Publication Information

{'id': 'https://openalex.org/W2917264363', 'doi': 'https://doi.org/10.1177/0022034519828710', 'title': 'Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma', 'display_name': 'Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma', 'publication_year': 2019, 'publication_date': '2019-02-20', 'ids': {'openalex': 'https://openalex.org/W2917264363', 'doi': 'https://doi.org/10.1177/0022034519828710', 'mag': '2917264363', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30786814'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1177/0022034519828710', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62865007', 'display_name': 'Journal of Dental Research', 'issn_l': '0022-0345', 'issn': ['0022-0345', '1544-0591'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051523779', 'display_name': 'Tomoaki Saito', 'orcid': 'https://orcid.org/0009-0008-1504-9823'}, 'institutions': [{'id': 'https://openalex.org/I4210099339', 'display_name': 'Chiba University Hospital', 'ror': 'https://ror.org/0126xah18', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099339']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'T. Saito', 'raw_affiliation_strings': ['Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210099339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036900348', 'display_name': 'Katsuhiro Uzawa', 'orcid': 'https://orcid.org/0000-0002-7036-0859'}, 'institutions': [{'id': 'https://openalex.org/I4210099339', 'display_name': 'Chiba University Hospital', 'ror': 'https://ror.org/0126xah18', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099339']}, {'id': 'https://openalex.org/I159385669', 'display_name': 'Chiba University', 'ror': 'https://ror.org/01hjzeq58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I159385669']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'K. Uzawa', 'raw_affiliation_strings': ['Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan', 'Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210099339']}, {'raw_affiliation_string': 'Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan', 'institution_ids': ['https://openalex.org/I159385669']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011051583', 'display_name': 'Masahiko Terajima', 'orcid': 'https://orcid.org/0000-0002-1502-7930'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. Terajima', 'raw_affiliation_strings': ['Department of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112311168', 'display_name': 'Masashi Shiiba', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159385669', 'display_name': 'Chiba University', 'ror': 'https://ror.org/01hjzeq58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I159385669']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'M. Shiiba', 'raw_affiliation_strings': ['Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan', 'institution_ids': ['https://openalex.org/I159385669']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008423138', 'display_name': 'Antonio L. Amelio', 'orcid': 'https://orcid.org/0000-0002-6295-2694'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A.L. Amelio', 'raw_affiliation_strings': ['Department of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA', 'Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}, {'raw_affiliation_string': 'Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110133940', 'display_name': 'H Tanzawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210099339', 'display_name': 'Chiba University Hospital', 'ror': 'https://ror.org/0126xah18', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099339']}, {'id': 'https://openalex.org/I159385669', 'display_name': 'Chiba University', 'ror': 'https://ror.org/01hjzeq58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I159385669']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'H. Tanzawa', 'raw_affiliation_strings': ['Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan', 'Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210099339']}, {'raw_affiliation_string': 'Department of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan', 'institution_ids': ['https://openalex.org/I159385669']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111730581', 'display_name': 'M. Yamauchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'M. Yamauchi', 'raw_affiliation_strings': ['Department of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5111730581'], 'corresponding_institution_ids': ['https://openalex.org/I114027177'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.136, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '98', 'issue': '5', 'first_page': '517', 'last_page': '525'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12688', 'display_name': 'Microbial metabolism and enzyme function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12688', 'display_name': 'Microbial metabolism and enzyme function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 0.956, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lysyl-oxidase', 'display_name': 'Lysyl Oxidase', 'score': 0.97114635}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.60672987}], 'concepts': [{'id': 'https://openalex.org/C193143273', 'wikidata': 'https://www.wikidata.org/wiki/Q419389', 'display_name': 'Lysyl oxidase', 'level': 3, 'score': 0.97114635}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.60672987}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.60431087}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.51558226}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48877355}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.45526958}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.44612023}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44086722}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3912265}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.28054592}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19727316}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.117408365}], 'mesh': [{'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000594', 'descriptor_name': 'Amino Acid Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008249', 'descriptor_name': 'Protein-Lysine 6-Oxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1177/0022034519828710', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62865007', 'display_name': 'Journal of Dental Research', 'issn_l': '0022-0345', 'issn': ['0022-0345', '1544-0591'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30786814', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.43}], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': 'JP18K09717'}], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1594321152', 'https://openalex.org/W1844836761', 'https://openalex.org/W1876890400', 'https://openalex.org/W1973713001', 'https://openalex.org/W1978262131', 'https://openalex.org/W1986241711', 'https://openalex.org/W2010457001', 'https://openalex.org/W2016279537', 'https://openalex.org/W2021757059', 'https://openalex.org/W2033363278', 'https://openalex.org/W2065420949', 'https://openalex.org/W2100303404', 'https://openalex.org/W2101858690', 'https://openalex.org/W2114843025', 'https://openalex.org/W2130410032', 'https://openalex.org/W2135139969', 'https://openalex.org/W2139593382', 'https://openalex.org/W2147016321', 'https://openalex.org/W2153056550', 'https://openalex.org/W2157852151', 'https://openalex.org/W2159744630', 'https://openalex.org/W2169283220', 'https://openalex.org/W2214074259', 'https://openalex.org/W2225944612', 'https://openalex.org/W2256076111', 'https://openalex.org/W2271528576', 'https://openalex.org/W2288742624', 'https://openalex.org/W2293425469', 'https://openalex.org/W2301594320', 'https://openalex.org/W2424797812', 'https://openalex.org/W2561313757', 'https://openalex.org/W2587713374', 'https://openalex.org/W2588314637', 'https://openalex.org/W2592181184', 'https://openalex.org/W2593027881', 'https://openalex.org/W2608652870', 'https://openalex.org/W2613848594', 'https://openalex.org/W2734498751', 'https://openalex.org/W2769472722', 'https://openalex.org/W2769533324', 'https://openalex.org/W2781999037', 'https://openalex.org/W2796997430', 'https://openalex.org/W2867045334'], 'related_works': ['https://openalex.org/W4387937397', 'https://openalex.org/W4313446361', 'https://openalex.org/W4234237736', 'https://openalex.org/W3157376430', 'https://openalex.org/W3140292702', 'https://openalex.org/W2597170953', 'https://openalex.org/W2423271224', 'https://openalex.org/W2138780853', 'https://openalex.org/W2076950581', 'https://openalex.org/W2069518226'], 'abstract_inverted_index': {'Tumor': [0], 'progression': [1, 25, 190], 'is': [2, 45, 156], 'a': [3, 181], 'complex': [4], 'process': [5, 174], 'involving': [6], 'extracellular': [7], 'matrix': [8], '(ECM)': [9], 'remodeling': [10], 'and': [11, 20, 37, 50, 78, 92, 102, 126, 143, 167, 191], 'stiffening.': [12], 'However,': [13], 'the': [14, 65, 82, 115, 130, 157, 162], 'mechanisms': [15], 'that': [16, 64], 'govern': [17], 'these': [18, 112], 'processes': [19], 'their': [21], 'roles': [22], 'in': [23, 56, 75, 99, 114, 123, 129, 141, 187], 'tumor': [24, 48, 189], 'are': [26, 72], 'still': [27], 'poorly': [28], 'understood.': [29], 'In': [30], 'this': [31, 155, 173], 'study,': [32], 'we': [33], 'performed': [34], 'bioinformatics,': [35], 'immunohistochemical,': [36], 'biochemical': [38], 'analyses': [39], 'to': [40, 160, 203], 'examine': [41], 'if': [42], 'collagen': [43, 137, 165, 185], 'cross-linking': [44, 71, 166, 186], 'associated': [46, 103], 'with': [47, 104, 175], 'stage': [49], 'regional': [51], 'lymph': [52], 'node': [53], 'metastasis': [54], '(RLNM)': [55], 'oral': [57], 'squamous': [58], 'cell': [59], 'carcinoma': [60], '(OSCC).': [61], 'We': [62], 'found': [63], 'genes': [66], 'encoding': [67], 'key': [68, 170], 'enzymes': [69, 83, 113, 171], 'for': [70, 184], 'frequently': [73], 'overexpressed': [74], 'oral,': [76], 'head,': [77], 'neck': [79], 'cancers.': [80], 'Specifically,': [81], 'lysyl': [84, 89], 'hydroxylase': [85], '2': [86, 94], '(LH2)': [87], 'or': [88], 'oxidase': [90], '(LOX)': [91], 'LOX-like': [93], '(LOXL2)': [95], 'were': [96, 119, 139, 149], 'significantly': [97, 121, 150], 'upregulated': [98], 'late-stage': [100, 124, 142], 'tumors': [101, 125], 'poor': [105], 'patient': [106], 'prognosis.': [107], 'The': [108, 178], 'protein': [109], 'levels': [110], 'of': [111, 164, 169, 199], 'primary': [116], 'human': [117], 'OSCC': [118, 176, 188, 205], 'also': [120], 'increased': [122], 'markedly': [127], 'elevated': [128], 'RLNM-positive': [131, 144], 'tumors.': [132], 'Notably,': [133], 'while': [134], 'overall': [135], 'LOX/LOXL2-catalyzed': [136], 'cross-links': [138, 148], 'enriched': [140], 'tumors,': [145], 'LH2-mediated': [146], 'stable': [147], 'increased.': [151], 'To': [152], 'our': [153], 'knowledge,': [154], 'first': [158], 'study': [159], 'investigate': [161], 'association': [163], 'expression': [168], 'regulating': [172], 'stage.': [177], 'data': [179], 'indicate': [180], 'critical': [182], 'role': [183], 'metastasis,': [192], 'which': [193], 'may': [194], 'provide': [195], 'insights': [196], 'into': [197], 'development': [198], 'novel': [200], 'therapeutic': [201], 'strategies': [202], 'prevent': [204], 'progression.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2917264363', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}], 'updated_date': '2024-12-10T09:09:45.772824', 'created_date': '2019-03-02'}