Title: Abstract 5009: The expression pattern of claudin-1, claudin-3, claudin-4, claudin-5 and claudin-7 in penile squamous cell carcinoma
Abstract: Abstract Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor progression, and altered expression of claudins has been reported in various human carcinomas. Penile squamous cell carcinoma (SCC) is a major health problem in Brazil, corresponding to 2,1% of all brazilian men tumors and 5-year survival rate drops dramatically in patients with lymph node metastasis. Purpose: The aim of this study was to investigate claudins expression profile in penile SCC. Method: We analyzed expressions of claudin-1, -3, -4, -5 and -7 in 14 cases of penile SCC by relative gene expression method using real time PCR. Results: The expression of claudin-1, -4 and -5 was downregulated 15.9-, 6.9- and 9.1-fold, respectively, in 72% of penile SCC cases in comparison to normal penile squamous cells (p=0.0052 for both claudin-1 and -4 and p=0.0002 for claudin-5). Claudin-3 expression was variable, with 7 of the 14 cases (50%) showing low expression of claudin-3. Claudin-7 was upregulated 101.4-fold in 10 of 14 cases analyzed (p=0.067). Conclusion: Our data suggests that loss of claudin-1,-4 and -5 expression and gain of claudin-7 expression might be associated with the tumorigenic process in penile SCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5009. doi:10.1158/1538-7445.AM2011-5009
Publication Year: 2011
Publication Date: 2011-04-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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