dong', 'orcid': 'https://orcid.org/0000-0002-7819-2183'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qing Dong', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100391407', 'display_name': 'Dong Wang', 'orcid': 'https://orcid.org/0000-0001-6267-8819'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dong Wang', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079604421', 'display_name': 'Jianhui Chang', 'orcid': 'https://orcid.org/0000-0002-8855-8521'}, 'institutions': [{'id': 'https://openalex.org/I79620101', 'display_name': 'University of Arkansas for Medical Sciences', 'ror': 'https://ror.org/00xcryt71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79620101']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jianhui Chang', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas', 'institution_ids': ['https://openalex.org/I79620101']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074520942', 'display_name': 'Christopher D. Wiley', 'orcid': 'https://orcid.org/0000-0002-7699-6866'}, 'institutions': [{'id': 'https://openalex.org/I1337826666', 'display_name': 'Buck Institute for Research on Aging', 'ror': 'https://ror.org/050sv4x28', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1337826666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher Wiley', 'raw_affiliation_strings': ['Buck Institute for Research on Aging, Novato, California'], 'affiliations': [{'raw_affiliation_string': 'Buck Institute for Research on Aging, Novato, California', 'institution_ids': ['https://openalex.org/I1337826666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080240316', 'display_name': 'Marco Demaria', 'orcid': 'https://orcid.org/0000-0002-8429-4813'}, 'institutions': [{'id': 'https://openalex.org/I1337826666', 'display_name': 'Buck Institute for Research on Aging', 'ror': 'https://ror.org/050sv4x28', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1337826666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marco Demaria', 'raw_affiliation_strings': ['Buck Institute for Research on Aging, Novato, California'], 'affiliations': [{'raw_affiliation_string': 'Buck Institute for Research on Aging, Novato, California', 'institution_ids': ['https://openalex.org/I1337826666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100610130', 'display_name': 'Joon Lee', 'orcid': 'https://orcid.org/0000-0001-8593-9321'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joon Lee', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026825612', 'display_name': 'James D. Kang', 'orcid': 'https://orcid.org/0000-0002-7499-2909'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Kang', 'raw_affiliation_strings': ["Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"], 'affiliations': [{'raw_affiliation_string': "Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts", 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I1283280774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043039694', 'display_name': 'Laura J. Niedernhofer', 'orcid': 'https://orcid.org/0000-0002-1074-1385'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura J. Niedernhofer', 'raw_affiliation_strings': ['Department of Biochemistry, Molecular Biology and Biophysics, The Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Molecular Biology and Biophysics, The Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040467127', 'display_name': 'Paul D. Robbins', 'orcid': 'https://orcid.org/0000-0003-1068-7099'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul D. Robbins', 'raw_affiliation_strings': ['Department of Biochemistry, Molecular Biology and Biophysics, The Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Molecular Biology and Biophysics, The Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031791772', 'display_name': 'Gwendolyn Sowa', 'orcid': 'https://orcid.org/0000-0002-5935-0916'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gwendolyn Sowa', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001970748', 'display_name': 'Judith Campisi', 'orcid': 'https://orcid.org/0000-0001-6858-9462'}, 'institutions': [{'id': 'https://openalex.org/I148283060', 'display_name': 'Lawrence Berkeley National Laboratory', 'ror': 'https://ror.org/02jbv0t02', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1330989302', 'https://openalex.org/I148283060', 'https://openalex.org/I39565521']}, {'id': 'https://openalex.org/I1337826666', 'display_name': 'Buck Institute for Research on Aging', 'ror': 'https://ror.org/050sv4x28', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1337826666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Judith Campisi', 'raw_affiliation_strings': ['Buck Institute for Research on Aging, Novato, California', 'Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California', 'institution_ids': ['https://openalex.org/I148283060']}, {'raw_affiliation_string': 'Buck Institute for Research on Aging, Novato, California', 'institution_ids': ['https://openalex.org/I1337826666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100781093', 'display_name': 'Daohong Zhou', 'orcid': 'https://orcid.org/0000-0002-2400-6461'}, 'institutions': [{'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}, {'id': 'https://openalex.org/I79620101', 'display_name': 'University of Arkansas for Medical Sciences', 'ror': 'https://ror.org/00xcryt71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79620101']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daohong Zhou', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas', 'Department of Pharmacodynamics, University of Florida, Gainesville, Florida'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacodynamics, University of Florida, Gainesville, Florida', 'institution_ids': ['https://openalex.org/I33213144']}, {'raw_affiliation_string': 'Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas', 'institution_ids': ['https://openalex.org/I79620101']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033101463', 'display_name': 'Nam Vo', 'orcid': 'https://orcid.org/0000-0002-1265-8921'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Nam Vo', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': 'Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5033101463'], 'corresponding_institution_ids': ['https://openalex.org/I170201317'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 13.516, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.999926, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '3', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10238', 'display_name': 'Spine and Intervertebral Disc Pathology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10238', 'display_name': 'Spine and Intervertebral Disc Pathology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11030', 'display_name': 'Scoliosis diagnosis and treatment', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10084', 'display_name': 'Musculoskeletal pain and rehabilitation', 'score': 0.9886, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/senescence', 'display_name': 'Senescence', 'score': 0.74829215}, {'id': 'https://openalex.org/keywords/aggrecan', 'display_name': 'Aggrecan', 'score': 0.715948}, {'id': 'https://openalex.org/keywords/intervertebral-disc', 'display_name': 'Intervertebral Disc', 'score': 0.68305933}, {'id': 'https://openalex.org/keywords/degeneration', 'display_name': 'Degeneration (medical)', 'score': 0.589072}, {'id': 'https://openalex.org/keywords/cellular-senescence', 'display_name': 'Cellular senescence', 'score': 0.50356644}], 'concepts': [{'id': 'https://openalex.org/C522857546', 'wikidata': 'https://www.wikidata.org/wiki/Q2070979', 'display_name': 'Senescence', 'level': 2, 'score': 0.74829215}, {'id': 'https://openalex.org/C197534660', 'wikidata': 'https://www.wikidata.org/wiki/Q21121862', 'display_name': 'Aggrecan', 'level': 5, 'score': 0.715948}, {'id': 'https://openalex.org/C2777755357', 'wikidata': 'https://www.wikidata.org/wiki/Q502781', 'display_name': 'Intervertebral disc', 'level': 2, 'score': 0.68305933}, {'id': 'https://openalex.org/C2779354088', 'wikidata': 'https://www.wikidata.org/wiki/Q15467261', 'display_name': 'Degeneration (medical)', 'level': 2, 'score': 0.589072}, {'id': 'https://openalex.org/C182220744', 'wikidata': 'https://www.wikidata.org/wiki/Q7251226', 'display_name': 'Proteases', 'level': 3, 'score': 0.5816273}, {'id': 'https://openalex.org/C2779335624', 'wikidata': 'https://www.wikidata.org/wiki/Q407976', 'display_name': 'Proteoglycan', 'level': 3, 'score': 0.5443773}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53936565}, {'id': 'https://openalex.org/C500499127', 'wikidata': 'https://www.wikidata.org/wiki/Q332154', 'display_name': 'Ageing', 'level': 2, 'score': 0.5151707}, {'id': 'https://openalex.org/C2779523775', 'wikidata': 'https://www.wikidata.org/wiki/Q9075999', 'display_name': 'Cellular senescence', 'level': 4, 'score': 0.50356644}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41978198}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3860939}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.36854905}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34053105}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.30000627}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2994532}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.16813955}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.14063036}, {'id': 'https://openalex.org/C2776164576', 'wikidata': 'https://www.wikidata.org/wiki/Q62736', 'display_name': 'Osteoarthritis', 'level': 3, 'score': 0.1255976}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.119675905}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1157794}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.10566732}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C3020332539', 'wikidata': 'https://www.wikidata.org/wiki/Q2014564', 'display_name': 'Articular cartilage', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053674', 'descriptor_name': 'Aggrecans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007403', 'descriptor_name': 'Intervertebral Disc', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000071121', 'descriptor_name': 'ADAMTS4 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055959', 'descriptor_name': 'Intervertebral Disc Degeneration', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053509', 'descriptor_name': 'Matrix Metalloproteinase 13', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013937', 'descriptor_name': 'Thymidine Kinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/acel.12927', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12927', 'source': {'id': 'https://openalex.org/S174672550', 'display_name': 'Aging Cell', 'issn_l': '1474-9718', 'issn': ['1474-9718', '1474-9728', '1474-9726'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.osti.gov/biblio/1560597', 'pdf_url': 'https://escholarship.org/content/qt0hr64592/qt0hr64592.pdf', 'source': {'id': 'https://openalex.org/S4306402487', 'display_name': 'OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I139351228', 'host_organization_name': 'Office of Scientific and Technical Information', 'host_organization_lineage': ['https://openalex.org/I139351228'], 'host_organization_lineage_names': ['Office of Scientific and Technical Information'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6516165', 'pdf_url': 'https://europepmc.org/articles/pmc6516165?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://research.rug.nl/en/publications/305060f6-7c02-43e6-aee3-1915795fb19e', 'pdf_url': 'https://research.rug.nl/files/84888028/Patil_et_al_2019_Aging_Cell.pdf', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/0hr64592', 'pdf_url': 'https://escholarship.org/content/qt0hr64592/qt0hr64592.pdf?t=px9fvv', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516165', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30900385', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/acel.12927', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12927', 'source': {'id': 'https://openalex.org/S174672550', 'display_name': 'Aging Cell', 'issn_l': '1474-9718', 'issn': ['1474-9718', '1474-9728', '1474-9726'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.75, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 CA211963'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P01 AG043376'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '1S10OD019973-01'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'U19 AG056278'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 AG044376'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 AG009909'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 CA122023'}], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W143623202', 'https://openalex.org/W1790117378', 'https://openalex.org/W1965267428', 'https://openalex.org/W1965282660', 'https://openalex.org/W1977362098', 'https://openalex.org/W1994867329', 'https://openalex.org/W1995083258', 'https://openalex.org/W2000723582', 'https://openalex.org/W2007257271', 'https://openalex.org/W2024209230', 'https://openalex.org/W2030271269', 'https://openalex.org/W2030604088', 'https://openalex.org/W2033289742', 'https://openalex.org/W2042000503', 'https://openalex.org/W2044146377', 'https://openalex.org/W2048657237', 'https://openalex.org/W2067542143', 'https://openalex.org/W2069519394', 'https://openalex.org/W2092798278', 'https://openalex.org/W2096587251', 'https://openalex.org/W2101276900', 'https://openalex.org/W2106862840', 'https://openalex.org/W2112211373', 'https://openalex.org/W2112458458', 'https://openalex.org/W2115852450', 'https://openalex.org/W2128807350', 'https://openalex.org/W2130458932', 'https://openalex.org/W2162229546', 'https://openalex.org/W2191745121', 'https://openalex.org/W2224886002', 'https://openalex.org/W2226260944', 'https://openalex.org/W2266290735', 'https://openalex.org/W2281598305', 'https://openalex.org/W2341294428', 'https://openalex.org/W2406721410', 'https://openalex.org/W2605403816', 'https://openalex.org/W2605453133', 'https://openalex.org/W2605562503', 'https://openalex.org/W2608899726', 'https://openalex.org/W2620650162', 'https://openalex.org/W2725477209', 'https://openalex.org/W2747412048', 'https://openalex.org/W2752676842', 'https://openalex.org/W2779444716', 'https://openalex.org/W2924714478'], 'related_works': ['https://openalex.org/W2880742748', 'https://openalex.org/W2094929868', 'https://openalex.org/W2034217710', 'https://openalex.org/W2032518686', 'https://openalex.org/W2011991834', 'https://openalex.org/W2009523345', 'https://openalex.org/W1997644757', 'https://openalex.org/W1997322142', 'https://openalex.org/W1905957769', 'https://openalex.org/W1579361735'], 'abstract_inverted_index': {'Abstract': [0], 'Rationale': [1], 'Age‐related': [2], 'changes': [3, 206, 228], 'in': [4, 48, 66, 78, 149, 219], 'the': [5, 9, 49, 103, 118, 128, 166, 195, 220, 230, 244], 'intervertebral': [6, 67], 'discs': [7, 150], 'are': [8, 76], 'predominant': [10], 'contributors': [11], 'to': [12, 45, 64, 85, 202, 242], 'back': [13], 'pain,': [14], 'a': [15, 27, 88, 239], 'common': [16], 'physical': [17], 'and': [18, 34, 40, 51, 95, 99, 135, 143, 147, 157, 177], 'functional': [19], 'impairment': [20], 'experienced': [21], 'by': [22, 127], 'older': [23], 'persons.': [24], 'Cellular': [25, 233], 'senescence,': [26], 'process': [28], 'wherein': [29], 'cells': [30, 60, 107, 126, 171, 193, 224], 'undergo': [31], 'growth': [32], 'arrest': [33], 'chronically': [35], 'secrete': [36], 'numerous': [37], 'inflammatory': [38, 140], 'molecules': [39], 'proteases,': [41], 'has': [42], 'been': [43, 62], 'reported': [44, 63], 'cause': [46], 'decline': [47], 'health': [50, 245], 'function': [52], 'of': [53, 105, 121, 139, 151, 169, 191, 197, 212, 222, 246], 'multiple': [54, 226], 'tissues': [55], 'with': [56, 155, 184, 251], 'age.': [57, 252], 'Although': [58], 'senescent': [59, 106, 125, 170, 192, 223], 'have': [61], 'increase': [65], 'degeneration': [68], '(IDD),': [69], 'it': [70], 'is': [71, 200], 'not': [72], 'known': [73], 'whether': [74, 87], 'they': [75], 'causative': [77], 'age‐related': [79, 96], 'IDD.': [80, 97], 'Objective': [81], 'The': [82, 210], 'study': [83, 214], 'aimed': [84], 'elucidate': [86], 'causal': [89], 'relationship': [90], 'exists': [91], 'between': [92], 'cellular': [93], 'senescence': [94, 234], 'Methods': [98], 'Results': [100], 'To': [101], 'examine': [102], 'impact': [104], 'on': [108], 'age‐associated': [109, 227], 'IDD,': [110], 'we': [111], 'used': [112], 'p16‐3MR': [113, 152], 'transgenic': [114], 'mice,': [115, 164], 'which': [116, 199], 'enables': [117], 'selective': [119], 'removal': [120], 'p16': [122], 'Ink4a': [123], '‐positive': [124], 'drug': [129], 'ganciclovir.': [130], 'Disc': [131], 'cellularity,': [132], 'aggrecan': [133, 174], 'content': [134, 182], 'fragmentation': [136], 'alongside': [137], 'expression': [138], 'cytokine': [141], '(IL‐6)': [142], 'matrix': [144, 181], 'proteases': [145], '(ADAMTS4': [146], 'MMP13)': [148], 'mice': [153], 'treated': [154], 'GCV': [156], 'untreated': [158], 'controls': [159], 'were': [160], 'assessed.': [161], 'In': [162], 'aged': [163], 'reducing': [165], 'per': [167], 'cent': [168], 'decreased': [172], 'disc': [173, 187, 204, 231, 247], 'proteolytic': [175], 'degradation': [176], 'increased': [178], 'overall': [179], 'proteoglycan': [180], 'along': [183], 'improved': [185], 'histological': [186], 'features.': [188], 'Additionally,': [189], 'reduction': [190, 218], 'lowered': [194], 'levels': [196], 'MMP13,': [198], 'purported': [201], 'promote': [203], 'degenerative': [205], 'during': [207], 'aging.': [208], 'Conclusions': [209], 'findings': [211], 'this': [213], 'suggest': [215], 'that': [216, 249], 'systemic': [217], 'number': [221], 'ameliorates': [225], 'within': [229], 'tissue.': [232], 'could': [235], 'therefore': [236], 'serve': [237], 'as': [238], 'therapeutic': [240], 'target': [241], 'restore': [243], 'tissue': [248], 'deteriorates': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2924714478', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 30}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 37}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-28T00:18:30.230961', 'created_date': '2019-04-01'}