Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1579361735', 'doi': 'https://doi.org/10.1016/s0021-9258(19)50175-2', 'title': 'The high molecular weight Cat-301 chondroitin sulfate proteoglycan from brain is related to the large aggregating proteoglycan from cartilage, aggrecan.', 'display_name': 'The high molecular weight Cat-301 chondroitin sulfate proteoglycan from brain is related to the large aggregating proteoglycan from cartilage, aggrecan.', 'publication_year': 1992, 'publication_date': '1992-05-01', 'ids': {'openalex': 'https://openalex.org/W1579361735', 'doi': 'https://doi.org/10.1016/s0021-9258(19)50175-2', 'mag': '1579361735', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1374409'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)50175-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(19)50175-2', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111845964', 'display_name': 'Hugh J.L. Fryer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H.J. Fryer', 'raw_affiliation_strings': ['Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077743415', 'display_name': 'Gregory M. Kelly', 'orcid': 'https://orcid.org/0000-0001-8612-364X'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G.M. Kelly', 'raw_affiliation_strings': ['Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090948359', 'display_name': 'L Molinaro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L Molinaro', 'raw_affiliation_strings': ['Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071311118', 'display_name': 'Susan Hockfield', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Hockfield', 'raw_affiliation_strings': ['Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 5.173, 'has_fulltext': False, 'cited_by_count': 93, 'citation_normalized_percentile': {'value': 0.921457, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '267', 'issue': '14', 'first_page': '9874', 'last_page': '9883'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11650', 'display_name': 'Skin and Cellular Biology Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11650', 'display_name': 'Skin and Cellular Biology Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11131', 'display_name': 'Proteoglycans and glycosaminoglycans research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aggrecan', 'display_name': 'Aggrecan', 'score': 0.9775492}, {'id': 'https://openalex.org/keywords/chondroitin-sulfate-proteoglycan', 'display_name': 'Chondroitin sulfate proteoglycan', 'score': 0.70161307}, {'id': 'https://openalex.org/keywords/versican', 'display_name': 'Versican', 'score': 0.55340725}], 'concepts': [{'id': 'https://openalex.org/C197534660', 'wikidata': 'https://www.wikidata.org/wiki/Q21121862', 'display_name': 'Aggrecan', 'level': 5, 'score': 0.9775492}, {'id': 'https://openalex.org/C2779335624', 'wikidata': 'https://www.wikidata.org/wiki/Q407976', 'display_name': 'Proteoglycan', 'level': 3, 'score': 0.90481734}, {'id': 'https://openalex.org/C2775895372', 'wikidata': 'https://www.wikidata.org/wiki/Q5104536', 'display_name': 'Chondroitin sulfate proteoglycan', 'level': 4, 'score': 0.70161307}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.690588}, {'id': 'https://openalex.org/C2779553658', 'wikidata': 'https://www.wikidata.org/wiki/Q408014', 'display_name': 'Chondroitin sulfate', 'level': 3, 'score': 0.5993754}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.58556664}, {'id': 'https://openalex.org/C159470946', 'wikidata': 'https://www.wikidata.org/wiki/Q14888030', 'display_name': 'Versican', 'level': 4, 'score': 0.55340725}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41764906}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34602016}, {'id': 'https://openalex.org/C153074725', 'wikidata': 'https://www.wikidata.org/wiki/Q407553', 'display_name': 'Glycosaminoglycan', 'level': 2, 'score': 0.32730114}, {'id': 'https://openalex.org/C3020332539', 'wikidata': 'https://www.wikidata.org/wiki/Q2014564', 'display_name': 'Articular cartilage', 'level': 4, 'score': 0.23816946}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.21516854}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20067576}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15600944}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.11559838}, {'id': 'https://openalex.org/C2776164576', 'wikidata': 'https://www.wikidata.org/wiki/Q62736', 'display_name': 'Osteoarthritis', 'level': 3, 'score': 0.11137664}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)50175-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)50175-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1225396209', 'https://openalex.org/W1748312647', 'https://openalex.org/W1823748583', 'https://openalex.org/W1976941391', 'https://openalex.org/W1985534974', 'https://openalex.org/W1986334292', 'https://openalex.org/W1988531832', 'https://openalex.org/W1991446864', 'https://openalex.org/W1992381021', 'https://openalex.org/W1998036640', 'https://openalex.org/W2000158011', 'https://openalex.org/W2008163789', 'https://openalex.org/W2013096956', 'https://openalex.org/W2013826368', 'https://openalex.org/W2016468092', 'https://openalex.org/W2017265815', 'https://openalex.org/W2028852297', 'https://openalex.org/W2044453539', 'https://openalex.org/W2044709834', 'https://openalex.org/W2048994493', 'https://openalex.org/W2055936328', 'https://openalex.org/W2063081845', 'https://openalex.org/W2067263021', 'https://openalex.org/W2072407487', 'https://openalex.org/W2076817979', 'https://openalex.org/W2089101779', 'https://openalex.org/W2096220364', 'https://openalex.org/W2101190148', 'https://openalex.org/W2119297613', 'https://openalex.org/W2122412289', 'https://openalex.org/W2125911728', 'https://openalex.org/W2137541387', 'https://openalex.org/W2146964179', 'https://openalex.org/W4248214406', 'https://openalex.org/W607434411', 'https://openalex.org/W650915465'], 'related_works': ['https://openalex.org/W3086777726', 'https://openalex.org/W2168221939', 'https://openalex.org/W2132853845', 'https://openalex.org/W2123146262', 'https://openalex.org/W2088890662', 'https://openalex.org/W2065530558', 'https://openalex.org/W2055108975', 'https://openalex.org/W2048958617', 'https://openalex.org/W2038737213', 'https://openalex.org/W1983833681'], 'abstract_inverted_index': {'Monoclonal': [0], 'antibodies': [1], 'Cat-301': [2, 80, 84], 'and': [3, 81, 85, 96, 113, 173, 188, 213, 230], 'Cat-304': [4], 'recognize': [5], 'a': [6, 67, 71, 124, 138, 180], 'neuronal': [7], 'cell': [8], 'surface-associated': [9], 'chondroitin': [10, 93], 'sulfate': [11, 94, 157], 'proteoglycan': [12], '(CSPG),': [13], 'which': [14, 60, 76, 227], 'is': [15, 43, 77, 204], 'expressed': [16], 'during': [17], 'critical': [18], 'periods': [19], 'of': [20, 64, 70, 101, 131, 144, 155, 166, 183, 191, 219, 222], 'postnatal': [21], 'development': [22], 'in': [23, 150], 'the': [24, 31, 37, 47, 102, 108, 132, 135, 153, 160, 167, 171, 192, 210, 220], 'mammalian': [25], 'central': [26], 'nervous': [27], 'system': [28], '(CNS).': [29], 'In': [30], 'present': [32], 'study': [33], 'we': [34], 'show': [35], 'that': [36, 143, 165], 'CNS': [38, 114, 136, 161, 172, 202], 'CSPG': [39, 51, 75], 'identified': [40], 'by': [41, 92, 99, 118], 'Cat-301/304': [42, 193], 'similar': [44], 'to': [45, 152, 177, 199, 209, 229], 'aggrecan,': [46, 65, 129], 'high': [48, 68, 72, 223], 'molecular': [49, 73, 224], 'weight': [50, 74, 225], 'from': [52, 110, 134, 195], 'cartilage.': [53, 145], 'By': [54], 'Western': [55], 'blot': [56], 'analysis,': [57], 'cartilaginous': [58], 'tissues,': [59], 'are': [61, 89, 97, 197], 'rich': [62], 'sources': [63], 'have': [66], 'concentration': [69], 'immunoreactive': [78], 'with': [79, 104, 164, 232], '304.': [82], 'The': [83, 185, 201], '304': [86], 'epitopes,': [87], 'however,': [88], 'partially': [90], 'masked': [91], 'glycosamino-glycan': [95], 'unmasked': [98], 'digestion': [100], 'antigen': [103, 109, 133, 162, 194, 203], 'chondroitinase': [105], 'ABC.': [106], 'Although': [107], 'both': [111], 'cartilage': [112, 168, 174, 196, 211], 'can': [115], 'be': [116, 148], 'purified': [117], 'CsCl': [119], 'buoyant': [120, 140], 'density': [121, 141], 'gradient': [122], 'centrifugation,': [123], 'standard': [125], 'technique': [126], 'for': [127], 'purifying': [128], 'most': [130], 'has': [137], 'lower': [139], 'than': [142], 'This': [146], 'may': [147, 214], 'due,': [149], 'part,': [151], 'paucity': [154], 'keratan': [156], 'substitution': [158], 'on': [159], 'compared': [163], 'antigen.': [169], 'Both': [170], 'antigens': [175], 'bind': [176, 228], 'hyaluronic': [178, 233], 'acid,': [179], 'feature': [181], 'characteristic': [182], 'aggrecan.': [184, 200], 'physiochemical,': [186], 'biochemical,': [187], 'functional': [189], 'properties': [190], 'identical': [198], 'similar,': [205], 'but': [206], 'not': [207], 'identical,': [208], 'antigen,': [212], 'thus': [215], 'represent': [216], 'another': [217], 'member': [218], 'family': [221], 'CSPGs': [226], 'aggregate': [231], 'acid.': [234]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1579361735', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-12T21:33:08.738210', 'created_date': '2016-06-24'}