Moyamoya Disease Susceptibility Variant <i>RNF213</i> p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis

Name: Work Video:
Duration: 3 min 30 s
Shuhei Okazaki; Takaaki Morimoto; Yoichiro Kamatani; Teppei Kamimura; Hatasu Kobayashi; Kouji H. Harada; Tsutomu Tomita; Aya Higashiyama; Jun Takahashi; Jyoji Nakagawara; Masatoshi Koga; Ḱazunori Toyoda; Kazuo Washida; Satoshi Saitô; Atsushi Takahashi; Makoto Hirata; Koichi Matsuda; Hideki Mochizuki; Michael Chong; Guillaume Paré; Martin O’Donnell; Tetsuro Ago; Jun Hata; Toshiharu Ninomiya; Martin Dichgans; Stéphanie Debette; Michiaki Kubo; Akio Koizumi; Masafumi Ihara
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40, 760, 779, 838, 841, 845, 848, 902, 907, 912, 919, 926, 952, 957, 1020, 1037, 1073, 1098, 1101, 1114, 1138, 1141, 1161, 1169, 1246, 1280, 1284, 1287, 1308, 1322, 1341, 1366, 1406, 1417, 1420, 1436, 1478, 1539, 1558, 1564, 1569, 1574, 1598, 1601, 1605, 1657, 1660, 1664, 1671, 1677, 1691, 1699, 1710, 1733, 1741, 2693, 3061, 3107, 3112, 3160, 3360, 3366, 3632, 3668, 3683, 3763, 3800, 3993, 4094, 4107, 4384, 4432, 4667, 4680, 4715, 4748], 'Risk': [11, 41, 3877, 3997], 'of': [12, 42, 146, 165, 180, 186, 196, 203, 230, 241, 260, 267, 277, 281, 296, 303, 349, 365, 381, 399, 417, 436, 455, 481, 486, 496, 501, 511, 517, 562, 577, 585, 597, 606, 618, 627, 653, 665, 695, 702, 719, 738, 763, 832, 840, 844, 879, 883, 911, 944, 992, 1000, 1031, 1062, 1125, 1149, 1157, 1238, 1245, 1307, 1311, 1340, 1394, 1405, 1416, 1419, 1429, 1477, 1497, 1568, 1600, 1622, 1685, 1698, 1712, 1717, 1735, 1750, 1769, 2663, 2692, 2714, 2779, 2832, 2902, 2908, 2943, 2996, 3060, 3106, 3115, 3159, 3269, 3301, 3354, 3365, 3519, 3604, 3617, 3626, 3631, 3636, 3687, 3710, 3762, 3765, 3812, 3818, 3879, 3890, 3947, 3988, 4051, 4093, 4106, 4216, 4298, 4344, 4386, 4435, 4486, 4563, 4574, 4594, 4609, 4662, 4669, 4679, 4708, 4717, 4723, 4747, 4789], 'Ischemic': [13, 43, 3121, 3524], 'Stroke': [14, 44, 640, 935, 949, 1103, 1455, 2683, 2697, 3279, 3382, 3891, 3996, 4261, 4302, 4742, 4795, 4838], 'Attributable': [15, 45], 'to': [16, 24, 46, 775, 940, 1129, 1509, 1551, 1631, 1636, 2955, 3991, 4160, 4569, 4829], 'Large-Artery': [17, 47], 'Atherosclerosis': [18, 48, 2997, 3605], 'Free': [19], 'AccessLetterPDF/EPUBAboutView': [20], 'PDFView': [21], 'EPUBSections': [22], 'ToolsAdd': [23], 'favoritesDownload': [25], 'citationsTrack': [26], 'citationsPermissions': [27], 'ShareShare': [28], 'onFacebookTwitterLinked': [29], 'InMendeleyReddit': [30], 'Jump': [31], 'toFree': [32], 'AccessLetterPDF/EPUBMoyamoya': [33], 'Shuhei': [49, 139, 142], 'Okazaki,': [50, 143, 1747], 'MD,': [51, 54, 57, 60, 63, 70, 73, 77, 80, 83, 86, 89, 92, 98, 101, 104, 110, 116, 119, 122, 125, 128, 131, 144, 717, 1748, 1767, 2206], 'Takaaki': [52, 192], 'Morimoto,': [53], 'Yoichiro': [55, 213], 'Kamatani,': [56], 'Teppei': [58, 237], 'Kamimura,': [59], 'Hatasu': [61, 256], 'Kobayashi,': [62], 'Kouji': [64, 292], 'Harada,': [65], 'PhD,': [66, 95, 113], 'MPH,': [67], 'Tsutomu': [68, 313], 'Tomita,': [69], 'Aya': [71, 328], 'Higashiyama,': [72], 'Jun': [74, 117, 343, 593], 'C.': [75, 344, 346], 'Takahashi,': [76, 94], 'Jyoji': [78, 361], 'Nakagawara,': [79], 'Masatoshi': [81, 377], 'Koga,': [82, 385, 403], 'Kazunori': [84, 395], 'Toyoda,': [85], 'Kazuo': [87, 413], 'Washida,': [88], 'Satoshi': [90, 432], 'Saito,': [91], 'Atsushi': [93, 451], 'Makoto': [96, 477, 2482], 'Hirata,': [97], 'Koichi': [99, 491], 'Matsuda,': [100], 'Hideki': [102, 507], 'Mochizuki,': [103], 'Michael': [105, 523], 'Chong,': [106], 'MSc,': [107], 'Guillaume': [108, 537], 'Paré,': [109], 'Martin': [111, 123, 551, 635], "O'Donnell,": [112], 'Tetsuro': [114, 573], 'Ago,': [115], 'Hata,': [118], 'Toshiharu': [120, 614], 'Ninomiya,': [121], 'Dichgans,': [124], 'Stéphanie': [126, 661], 'Debette,': [127], 'Michiaki': [129, 677], 'Kubo,': [130], 'Akio': [132, 691, 1720], 'Koizumi,': [133], 'MD': [134, 138], 'and': [135, 150, 174, 198, 250, 262, 283, 298, 322, 337, 355, 371, 389, 407, 426, 445, 463, 565, 579, 599, 620, 641, 697, 711, 723, 747, 765, 819, 836, 856, 860, 890, 901, 906, 915, 930, 967, 976, 997, 1058, 1093, 1097, 1100, 1109, 1119, 1127, 1147, 1154, 1163, 1216, 1276, 1352, 1441, 1449, 1464, 1467, 1484, 1527, 1548, 1635, 1652, 1680, 1702, 1705, 1715, 1754, 1773, 2653, 2723, 2788, 2900, 2978, 2998, 3055, 3074, 3101, 3125, 3144, 3193, 3200, 3262, 3296, 3317, 3348, 3378, 3388, 3432, 3458, 3506, 3517, 3531, 3583, 3590, 3606, 3612, 3621, 3629, 3661, 3675, 3698, 3703, 3713, 3749, 3788, 3803, 3807, 3870, 3875, 3892, 3922, 3936, 3942, 3981, 3986, 4046, 4061, 4088, 4124, 4129, 4136, 4152, 4168, 4210, 4247, 4252, 4290, 4296, 4339, 4377, 4388, 4423, 4442, 4446, 4454, 4481, 4498, 4523, 4558, 4582, 4602, 4657, 4702, 4711, 4720, 4733, 4784], 'Masafumi': [136, 712, 715], 'Ihara,': [137, 716, 1766], 'OkazakiShuhei': [140], 'Okazaki': [141, 2964, 3725, 4758], 'Department': [145, 164, 179, 195, 240, 259, 276, 295, 348, 364, 380, 398, 416, 435, 454, 510, 576, 596, 617, 664, 694, 718, 737, 1749, 1768], 'Neurology,': [147, 181, 512, 666, 720, 1751, 1770, 3076, 3127, 3204, 3477, 3718, 3819, 3948, 4013, 4066, 4395], 'National': [148, 172, 248, 320, 335, 353, 369, 387, 405, 424, 443, 461, 560, 721, 745, 913, 1462, 1700, 1752, 1771], 'Cerebral': [149, 173, 249, 321, 336, 354, 370, 388, 406, 425, 444, 462, 722, 746, 914, 1463, 1701, 1753, 1772], 'Cardiovascular': [151, 175, 251, 323, 338, 356, 372, 390, 408, 427, 446, 464, 724, 748, 916, 1465, 1696, 1703, 1755, 1774], 'Center,': [152, 176, 252, 324, 339, 357, 373, 391, 409, 428, 447, 465, 647, 725, 749, 1704, 1756, 1775], '5-7-1': [153, 726, 1757, 1776], 'Fujishiro-dai,': [154, 727, 1758, 1777], 'Suita,': [155, 728, 1759, 1778], 'Osaka': [156, 182, 513, 729, 1760, 1779], '565-8565,': [157, 730, 1761, 1780], 'Japan.': [158, 178, 223, 254, 326, 341, 359, 375, 393, 411, 430, 449, 467, 475, 591, 612, 633, 689, 731, 751, 1762, 1781], 'Email': [159, 732, 1763, 1782], 'E-mail': [160, 733], 'Address:': [161, 734], '[email': [162, 735, 1764, 1783], 'protected]': [163, 736], 'Neurology': [166, 242, 418, 437, 655, 739, 2689], '(S.O.,': [167, 189, 243, 419, 438, 520, 740], 'T.K.,': [168, 244, 420, 439, 741], 'K.W.,': [169, 245, 421, 440, 742], 'S.S.,': [170, 246, 422, 441, 743], 'M.I.),': [171, 247, 423, 442, 744], 'Osaka,': [177, 253, 325, 340, 358, 374, 392, 410, 429, 448, 466, 750], 'University': [183, 485, 500, 514, 561, 566, 672], 'Graduate': [184, 201, 228, 265, 301, 494, 515, 583, 604, 625, 700], 'School': [185, 202, 229, 266, 302, 495, 516, 584, 605, 626, 701], 'Medicine,': [187, 204, 227, 231, 268, 304, 457, 518, 703, 4725], 'Japan': [188, 207, 234, 271, 289, 307, 488, 504, 519, 706, 1665, 1672, 1718, 2672], 'H.M.).': [190, 521], ',': [191, 212, 236, 255, 291, 312, 327, 342, 360, 376, 394, 412, 431, 450, 476, 490, 506, 522, 536, 550, 572, 592, 613, 634, 660, 676, 690, 3816, 4065], 'MorimotoTakaaki': [193], 'Morimoto': [194, 2801, 3743, 4760], 'Health': [197, 261, 284, 297, 527, 541, 554, 601, 622, 696, 1667], 'Environmental': [199, 263, 299, 698], 'Sciences,': [200, 264, 279, 285, 300, 498, 587, 608, 629, 699, 3368, 4576, 4682], 'Kyoto': [205, 232, 269, 305, 704], 'University,': [206, 233, 270, 287, 306, 531, 545, 589, 610, 631, 705], '(T.M.,': [208, 272, 308, 707], 'H.K.,': [209, 273, 309, 708], 'K.H.,': [210, 274, 310, 709], 'A.K.).': [211, 275, 311, 710], 'KamataniYoichiro': [214], 'Kamatani': [215, 2128, 2642], 'Laboratory': [216, 468], 'for': [217, 225, 469, 639, 668, 682, 851, 853, 1432, 1543, 1642, 1649, 1682, 1695, 1725, 2651, 2785, 2911, 3068, 3306, 3998, 4259, 4383, 4391, 4588], 'Statistical': [218, 470], 'Analysis': [219, 471], '(Y.K.,': [220, 472], 'A.T.),': [221, 473], 'Kanagawa,': [222, 474, 688], 'Center': [224, 681, 917], 'Genomic': [226, 456, 2657], '(Y.K.).': [235], 'KamimuraTeppei': [238], 'Kamimura': [239], 'KobayashiHatasu': [257], 'Kobayashi': [258, 2740, 2827, 3177, 3297, 4413, 4762], 'Biomedical': [278], 'College': [280], 'Life': [282], 'Chubu': [286], 'Aichi,': [288], '(H.K.).': [290], 'HaradaKouji': [293], 'Harada': [294, 2756, 2811, 4415, 4764], 'TomitaTsutomu': [314], 'Tomita': [315, 4766], 'NCVC': [316, 331, 1658], 'Biobank': [317, 332, 1678], '(T.T.,': [318, 333], 'A.H.),': [319, 334], 'HigashiyamaAya': [329], 'Higashiyama': [330, 4768], 'TakahashiJun': [345], 'Takahashi': [347, 453, 3252, 3653, 4635, 4772], 'Neurosurgery': [350, 366, 3820, 3949], '(J.C.T.,': [351, 367], 'J.N.),': [352, 368], 'NakagawaraJyoji': [362], 'Nakagawara': [363, 4774], 'KogaMasatoshi': [378], 'Koga': [379, 3051, 3099, 3739, 4734, 4776], 'Cerebrovascular': [382, 400, 3768, 3893], 'Medicine': [383, 401, 578, 3530, 4743], '(M.': [384, 402, 686], 'K.T.),': [386, 404], 'ToyodaKazunori': [396], 'Toyoda': [397, 2750, 3049, 3097, 3581, 3741, 4729, 4778], 'WashidaKazuo': [414], 'Washida': [415, 3041, 3737], 'SaitoSatoshi': [433], 'Saito': [434, 2809, 2934, 3013, 3087, 3089, 3263, 3735, 4211, 4583], 'TakahashiAtsushi': [452], 'Research': [458, 528, 542, 555, 558, 1693, 2655, 3319, 4456], 'Institute': [459, 480, 638, 667], '(A.T.),': [460], 'HirataMakoto': [478], 'Hirata': [479, 3250], 'Medical': [482, 586, 607, 628, 646, 684, 1662], 'Science,': [483], 'The': [484, 499, 984, 1028, 1048, 1078, 1235, 1391, 1502, 1532, 1729, 3202, 3665, 4706], 'Tokyo,': [487, 502], '(M.H.).': [489], 'MatsudaKoichi': [492], 'Matsuda': [493, 2486, 3254, 3258, 3659], 'Frontier': [497], 'Chiba,': [503], '(K.M.).': [505], 'MochizukiHideki': [508], 'Mochizuki': [509, 2979], 'ChongMichael': [524], 'Chong': [525, 1809, 2158], 'Population': [526, 540], 'Institute,': [529, 543], 'McMaster': [530, 544], 'Hamilton,': [532, 546], 'Canada': [533, 547], '(M.C.,': [534, 548], 'G.P.).': [535, 549], 'ParéGuillaume': [538], 'Paré': [539], "O'DonnellMartin": [552], "O'Donnell": [553, 1957, 2305, 2843], 'Board': [556], 'Clinical': [557, 580, 3389, 3591, 3874, 4130, 4724], 'Facility,': [559], 'Ireland': [563, 570], 'Galway,': [564, 568, 569], 'Hospital': [567, 2674], '(M.O.).': [571], 'AgoTetsuro': [574], 'Ago': [575, 1813, 2162], 'Science': [581, 1714], '(T.A.),': [582], 'Kyushu': [588, 609, 630], 'Fukuoka,': [590, 611, 632], 'HataJun': [594], 'Hata': [595, 2102, 2616], 'Epidemiology': [598, 619, 2658], 'Public': [600, 621, 1666], '(J.H.,': [602, 623], 'T.N.),': [603, 624], 'NinomiyaToshiharu': [615], 'Ninomiya': [616, 1955, 2303], 'DichgansMartin': [636], 'Dichgans': [637, 2132, 2646], 'Dementia': [642], 'Research,': [643, 3280, 3392, 4303], 'Ludwig-Maximilians-University': [644], 'Munich,': [645, 648, 657], 'Germany': [649, 658], '(M.D.).': [650, 659], 'Munich': [651], 'Cluster': [652], 'Systems': [654], '(SyNergy),': [656], 'DebetteStéphanie': [662], 'Debette': [663, 2130, 2644, 3376, 4373], 'Neurodegenerative': [669], 'Disease,': [670, 3769, 4536], 'Bordeaux': [671], 'Hospital,': [673], 'France': [674], '(S.D.).': [675], 'KuboMichiaki': [678], 'Kubo': [679, 1915, 2263], 'RIKEN': [680], 'Integrative': [683], 'Sciences': [685], 'Kubo),': [687], 'KoizumiAkio': [692], 'Koizumi': [693, 1721, 2776, 2829, 3194, 3294, 3747, 4291, 4421, 4782], 'IharaMasafumi': [713], 'Ihara': [714, 2825, 2976, 3056, 3102, 3169, 3545, 3750, 4785], 'Originally': [752, 4823], 'published7': [753], 'Jan': [754], '2019https://doi.org/10.1161/CIRCULATIONAHA.118.038439Circulation.': [755], '2019;139:295–298Ischemic': [756], 'stroke': [757, 974, 996, 1032, 1153, 1239, 1395, 1434, 1446, 2722, 2724, 3806, 4165], '(IS)': [758], 'is': [759, 778, 812, 1505], 'leading': [761], 'cause': [762], 'disability': [764], 'early': [766], 'death': [767], 'in': [768, 809, 834, 947, 990, 998, 1036, 1087, 1145, 1155, 1160, 1175, 1185, 1193, 1196, 1206, 1214, 1217, 1225, 1233, 1243, 1250, 1258, 1266, 1333, 1371, 1378, 1386, 1403, 1410, 1492, 1507, 1511, 1538, 1573, 1585, 1611, 1618, 1626, 2656, 2792, 2940, 3118, 3150, 3359, 3466, 3476, 3527, 3593, 3679, 3705, 3717, 3767, 3771, 3799, 3884, 3887, 3929, 4009, 4012, 4097, 4100, 4163, 4255, 4350, 4431, 4448, 4489, 4494, 4532, 4538, 4612, 4617, 4666, 4673, 4741, 4744, 4793], 'Asia,': [769, 811], 'where': [770], 'large-artery': [771], 'atherosclerosis': [772], '(LAA)': [773], 'attributable': [774], 'intracranial': [776, 1063, 1516, 1583, 2944, 3355, 4161, 4222, 4491, 4670], 'stenosis': [777, 1066, 3358, 3928, 4162], 'predominant': [780], 'etiology.': [781], 'Recently,': [782], 'a': [783, 804, 815, 828, 877, 961, 1327, 1337, 1474, 1638, 1707, 1723, 2782, 2904, 2991, 3303, 3624, 3680, 3943, 3989], 'large': [784, 3356], 'transethnic': [785], 'genome-wide': [786, 1084, 1494, 2711], 'association': [787, 839, 1075, 1115, 1300, 1339, 1367, 1418, 1476, 2712, 3666], 'study': [788, 895, 1106, 1472, 1554, 1560, 1687, 1737, 2713, 2907], 'identified': [789], '32': [790, 2718], 'loci': [791, 2719], 'associated': [792, 813, 1018, 2720, 3804, 4220], 'with': [793, 814, 858, 876, 965, 981, 994, 1019, 1133, 1151, 1167, 1198, 1317, 1326, 1343, 1424, 1482, 1486, 1515, 2721, 2986, 3523, 3805, 3934, 4221, 4676], 'IS1;': [794], 'however,': [795], 'Asian-specific': [796], 'genetic': [797, 1135], 'determinants': [798, 3353], 'remain': [799], 'unknown.': [800], 'Moyamoya': [801, 3153, 3197, 3436, 3467, 3525, 3669, 3706, 3885, 4002, 4059, 4132, 4294, 4348, 4427, 4535, 4709], 'disease': [802, 807, 2787, 3670, 3678, 4428, 4672], '(MMD),': [803], 'rare': [805, 1617], 'cerebrovascular': [806, 3622], 'endemic': [808], 'East': [810, 884, 1612], 'susceptibility': [816, 2783, 3304], 'gene': [817, 2784, 3305, 3672], 'RNF213,': [818, 3302], 'its': [820, 861, 1498, 2789, 4438], 'dysregulation': [821], 'experimentally': [822], 'impairs': [823], 'cerebral': [824, 1544, 2835], 'perfusion.2,3': [825], 'We': [826, 1112, 1655], 'hypothesized': [827], 'more': [829, 1052, 1369, 3795], 'general': [830, 3681, 3801], 'role': [831, 2791], 'IS': [835, 859, 1091, 1120, 1177, 1345], 'examined': [837, 956], 'variant': [843, 850, 987, 1021, 1038, 1049, 1142, 1248, 1342, 1408, 1423, 1439, 1481, 1504, 1534, 1607, 2937, 3674, 4665], 'gene,': [847], 'founder': [849], 'MMD': [852, 982, 1514, 1526], 'Japanese,': [854], 'Korean,': [855], 'Chinese,2': [857], 'subtypes.In': [862], 'this': [863, 1736], '2-stage': [864], 'case-control': [865, 2906], 'study,': [866, 1670, 3363, 3685], 'we': [867, 955, 1270], 'analyzed': [868, 1271], 'data': [869, 969, 1086, 1521, 1730], 'from': [870, 1083, 1279, 1709, 1740], '3': [871, 1334], 'independent': [872], 'Japanese': [873, 4592], 'population': [874, 964, 3802], 'studies': [875, 1335, 1495, 1621], 'total': [878], '46': [880], '958': [881], 'individuals': [882, 1273], 'Asian': [885], 'ancestry': [886], '(17': [887], '752': [888], 'cases': [889, 975, 1092, 1108, 1178, 1275, 3628], '29': [891], '206': [892], 'controls).': [893, 1111], 'All': [894], 'participants': [896, 3815], 'provided': [897], 'written': [898], 'informed': [899], 'consent,': [900], 'responsible': [903], 'ethics': [904, 909], 'committees': [905], 'local': [908], 'committee': [910], 'approved': [918], 'study.': [920], 'Variables': [921], 'were': [922, 937, 1081, 1298], 'compared': [923], 'by': [924, 1012, 1121, 1364, 1445, 1690, 1706, 3274], 'using': [925, 960, 1321], 'Student': [927], 't': [928], 'test': [929, 932], 'χ2': [931], 'as': [933, 1592, 2781], 'appropriate.': [934], 'subtypes': [936, 1447], 'classified': [938], 'according': [939], 'TOAST': [941], 'criteria': [942], '(Trial': [943], 'Org': [945], '10172': [946], 'Acute': [948, 3594], 'Treatment).': [950], 'In': [951, 1137, 1165, 1283], 'primary': [953, 1559], 'stage,': [954, 1140], 'genotype': [959], 'single': [962], 'hospital-based': [963], 'clinical': [966], 'radiological': [968], '(NCVC': [970], 'Biobank:': [971], '383': [972], 'noncardioembolic': [973, 995], '1011': [977], 'controls),': [978, 1096], 'excluding': [979], 'patients': [980, 993, 1150, 1512, 3933, 4674], '(n=12).': [983], 'was': [988, 1016, 1034, 1076, 1143, 1172, 1241, 1291, 1315, 1368, 1397, 1489, 1580, 1608, 1615, 1688], 'found': [989, 1144, 1506, 1609], '5.2%': [991], '2.1%': [999], 'controls': [1001, 1159], '(odds': [1002], 'ratio': [1003], '[OR],': [1004], '2.60': [1005], '[95%': [1006, 1024, 1181, 1189, 1202, 1210, 1221, 1229, 1348, 1356, 1375, 1383], 'CI,': [1007, 1025, 1182, 1190, 1203, 1211, 1222, 1230, 1349, 1357, 1376, 1384], '1.39–4.85],': [1008], 'P=0.0019).': [1009], 'When': [1010, 1362], 'stratified': [1011, 1363], 'subtypes,': [1013], 'only': [1014, 1610], 'LAA': [1015, 1199, 1353, 1593], 'significantly': [1017, 1173], '(OR,': [1022, 1179, 1200, 1219, 1346, 1354, 1373], '5.19': [1023], '2.53–10.64],': [1026], 'P=2.6×10–6).': [1027], 'mean': [1029, 1236, 1392], 'age': [1030, 1237, 1393], 'onset': [1033, 1240, 1396], 'lower': [1035, 1242, 1400], 'carriers': [1039, 1050, 1244, 1297, 1404], 'than': [1040, 1249, 1409, 3797], 'noncarriers': [1041, 1251, 1411], '(58.1±15.5': [1042], 'years': [1043, 1253, 1261, 1399], 'versus': [1044, 1055, 1068, 1254, 1262, 3931], '69.1±13.2': [1045], 'years,': [1046, 1256, 1264], 'P=0.0003).': [1047], 'included': [1051], 'women': [1053, 1218, 1372], '(55.0%': [1054], '27.3%,': [1056, 1069], 'P=0.011),': [1057], 'showed': [1059, 1336], 'greater': [1060], 'frequency': [1061, 1171, 1290, 1566], 'anterior': [1064], 'circulation': [1065], '(60.0%': [1067], 'P=0.004).We': [1070], 'investigated': [1071, 1113], 'whether': [1072], 'significant': [1074, 1475], 'replicable.': [1077], 'genotypes': [1080], 'derived': [1082], 'genotyping': [1085], 'Biobank-Japan': [1088, 1162], '(16': [1089], '256': [1090], '27': [1094], '294': [1095], 'Hisayama': [1099], 'Fukuoka': [1102, 1454], 'Registry': [1104], '(FSR)': [1105], '(1113': [1107], '901': [1110], 'between': [1116, 1435, 1525, 3667], 'R4810K': [1118, 1126, 3148], 'imputed': [1122], 'allele': [1123, 1289, 1500], 'dosage': [1124], 'fitted': [1128], 'logistic': [1130], 'regression': [1131], 'model': [1132], 'additive': [1134], 'model.1': [1136], 'replication': [1139, 1586], '2.3%': [1146], '3.8%': [1148], 'ischemic': [1152, 1425, 1433, 4164], '1.3%': [1156], 'both': [1158], 'Hisayama-FSR.': [1164], 'comparison': [1166], 'controls,': [1168], 'carrier': [1170, 1440, 1565], 'higher': [1174], 'all': [1176, 1344], '1.77': [1180], '1.40–2.24],': [1183], 'P=1.6×10–6': [1184], 'Biobank-Japan;': [1186, 1207, 1226, 1259], 'OR,': [1187, 1208, 1227, 1381, 1824, 2173], '2.90': [1188], '1.39–6.04],': [1191], 'P=0.0045': [1192], 'Hisayama-FSR),': [1194], 'especially': [1195, 1485], 'those': [1197], '3.10': [1201], '1.98–4.84],': [1204], 'P=6.9×10–7': [1205], '4.20': [1209], '1.90–9.28],': [1212], 'P=3.8×10–4': [1213], 'Hisayama-FSR)': [1215], '2.42': [1220], '1.69–3.45],': [1223], 'P=1.3×10–6': [1224], '3.73': [1228], '1.10–12.73],': [1231], 'P=0.035': [1232], 'Hisayama-FSR).': [1234], '(56.9±10.2': [1252], '65.0±9.7': [1255], 'P=6.3×10–5': [1257], '66.6±12.4': [1260], '69.8±10.7': [1263], 'P=0.058': [1265], 'Hisayama-FSR).For': [1267], 'ethnic': [1268], 'comparison,': [1269], 'European': [1272, 1285], '(826': [1274], '863': [1277], 'controls)': [1278], 'INTERSTROKE': [1281, 1681, 2897], 'study.4': [1282], 'cohort,': [1286], 'maximum': [1288], '0.0006.': [1292], 'Although': [1293], '2': [1294, 4812], 'heterozygote': [1295], 'mutation': [1296, 1313], 'identified,': [1299], 'testing': [1301], 'could': [1302], 'not': [1303, 1490], 'be': [1304, 1536], 'performed': [1305, 1316], 'because': [1306, 1496, 1567], 'low': [1309, 1499], 'number': [1310], 'putative': [1312], 'carriers.Meta-analysis': [1314], 'RevMan': [1318], '5.3': [1319], 'software': [1320], 'weighted': [1323], 'inverse-variance/mean-difference': [1324], 'method': [1325], 'fixed-effects': [1328], 'model.': [1329], 'A': [1330, 3195, 3295, 3473, 3599, 3748, 4004, 4045, 4123, 4292, 4379, 4422, 4606, 4783], 'combined': [1331], 'meta-analysis': [1332], 'consistent': [1338], '1.91': [1347], '1.55–2.36],': [1350], 'P=1.5×10–9)': [1351], '3.58': [1355], '2.55–5.03],': [1358], 'P=2.0×10–13;': [1359], 'Figure': [1360, 1389], '[A]).': [1361], 'sex,': [1365], 'prominent': [1370], '1.50': [1374], '1.14–1.98]': [1377], 'men,': [1379], 'P=0.004;': [1380], '2.69': [1382], '1.95–3.69]': [1385], 'women,': [1387], 'P=1.2×10–9;': [1388], '[B]).': [1390], '4.1': [1398], '(2.7–5.5': [1401], 'years)': [1402], '(P=1.1×10–8).Download': [1412], 'figureDownload': [1413], 'PowerPointFigure.': [1414], 'Meta-analysis': [1415], 'stroke.': [1426], 'Forest': [1427], 'plots': [1428], 'odds': [1430], 'ratios': [1431], 'noncarrier': [1442], 'are': [1443, 1629, 1738, 3794], 'shown': [1444], '(A)': [1448], 'sex': [1450], '(B).': [1451], 'FSR': [1452], 'indicates': [1453], 'registry;': [1456], 'IV,': [1457], 'inverse': [1458], 'variance': [1459], 'method;': [1460], 'NCVC,': [1461], 'Center;': [1466], 'SE,': [1468], 'standard': [1469], 'error.The': [1470], 'current': [1471], 'demonstrated': [1473], 'IS,': [1483], 'LAA,': [1487, 1528], 'which': [1488], 'reported': [1491], 'previous': [1493], 'frequency.1': [1501], '20%': [1508], '30%': [1510], 'without': [1513], 'major': [1517, 2945], 'artery': [1518, 2946, 3357, 4223], 'stenosis/occlusion.5': [1519], 'These': [1520], 'indicate': [1522], 'considerable': [1523], 'continuity': [1524], 'namely,': [1529], 'RNF213-related': [1530], 'vasculopathy.': [1531], 'may': [1535, 1561, 1594], 'deficient': [1537], 'vascular': [1540, 2793, 3808], 'remodeling': [1541], 'required': [1542], 'blood': [1545], 'flow': [1546], 'autoregulation': [1547], 'thus': [1549], 'susceptible': [1550, 3671], 'IS.': [1552], 'Our': [1553], 'has': [1555, 1722], 'limitations.': [1556], 'First,': [1557], 'have': [1562, 1595], 'overestimated': [1563], 'potential': [1570, 1639], 'selection': [1571], 'biases': [1572], 'single-center': [1575], 'setting.': [1576], 'Second,': [1577], 'no': [1578], 'information': [1579], 'available': [1581, 1739], 'regarding': [1582], 'vessels': [1584], 'studies.': [1587], 'Therefore,': [1588], 'variants': [1590, 1625, 3793, 4219, 4488], 'labeled': [1591], 'MMD,': [1596], 'overestimating': [1597], 'risk': [1599, 2909], 'variant.': [1603], 'Third,': [1604], 'Asians,': [1613], 'but': [1614, 4738], 'extremely': [1616], 'whites.': [1619], 'Further': [1620], 'various': [1623, 1627, 2941], 'populations': [1628], 'needed': [1630], 'confirm': [1632], 'these': [1633], 'findings': [1634, 1734], 'explore': [1637], 'therapeutic': [1640, 4389], 'target': [1641], 'LAA.AcknowledgmentsThe': [1643], 'authors': [1644, 1743], 'thank': [1645, 1656], 'Dr': [1646], 'Ahmad': [1647], 'Khundakar': [1648], 'scientific': [1650], 'input': [1651], 'editorial': [1653], 'assistance.': [1654], 'Biobank,': [1659], 'Tohoku': [1661], 'Megabank,': [1663], 'Center-based': [1668], 'Prospective': [1669, 3601], 'Multi-institutional': [1673], 'Collaborative': [1674], 'Cohort': [1675, 4007], 'Study,': [1676, 3277, 3602], 'Japan,': [1679, 4745], 'providing': [1683], 'data.Sources': [1684], 'FundingThis': [1686], 'supported': [1689], 'Intramural': [1692], 'Fund': [1694], 'Diseases': [1697], 'Grant-in-Aid': [1708], 'Ministry': [1711], 'Culture': [1713], 'Sports': [1716], '(JP17H06397).DisclosuresDr': [1719], 'patent': [1724], '(P130009545).FootnotesData': [1727], 'sharing:': [1728], 'that': [1731], 'support': [1732], 'corresponding': [1742], 'on': [1744, 3065, 4714], 'reasonable': [1745], 'request.https://www.ahajournals.org/journal/circShuhei': [1746], 'protected]ac.jpMasafumi': [1765], 'protected]go.jpReferences1.': [1784], 'Malik': [1785, 2134], 'R,': [1786, 1928, 1994, 2135, 2276, 2342, 2517, 2531, 2761, 2850, 2874, 3343, 3403, 3485, 3568, 3861, 3905, 4472], 'Chauhan': [1787, 2136], 'G,': [1788, 1886, 2014, 2109, 2137, 2234, 2362, 2423, 2545, 2623, 2878, 3141, 3190, 3335, 3413, 3417, 3429, 4372], 'Traylor': [1789, 2138], 'M,': [1790, 1792, 1810, 1858, 1906, 1916, 2027, 2055, 2123, 2133, 2139, 2141, 2159, 2254, 2264, 2375, 2403, 2421, 2439, 2441, 2453, 2459, 2497, 2511, 2521, 2535, 2539, 2637, 2769, 2826, 2844, 2882, 2888, 2923, 2961, 3030, 3038, 3052, 3170, 3223, 3253, 3293, 3329, 3546, 3562, 3574, 3652, 3654, 3740, 3843, 3859, 4019, 4025, 4041, 4183, 4322, 4332, 4334, 4404, 4408, 4468, 4547, 4628, 4630, 4636, 4640, 4648, 4691, 4777], 'Sargurupremraj': [1791, 2140], 'Okada': [1793, 2142, 3260], 'Y,': [1794, 2129, 2143, 2643, 2739, 2755, 2806, 2816, 2818, 2967, 3018, 3040, 3092, 3135, 3172, 3174, 3227, 3231, 3243, 3339, 3453, 3487, 3489, 3491, 3503, 3558, 3566, 3572, 3646, 3835, 3855, 3915, 4083, 4197, 4242, 4314, 4336, 4412, 4476, 4512, 4545, 4695], 'Mishra': [1795, 2144], 'A,': [1796, 1844, 1878, 1944, 2002, 2045, 2101, 2145, 2193, 2226, 2292, 2350, 2411, 2429, 2433, 2437, 2513, 2549, 2569, 2615, 2751, 2759, 2866, 2872, 2886, 2929, 3233, 3239, 3257, 3408, 4017, 4021, 4023, 4035, 4199, 4366, 4644, 4769], 'Rutten-Jacobs': [1797, 2146], 'L,': [1798, 2147, 2431, 2435, 2451, 2471, 2473, 2571, 2765, 2852, 2864, 3411, 3423, 3863, 3865, 3913, 3976, 4143, 4324, 4364], 'Giese': [1799, 2148], 'AK,': [1800, 2149], 'van': [1801, 2023, 2076, 2150, 2371, 2582], 'der': [1802, 2077, 2151, 2583], 'Laan': [1803, 2152], 'SW,': [1804, 2153], 'Gretarsdottir': [1805, 2154], 'S,': [1806, 1826, 1872, 1986, 2018, 2020, 2031, 2039, 2049, 2121, 2131, 2155, 2175, 2220, 2334, 2366, 2368, 2379, 2387, 2449, 2501, 2515, 2577, 2635, 2645, 2737, 2749, 2771, 2808, 2810, 2820, 2824, 2862, 2919, 2925, 2965, 3014, 3020, 3086, 3090, 3139, 3184, 3213, 3217, 3219, 3283, 3291, 3331, 3406, 3421, 3481, 3552, 3580, 3726, 3730, 3736, 3779, 3785, 4027, 4031, 4033, 4039, 4117, 4179, 4185, 4207, 4287, 4328, 4368, 4374, 4420, 4638, 4654, 4693, 4759], 'Anderson': [1807, 2156], 'CD,': [1808, 1920, 2157, 2268], 'Adams': [1811, 2160], 'HHH,': [1812, 2161], 'T,': [1814, 1956, 1982, 2008, 2043, 2163, 2304, 2330, 2356, 2455, 2555, 2563, 2601, 2743, 2802, 2858, 2892, 2933, 2963, 2971, 3008, 3026, 3034, 3036, 3084, 3133, 3182, 3186, 3245, 3247, 3285, 3345, 3548, 3550, 3656, 3658, 3724, 3744, 3962, 3970, 3974, 4145, 4205, 4406, 4418, 4632, 4634, 4757, 4761, 4767, 4771], 'Almgren': [1815, 2164], 'P,': [1816, 1818, 2000, 2079, 2081, 2165, 2167, 2348, 2419, 2447, 2856, 2880, 2890, 2894, 3419, 4029], 'Amouyel': [1817, 2166], 'Ay': [1819, 2168], 'H,': [1820, 2169, 2417, 2483, 2565, 2587, 2599, 2741, 2745, 2814, 2822, 2828, 2854, 2921, 2927, 2931, 3016, 3044, 3178, 3180, 3221, 3225, 3235, 3237, 3289, 3501, 3544, 3560, 3648, 3746, 3857, 3964, 3968, 4075, 4119, 4177, 4181, 4189, 4201, 4203, 4234, 4277, 4283, 4414, 4549, 4553, 4763, 4781], 'Bartz': [1821, 2170], 'TM,': [1822, 2171], 'Benavente': [1823, 2172], 'Bevan': [1825, 2174], 'Boncoraglio': [1827, 2176], 'GB,': [1828, 2177], 'Brown': [1829, 2178], 'RD,': [1830, 2179, 2443], 'Butterworth': [1831, 2180], 'AS,': [1832, 1880, 2181, 2228, 2397], 'Carrera': [1833, 2182], 'C,': [1834, 1848, 1914, 1922, 2006, 2022, 2063, 2093, 2183, 2197, 2262, 2270, 2354, 2370, 2399, 2533, 2553, 2607, 2848, 2868, 3341, 3849, 4149, 4281, 4508, 4510, 4514, 4555], 'Carty': [1835, 2184], 'CL,': [1836, 2185, 2537], 'Chasman': [1837, 2186], 'DI,': [1838, 2187], 'Chen': [1839, 2188, 3496, 4521], 'WM,': [1840, 2189], 'Cole': [1841, 2190], 'JW,': [1842, 1904, 2191, 2252], 'Correa': [1843, 2192], 'Cotlarciuc': [1845, 2194], 'I,': [1846, 2097, 2195, 2425, 2519, 2611], 'Cruchaga': [1847, 2196], 'Danesh': [1849, 2198], 'J,': [1850, 1874, 1900, 1942, 2075, 2103, 2107, 2199, 2222, 2248, 2290, 2395, 2463, 2491, 2509, 2525, 2617, 2621, 2876, 2973, 3012, 3046, 3137, 3251, 3287, 3401, 3966, 4079, 4081, 4187, 4191, 4238, 4240, 4273, 4279, 4285, 4362, 4410, 4470, 4474, 4516, 4543, 4551, 4642, 4773, 4775], 'de': [1851, 2200], 'Bakker': [1852, 2201], 'PIW,': [1853, 2202], 'DeStefano': [1854, 2203], 'AL,': [1855, 2204], 'den': [1856], 'Hoed': [1857, 2205], 'Duan': [1859, 2207, 3484, 3871], 'Q,': [1860, 2037, 2208, 2385, 2597, 3499, 4318, 4326], 'Engelter': [1861, 2209], 'ST,': [1862, 2210], 'Falcone': [1863, 2211], 'GJ,': [1864, 2212], 'Gottesman': [1865, 2213], 'RF,': [1866, 2214], 'Grewal': [1867, 2215], 'RP,': [1868, 2216], 'Gudnason': [1869, 2217], 'V,': [1870, 1990, 2053, 2218, 2338, 2405, 2477, 3399, 3919], 'Gustafsson': [1871, 2219], 'Haessler': [1873, 2221], 'Harris': [1875, 2223], 'TB,': [1876, 2224], 'Hassan': [1877, 2225], 'Havulinna': [1879, 2227], 'Heckbert': [1881, 2229], 'SR,': [1882, 2230, 2593], 'Holliday': [1883, 2231], 'EG,': [1884, 2232], 'Howard': [1885, 2233], 'Hsu': [1887, 2235], 'FC,': [1888, 2236], 'Hyacinth': [1889, 2237], 'HI,': [1890, 2238], 'Ikram': [1891, 2239], 'MA,': [1892, 1954, 2240, 2302], 'Ingelsson': [1893, 2241, 2438], 'E,': [1894, 1938, 2242, 2286, 2495, 2575, 3024, 3082, 3570, 3732, 3781, 4077, 4236], 'Irvin': [1895, 2243], 'MR,': [1896, 2244], 'Jian': [1897, 2245], 'X,': [1898, 2246, 3483, 3495, 3497, 3831, 3853, 3903, 3907, 3972, 3978, 4312, 4466, 4478], 'Jiménez-Conde': [1899, 2247], 'Johnson': [1901, 2086, 2249], 'JA,': [1902, 2250], 'Jukema': [1903, 2251], 'Kanai': [1905, 2253], 'Keene': [1907, 2255], 'KL,': [1908, 2035, 2256, 2383], 'Kissela': [1909, 2257], 'BM,': [1910, 1960, 2258, 2308], 'Kleindorfer': [1911, 2259], 'DO,': [1912, 2260], 'Kooperberg': [1913, 2261], 'Lange': [1917, 2265], 'LA,': [1918, 2266], 'Langefeld': [1919, 2267], 'Langenberg': [1921, 2269], 'Launer': [1923, 2271], 'LJ,': [1924, 2272], 'Lee': [1925, 2273, 2584, 3142, 3145, 4690], 'JM,': [1926, 2274], 'Lemmens': [1927, 2275], 'Leys': [1929, 2277], 'D,': [1930, 2095, 2105, 2113, 2278, 2591, 2609, 2619, 2627, 2735, 2846, 2884, 3028, 3415, 3783, 3845, 4037, 4043, 4275, 4697], 'Lewis': [1931, 2279], 'CM,': [1932, 2025, 2280, 2373, 2475], 'Lin': [1933, 2281, 4473], 'WY,': [1934, 2282], 'Lindgren': [1935, 2283, 2474], 'AG,': [1936, 2284, 2527, 2579], 'Lorentzen': [1937, 2285], 'Magnusson': [1939, 2287], 'PK,': [1940, 2288], 'Maguire': [1941, 2289], 'Manichaikul': [1943, 2291], 'McArdle': [1945, 2293], 'PF,': [1946, 2294], 'Meschia': [1947, 2295], 'JF,': [1948, 2296, 2415], 'Mitchell': [1949, 2297], 'BD,': [1950, 2298], 'Mosley': [1951, 2299], 'TH,': [1952, 2300], 'Nalls': [1953, 2301], 'MJ,': [1958, 2306], 'Psaty': [1959, 2307], 'Pulit': [1961, 2309], 'SL,': [1962, 2310, 2860], 'Rannikmäe': [1963, 2311], 'K,': [1964, 1970, 2115, 2312, 2318, 2445, 2487, 2551, 2561, 2567, 2589, 2629, 2753, 2773, 2969, 3010, 3022, 3042, 3050, 3088, 3094, 3096, 3098, 3215, 3229, 3241, 3249, 3255, 3542, 3554, 3556, 3564, 3576, 3578, 3650, 3728, 3734, 3738, 3742, 3909, 3917, 4121, 4193, 4320, 4370, 4416, 4646, 4650, 4652, 4699, 4730, 4765, 4779], 'Reiner': [1965, 2313], 'AP,': [1966, 2314, 2493, 2529], 'Rexrode': [1967, 2315], 'KM,': [1968, 2316], 'Rice': [1969, 2317], 'Rich': [1971, 2319], 'SS,': [1972, 2320], 'Ridker': [1973, 2321], 'PM,': [1974, 1978, 2322, 2326], 'Rost': [1975, 2323], 'NS,': [1976, 2324], 'Rothwell': [1977, 2325, 3923], 'Rotter': [1979, 2327], 'JI,': [1980, 2328, 2804], 'Rundek': [1981, 2329, 3344], 'Sacco': [1983, 2331, 2849, 3342], 'RL,': [1984, 2332], 'Sakaue': [1985, 2333, 3218], 'Sale': [1987, 2335], 'MM,': [1988, 2336], 'Salomaa': [1989, 2337], 'Sapkota': [1991, 2339], 'BR,': [1992, 2340], 'Schmidt': [1993, 1995, 2341, 2343], 'CO,': [1996, 2344], 'Schminke': [1997, 2345], 'U,': [1998, 2016, 2346, 2364], 'Sharma': [1999, 2347], 'Slowik': [2001, 2349], 'Sudlow': [2003, 2351], 'CLM,': [2004, 2352], 'Tanislav': [2005, 2353], 'Tatlisumak': [2007, 2355], 'Taylor': [2009, 2357], 'KD,': [2010, 2358], 'Thijs': [2011, 2359], 'VNS,': [2012, 2360], 'Thorleifsson': [2013, 2361], 'Thorsteinsdottir': [2015, 2363], 'Tiedt': [2017, 2365, 4367], 'Trompet': [2019, 2367], 'Tzourio': [2021, 2369], 'Duijn': [2024, 2372], 'Walters': [2026, 2374], 'Wareham': [2028, 2376], 'NJ,': [2029, 2377], 'Wassertheil-Smoller': [2030, 2378], 'Wilson': [2032, 2380], 'JG,': [2033, 2381], 'Wiggins': [2034, 2382], 'Yang': [2036, 2384, 3854, 3860, 3866, 3973, 4323, 4335], 'Yusuf': [2038, 2386, 2895], 'Bis': [2040], 'JC,': [2041, 2083, 2111, 2625], 'Pastinen': [2042], 'Ruusalepp': [2044], 'Schadt': [2046], 'EE,': [2047], 'Koplev': [2048], 'Björkegren': [2050], 'JLM,': [2051], 'Codoni': [2052], 'Civelek': [2054], 'Smith': [2056, 2548], 'NL,': [2057, 2507], 'Trégouët': [2058], 'DA,': [2059], 'Christophersen': [2060], 'IE,': [2061], 'Roselli': [2062], 'Lubitz': [2064], 'SA,': [2065], 'Ellinor': [2066], 'PT,': [2067], 'Tai': [2068], 'ES,': [2069], 'Kooner': [2070], 'JS,': [2071], 'Kato': [2072], 'N,': [2073, 2389, 2413, 2485, 2489, 2541, 2543, 2747, 2775, 2975, 3032, 3337, 3839], 'He': [2074, 3480], 'Harst': [2078], 'Elliott': [2080], 'Chambers': [2082], 'Takeuchi': [2084], 'F,': [2085, 2870, 3259, 3333, 3425, 3427, 3722, 3841, 3847, 3851, 3911, 3960, 4316, 4330, 4520], 'AD,': [2087], 'Sanghera': [2088, 2602], 'DK,': [2089, 2393, 2603], 'Melander': [2090, 2604], 'O,': [2091, 2457, 2605, 3048, 3188, 4271], 'Jern': [2092, 2606], 'Strbian': [2094, 2608], 'Fernandez-Cadenas': [2096, 2610], 'Longstreth': [2098, 2612], 'WT,': [2099, 2613], 'Rolfs': [2100, 2614], 'Woo': [2104, 2618, 4546], 'Rosand': [2106, 2620], 'Pare': [2108, 2622], 'Hopewell': [2110, 2624], 'Saleheen': [2112, 2626], 'Stefansson': [2114, 2628], 'Worrall': [2116, 2630], 'BB,': [2117, 2631], 'Kittner': [2118, 2632], 'SJ,': [2119, 2585, 2633], 'Seshadri': [2120, 2634], 'Fornage': [2122, 2636], 'Markus': [2124, 2638, 3379, 3789], 'HS,': [2125, 2391, 2639], 'Howson': [2126, 2640], 'JMM,': [2127, 2641], 'Amin': [2388], 'Aparicio': [2390], 'Arnett': [2392], 'Attia': [2394], 'Beiser': [2396], 'Berr': [2398], 'Buring': [2400], 'JE,': [2401, 2767], 'Bustamante': [2402, 4378], 'Caso': [2404], 'Cheng': [2406], 'YC,': [2407], 'Choi': [2408, 4076, 4235, 4409], 'SH,': [2409], 'Chowhan': [2410], 'Cullell': [2412], 'Dartigues': [2414], 'Delavaran': [2416], 'Delgado': [2418], 'Dörr': [2420], 'Engström': [2422], 'Ford': [2424], 'Gurpreet': [2426], 'WS,': [2427], 'Hamsten': [2428], 'Heitsch': [2430], 'Hozawa': [2432], 'Ibanez': [2434], 'Ilinca': [2436], 'Iwasaki': [2440], 'Jackson': [2442], 'Jood': [2444], 'Jousilahti': [2446], 'Kaffashian': [2448], 'Kalra': [2450], 'Kamouchi': [2452], 'Kitazono': [2454], 'Kjartansson': [2456], 'Kloss': [2458], 'Koudstaal': [2460], 'PJ,': [2461], 'Krupinski': [2462], 'Labovitz': [2464], 'DL,': [2465], 'Laurie': [2466], 'CC,': [2467], 'Levi': [2468], 'CR,': [2469], 'Li': [2470, 3613, 3844, 3912, 3965, 3967, 3979, 4317, 4469], 'Lind': [2472], 'Lioutas': [2476], 'Liu': [2478, 2732, 3175, 3328, 3492, 3868, 4321, 4327, 4337, 4340], 'YM,': [2479], 'Lopez': [2480], 'OL,': [2481], 'Martinez-Majander': [2484], 'Minegishi': [2488], 'Montaner': [2490, 4361], 'Morris': [2492], 'Muiño': [2494], 'Müller-Nurasyid': [2496], 'Norrving': [2498], 'B,': [2499, 2763, 3777, 4147], 'Ogishima': [2500], 'Parati': [2502], 'EA,': [2503], 'Peddareddygari': [2504], 'LR,': [2505], 'Pedersen': [2506], 'Pera': [2508], 'Perola': [2510], 'Pezzini': [2512], 'Pileggi': [2514], 'Rabionet': [2516], 'Riba-Llena': [2518], 'Ribasés': [2520], 'Romero': [2522], 'JR,': [2523], 'Roquer': [2524], 'Rudd': [2526], 'Sarin': [2528], 'Sarju': [2530], 'Sarnowski': [2532], 'Sasaki': [2534, 2970], 'Satizabal': [2536], 'Satoh': [2538], 'Sattar': [2540], 'Sawada': [2542], 'Sibolt': [2544], 'Sigurdsson': [2546], 'Á,': [2547], 'Sobue': [2550], 'Soriano-Tárraga': [2552], 'Stanne': [2554], 'Stine': [2556], 'OC,': [2557], 'Stott': [2558], 'DJ,': [2559], 'Strauch': [2560], 'Takai': [2562], 'Tanaka': [2564, 3009, 3547], 'Tanno': [2566], 'Teumer': [2568], 'Tomppo': [2570], 'Torres-Aguila': [2572], 'NP,': [2573], 'Touze': [2574], 'Tsugane': [2576], 'Uitterlinden': [2578], 'Valdimarsson': [2580], 'EM,': [2581], 'Völzke': [2586], 'Wakai': [2588], 'Weir': [2590], 'Williams': [2592], 'Wolfe': [2594], 'CDA,': [2595], 'Wong': [2596, 3916], 'Xu': [2598, 4477], 'Yamaji': [2600], 'M;': [2647], 'AFGen': [2648], 'Consortium;': [2649, 2660, 2667, 2669, 2677, 2679, 2681, 2688, 2695, 2707], 'Cohorts': [2650], 'Heart': [2652, 3162, 4109, 4750, 4819], 'Aging': [2654, 3772], '(CHARGE)': [2659], 'International': [2661, 2682, 4572], 'Genomics': [2662], 'Blood': [2664], 'Pressure': [2665], '(iGEN-BP)': [2666], 'INVENT': [2668], 'STARNET;': [2670], 'BioBank': [2671], 'Cooperative': [2673], 'Group;': [2675], 'COMPASS': [2676], 'EPIC-CVD': [2678], 'EPIC-InterAct': [2680], 'Genetics': [2684, 2698, 4497], 'Consortium': [2685], '(ISGC);': [2686], 'METASTROKE': [2687], 'Working': [2690], 'Group': [2691], 'CHARGE': [2694], 'NINDS': [2696], 'Network': [2699], '(SiGN);': [2700], 'UK': [2701], 'Young': [2702], 'Lacunar': [2703], 'DNA': [2704], 'Study;': [2705], 'MEGASTROKE': [2706, 2708], 'Consortium.': [2709], 'Multiancestry': [2710], '520,000': [2715], 'subjects': [2716], 'identifies': [2717], 'subtypes.Nat': [2725], 'Genet.': [2726], '2018;': [2727, 2838], '50:524–537.': [2728], 'doi:': [2729, 2798, 2840, 2915, 2950], '10.1038/s41588-018-0058-3CrossrefMedlineGoogle': [2730], 'Scholar2.': [2731], 'W,': [2733, 3176, 4085, 4195, 4244, 4518], 'Morito': [2734], 'Takashima': [2736], 'Mineharu': [2738, 2815, 3696], 'Hitomi': [2742], 'Hashikata': [2744], 'Matsuura': [2746], 'Yamazaki': [2748], 'Kikuta': [2752], 'Takagi': [2754, 2817], 'KH,': [2757, 2812], 'Fujiyama': [2758], 'Herzig': [2760], 'Krischek': [2762], 'Zou': [2764, 3836], 'Kim': [2766, 3136, 3286, 4074, 4080, 4082, 4086, 4233, 4239, 4241, 4245, 4274, 4284, 4288, 4407, 4542, 4550, 4556, 4559], 'Kitakaze': [2768], 'Miyamoto': [2770, 2823, 3699], 'Nagata': [2772], 'Hashimoto': [2774], 'A.': [2777, 2830], 'Identification': [2778], 'moyamoya': [2786, 3307, 4613], 'possible': [2790], 'development.PLoS': [2794], 'One.': [2795], '2011;': [2796], '6:e22542.': [2797], '10.1371/journal.pone.0022542CrossrefMedlineGoogle': [2799], 'Scholar3.': [2800], 'Enmi': [2803], 'Hattori': [2805, 3039, 3091, 3173], 'Iguchi': [2807], 'Okuda': [2813, 3288], 'Youssefian': [2819, 4424], 'Iida': [2821], 'Dysregulation': [2831], 'promotes': [2834], 'hypoperfusion.Sci': [2836], 'Rep.': [2837], '8:3607.': [2839], '10.1038/s41598-018-22064-8CrossrefMedlineGoogle': [2841], 'Scholar4.': [2842], 'Xavier': [2845], 'Diener': [2847], 'Lisheng': [2851], 'Zhang': [2853, 3832, 3971, 4144, 4146, 4148, 4319, 4325, 4515], 'Pias': [2855], 'Truelsen': [2857], 'Chin': [2859], 'Rangarajan': [2861], 'Devilliers': [2863], 'Damasceno': [2865], 'Mondo': [2867], 'Lanas': [2869], 'Avezum': [2871], 'Diaz': [2873], 'Varigos': [2875], 'Hankey': [2877], 'Teal': [2879], 'Kapral': [2881], 'Ryglewicz': [2883], 'Czlonkowska': [2885], 'Skowronska': [2887], 'Lopez-Jaramillo': [2889], 'Dans': [2891], 'Langhorne': [2893], 'S;': [2896], 'investigators.': [2898], 'Rationale': [2899], 'design': [2901], 'INTERSTROKE:': [2903], 'global': [2905], 'factors': [2910], 'stroke.Neuroepidemiology.': [2912], '2010;': [2913], '35:36–44.': [2914], '10.1159/000306058CrossrefMedlineGoogle': [2916], 'Scholar5.': [2917], 'Miyawaki': [2918, 3183, 3216, 4178, 4580], 'Imai': [2920, 3220, 4180], 'Shimizu': [2922, 2932, 3222, 4182, 4204], 'Yagi': [2924, 4184], 'Ono': [2926, 3234, 4200], 'Mukasa': [2928], 'Nakatomi': [2930, 3236, 4202], 'N.': [2935], 'Genetic': [2936, 3352, 3876, 4345, 4586], 'c.14576G>A': [2939], 'phenotypes': [2942], 'stenosis/occlusion.Stroke.': [2947], '2013;': [2948], '44:2894–2897.': [2949], '10.1161/STROKEAHA.113.002477LinkGoogle': [2951], 'Scholar': [2952], 'Previous': [2953], 'Back': [2954], 'top': [2956], 'Next': [2957], 'FiguresReferencesRelatedDetailsCited': [2958], 'By': [2959], 'Ohara': [2960, 2974, 3228], 'Yoshimoto': [2962, 3007, 3083, 3181, 3723, 4770], 'Gon': [2966], 'Todo': [2968, 3575], 'Takasugi': [2972], 'M': [2977, 3057, 3100, 3103, 3347, 3751, 4601, 4701, 4732, 4735, 4786], 'H': [2980, 3054, 3298, 3380, 3790], '(2022)': [2981, 3058, 3104, 3147, 3196, 3265, 3299, 3351, 3381, 3435, 3461, 3509, 3586], 'Carriers': [2985], 'Intracranial': [2987, 3270, 3926, 4103, 4256, 4564, 4589, 4797], 'Arterial': [2988, 3471, 4257, 4798], 'Stenosis': [2989, 3272], 'Have': [2990], 'Low': [2992], 'Atherosclerotic': [2993, 3597], 'Burden,': [2994], 'Journal': [2995, 3158, 3364, 3603, 3635, 3686, 3817, 3889, 3946, 4105, 4573, 4593, 4678, 4722, 4746], 'Thrombosis,': [2999, 3607], '10.5551/jat.63379,': [3000], '29:11,': [3001], '(1655-1662),': [3002], 'Online': [3003, 3078, 3129, 3165, 3208, 3324, 3372, 3395, 3448, 3537, 3641, 3692, 3826, 3898, 3955, 4070, 4112, 4172, 4229, 4266, 4307, 4357, 4399, 4461, 4503, 4623, 4686, 4753, 4803], 'publication': [3004, 3079, 3130, 3166, 3209, 3325, 3373, 3396, 3449, 3538, 3642, 3693, 3827, 3899, 3956, 4071, 4113, 4173, 4230, 4267, 4308, 4358, 4400, 4462, 4504, 4624, 4687, 4754, 4804], 'date:': [3005, 3080, 3131, 3167, 3210, 3326, 3374, 3397, 3450, 3539, 3643, 3694, 3828, 3900, 3957, 4072, 4114, 4174, 4231, 4268, 4309, 4359, 4401, 4463, 4505, 4625, 4688, 4755, 4805], '1-Nov-2022.': [3006], 'Koge': [3011], 'Yamagami': [3015, 3543], 'Nakaoku': [3017, 3557], 'Ogata': [3019], 'Nishimura': [3021, 3095, 3555, 3727], 'Yamaguchi': [3023, 3731, 4120], 'Chiba': [3025], 'Kawakami': [3027], 'Shiozawa': [3029], 'Kamogawa': [3031], 'Ohta': [3033], 'Satow': [3035], 'Inoue': [3037, 4731], 'Kataoka': [3043], 'Chung': [3045, 4078, 4237, 4272], 'Bang': [3047, 3187, 4089, 4248, 4270], 'Maruyama': [3053, 3745, 4780], 'Impact': [3059, 4707], 'Endovascular': [3066], 'Therapy': [3067], 'Large‐Vessel': [3069], 'Occlusion': [3070], 'Stroke,': [3071, 3122, 3445, 4263, 4354, 4800], 'Stroke:': [3072, 3123, 3598], 'Vascular': [3073, 3124, 3714, 4098], 'Interventional': [3075, 3126], '2:6,': [3077, 3128], '1-Nov-2022.Yamaguchi': [3081], 'Ogura': [3085, 3729], 'Wasida': [3093], 'Association': [3105, 3267, 3276, 3511, 3518, 4050, 4343], 'With': [3111, 3120, 3469, 4001, 4056, 4102, 4347, 4534, 4796], 'Outer': [3113], 'Diameter': [3114], 'Cervical': [3116], 'Arteries': [3117], 'Patients': [3119, 4000, 4101, 4533], '1-Nov-2022.Ok': [3132], 'Jung': [3134], 'Park': [3138, 3140, 4544, 4552], 'S': [3143, 3377, 3457, 3663, 3700, 3787, 4209, 4425, 4480, 4581], 'K': [3146, 3582, 3585, 4656, 4704], 'Suspected': [3151], 'Unilateral': [3152], 'Predicts': [3155], 'Contralateral': [3156], 'Progression,': [3157], 'American': [3161, 4108, 4749, 4818], 'Association,': [3163, 4110, 4751, 4820], '11:15,': [3164], '2-Aug-2022.': [3168], 'Yamamoto': [3171, 3240, 3559], 'Ishiyama': [3179], 'Clausen': [3185], 'Steinberg': [3189], 'Tournier-Lasserve': [3191], 'E': [3192, 3508], 'disease:': [3198], 'diagnosis': [3199], 'interventions,': [3201], 'Lancet': [3203], '10.1016/S1474-4422(22)00165-X,': [3205], '21:8,': [3206], '(747-758),': [3207], '1-Aug-2022.': [3211], 'Dofuku': [3212], 'Sonehara': [3214], 'Hongo': [3224, 4176], 'Shinya': [3226], 'Teranishi': [3230, 4196], 'Okano': [3232, 4198], 'Teraoka': [3238], 'Maeda': [3242], 'Nii': [3244], 'Kishikawa': [3246], 'Suzuki': [3248], 'Kumanogoh': [3256], 'Y': [3261, 3697], 'N': [3264, 3431, 4212, 4560, 4584], 'Genome-Wide': [3266], 'Study': [3268, 3512, 4008], 'Artery': [3271, 3596, 4566, 4590], 'Followed': [3273], 'Phenome-Wide': [3275], 'Translational': [3278, 4301], '10.1007/s12975-022-01049-w': [3281], 'Ahmed': [3282], 'Habu': [3284], 'Oikawa': [3290], 'Murata': [3292], 'Suppression': [3300], 'disease,': [3308, 4614], 'inhibits': [3309], 'endoplasmic': [3310], 'reticulum': [3311], 'stress': [3312], 'through': [3313], 'SEL1L': [3314], 'upregulation,': [3315], 'Biochemical': [3316, 4453], 'Biophysical': [3318, 4455], 'Communications,': [3320, 4457], '10.1016/j.bbrc.2022.04.007,': [3321], '609,': [3322], '(62-68),': [3323], '1-Jun-2022.': [3327], 'Sariya': [3330], 'Khasiyev': [3332], 'Tosto': [3334], 'Dueker': [3336], 'Cheung': [3338], 'Wright': [3340], 'Elkind': [3346], 'Gutierrez': [3349], 'J': [3350, 4376], 'northern': [3361], 'Manhattan': [3362], 'Neurological': [3367, 4618, 4681], '10.1016/j.jns.2022.120218,': [3369], '436,': [3370], '(120218),': [3371], '1-May-2022.': [3375], 'Genetics:': [3383], 'Discovery,': [3384], 'Insight': [3385], 'Into': [3386], 'Mechanisms,': [3387], 'Perspectives,': [3390, 4138], 'Circulation': [3391], '130:8,': [3393], '(1095-1111),': [3394], '15-Apr-2022.Roy': [3398], 'Ross': [3400], 'Pépin': [3402], 'Cortez': [3404], 'Ghio': [3405], 'Brodeur': [3407], 'Touzel': [3409], 'Deschênes': [3410], 'Le-Bel': [3412], 'Phillips': [3414], 'Milot': [3416], 'Dion': [3418], 'Guérin': [3420], 'Germain': [3422], 'Berthod': [3424], 'Auger': [3426], 'Rouleau': [3428], 'Dupré': [3430], 'Gros-Louis': [3433], 'F': [3434, 3660], 'Gene': [3439, 3520], 'Regulates': [3441], 'Endothelial': [3442], 'Barrier': [3443], 'Function,': [3444], '53:4,': [3446], '(1263-1275),': [3447], '1-Apr-2022.': [3451], 'Luo': [3452, 4467], 'Cao': [3454], 'Z,': [3455, 3493, 3833, 3837, 3867], 'Wu': [3456, 3977, 4479], 'Sun': [3459, 4465], 'X': [3460, 3611, 4338], 'Ring': [3462], 'Finger': [3463], 'Protein': [3464, 4719], '213': [3465], 'Pulmonary': [3470], 'Hypertension:': [3472], 'Mini-Review,': [3474], 'Frontiers': [3475, 3716, 3770, 4011, 4537], '10.3389/fneur.2022.843927,': [3478], '13': [3479, 3775, 4351], 'Ye': [3482, 3959], 'Zhao': [3486, 3502], 'Wei': [3488], 'Wang': [3490, 3500, 3504, 3830, 3834, 3856, 3961, 4311, 4313, 4475, 4513, 4703], 'Hao': [3494, 3498, 3840], 'R': [3505], 'Tahmasbpour': [3507], 'Epigenome-Wide': [3510], 'Reveals': [3513], 'Differential': [3514], 'Methylation': [3515], 'Sites': [3516], 'Expression': [3521], 'Regulation': [3522], 'Adults,': [3528], 'Oxidative': [3529], 'Cellular': [3532], 'Longevity,': [3533], '10.1155/2022/7192060,': [3534], '2022,': [3535], '(1-13),': [3536], '24-Mar-2022.': [3540], 'Fukuma': [3541, 3733], 'Miyata': [3549, 3551], 'Kokame': [3553], 'Hayakawa': [3561], 'Kamiyama': [3563], 'Enomoto': [3565], 'Itabashi': [3567], 'Furui': [3569], 'Manabe': [3571], 'Ezura': [3573], 'Hashikawa': [3577], 'Uchiyama': [3579], 'Nagatsuka': [3584], 'P2Y12': [3587], 'Reaction': [3588], 'Units': [3589], 'Outcomes': [3592, 3881, 4099], 'Large': [3595], 'Multicenter': [3600, 4005], '10.5551/jat.63369,': [3608], '.': [3609, 4141, 4599], 'Song': [3610], 'Z': [3614], '(2021)': [3615, 3664, 3701, 3752, 3791, 3873, 3925, 3984, 4049, 4127], 'Co-existing': [3616], 'craniofacial': [3618], 'fibrous': [3619], 'dysplasia': [3620], 'diseases:': [3623], 'series': [3625], '22': [3627], 'review': [3630], 'literature,': [3633], 'Orphanet': [3634], 'Rare': [3637], 'Diseases,': [3638, 3894], '10.1186/s13023-021-02102-x,': [3639], '16:1,': [3640], '1-Dec-2021.': [3644, 3695], 'Tabara': [3645], 'Yamada': [3647], 'Setoh': [3649], 'Matsukawa': [3651], 'Kawaguchi': [3655], 'Nakayama': [3657], 'Kosugi': [3662], 'incident': [3676], 'cardiovascular': [3677], 'population:': [3682], 'Nagahama': [3684], 'Hypertension,': [3688], '10.1097/HJH.0000000000002964,': [3689], '39:12,': [3690], '(2521-2526),': [3691], 'GUCY1A3': [3704], 'Disease:': [3707, 4003, 4133], 'Key': [3708], 'Regulators': [3709], 'Metabolism,': [3711], 'Inflammation,': [3712], 'Stability,': [3715], '10.3389/fneur.2021.687088,': [3719], '12': [3720, 4015], 'Eto': [3721], '(c.14429G': [3755], '>': [3756], 'A)': [3757], 'Determines': [3759], 'Anatomical': [3760], 'Variations': [3761], 'Circle': [3764], 'Willis': [3766], 'Neuroscience,': [3773, 4539], '10.3389/fnagi.2021.681743,': [3774], 'Cho': [3776], 'Nannoni': [3778], 'Harshfield': [3780], 'Tozer': [3782], 'Gräf': [3784], 'Bell': [3786], 'NOTCH3': [3792], 'common': [3796], 'expected': [3798], 'dementia:': [3809], 'an': [3810, 4449], 'analysis': [3811], '200': [3813], '000': [3814, 4352], '&': [3821, 3950], 'Psychiatry,': [3822, 3951], '10.1136/jnnp-2020-325838,': [3823], '92:7,': [3824], '(694-701),': [3825], '1-Jul-2021.': [3829, 3901], 'Ta': [3838], 'Shang': [3842, 4331], 'Zeng': [3846, 4329], 'Han': [3848, 4517], 'Nie': [3850, 4315], 'Bao': [3852], 'Liang': [3858, 4333], 'Ou': [3862], 'Wen': [3864], 'W': [3869, 3983, 4151, 4154, 4341, 4483], 'L': [3872], 'Factors': [3878], 'Long-Term': [3880], 'after': [3882], 'Encephaloduroarteriosynangiosis': [3883], 'China,': [3888, 4010, 4495], '10.1016/j.jstrokecerebrovasdis.2021.105847,': [3895], '30:7,': [3896], '(105847),': [3897], 'Leng': [3902], 'Hurford': [3904], 'Feng': [3906], 'Chan': [3908], 'Wolters': [3910], 'Soo': [3914], 'Mok': [3918], 'Leung': [3920], 'T': [3921, 4126], 'P': [3924, 4525], 'arterial': [3927, 4492, 4671], 'Caucasian': [3930], 'Chinese': [3932], 'TIA': [3935], 'minor': [3937], 'stroke:': [3938], 'two': [3939], 'contemporaneous': [3940], 'cohorts': [3941], 'systematic': [3944], 'review,': [3945], '10.1136/jnnp-2020-325630,': [3952], '92:6,': [3953], '(590-597),': [3954], '1-Jun-2021.': [3958], 'Yin': [3963], 'Guo': [3969, 4036, 4511], 'Jie': [3975], 'Q': [3980], 'Sheng': [3982, 4482], 'Development': [3985], 'Validation': [3987], 'Nomogram': [3990], 'Predict': [3992], 'Individual': [3994], 'Future': [3995, 4137], 'Adult': [3999], 'Retrospective': [4006], '10.3389/fneur.2021.669025,': [4014], 'Pinard': [4016], 'Fiander': [4018], 'Cecchi': [4020], 'Rideout': [4022], 'Azouz': [4024], 'Fraser': [4026], 'McNeely': [4028], 'Walling': [4030], 'Novara': [4032], 'Hurst': [4034], 'Parkash': [4038], 'Bamshad': [4040], 'Nickerson': [4042], 'Vandersteen': [4044], 'Milewicz': [4047], 'D': [4048, 4289, 4522], 'De': [4052], 'Novo': [4053], 'Variants': [4055, 4346], 'Childhood': [4057], 'Onset': [4058], 'Diffuse': [4062], 'Occlusive': [4063], 'Vasculopathy': [4064], '10.1212/WNL.0000000000011653,': [4067], '96:13,': [4068], '(e1783-e1791),': [4069], '30-Mar-2021.': [4073], 'Seo': [4084, 4243], 'G': [4087, 4246], 'O': [4090, 4249, 4557, 4659], '(2020)': [4091, 4155, 4213, 4250, 4342, 4380, 4426, 4484, 4526, 4561, 4585, 4605, 4660], 'Role': [4092, 4661], 'Atherosclerosis,': [4104], '10:1,': [4111, 4228], '5-Jan-2021.': [4115], 'Nomura': [4116], 'Akagawa': [4118], 'Kawashima': [4122], 'Kawamata': [4125], 'Feature': [4131], 'Current': [4134], 'Knowledge': [4135], '10.1007/978-981-33-6404-2_5,': [4139], '(61-72),': [4140], 'Xiang': [4142], 'Cui': [4150, 4509], 'Yue': [4153], 'Positive': [4156], 'syphilis': [4157], 'serology': [4158], 'contributes': [4159], 'patients,': [4166], 'Brain': [4167], 'Behavior,': [4169], '10.1002/brb3.1906,': [4170], '11:1,': [4171], '1-Jan-2021.': [4175], 'Mitsui': [4186], 'Ishiura': [4188], 'Yoshimura': [4190], 'Doi': [4192], 'Qu': [4194], 'Morishita': [4206], 'Tsuji': [4208], 'Comprehensive': [4214], 'investigation': [4215], 'nonsynonymous': [4218], 'stenosis,': [4224], 'Scientific': [4225], 'Reports,': [4226], '10.1038/s41598-020-68888-1,': [4227], '1-Dec-2020.': [4232], 'Luminal': [4251], 'Wall': [4253], 'Changes': [4254], 'Lesions': [4258], 'Predicting': [4260], 'Occurrence,': [4262], '51:8,': [4264], '(2495-2504),': [4265], '1-Aug-2020.': [4269, 4310], 'Won': [4276], 'Yeon': [4278], 'Ki': [4280], 'Shin': [4282], 'Hong': [4286], '(2019)': [4293, 4705, 4736, 4787], 'Spectrums': [4297], 'Vasculopathy,': [4300], '10.1007/s12975-019-00743-6,': [4304], '11:4,': [4305], '(580-589),': [4306], 'Individuals,': [4353], '51:6,': [4355], '(1647-1655),': [4356], '1-Jun-2020.': [4360], 'Ramiro': [4363], 'Simats': [4365], 'Makris': [4369], 'Jickling': [4371], 'Sanchez': [4375], 'Multilevel': [4381], 'omics': [4382], 'discovery': [4385], 'biomarkers': [4387], 'targets': [4390], 'stroke,': [4392], 'Nature': [4393], 'Reviews': [4394], '10.1038/s41582-020-0350-6,': [4396], '16:5,': [4397], '(247-264),': [4398], '1-May-2020.': [4402, 4464, 4506], 'Takeda': [4403], 'Tezuka': [4405], 'Oichi': [4411], 'Mizushima': [4417], 'Taketani': [4419], 'patient': [4429], 'mutations': [4430], 'RING': [4433], 'domain': [4434], 'reduce': [4437], 'ubiquitin': [4439], 'ligase': [4440], 'activity': [4441], 'enhance': [4443], 'NFκB': [4444], 'activation': [4445], 'apoptosis': [4447], 'AAA+': [4450], 'domain-dependent': [4451], 'manner,': [4452], 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[4611], 'Therapeutic': [4615], 'Advances': [4616], 'Disorders,': [4619], '10.1177/1756286420921092,': [4620], '13,': [4621], '(175628642092109),': [4622], '1-Jan-2020.': [4626, 4689], 'Uemura': [4627], 'Kanazawa': [4629], 'Yamagishi': [4631], 'Nagai': [4633], 'Koide': [4637], 'Tada': [4639], 'Shimbo': [4641], 'Isami': [4643], 'Makino': [4645], 'Masuko': [4647], 'Nikkuni': [4649], 'Okamoto': [4651], 'Igarashi': [4653], 'Morita': [4655], 'Onodera': [4658], 'p.4810K': [4664], 'development': [4668], 'treated': [4675], 'nilotinib,': [4677], '10.1016/j.jns.2019.116577,': [4683], '408,': [4684], '(116577),': [4685], 'Fallen': [4692], 'Zhou': [4694], 'Baxter': [4696], 'Scherler': [4698], 'Kuo': [4700], 'Mutations': [4713], 'Spectrum': [4716], 'Plasma': [4718], 'MicroRNA,': [4721], '10.3390/jcm8101648,': [4726], '8:10,': [4727], '(1648)': [4728], 'Small': [4737], 'Steady': [4739], 'Steps': [4740], '8:16,': [4752], '20-Aug-2019.Kamimura': [4756], 'Early-Onset': [4794], 'Stenosis,': [4799], 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'created_date': '2019-01-11'}
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