Publication Information

{'id': 'https://openalex.org/W2902656536', 'doi': 'https://doi.org/10.1158/1541-7786.mcr-18-0837', 'title': 'PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance', 'display_name': 'PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance', 'publication_year': 2018, 'publication_date': '2018-12-05', 'ids': {'openalex': 'https://openalex.org/W2902656536', 'doi': 'https://doi.org/10.1158/1541-7786.mcr-18-0837', 'mag': '2902656536', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30518628', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6359980'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1541-7786.mcr-18-0837', 'pdf_url': 'https://mcr.aacrjournals.org/content/molcanres/17/2/618.full.pdf', 'source': {'id': 'https://openalex.org/S192067876', 'display_name': 'Molecular Cancer Research', 'issn_l': '1541-7786', 'issn': ['1541-7786', '1557-3125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://mcr.aacrjournals.org/content/molcanres/17/2/618.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010219575', 'display_name': 'Kenji Zennami', 'orcid': 'https://orcid.org/0000-0001-8455-7364'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenji Zennami', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074180688', 'display_name': 'Su‐Mi Choi', 'orcid': 'https://orcid.org/0000-0002-8187-5110'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Su Mi Choi', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070240832', 'display_name': 'Ross Liao', 'orcid': 'https://orcid.org/0000-0001-7977-3767'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ross Liao', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100413989', 'display_name': 'Ying Li', 'orcid': 'https://orcid.org/0000-0001-5062-0230'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ying Li', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030368661', 'display_name': 'Wikum Dinalankara', 'orcid': 'https://orcid.org/0000-0002-8017-6916'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wikum Dinalankara', 'raw_affiliation_strings': ['2Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '2Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948', 'https://openalex.org/I4210164401']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079978893', 'display_name': 'Luigi Marchionni', 'orcid': 'https://orcid.org/0000-0002-7336-8071'}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Luigi Marchionni', 'raw_affiliation_strings': ['2Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '2Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029912474', 'display_name': 'Fatema H. Rafiqi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fatema H. Rafiqi', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026614685', 'display_name': 'Akira Kurozumi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Akira Kurozumi', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032407607', 'display_name': 'Koji Hatano', 'orcid': 'https://orcid.org/0000-0002-8409-5152'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Koji Hatano', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081198528', 'display_name': 'Shawn E. Lupold', 'orcid': 'https://orcid.org/0000-0002-5449-0362'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Shawn E. Lupold', 'raw_affiliation_strings': ['1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', '2Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': '1Department of Urology, The James Buchanan Brady Urologic Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': '2Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5081198528'], 'corresponding_institution_ids': ['https://openalex.org/I145311948', 'https://openalex.org/I4210164401'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.409, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.890108, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '17', 'issue': '2', 'first_page': '618', 'last_page': '627'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8699376}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.7529849}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7314153}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.7090874}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.58050466}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.57145834}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51213837}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.448431}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43963715}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38054356}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2637318}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.24848968}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D048708', 'descriptor_name': 'Cell Growth Processes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064593', 'descriptor_name': 'Heterografts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060787', 'descriptor_name': 'Neoplasm Grading', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1541-7786.mcr-18-0837', 'pdf_url': 'https://mcr.aacrjournals.org/content/molcanres/17/2/618.full.pdf', 'source': {'id': 'https://openalex.org/S192067876', 'display_name': 'Molecular Cancer Research', 'issn_l': '1541-7786', 'issn': ['1541-7786', '1557-3125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6359980', 'pdf_url': 'https://europepmc.org/articles/pmc6359980?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359980', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supplementary_Tables_S1-S2_Supplementary_Figures_S1-S5_from_PDCD4_Is_an_Androgen-Repressed_Tumor_Suppressor_that_Regulates_Prostate_Cancer_Growth_and_Castration_Resistance/22512904', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30518628', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1541-7786.mcr-18-0837', 'pdf_url': 'https://mcr.aacrjournals.org/content/molcanres/17/2/618.full.pdf', 'source': {'id': 'https://openalex.org/S192067876', 'display_name': 'Molecular Cancer Research', 'issn_l': '1541-7786', 'issn': ['1541-7786', '1557-3125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.8, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320306078', 'funder_display_name': 'U.S. Department of Defense', 'award_id': 'PC073745 and W81XWH-17-1-0581'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '1R01CA143299, 5P50CA058236, P30CA006973'}], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1566823022', 'https://openalex.org/W1787418231', 'https://openalex.org/W1964304618', 'https://openalex.org/W1965598882', 'https://openalex.org/W1968100517', 'https://openalex.org/W1970111367', 'https://openalex.org/W1972250842', 'https://openalex.org/W1972892962', 'https://openalex.org/W1973921593', 'https://openalex.org/W1977281562', 'https://openalex.org/W1980718338', 'https://openalex.org/W1981298542', 'https://openalex.org/W1994216821', 'https://openalex.org/W2000093333', 'https://openalex.org/W2010180766', 'https://openalex.org/W2015123884', 'https://openalex.org/W2023097049', 'https://openalex.org/W2046245088', 'https://openalex.org/W2046409229', 'https://openalex.org/W2047227271', 'https://openalex.org/W2050079849', 'https://openalex.org/W2066086539', 'https://openalex.org/W2067915426', 'https://openalex.org/W2071753433', 'https://openalex.org/W2072133788', 'https://openalex.org/W2075258024', 'https://openalex.org/W2076089982', 'https://openalex.org/W2083381199', 'https://openalex.org/W2096528675', 'https://openalex.org/W2097325727', 'https://openalex.org/W2104052951', 'https://openalex.org/W2104517740', 'https://openalex.org/W2112027064', 'https://openalex.org/W2115619054', 'https://openalex.org/W2118054479', 'https://openalex.org/W2131687108', 'https://openalex.org/W2134314788', 'https://openalex.org/W2140617443', 'https://openalex.org/W2146866082', 'https://openalex.org/W2151317340', 'https://openalex.org/W2151383898', 'https://openalex.org/W2161112598', 'https://openalex.org/W2169354377', 'https://openalex.org/W2337455452', 'https://openalex.org/W2624514631', 'https://openalex.org/W2744101562', 'https://openalex.org/W2752942423', 'https://openalex.org/W2753561949', 'https://openalex.org/W2781525129', 'https://openalex.org/W2917837889', 'https://openalex.org/W3145395549'], 'related_works': ['https://openalex.org/W4387341186', 'https://openalex.org/W3111390827', 'https://openalex.org/W3009569511', 'https://openalex.org/W2611803138', 'https://openalex.org/W2365928272', 'https://openalex.org/W2327862400', 'https://openalex.org/W2131077462', 'https://openalex.org/W2071753433', 'https://openalex.org/W2033566079', 'https://openalex.org/W1864918391'], 'abstract_inverted_index': {'Abstract': [0], 'Androgen': [1, 64], 'receptor': [2], '(AR)': [3], 'transcriptional': [4], 'activity': [5], 'contributes': [6], 'to': [7, 29, 144], 'prostate': [8, 42, 86, 167, 203, 224], 'cancer': [9, 43, 87, 168, 204], 'development': [10], 'and': [11, 16, 37, 47, 73, 100, 105, 108, 121, 128, 136, 141, 157, 180, 208, 215], 'castration': [12, 48, 209], 'resistance.': [13, 49, 210], 'The': [14, 50, 91, 160], 'growth': [15, 156], 'survival': [17], 'pathways': [18, 217], 'driven': [19], 'by': [20, 59], 'AR': [21, 35, 77], 'remain': [22], 'incompletely': [23], 'defined.': [24], 'Here,': [25], 'we': [26, 96], 'found': [27, 97], 'PDCD4': [28, 55, 67, 81, 106, 126, 130, 152, 164, 195], 'be': [30], 'a': [31, 38, 70, 98], 'new': [32, 220], 'target': [33], 'of': [34, 41, 54, 119, 125, 163, 201], 'signaling': [36], 'potent': [39], 'regulator': [40], 'cell': [44, 134, 205], 'growth,': [45, 179], 'survival,': [46], '3′': [51], 'untranslated': [52], 'region': [53], 'is': [56, 196], 'directly': [57], 'targeted': [58], 'the': [60, 149, 191], 'androgen-induced': [61], 'miRNA,': [62], 'miR-21.': [63], 'treatment': [65], 'suppressed': [66], 'expression': [68], 'in': [69, 90, 165, 175], 'dose': [71], 'responsive': [72], 'miR-21–dependent': [74], 'manner.': [75], 'Correspondingly,': [76], 'inhibition': [78], 'dose-responsively': [79], 'induced': [80], 'expression.': [82], 'Using': [83], 'data': [84], 'from': [85], 'tissue': [88], 'samples': [89], 'Cancer': [92], 'Genome': [93], 'Atlas': [94], '(TCGA),': [95], 'significant': [99], 'inverse': [101], 'correlation': [102], 'between': [103], 'miR-21': [104, 120, 214], 'mRNA': [107, 127], 'protein': [109, 199], 'levels.': [110], 'Higher': [111], 'Gleason': [112], 'grade': [113], 'tumors': [114], 'exhibited': [115], 'significantly': [116, 122], 'higher': [117], 'levels': [118, 124], 'lower': [123], 'protein.': [129], 'knockdown': [131, 162], 'enhanced': [132, 170], 'androgen-dependent': [133, 166], 'proliferation': [135], 'cell-cycle': [137], 'progression,': [138], 'inhibited': [139, 154], 'apoptosis,': [140, 207], 'was': [142, 181], 'sufficient': [143, 182], 'drive': [145], 'androgen-independent': [146], 'growth.': [147, 186], 'On': [148], 'other': [150], 'hand,': [151], 'overexpression': [153], 'miR-21–mediated': [155], 'androgen': [158], 'independence.': [159], 'stable': [161], 'cells': [169], 'subcutaneous': [171], 'tumor': [172, 178, 185], 'take': [173], 'rate': [174], 'vivo,': [176], 'accelerated': [177], 'for': [183, 222], 'castration-resistant': [184, 223], 'Implications:': [187], 'This': [188], 'study': [189], 'provides': [190], 'first': [192], 'evidence': [193], 'that': [194], 'an': [197], 'androgen-suppressed': [198], 'capable': [200], 'regulating': [202], 'proliferation,': [206], 'These': [211], 'results': [212], 'uncover': [213], 'PDCD4-regulated': [216], 'as': [218], 'potential': [219], 'targets': [221], 'cancer.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2902656536', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2025-01-08T02:43:03.170665', 'created_date': '2018-12-11'}