Title: Serum Club cell16 levels as a biomarker in tobacco-smoke COPD and biomass-smoke COPD
Abstract:<b>Introduction:</b> COPD is the second leading cause of death in India and third leading cause of death in the world. We studied serum Club cell 16 (Clara cell 16 or CC16) levels to evaluate its role...<b>Introduction:</b> COPD is the second leading cause of death in India and third leading cause of death in the world. We studied serum Club cell 16 (Clara cell 16 or CC16) levels to evaluate its role as a biomarker in COPD (Chronic Obstructive Pulmonary Disease). <b>Objective:</b> To assess serum levels of CC16 between tobacco-smoke COPD, smokers without COPD, Biomass-fuel smoke COPD and non smokers without COPD(normal population) and to correlate between CC16 levels and known clinical as well as functional markers of COPD severity. <b>Methodology:</b> A total of 200 participants satisfying the inclusion and exclusion criteria, recruited from a tertiary care university teaching hospital and BOLD cohort were included in the study. Participants underwent Spirometry, 6-minute walk test, serum CC16, BODE index, SGRQ-C and CAT scores. Statistical analysis included chi2 test, one-way ANOVA, Independent 't' test and ROC analysis. <b>Results:</b> In the study population mean age was 60.22 ± 10.37 years and mean CC16 levels were 3.16±1.77. Mean levels of CC16 were found to be significantly low in COPD patients {in both smoker COPD (1.91) & non-smoker COPD (1.84)} when compared with smokers without COPD (3.21) and normal age and gender matched controls (5.68) (p value - 0.001). Lower baseline CC16 levels was associated with lower FEV1 and six minute walk distance and higher SGRQ-C scores, CAT scores, BODE index, GOLD grading and mMRC dyspnoea score. <b>Conclusion:</b> We observed a significantly lower Club cell16 (CC16) levels in both tobacco smoke COPD and Biomass smoke COPD. Lower levels of CC16 were associated with more severe COPD. Whether serum CC16 levels can be used to identify smokers at risk of developing COPD needs to be explored.Read More
Publication Year: 2018
Publication Date: 2018-09-15
Language: en
Type: article
Indexed In: ['crossref']
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