Publication Information

{'id': 'https://openalex.org/W2906511232', 'doi': 'https://doi.org/10.18632/oncotarget.26427', 'title': 'Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer', 'display_name': 'Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer', 'publication_year': 2018, 'publication_date': '2018-12-21', 'ids': {'openalex': 'https://openalex.org/W2906511232', 'doi': 'https://doi.org/10.18632/oncotarget.26427', 'mag': '2906511232', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30647838', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6324772'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.26427', 'pdf_url': 'https://www.oncotarget.com/article/26427/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/26427/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089544810', 'display_name': 'Rina Fujiwara‐Tani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Rina Fujiwara-Tani', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102021442', 'display_name': 'Takamitsu Sasaki', 'orcid': 'https://orcid.org/0000-0002-2248-5382'}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takamitsu Sasaki', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084164951', 'display_name': 'Yi Luo', 'orcid': 'https://orcid.org/0000-0001-5587-0431'}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}, {'id': 'https://openalex.org/I199305430', 'display_name': 'Nantong University', 'ror': 'https://ror.org/02afcvw97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I199305430']}], 'countries': ['CN', 'JP'], 'is_corresponding': False, 'raw_author_name': 'Yi Luo', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}, {'raw_affiliation_string': 'Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China', 'institution_ids': ['https://openalex.org/I199305430']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106722626', 'display_name': 'Kei Goto', 'orcid': 'https://orcid.org/0009-0005-2801-1750'}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kei Goto', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051331714', 'display_name': 'Isao Kawahara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Isao Kawahara', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077823763', 'display_name': 'Yukiko Nishiguchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yukiko Nishiguchi', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110741067', 'display_name': 'Shingo Kishi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shingo Kishi', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109468894', 'display_name': 'Shiori Mori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shiori Mori', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086433486', 'display_name': 'Hitoshi Ohmori', 'orcid': 'https://orcid.org/0000-0002-4569-5841'}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hitoshi Ohmori', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054512353', 'display_name': 'Masuo Kondoh', 'orcid': 'https://orcid.org/0000-0001-5624-1135'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masuo Kondoh', 'raw_affiliation_strings': ['Drug Innovation Center, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan'], 'affiliations': [{'raw_affiliation_string': 'Drug Innovation Center, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046783529', 'display_name': 'Hiroki Kuniyasu', 'orcid': 'https://orcid.org/0000-0003-2298-8825'}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroki Kuniyasu', 'raw_affiliation_strings': ['Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.063, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.832421, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '9', 'issue': '100', 'first_page': '37367', 'last_page': '37378'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chemotherapeutic-drugs', 'display_name': 'Chemotherapeutic drugs', 'score': 0.6226126}, {'id': 'https://openalex.org/keywords/claudin', 'display_name': 'Claudin', 'score': 0.61474574}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.68695545}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6466204}, {'id': 'https://openalex.org/C3020391286', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapeutic drugs', 'level': 3, 'score': 0.6226126}, {'id': 'https://openalex.org/C51872919', 'wikidata': 'https://www.wikidata.org/wiki/Q420863', 'display_name': 'Claudin', 'level': 3, 'score': 0.61474574}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5655642}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.547976}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44209355}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.39356983}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.35666746}, {'id': 'https://openalex.org/C177779419', 'wikidata': 'https://www.wikidata.org/wiki/Q1053832', 'display_name': 'Tight junction', 'level': 2, 'score': 0.21657085}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2004663}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17564178}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.26427', 'pdf_url': 'https://www.oncotarget.com/article/26427/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6324772', 'pdf_url': 'https://europepmc.org/articles/pmc6324772?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324772', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30647838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.26427', 'pdf_url': 'https://www.oncotarget.com/article/26427/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1549719228', 'https://openalex.org/W1554042779', 'https://openalex.org/W1669445088', 'https://openalex.org/W1977437890', 'https://openalex.org/W1992364394', 'https://openalex.org/W1993728532', 'https://openalex.org/W2003445994', 'https://openalex.org/W2009070960', 'https://openalex.org/W2010842826', 'https://openalex.org/W2027269125', 'https://openalex.org/W2032716405', 'https://openalex.org/W2035926815', 'https://openalex.org/W2048234078', 'https://openalex.org/W2064252617', 'https://openalex.org/W2066840282', 'https://openalex.org/W2067564721', 'https://openalex.org/W2070564091', 'https://openalex.org/W2071918867', 'https://openalex.org/W2072564570', 'https://openalex.org/W2076572440', 'https://openalex.org/W2079482620', 'https://openalex.org/W2085849521', 'https://openalex.org/W2092016735', 'https://openalex.org/W2095412389', 'https://openalex.org/W2101976554', 'https://openalex.org/W2107601924', 'https://openalex.org/W2110233989', 'https://openalex.org/W2127465578', 'https://openalex.org/W2129269286', 'https://openalex.org/W2138569498', 'https://openalex.org/W2140308222', 'https://openalex.org/W2148198816', 'https://openalex.org/W2149513986', 'https://openalex.org/W2154594288', 'https://openalex.org/W2159369046', 'https://openalex.org/W2163039825', 'https://openalex.org/W2170505336', 'https://openalex.org/W2298727513', 'https://openalex.org/W2555027049', 'https://openalex.org/W2587768298'], 'related_works': ['https://openalex.org/W4243610700', 'https://openalex.org/W2950746056', 'https://openalex.org/W2950199347', 'https://openalex.org/W2629996009', 'https://openalex.org/W2120914031', 'https://openalex.org/W2112715338', 'https://openalex.org/W2047267861', 'https://openalex.org/W1989259561', 'https://openalex.org/W1968623339', 'https://openalex.org/W1850146802'], 'abstract_inverted_index': {'//': [0], 'Rina': [1], 'Fujiwara-Tani': [2], '1': [3, 7, 16, 20, 24, 28, 32, 36, 44, 45], ',': [4, 8, 13, 17, 21, 25, 29, 33, 37], 'Takamitsu': [5], 'Sasaki': [6], 'Yi': [9], 'Luo': [10], '1,': [11], '2': [12, 57], 'Kei': [14], 'Goto': [15], 'Isao': [18], 'Kawahara': [19], 'Yukiko': [22], 'Nishiguchi': [23], 'Shingo': [26], 'Kishi': [27], 'Shiori': [30], 'Mori': [31], 'Hitoshi': [34], 'Ohmori': [35], 'Masuo': [38], 'Kondoh': [39], '3': [40, 70], 'and': [41, 196, 209, 227, 249, 272, 305], 'Hiroki': [42, 87], 'Kuniyasu': [43], 'Department': [46], 'of': [47, 62, 76, 135, 165, 186, 222, 247, 251, 260, 284, 296, 302], 'Molecular': [48], 'Pathology,': [49], 'Nara': [50, 54], 'Medical': [51], 'University,': [52, 65, 80], 'Kashihara,': [53], '634-8521,': [55], 'Japan': [56, 84], 'Jiangsu': [58, 67], 'Province': [59], 'Key': [60], 'Laboratory': [61], 'Neuroregeneration,': [63], 'Nantong': [64], 'Nantong,': [66], '226001,': [68], 'China': [69], 'Drug': [71], 'Innovation': [72], 'Center,': [73], 'Graduate': [74], 'School': [75], 'Pharmaceutical': [77], 'Sciences,': [78], 'Osaka': [79, 82], 'Suita,': [81], '565-0871,': [83], 'Correspondence': [85], 'to:': [86], 'Kuniyasu,': [88], 'email:': [89], '[email protected]': [90], 'Keywords:': [91], 'claudin;': [92], 'tight': [93, 114], 'junction': [94, 115], 'Received:': [95], 'August': [96], '20,': [97], '2018': [98, 102, 106], 'Accepted:': [99], 'November': [100], '26,': [101], 'Published:': [103], 'December': [104], '21,': [105], 'ABSTRACT': [107], 'Claudin-4': [108], '(CLDN4)': [109], 'is': [110], 'a': [111, 179, 264, 275], 'major': [112], 'epithelial': [113], 'protein': [116], 'overexpressed': [117], 'in': [118, 138, 152, 158, 218, 223, 230, 280, 311], 'many': [119], 'cancers': [120], 'to': [121, 131, 199, 234], 'maintain': [122], 'the': [123, 133, 241, 245, 257, 294, 299], 'tumor': [124, 228, 285], 'environment.': [125], 'In': [126, 178, 263], 'this': [127], 'report,': [128], 'we': [129], 'aimed': [130], 'determine': [132], 'efficacy': [134], 'targeting': [136, 295, 307], 'CLDN4': [137, 149, 156, 297], 'colorectal': [139], 'cancer': [140], '(CRC)': [141], 'using': [142], 'an': [143], 'anti-CLDN4': [144], 'extracellular': [145], 'domain': [146], 'antibody,': [147], '4D3.': [148], 'was': [150, 161, 168, 188, 253], 'upregulated': [151], 'CRC': [153, 159], 'metastatic': [154], 'foci.': [155], 'expression': [157], 'cells': [160], 'reduced': [162], 'by': [163, 170, 175, 190], 'upregulation': [164], 'TNFα,': [166], 'which': [167], 'induced': [169], 'Clostridium': [171], 'perfringens': [172], 'enterotoxin': [173], 'produced': [174], 'gut': [176], 'flora.': [177], 'nude': [180, 231, 265], 'mouse': [181, 266], 'liver': [182], 'metastasis': [183, 187], 'model,': [184, 267], 'inhibition': [185, 221, 259, 283], 'increased': [189], 'combination': [191, 205], 'treatment': [192, 206, 269], 'with': [193, 201, 207, 237, 270, 274], '5-fluorouracil': [194], '(FU)': [195], '4D3': [197, 208, 248, 271], 'compared': [198, 233], 'that': [200, 235, 250, 293], '5-FU': [202], 'alone.': [203, 239], 'Moreover,': [204, 240], 'anti-epithelial': [210], 'growth': [211, 229, 286], 'factor': [212], 'receptor': [213], '(EGFR)': [214], 'antibody': [215], 'C225': [216, 238, 252, 273], 'resulted': [217, 279], 'more': [219, 281], 'pronounced': [220, 282], 'vitro': [224], 'sphere': [225], 'formation': [226], 'mice': [232], 'observed': [236], 'time': [242, 277], 'interval': [243, 278], 'between': [244], 'administration': [246], 'important': [254], 'for': [255], 'maximizing': [256], 'C225-induced': [258], 'EGFR': [261], 'phosphorylation.': [262], 'sequential': [268], '6-h': [276], 'than': [287], 'concurrent': [288], 'treatment.': [289], 'These': [290], 'findings': [291], 'suggest': [292], 'enhances': [298], 'antitumoral': [300], 'effects': [301], 'chemotherapeutic': [303], 'agents': [304], 'molecular': [306], 'antibodies': [308], 'when': [309], 'used': [310], 'combination.': [312]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2906511232', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}], 'updated_date': '2024-12-17T13:37:00.606778', 'created_date': '2019-01-01'}