2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Name: Work Video:
Duration: 3 min 30 s
Scott M. Grundy; Neil J. Stone; Alison L. Bailey; Craig Beam; Kim K. Birtcher; Roger S. Blumenthal; Lynne T. Braun; Sarah D. de Ferranti; Joseph Faiella-Tommasino; Daniel E. Forman; Ronald Goldberg; Paul A. Heidenreich; Mark A. Hlatky; Daniel W. Jones; Donald M. Lloyd‐Jones; Nuria Lopez-Pajares; Chiadi E Ndumele; Carl E. Orringer; Carmen Peralta; Joseph J. Saseen; Sidney C. Smith; Laurence S. Sperling; Salim S. Virani; Joseph Yeboah
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87], 'Neil': [80, 220], 'J.': [81, 182, 221, 223, 319, 321], 'Stone,': [82], 'FACC,': [84, 92, 108, 141, 147, 158, 174, 197, 205, 212, 2022], 'Vice': [86], 'Alison': [88, 226], 'L.': [89, 227, 229], 'Bailey,': [90], 'FAACVPR,': [93], 'Craig': [94, 232], 'Beam,': [95], 'CRE,': [96], 'Kim': [97, 236], 'K.': [98, 237, 239], 'Birtcher,': [99], 'MS,': [100, 140, 211], 'PharmD,': [101, 184], 'AACC,': [102], 'FNLA,': [103, 110, 118, 175, 185], 'Roger': [104, 242], 'S.': [105, 201, 243, 245, 337, 339], 'Blumenthal,': [106], 'Lynne': [111, 248], 'T.': [112, 249, 251], 'Braun,': [113], 'CNP,': [115], 'FPCNA,': [117], 'Sarah': [119, 254], 'de': [120, 255, 257], 'Ferranti,': [121], 'MPH,': [123, 163], 'Joseph': [124, 181, 208, 260, 318, 342], 'Faiella-Tommasino,': [125], 'PA-C,': [127], 'Daniel': [128, 149, 264, 286], 'E.': [129, 165, 171, 265, 267, 301, 303, 307, 309], 'Forman,': [130], 'Ronald': [133, 270], 'Goldberg,': [134], 'Paul': [136, 274], 'A.': [137, 144, 177, 275, 277, 281, 283, 313, 315], 'Heidenreich,': [138], 'Mark': [143, 280], 'Hlatky,': [145], 'W.': [150, 287, 289], 'Jones,': [151], 'Donald': [154, 292], 'Lloyd-Jones,': [155], 'SCM,': [157], 'Nuria': [160, 296], 'Lopez-Pajares,': [161], 'Chiadi': [164, 300], 'Ndumele,': [166], 'Carl': [170, 306], 'Orringer,': [172], 'Carmen': [176, 312], 'Peralta,': [178], 'MAS,': [180], 'Saseen,': [183], 'Sidney': [187, 324], 'C.': [188, 325, 328], 'Smith': [189, 326, 329], 'Jr,': [190], 'MACC,': [192], 'Laurence': [194, 332], 'Sperling,': [195], 'FASPC,': [199], 'Salim': [200, 336], 'Virani,': [202], 'FAHA': [206, 213], 'and': [207, 341, 420, 432, 443, 453, 459, 464, 470, 474, 482, 489, 511, 517, 562, 612, 620, 631, 660, 676, 696, 757, 787, 884, 931, 948, 1003, 1030, 1049, 1143, 1162, 1170, 1179, 1182, 1197, 1259, 1280, 1371, 1411, 1463, 1519, 1525, 1554, 1602, 1631, 1646, 1651, 1660, 1668, 1726, 1748, 1757, 1765, 1768, 1779, 1792, 1807, 1810, 1831, 1857, 1862, 1866, 1872, 1882, 1887, 1907, 1924, 1933, 1940, 1984, 1992, 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'GoldbergRonald': [271], 'Goldberg': [272], 'HeidenreichPaul': [276], 'Heidenreich': [278], 'HlatkyMark': [282], 'Hlatky': [284], 'JonesDaniel': [288], 'Jones': [290], 'Lloyd-JonesDonald': [293], 'Lloyd-Jones': [294], 'Lopez-PajaresNuria': [297], 'Lopez-Pajares': [298], 'NdumeleChiadi': [302], 'Ndumele': [304], 'OrringerCarl': [308], 'Orringer': [310], 'PeraltaCarmen': [314], 'Peralta': [316], 'SaseenJoseph': [320], 'Saseen': [322], 'JrSidney': [327], 'Jr': [330], 'SperlingLaurence': [333], 'Sperling': [334], 'ViraniSalim': [338], 'Virani': [340], 'YeboahJoseph': [343], 'Yeboah': [344], 'Originally': [345], 'published10': [346], 'Nov': [347], '2018https://doi.org/10.1161/CIR.0000000000000625Circulation.': [348], '2019;139:e1082–e1143is': [349], 'corrected': [350], 'byCorrection': [351], 'to:': [352], '2018': [353, 2157, 2304, 2548], 'GuidelinesOther': [377], 'version(s)': [378], 'this': [380, 389, 2262, 2569, 2574, 2611, 2851, 2943, 3479, 3760], 'articleYou': [381], 'are': [382, 1252, 1578, 1624, 1700, 1732, 1771, 1893, 1938, 1973, 2182, 2209, 2349, 2516, 2935, 3005, 3014, 3138, 3338, 3455, 3712, 3757, 3898], 'viewing': [383], 'most': [385, 3119, 3848], 'recent': [386], 'version': [387, 2016, 2218], 'article.': [390], 'Previous': [391], 'versions:': [392], 'November': [393], '10,': [394, 2547], '2018:': [395], 'Ahead': [396], 'Print': [398], 'Table': [399, 2915], 'ContentsTop': [401], '10': [402, 711], 'Take-Home': [403, 712], 'Messages': [404, 713], 'Reduce': [406, 715], 'Risk': [407, 476, 563, 604, 639, 650, 656, 716, 1122, 3541], 'Atherosclerotic': [409, 718], 'Cardiovascular': [410, 719, 2720, 2767], 'Disease': [411, 720], 'Through': [412, 721], 'Cholesterol': [413, 452, 687, 707, 722, 2305, 3313], 'e1083Preamble': [415], 'e10841.': [416], 'Introduction': [417], 'e10851.1.': [418], 'Methodology': [419, 2032], 'Evidence': [421, 446, 2034, 2475, 3214, 3237], 'Review': [422, 431, 2476, 2805], 'e10851.2.': [423], 'Organization': [424, 2671], 'Writing': [427, 2674], 'Committee': [428], 'e10861.3.': [429], 'Document': [430, 2804], 'Approval': [433], 'e10861.4.': [434], 'Scope': [435, 2879], 'e10861.5.': [439], 'Class': [440, 3131, 3208, 3231], 'Recommendation': [442, 3133, 3210, 3233], 'Level': [444, 3135, 3212, 3235], 'e10871.6.': [447], 'Abbreviations': [448], 'e10872.': [449], 'High': [450, 3311], 'ASCVD': [454, 460, 471, 542, 762, 877, 882, 891, 971, 1014, 1062, 1111, 1208, 1425, 1567, 2137, 3004, 3037, 3126, 3431, 3599, 3675, 4003], 'e10872.1.': [455], 'Serum': [456, 3316], 'Cholesterol,': [457, 462, 468, 3317, 3321, 3422], 'Lipoproteins,': [458, 463, 3318, 3322], 'e10872.1.1.': [461], 'Apolipoprotein': [465, 487, 3324], 'B': [466, 488, 1360, 3407], 'e10872.1.2.': [467], 'LDL-C,': [469, 1138, 2111, 2478, 2533, 3423, 3865], 'e10872.1.3.': [472], 'LDL-C': [473, 481, 496, 576, 825, 845, 854, 906, 920, 979, 992, 1050, 1097, 1199, 1255, 1266, 1309, 1413, 1561, 1582, 2393, 3345, 3383, 3420, 3465, 3495, 3538, 3543, 3740, 3747, 3769, 3777, 3818, 3855, 3880, 3888, 3940, 3966], 'Other': [475, 597, 601, 677, 697, 3540], 'Factors': [477], 'e10872.2.': [478], 'Measurements': [479, 485, 3738], 'Non–HDL-C': [483], 'e10882.3.': [484], 'Lipoprotein': [490], '(a)': [491, 1373], 'e10892.4.': [492], 'Monitoring': [493, 587, 659], 'Response': [494, 589], 'Statin': [498, 524, 534, 610], 'Therapy': [499, 525, 535, 592], 'e10903.': [500], 'Therapeutic': [501], 'Modalities': [502], 'e10903.1.': [503], 'Lifestyle': [504, 515], 'Therapies': [505, 516, 528], 'e10903.1.1.': [506], 'Diet': [507], 'Composition,': [508], 'Weight': [509], 'Control,': [510], 'Physical': [512], 'Activity': [513], 'e10903.1.2.': [514], 'Metabolic': [518], 'Syndrome': [519], 'e10903.2.': [520], 'Lipid-Lowering': [521], 'Drugs': [522, 532], 'e10903.2.1.': [523], 'e10903.2.2.': [526], 'Nonstatin': [527, 530], 'e10913.2.3.': [529], 'Add-on': [531], 'e10914.': [536], 'Patient': [537, 3224, 3247], 'Groups': [539, 599], 'e10914.1.': [540], 'Secondary': [541], 'Prevention': [543, 559, 567, 595], 'e10914.2.': [544], 'Severe': [545], 'Hypercholesterolemia': [546], '(LDL-C': [547, 962], '≥190': [548, 964], 'mg/dL': [549, 581, 858, 910, 924, 965, 983, 1000, 1052, 1202, 1312, 1350, 1375, 1416, 1419, 1585, 2520, 2530, 3458, 3470, 3868, 3892, 3900], '[≥4.9': [550, 966], 'mmol/L])': [551], 'e10954.3.': [552], 'Diabetes': [553, 2744], 'Mellitus': [554], 'in': [555, 588, 596, 648, 1184, 1356, 1392, 1456, 1484, 1560, 1693, 1742, 1797, 1915, 1942, 1948, 2038, 2062, 2066, 2184, 2205, 2215, 2311, 2357, 2381, 2395, 2518, 2529, 2556, 2659, 2850, 2917, 2942, 2988, 3022, 3097, 3170, 3223, 3246, 3401, 3478, 3490, 3500, 3524, 3610, 3617, 3646, 3707, 3810, 3826, 3913, 3945, 3965, 3990], 'Adults': [556, 568], 'e10974.4.': [557], 'Primary': [558, 566, 594], 'e10994.4.1.': [560], 'Evaluation': [561], 'Assessment': [564, 640], 'e10994.4.2.': [565], '40': [569, 1040, 1102, 1188, 1271, 1402, 3024], '75': [571, 1042, 1082, 1104, 1190, 1273, 1404, 3026], 'Years': [572], 'Age': [574, 598], 'With': [575, 674, 694], 'Levels': [577], '70': [578, 857], '189': [580, 1418], '(1.7': [582], '4.8': [584], 'mmol/L)': [585, 860, 926, 1002, 1587, 3894], 'e11024.4.3.': [586], 'LDL-C–Lowering': [591], 'e11064.4.4.': [593], 'e11074.5.': [600], 'Populations': [602], 'at': [603, 743, 915, 953, 1035, 1069, 1205, 1380, 1394, 1422, 1569, 1680, 2344, 2990, 3035, 3861], 'e11114.5.1.': [605], 'Ethnicity': [606], 'e11114.5.2.': [607], 'Hypertriglyceridemia': [608], 'e11125.': [609], 'Safety': [611], 'Statin-Associated': [613], 'Side': [614], 'Effects': [615], 'e11176.': [616], 'Implementation': [617], 'e11207.': [618], 'Cost': [619], 'Value': [621, 625], 'Considerations': [622], 'e11217.1.': [623], 'Economic': [624], 'Considerations:': [626], 'PCSK9': [627, 936, 1017, 2117, 2977], 'Inhibitors': [628], 'e11218.': [629], 'Limitations': [630], 'Knowledge': [632], 'Gaps': [633], 'e11228.1.': [634], 'Randomized': [635], 'Controlled': [636], 'Trials': [637], 'e11228.2.': [638], 'e11228.2.1.': [641], 'Continuing': [642], 'Refinement': [643, 653], 'PCE': [645], 'e11238.2.2.': [646], 'Improvement': [647], 'Lifetime': [649], 'Estimate': [651], 'e11238.2.3.': [652], 'Clinician–Patient': [655], 'Discussion': [657], 'e11238.2.4.': [658], 'Adjustment': [661], 'Treatment': [663, 3272], 'e11238.2.5.': [664], 'Prognostic': [665], 'Significance': [666], 'CAC': [668, 1443, 1474, 1495], 'e1123References': [669], 'e1124Appendix': [670], '1:': [671], 'Author': [672], 'Relationships': [673, 693], 'Industry': [675, 695], 'Entities': [678, 698], '(Relevant)—2018': [679], '(August': [688, 708], '2018)': [689, 709], 'e1139Appendix': [690], '2:': [691], 'Reviewer': [692], '(Comprehensive)—2018': [699], 'e1141Top': [710], 'ManagementIn': [723], 'all': [724, 744, 793, 2459, 2647, 3586], 'individuals,': [725, 748, 1358], 'emphasize': [726], 'a': [727, 839, 853, 872, 935, 1016, 1091, 1114, 1126, 1206, 1213, 1217, 1423, 1432, 1466, 1635, 1843, 1943, 1953, 1957, 1993, 2231, 2412, 2549, 2586, 2596, 2686, 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1008, 1077, 1131, 1153, 1226, 1290, 1300, 1387, 3063, 3552, 3559, 3589, 3702, 3724, 3727], 'is': [758, 798, 826, 894, 938, 946, 951, 988, 1028, 1033, 1087, 1236, 1263, 1437, 1444, 1497, 1506, 1689, 1720, 1832, 2009, 2309, 2801, 2848, 2888, 2982, 3049, 3083, 3091, 3115, 3121, 3346, 3354, 3364, 3368, 3378, 3386, 3390, 3405, 3413, 3509, 3544, 3748, 3762, 3834, 3845, 3890, 3958, 3978, 4011], 'foundation': [760, 1636], 'reduction.': [764, 837], 'young': [766, 3107], 'adults': [767, 1101, 1187, 1270, 1401, 2327, 3023, 3098, 3996], '20': [768], '39': [770], 'years': [771, 1043, 1083, 1105, 1191, 1274, 1405, 1487, 2329, 3027, 3100], 'age,': [773, 1085, 3574], 'an': [774, 2010, 2222, 2557, 3092, 3464, 3594, 3876, 3905, 3909], 'assessment': [775, 3809, 3815], 'lifetime': [777, 3125], 'facilitates': [779], 'clinician–patient': [781, 1115, 1515, 3053, 3071], 'discussion': [783, 1117, 1123, 1218, 3055, 3073], '(see': [784, 1154, 1230, 1247, 1296, 1592], '6)': [786], 'emphasizes': [788], 'intensive': [789], 'efforts.': [791], 'age': [794, 1045, 1107, 1193, 1276, 1407, 2331, 3029, 3577], 'groups,': [795], 'therapy': [797, 817, 903, 1058, 1229, 1295, 1391, 1436, 1449, 1505, 1556, 1577, 1591, 2410, 3989], 'primary': [800, 960, 1110, 2126, 2931, 3011, 3546, 3811, 3827], 'intervention': [801, 3186], 'for': [802, 1109, 1167, 1573, 1637, 1754, 1975, 1997, 2076, 2254, 2302, 2501, 2531, 2542, 2757, 2858, 3016, 3056, 3511, 3687, 3746, 3807, 3814, 3847, 4013], 'metabolic': [803, 1315], 'syndrome.In': [804], 'patients': [805, 914, 957, 1039, 1065, 1393, 1568, 1677, 1703, 1741, 2895, 2989, 3002, 3017, 3492], 'with': [806, 814, 958, 1046, 1066, 1074, 1198, 1412, 1447, 1460, 1465, 1528, 1564, 1615, 1678, 1728, 1794, 1869, 1905, 2013, 2261, 2313, 2332, 2408, 2417, 2430, 2589, 2609, 2783, 2896, 2948, 3003, 3007, 3018, 3031, 3111, 3140, 3297, 3475, 3572, 3704, 3780, 3798, 3969, 3992, 3997], 'clinical': [807, 1612, 1654, 1752, 1761, 1860, 2237, 2333, 3199, 3993], 'ASCVD,': [808, 851, 2347, 3705], 'low-density': [810, 2479, 2506, 3306, 3308, 3333], 'lipoprotein': [811, 1372, 1384, 2480, 2507, 2511, 3283, 3309, 3329, 3334, 3395, 3567], 'cholesterol': [812, 2241, 2504, 2508, 2512, 2899, 2959, 3326, 3362, 3428, 3453, 3476, 3621], '(LDL-C)': [813], 'high-intensity': [815, 974, 1092], 'statin': [816, 821, 829, 842, 867, 902, 930, 975, 995, 1057, 1093, 1120, 1163, 1177, 1215, 1223, 1228, 1294, 1390, 1435, 1448, 1481, 1504, 1537, 1555, 1590, 2140, 2409, 2418, 3825, 3954, 3988], 'or': [818, 879, 1078, 1323, 1336, 1376, 1453, 1501, 1539, 1679, 1715, 1878, 1897, 1968, 2341, 2343, 2437, 2440, 2442, 2451, 2664, 2669, 3034, 3220, 3243, 4004], 'maximally': [819, 840, 900, 928], 'tolerated': [820, 841, 901, 929], 'therapy.': [822, 868, 976, 1121, 1224], 'The': [823, 1644, 1687, 1880, 1900, 2178, 2277, 2299, 2618, 2652, 2701, 2903, 2930, 3153, 3174, 3380, 3397, 3513, 3556, 3603, 3850], 'more': [824, 3391, 3832], 'reduced': [827], 'therapy,': [830, 933, 1482, 1758, 2141, 3955], 'greater': [832], 'will': [833, 3942], 'be': [834, 1020, 1451, 1710, 1785, 1912, 1927, 2603, 3341, 3601, 3729, 3771, 3805, 3839, 3859, 3920, 3943], 'subsequent': [835, 1011], 'Use': [838], 'lower': [844, 3862], 'levels': [846, 1200, 1256, 1267, 1310, 1414, 1562, 1583, 3454, 3756, 3788, 3819, 3856, 3863, 3881, 3889, 3897, 3967, 3984], 'by': [847, 1099, 1257, 1268, 1511, 1557, 1580, 1776, 1787, 1839, 1863, 2166, 2194, 2250, 2539, 2544, 2622, 2631, 2635, 2646, 2811, 2817, 2860, 3623, 3683], '≥50%.In': [848, 1100, 1269], 'very': [849, 889, 916, 1570, 2991, 3332], 'high-risk': [850, 870, 886, 890, 1339, 2345, 2992, 3491], 'use': [852, 1090, 2981, 3973], 'threshold': [855, 1581], '(1.8': [859], 'consider': [862, 1238, 1439], 'addition': [863], 'nonstatins': [865], 'Very': [869], 'includes': [871, 1952, 2318, 2424], 'history': [873, 1303, 1320, 1469, 2431, 4000], 'multiple': [875, 885, 1007, 1075], 'major': [876, 881, 1129, 3061, 3557, 3587, 3722], 'events': [878, 2363, 2385], '1': [880, 1477, 2772], 'event': [883, 3679], 'conditions.': [887], 'patients,': [892, 1793], 'it': [893, 1086, 2581, 3918], 'reasonable': [895, 1088, 3846, 4012], 'add': [897], 'ezetimibe': [898, 932, 987, 997, 2975], 'when': [904, 1774, 1964, 2176, 2573, 3080, 3678, 3887], 'level': [907, 921, 963, 980, 993, 1098, 3149, 3175, 3466, 3941], 'remains': [908, 922, 981, 998], '≥70': [909, 923, 1051, 1201, 1415, 1584], '(≥1.8': [911, 925, 1053, 1203, 1586], 'mmol/L).': [912, 3472], 'high': [917, 2897], 'whose': [919], 'adding': [934, 986, 1574], 'inhibitor': [937, 1018], 'reasonable,': [939], 'although': [940, 1022], 'long-term': [942, 1024], 'safety': [943, 1025], '(>3': [944, 1026], 'years)': [945, 1027], 'uncertain': [947, 1029, 1034], 'cost': [949], 'effectiveness': [950], 'low': [952, 3482], 'mid-2018': [954, 1036], 'list': [955, 1037, 2923], 'prices.In': [956, 1038], 'severe': [959, 3019], 'hypercholesterolemia': [961, 3020, 3113], 'mmol/L]),': [967], 'without': [968, 1059, 1194, 1277, 1408, 1657, 1895], 'calculating': [969, 1060], '10-year': [970, 1061, 1145, 1207, 1261, 1281, 1395, 1424], 'risk,': [972, 1071], 'begin': [973], 'If': [977, 990, 1233, 1250, 1442, 3831], '≥100': [982, 999, 1498], '(≥2.6': [984, 1001], 'mmol/L),': [985, 1054, 1204, 1421, 3460], 'reasonable.': [989], 'plus': [996, 2411], 'patient': [1005, 1180, 1795, 3533, 3931], 'has': [1006, 3907], 'that': [1009, 1822, 1891, 2595, 3426, 3450, 3494, 3507, 3630, 3669, 3695, 3957], 'increase': [1010], 'events,': [1015], 'may': [1019, 1388, 1450, 1709, 3919], 'considered,': [1021], 'economic': [1031], 'value': [1032, 3795], 'diabetes': [1047, 1067, 1195, 1278, 1409, 1461, 2142, 2389, 3032], 'mellitus': [1048, 1068, 1196, 1279, 1410, 3033], 'start': [1055, 1212], 'moderate-intensity': [1056, 1214], 'risk.': [1063, 3038, 3173, 3676], 'higher': [1070, 1381, 3036], 'especially': [1072, 1379, 1483], 'those': [1073, 1079, 1459, 1464, 1485, 2429, 3110], '50': [1080], 'evaluated': [1108, 2267], 'prevention,': [1112, 2127, 2129, 3012], 'have': [1113, 1607, 1884, 1922, 2945, 2966, 3643, 3791, 3874], 'before': [1118, 3820, 3985], 'starting': [1119], 'should': [1124, 1749], 'include': [1125, 1301, 2974, 3075, 3560], 'review': [1127, 1669, 2225, 2234, 2282, 2301, 2665], '(eg,': [1132, 1332, 1342, 2336, 2364, 2386], 'cigarette': [1133, 1457, 3561], 'smoking,': [1134, 3562], 'elevated': [1135, 1308], 'blood': [1136, 2898], 'pressure,': [1137], 'hemoglobin': [1139], 'A1C': [1140], '[if': [1141], 'indicated],': [1142], 'calculated': [1144], 'ASCVD);': [1148], 'presence': [1150], 'risk-enhancing': [1152, 1289, 2138, 3077, 3714, 3726], '8);': [1156], 'potential': [1158, 1166], 'benefits': [1159], 'therapies;': [1164], 'adverse': [1168, 2384], 'effects': [1169], 'drug–drug': [1171], 'interactions;': [1172], 'consideration': [1173], 'costs': [1175], 'therapy;': [1178], 'preferences': [1181], 'values': [1183, 1382, 2500, 2528], 'shared': [1185, 1788, 3058], 'decision-making.In': [1186], '≥7.5%,': [1211], 'if': [1216, 1260, 1354, 1431, 1493, 3956], 'treatment': [1220, 1446], 'options': [1221], 'favors': [1222, 1480], 'Risk-enhancing': [1225, 1299, 1386], 'favor': [1227, 1291, 1389], '8).': [1232], 'status': [1235, 3082], 'uncertain,': [1237, 1438, 3084], 'using': [1239, 2577], 'coronary': [1240, 2132, 2426, 2441, 2468, 3086, 3254], 'artery': [1241, 2133, 2339, 2453, 3087, 3263], 'calcium': [1242, 3088], '(CAC)': [1243, 3089], 'improve': [1245, 1618, 1722], 'specificity': [1246], '9).': [1249], 'statins': [1251, 2949, 3008, 3013], 'indicated,': [1253], '≥30%,': [1258], '≥20%,': [1264], '7.5%': [1284], '19.9%': [1286], '(intermediate': [1287], 'risk),': [1288], 'initiation': [1292, 1538, 3822, 3952, 3986], '7).': [1298], 'family': [1302, 1468, 3999], 'premature': [1305, 1324, 1471, 4002], 'ASCVD;': [1306], 'persistently': [1307], '≥160': [1311], '(≥4.1': [1313], 'mmol/L);': [1314, 1352], 'syndrome;': [1316], 'chronic': [1317, 1329, 1337], 'kidney': [1318, 3268], 'disease;': [1319, 2466, 2470, 2473], 'preeclampsia': [1322], 'menopause': [1325], '(age': [1326], '<40': [1327], 'years);': [1328], 'inflammatory': [1330], 'disorders': [1331], 'rheumatoid': [1333], 'arthritis,': [1334], 'psoriasis,': [1335], 'HIV);': [1338], 'ethnic': [1340], 'groups': [1341], 'South': [1343, 2147], 'Asian);': [1344], 'persistent': [1345], 'elevations': [1346], 'triglycerides': [1348, 3896], '≥175': [1349], '(≥1.97': [1351], 'and,': [1353, 1963], 'measured': [1355], 'selected': [1357, 2083, 2202], 'apolipoprotein': [1359, 3406], '≥130': [1361], 'mg/dL,': [1362], 'high-sensitivity': [1363], 'C-reactive': [1364], 'protein': [1365, 3399], '≥2.0': [1366], 'mg/L,': [1367], 'ankle-brachial': [1368], 'index': [1369], '<0.9': [1370], '≥50': [1374], '125': [1377], 'nmol/L,': [1378], '(a).': [1385], '5-7.5%': [1398], '(borderline': [1399], 'risk).In': [1400], '(≥1.8-4.9': [1420], '≥7.5%': [1428], '19.9%,': [1430], 'decision': [1433], 'about': [1434, 3456, 3468], 'measuring': [1440], 'CAC.': [1441], 'zero,': [1445], 'withheld': [1452], 'delayed,': [1454], 'except': [1455], 'smokers,': [1458], 'mellitus,': [1462, 2143], 'strong': [1467], 'ASCVD.': [1472, 3344, 3501], 'score': [1475, 1496, 3090], '99': [1479], '≥55': [1486], 'age.': [1489, 3102], 'For': [1490, 2788], 'any': [1491, 2606, 2660], 'patient,': [1492], 'Agatston': [1499], 'units': [1500], '≥75th': [1502], 'percentile,': [1503], 'indicated': [1507], 'unless': [1508], 'otherwise': [1509], 'deferred': [1510], 'outcome': [1513], 'discussion.Assess': [1517], 'adherence': [1518], 'percentage': [1520, 1558], 'response': [1521, 3949], 'LDL-C–lowering': [1523], 'medications': [1524], 'changes': [1527], 'repeat': [1529], 'lipid': [1530, 3885, 3983, 4009], 'measurement': [1531], '4': [1532], '12': [1534, 1546], 'weeks': [1535], 'after': [1536, 3928], 'dose': [1540], 'adjustment,': [1541], 'repeated': [1542], 'every': [1543], '3': [1544], 'months': [1547], 'as': [1548, 1876, 2831, 2833, 2950, 3554, 3580], 'needed.': [1549], 'Define': [1550], 'responses': [1551], 'reductions': [1559, 3499], 'compared': [1563, 2416], 'baseline.': [1565], 'high-risk,': [1571], 'triggers': [1572], 'nonstatin': [1575], 'drug': [1576], 'defined': [1579], 'maximal': [1589], '3).PreambleSince': [1594], '1980,': [1595], 'Cardiology': [1600, 2715, 2759], '(ACC)': [1601], '(AHA)': [1606], 'translated': [1608], 'scientific': [1609, 3182], 'evidence': [1610, 2045, 2050, 2174, 2180, 2192, 2224, 2281, 2910, 2934, 3151, 3177, 3183, 3518], 'into': [1611, 2256, 3590], 'practice': [1613, 1655, 1671, 1692], 'guidelines': [1614, 1656, 1672, 1699, 1708, 1921, 1931, 3041], 'recommendations': [1616, 1674, 1783, 2036, 2296], 'health.': [1620], 'These': [1621, 3614, 3638], 'guidelines,': [1622, 2909, 3046], 'which': [1623, 1759, 1949, 2052, 2247, 2561, 3461], 'based': [1625], 'systematic': [1627, 2233, 2300], 'methods': [1628, 1888], 'evaluate': [1630], 'classify': [1632], 'evidence,': [1633], 'provide': [1634, 1673, 3535], 'delivery': [1639], 'quality': [1641, 1723, 3180], 'care.': [1643], 'ACC': [1645, 1881], 'AHA': [1647, 1883], 'sponsor': [1648], 'publication': [1652, 2859], 'commercial': [1658], 'support,': [1659], 'members': [1661, 2266, 2288], 'volunteer': [1662], 'their': [1663, 2554, 2980], 'time': [1664], 'writing': [1667, 1825, 2161, 2168, 2196, 2252, 2264, 2286, 2550, 2599, 2624, 2649, 2653, 2676, 2702, 2778, 2795, 2845, 2904], 'efforts.Clinical': [1670], 'applicable': [1675], 'developing': [1683, 3598], '(CVD).': [1686], 'focus': [1688], 'medical': [1691, 1837, 2680], 'United': [1695], 'States,': [1696], 'but': [1697, 1744, 1999, 2102, 3841], 'these': [1698, 3040, 3670, 3711], 'relevant': [1701, 2085, 2152, 2270, 2567, 2587, 2607, 2781], 'throughout': [1704], 'world.': [1706], 'Although': [1707], 'used': [1711, 2193, 3730, 3806], 'inform': [1713], 'regulatory': [1714], 'payer': [1716], 'decisions,': [1717], 'intent': [1719], 'care': [1725], 'align': [1727], "patients'": [1729], 'interests.': [1730], 'intended': [1733], 'define': [1735], 'practices': [1736], 'meeting': [1737], 'needs': [1739], 'most,': [1743], 'not': [1745, 1750, 2104, 2212, 2566, 2657, 3370, 3758], 'all,': [1746], 'circumstances,': [1747], 'replace': [1751], 'judgment.Recommendations': [1753], 'guideline-directed': [1755], 'management': [1756, 2893], 'encompasses': [1760], 'evaluation,': [1762], 'diagnostic': [1763], 'testing,': [1764], 'both': [1766, 1777, 1827, 2519, 3141], 'pharmacological': [1767], 'procedural': [1769], 'treatments,': [1770], 'effective': [1772, 3979], 'only': [1773, 2952], 'followed': [1775], 'practitioners': [1778], 'patients.': [1780], 'Adherence': [1781], 'enhanced': [1786], 'decision-making': [1789, 3096], 'between': [1790], 'clinicians': [1791], 'engagement': [1796], 'selecting': [1798, 1840], 'interventions': [1799], 'basis': [1802, 3189], 'individual': [1804, 2358, 2835, 3532, 3906], 'values,': [1805], 'preferences,': [1806], 'associated': [1808, 3968], 'conditions': [1809], 'comorbidities.The': [1811], 'ACC/AHA': [1812, 2024, 2579, 2958, 3620], 'strives': [1819], 'ensure': [1821, 1890], 'guideline': [1824, 1995, 2041, 2160, 2598, 2637, 2662, 2887, 3515], 'committee': [1826, 2169, 2197, 2226, 2253, 2265, 2283, 2287, 2551, 2600, 2625, 2650, 2654, 2677, 2703, 2779, 2796, 2846, 2905], 'contains': [1828, 2921], 'requisite': [1829], 'expertise': [1830, 1873], 'representative': [1833, 2210, 3633], 'broader': [1836], 'community': [1838], 'experts': [1841, 2681], 'from': [1842, 2056, 2092, 2392, 2615, 2706, 3198, 3433, 3519, 3626, 3654, 3685, 3721, 3882], 'broad': [1844], 'array': [1845], 'backgrounds,': [1847], 'representing': [1848], 'different': [1849], 'geographic': [1850], 'regions,': [1851], 'sexes,': [1852], 'races,': [1853], 'ethnicities,': [1854], 'intellectual': [1855], 'perspectives/biases,': [1856], 'scopes': [1858], 'practice,': [1861], 'inviting': [1864], 'organizations': [1865], 'professional': [1867], 'societies': [1868], 'related': [1870, 2239, 2901, 2913, 3342], 'interests': [1871], 'participate': [1875, 2658], 'partners': [1877], 'collaborators.': [1879], 'rigorous': [1885], 'policies': [1886], 'documents': [1892], 'developed': [1894], 'bias': [1896], 'improper': [1898], 'influence.': [1899], 'complete': [1901], 'policy': [1902, 2594], 'relationships': [1904, 2608, 2782], 'industry': [1906, 2784, 3298], 'other': [1908, 2082, 2443, 2786, 3001, 3076, 3202, 3300, 3550, 3566, 3701], 'entities': [1909], '(RWI)': [1910], 'found': [1913, 3694], 'online.Beginning': [1914], '2017,': [1916], 'numerous': [1917], 'modifications': [1918], 'been': [1923, 2946, 2967, 3644], 'continue': [1925], 'implemented': [1928], 'make': [1930], 'shorter': [1932], 'enhance': [1934], '"user': [1935], 'friendliness."': [1936], 'written': [1939, 2634], 'presented': [1941, 2291], 'modular': [1944, 1977], 'knowledge': [1945, 1978], 'chunk': [1946, 1951, 1979], 'format,': [1947], 'each': [1950, 1976, 2815], 'table': [1954], 'recommendations,': [1956], 'brief': [1958], 'synopsis,': [1959], 'recommendation-specific': [1960], 'supportive': [1961], 'text': [1962], 'appropriate,': [1965], 'flow': [1966], 'diagrams': [1967], 'additional': [1969], 'tables.': [1970], 'Hyperlinked': [1971], 'references': [1972], 'provided': [1974], 'facilitate': [1981, 3095], 'quick': [1982], 'access': [1983], 'review.': [1985], 'More': [1986], 'structured': [1987], 'guidelines—including': [1988], 'word': [1989], 'limits': [1990], '("targets")': [1991], 'web': [1994], 'supplement': [1996], 'useful': [1998, 3944], 'noncritical': [2000], 'tables': [2001, 2175, 2181], 'figures—are': [2003], '2': [2004, 2619], 'such': [2005, 3934], 'changes.': [2006], 'This': [2007, 3502], 'Preamble': [2008], 'abbreviated': [2011], 'version,': [2012], 'detailed': [2015, 2217], 'available': [2017, 2802], 'online.Glenn': [2018], 'N.': [2019], 'Levine,': [2020], 'FAHAChair,': [2023], 'Guidelines1.': [2030], 'Introduction1.1.': [2031], 'ReviewThe': [2035], 'listed': [2037], 'present': [2040, 2088, 2207, 2258, 2315, 2775, 2886, 3514, 3709], 'are,': [2042], 'whenever': [2043], 'possible,': [2044], 'based.': [2046], 'An': [2047], 'initial': [2048, 4014], 'extensive': [2049], 'review,': [2051], 'included': [2053, 2101, 2183, 2704], 'literature': [2054], 'derived': [2055, 2391, 3720], 'research': [2057], 'involving': [2058], 'human': [2059], 'subjects,': [2060], 'published': [2061, 2154, 2204, 2310, 2849, 2908], 'English,': [2063], 'indexed': [2065], 'MEDLINE': [2067], '(through': [2068], 'PubMed),': [2069], 'EMBASE,': [2070], 'Cochrane': [2072], 'Library,': [2073], 'Agency': [2075], 'Healthcare': [2077], 'Research': [2078], 'Quality,': [2080], 'databases': [2084], 'guideline,': [2089, 2316], 'was': [2090, 2227, 2565, 2575, 2582, 2613, 2809, 2841, 2856, 3681], 'conducted': [2091], 'May': [2093, 2546], '1980': [2094], 'July': [2096], '2017.': [2097], 'Key': [2098], 'search': [2099], 'words': [2100], 'were': [2103, 2163, 2248, 2289, 2297, 2537, 2627, 3615, 3631], 'limited': [2105, 2983], 'following:': [2108], 'hyperlipidemia,': [2109, 4006], 'cholesterol,': [2110], 'HDL-C,': [2112, 2534], 'ezetimibe,': [2113], 'bile': [2114], 'acid': [2115], 'sequestrants,': [2116], 'inhibitors,': [2118, 2978], 'lifestyle,': [2119], 'diet,': [2120], 'exercise,': [2121], 'medications,': [2122], 'child,': [2123], 'adolescent,': [2124], 'screening,': [2125], 'secondary': [2128, 2986, 3829], 'disease,': [2131, 2340], 'calcium,': [2134], 'familial': [2135, 3112], 'hypercholesterolemia.': [2136], 'factors,': [2139, 3078], 'women,': [2144, 3665], 'adherence,': [2145], 'Hispanic/Latino,': [2146], 'Asian,': [2148], 'African': [2149], 'American.': [2150], 'Additional': [2151], 'studies': [2153], 'through': [2155, 3128], 'August': [2156, 3227, 3250], 'during': [2158], 'process,': [2162, 2263], 'also': [2164, 3365, 3578], 'considered': [2165, 2249, 2583], 'added': [2171], 'appropriate.': [2177], 'final': [2179], 'Online': [2186], 'Data': [2187], 'Supplement': [2188, 2920], 'summarize': [2190], 'formulate': [2199], 'recommendations.': [2200], 'References': [2201], 'document': [2208, 2776, 2808, 2852, 2855, 3710, 3981], 'all-inclusive.As': [2213], 'noted': [2214], 'Preamble,': [2221], 'independent': [2223], 'commissioned': [2228], 'perform': [2230], 'formal': [2232], 'critical': [2236], 'questions': [2238], '(Table': [2242, 3204], '1),': [2243], 'results': [2245], 'incorporation': [2255], 'guideline.': [2259, 2276, 2571], 'Concurrent': [2260], 'study': [2268], 'data': [2269, 2321, 3197, 3529, 3625, 3653, 3684], 'rest': [2273], 'findings': [2278], 'formally': [2290], 'discussed,': [2293], 'then': [2295], 'developed.': [2298], 'GuidelinesS1.1-1': [2308], 'conjunction': [2312], 'its': [2319, 3328], 'respective': [2320], 'supplements.Table': [2322], '1.': [2323], 'ERC': [2324], 'QuestionsQuestionSection': [2325], 'NumberIn': [2326], '≥20': [2328], 'CHD,': [2337, 2467], 'peripheral': [2338, 2452], 'CVD)': [2342], 'what': [2348], 'magnitude': [2351, 2375, 3165], 'benefit': [2353, 3169], '(absolute': [2354, 2378], 'reduction;': [2355], 'NNT)': [2356], 'endpoints': [2359], 'composite': [2361], 'ischemic': [2362, 2448], 'fatal': [2365], 'event,': [2367], 'nonfatal': [2368, 2370], 'MI,': [2369, 2482], 'stroke,': [2371, 2446], 'unstable': [2372, 2438], 'angina/revascularization)': [2373], 'harm': [2377], 'increase;': [2379], 'NNH)': [2380], 'terms': [2382], 'cancer,': [2387], 'rhabdomyolysis,': [2388], 'mellitus)': [2390], 'lowering': [2394, 3496], 'large': [2396, 3648], 'RCTs': [2397, 2941, 3486, 3521], '(>1': [2398], '000': [2399], 'participants': [2400], 'originally': [2402], 'designed': [2403], 'last': [2405], '>12': [2406], 'months)': [2407], 'second': [2413], 'lipid-modifying': [2414], 'agent': [2415], 'alone?4.1Clinical': [2419], 'acute': [2425], 'syndrome': [2427], '(ACS),': [2428], 'myocardial': [2433, 2483], 'infarction': [2434], '(MI),': [2435], 'stable': [2436], 'angina': [2439], 'arterial': [2444], 'revascularization,': [2445], 'transient': [2447], 'attack': [2449], '(TIA),': [2450], '(PAD)': [2455], 'including': [2456, 2682], 'aortic': [2457], 'aneurysm,': [2458], 'origin.ASCVD': [2462], 'indicates': [2463, 3157], 'heart': [2469, 3265], 'CVD,': [2471], 'ERC,': [2474], 'Committee;': [2477], 'cholesterol;': [2481], 'infarction;': [2484], 'NNH,': [2485], 'number': [2486, 2491], 'needed': [2487, 2492], 'harm;': [2489], 'NNT': [2490], 'treat;': [2494], 'RCT,': [2496], 'randomized': [2497, 2936], 'controlled': [2498, 2937, 3293], 'trial.Numerical': [2499], 'triglycerides,': [2502, 2543, 3359], 'total': [2503, 3452], '(TC),': [2505], '(LDL-C),': [2509], 'high-density': [2510], '(HDL-C),': [2513], 'non–HDL-C': [2515, 2536, 3388], 'given': [2517, 3050, 3122, 3961], 'mmol/L.': [2522], 'To': [2523], 'convert': [2524], 'mmol/L,': [2526], 'TC,': [2532], 'divided': [2538], '38.6': [2540], '88.6.On': [2545], 'member': [2552, 2601, 2612, 2626, 2655], 'discussed': [2553], 'participation': [2555], 'industry-supported,': [2558], 'multicenter': [2559], 'study,': [2560], 'they': [2562], 'had': [2563], 'thought': [2564], 'prevention': [2570, 2597, 2987, 3812], 'However,': [2572, 3118, 3677], 'reviewed': [2576, 2643, 2810, 2906], 'specific': [2578], 'criteria': [2580], 'represent': [2585], 'relationship': [2588], 'industry.': [2590], 'Given': [2591], 'current': [2593], 'must': [2602], 'free': [2604], 'industry,': [2610], 'removed': [2614, 2628], 'committee.': [2617], 'sections': [2620, 2642], 'authored': [2621], 'replaced': [2630], 'new': [2632, 2994, 3520], 'material': [2633], 'chairs,': [2638], 'revised': [2641], 'approved': [2645, 2857], 'remaining': [2648], 'members.': [2651], 'did': [2656], 'further': [2661], 'discussions': [2663], 'manuscript': [2668], 'recommendations.1.2.': [2670], 'CommitteeThe': [2675], 'consisted': [2678], 'cardiologists,': [2683], 'internists,': [2684], 'interventionalists,': [2685], 'nurse': [2687], 'practitioner,': [2688], 'pharmacists,': [2689], 'physician': [2691], 'assistant,': [2692], 'pediatrician,': [2694], 'nephrologist,': [2696], 'lay/patient': [2699], 'representative.': [2700], 'representatives': [2705], '(AHA),': [2711], '(ACC),': [2716], 'Pulmonary': [2722], 'Rehabilitation': [2723], '(AACVPR),': [2724], 'Academy': [2727], 'Physician': [2729], 'Assistants': [2730], '(AAPA),': [2731], 'Black': [2734], 'Cardiologists': [2735], '(ABC),': [2736], 'Preventive': [2740, 2758, 2766], 'Medicine': [2741], '(ACPM),': [2742], '(ADA),': [2746], 'Geriatrics': [2748], 'Society': [2749, 2756], '(AGS),': [2750], 'Pharmacists': [2752], '(APhA),': [2754], '(ASPC),': [2760], 'National': [2761], 'Lipid': [2762], '(NLA),': [2764], 'Nurses': [2768], '(PCNA).': [2770], 'Appendix': [2771], 'lists': [2777], "members'": [2780, 2797], 'entities.': [2787], 'purposes': [2790], 'full': [2792], 'transparency,': [2793], 'comprehensive': [2798], 'disclosure': [2799], 'information': [2800, 2840], 'online.1.3.': [2803], 'ApprovalThis': [2807], '21': [2812], 'official': [2813], 'reviewers': [2814], 'nominated': [2816], 'ACC,': [2819, 2868], 'AHA,': [2820, 2866], 'AAPA,': [2821, 2869], 'ABC,': [2822, 2870], 'ACPM,': [2823, 2871], 'ADA,': [2824, 2872], 'AGS,': [2825, 2873], 'APhA,': [2826, 2874], 'ASPC,': [2827, 2875], 'NLA,': [2828, 2876], 'PCNA,': [2830], 'well': [2832], '27': [2834], 'content': [2836], 'reviewers.': [2837], "Reviewers'": [2838], 'RWI': [2839], 'distributed': [2842], '(Appendix': [2853], '2).This': [2854], 'governing': [2862], 'bodies': [2863], 'PCNA.1.4.': [2878], 'GuidelineThe': [2882], 'purpose': [2883], 'address': [2890], 'practical': [2892], 'disorders.': [2902], 'previously': [2907], 'reviews,': [2911], 'statements.': [2914], 'S1': [2916], 'Web': [2919], 'publications': [2925], 'statements': [2927], 'deemed': [2928], 'pertinent.': [2929], 'sources': [2932, 3203], 'trials': [2938, 3200], '(RCTs).': [2939], 'Most': [2940, 3000], 'area': [2944], 'performed': [2947], 'cholesterol-lowering': [2953, 2962, 3488], 'drug.S1.4-1–S1.4-3': [2954], 'Since': [2955], '2013': [2957, 3045, 3619], 'guideline,S1.4-4': [2960], 'newer': [2961], 'agents': [2963], '(nonstatin': [2964], 'drugs)': [2965], 'introduced': [2968], 'subjected': [2970], 'RCTs.': [2972, 3445], 'They': [2973], 'mainly': [2984], 'events.': [2999], 'treated': [3006], 'alone.': [3009, 3396], 'recommended': [3015], 'either': [3030, 3394], 'Throughout': [3039], 'similar': [3042, 3793], 'consistent': [3047], 'attention': [3048, 3120], 'making': [3057], 'decisions.': [3059], 'Besides': [3060], 'pooled': [3066, 3671], 'cohort': [3067, 3289, 3641, 3662, 3672], 'equations': [3068, 3642, 3673, 3697], '(PCE),': [3069], 'option': [3093], '≥40': [3099], 'children,': [3104], 'adolescents,': [3105], 'adults,': [3108], 'identifying': [3109], '(FH)': [3114], 'priority.': [3117], 'reducing': [3124], 'therapies.1.5.': [3130], 'EvidenceRecommendations': [3137], 'designated': [3139], 'class': [3143, 3154], 'recommendation': [3145, 3156], '(COR)': [3146], '(LOE).': [3152], 'strength': [3159], 'recommendation,': [3161], 'encompassing': [3162], 'estimated': [3164], 'certainty': [3167], 'proportion': [3171], 'rates': [3178, 3483], 'supporting': [3184], 'type,': [3192], 'quantity,': [3193], 'consistency': [3195], '2).S1.5-1Table': [3205], '2.': [3206, 3229], 'Applying': [3207, 3230], 'Strategies,': [3217, 3240], 'Interventions,': [3218, 3241], 'Treatments,': [3219, 3242], 'Diagnostic': [3221, 3244], 'Testing': [3222, 3245], 'Care*': [3225, 3248], '(Updated': [3226, 3249], '2015)Table': [3228], '2015)1.6.': [3251], 'AbbreviationsAbbreviationMeaning/PhraseABIankle-brachial': [3252], 'indexACSacute': [3253], 'syndromeAIDSacquired': [3255], 'immunodeficiency': [3256, 3281], 'syndromeapoBapolipoprotein': [3257], 'BARRabsolute': [3258], 'reductionASCVDatherosclerotic': [3260], 'diseaseCACcoronary': [3262], 'calciumCHDcoronary': [3264], 'diseaseCKcreatine': [3266], 'kinaseCKDchronic': [3267], 'diseaseCORClass': [3269], 'RecommendationCTTCholesterol': [3271], 'TrialistsCVDcardiovascular': [3273], 'diseaseeGFRestimated': [3274], 'glomerular': [3275], 'filtration': [3276], 'rateFHfamilial': [3277], 'hypercholesterolemiaHDLhigh-density': [3278], 'lipoproteinHFheart': [3279], 'failureHIVhuman': [3280], 'virusLDL-Clow-density': [3282], 'cholesterolLOELevel': [3284], 'EvidenceLp(a)lipoprotein': [3286], '(a)MImyocardial': [3287], 'infarctionPCEpooled': [3288], 'equationsQALYquality-adjusted': [3290], 'life-yearRArheumatoid': [3291], 'arthritisRCTrandomized': [3292], 'trialsRRRrelative': [3294], 'reductionRWIrelationships': [3296], 'entitiesSAMSstatin-associated': [3301], 'muscle': [3302], 'symptomsSRsystematic': [3303], 'reviewTCtotal': [3304], 'cholesterolVLDLvery': [3305], 'lipoproteinVLDL-Cvery': [3307], 'cholesterol2.': [3310], 'ASCVD2.1.': [3315], 'ASCVD2.1.1.': [3320], 'BSerum': [3325], 'carriers': [3330], '(LDL,': [3331], '[VLDL],': [3335], 'HDL)': [3337], 'known': [3339], 'dominant': [3348], 'form': [3349], 'atherogenic': [3351, 3392], 'cholesterol.': [3352], 'VLDL': [3353, 3361, 3404], 'chief': [3356], 'carrier': [3357], '(VLDL-C)': [3363], 'atherogenic.': [3366, 3371], 'HDL-C': [3367, 3787], 'seemingly': [3369], 'Chylomicrons': [3372], 'transport': [3373], 'dietary': [3374], 'fat;': [3375], 'chylomicron': [3376], 'atherogenicity': [3377, 3418], 'uncertain.': [3379], 'combination': [3381], 'VLDL-C': [3385], 'called': [3387, 3713], 'than': [3393, 3419], 'main': [3398], 'embedded': [3400], 'LDL': [3402], '(apoB),': [3408], 'like': [3410], 'non–HDL-C,': [3411], 'apoB': [3412], 'stronger': [3415], 'indicator': [3416], 'alone.2.1.2.': [3421], 'ASCVDEvidence': [3425], 'serum': [3427], 'contributes': [3429], 'comes': [3432], 'several': [3434], 'sources:': [3435], 'animal': [3436], 'studies,': [3437, 3443], 'genetic': [3438, 4005], 'forms': [3439], 'hypercholesterolemia,': [3441], 'epidemiological': [3442], 'US': [3446, 3636, 3650], 'population': [3447, 3640], 'studiesS2.1.2-1,S2.1.2-2': [3448], 'suggest': [3449], 'optimal': [3451], '150': [3457], '(3.8': [3459], 'corresponds': [3462], '100': [3469], '(2.6': [3471], 'Adult': [3473], 'populations': [3474], 'concentrations': [3477], 'range': [3480], 'manifest': [3481], 'ASCVD.S2.1.2-3': [3485], 'drugs': [3489], 'confirm': [3493], 'produces': [3497], 'marked': [3498], 'confirms': [3503], 'general': [3505], 'principle': [3506], '"lower': [3508], 'better"': [3510], 'LDL-C.S2.1.2-4–S2.1-6': [3512], 'looks': [3516], 'aid': [3523], 'translation': [3526], 'RCT': [3528], 'net': [3536], 'benefit.S2.1.2-72.1.3.': [3537], 'FactorsAlthough': [3542], 'cause': [3547], 'atherosclerosis,': [3549], 'contribute,': [3553], 'well.': [3555], 'hypertension,': [3563], 'dysglycemia,': [3564], 'abnormalities.': [3568], 'Because': [3569], 'atherosclerosis': [3570], 'progresses': [3571], 'advancing': [3573], "person's": [3576], 'counts': [3579], 'factor.': [3583], 'By': [3584], 'combining': [3585], 'prediction': [3592], 'equation,': [3593], "individual's": [3595], 'probability': [3596], 'estimated.': [3602], 'Framingham': [3604], 'StudyS2.1.3-1': [3606], 'took': [3607], 'lead': [3609], 'creating': [3611], 'risk-prediction': [3612], 'equations.': [3613], 'improved': [3616, 3682], 'guidelinesS2.1.3-2': [3622], 'compiling': [3624], '5': [3627], 'community-based': [3628, 3649], 'cohorts': [3629], 'broadly': [3632], 'population.': [3637], 'so-called': [3639], 'validated': [3645, 3875], 'population.S2.1.3-3': [3651], 'Initially,': [3652], "Women's": [3656], 'Health': [3657], 'Initiative,': [3658], 'contemporary': [3660], 'multiethnic': [3661], 'postmenopausal': [3664], 'appeared': [3666], 'indicate': [3668], 'overestimated': [3674], 'surveillance': [3680], 'Centers': [3686], 'Medicare': [3688], '&': [3689], 'Medicaid': [3690], 'Services,': [3691], 'authors': [3693], 'discriminated': [3698], 'well.S2.1.3-4Several': [3700], 'associate': [3703], 'factors.': [3715], 'Projections': [3716], 'future': [3718], 'adjust': [3732], 'intensity': [3734], 'LDL-lowering': [3736], 'therapy.2.2.': [3737], 'Non–HDL-CSynopsisThe': [3742], 'standard': [3743, 3884], 'calculation': [3744], 'method': [3745], 'Friedewald': [3750], 'formula:': [3751], 'LDL-C=(TC)–(triglycerides/5)–': [3752], '(HDL-C).': [3753], 'When': [3754], 'triglyceride': [3755], 'elevated,': [3759], 'equation': [3761], 'sufficiently': [3763], 'accurate.': [3764], 'hypertriglyceridemia,': [3766], 'however,': [3767], 'Friedewald-calculated': [3768, 3854], 'erroneous.': [3772], 'After': [3773], 'normal': [3774], 'food': [3775], 'intake,': [3776], 'differs': [3778], 'minimally': [3779], 'time.S2.2-10': [3781], 'Fasting': [3782], 'nonfasting': [3784, 3802, 3843, 3976], 'TC': [3785], 'appear': [3789], 'fairly': [3792], 'prognostic': [3794], 'associations': [3797], 'CVD': [3799], 'outcomes.S2.2-1–S2.2-6,S2.2-11': [3800], 'Thus,': [3801], 'samples': [3803], 'baseline': [3817, 3939, 3982], 'prevention.': [3830], 'precision': [3833], 'necessary,': [3835], 'fasting': [3836, 4008], 'lipids': [3837, 3924], 'measured,': [3840], 'sample': [3844, 3977], 'situations.': [3849], 'unreliability': [3851], 'appears': [3857], 'greatest': [3860], 'particularly': [3866], '<70': [3867, 3891], '(<1.8': [3869, 3893], 'mmol/L).S2.2-7': [3870], 'Martin': [3871], 'et': [3872], 'al.': [3873], 'approach': [3877], 'estimating': [3879], 'panel': [3886], '>150': [3899], '(>1.7': [3901], 'mmol/L).S2.2-7–S2.2-9Recommendation-Specific': [3902], 'Supportive': [3903], 'TextIf': [3904], 'ingested': [3908], 'extremely': [3910], 'high-fat': [3911], 'meal': [3912], 'preceding': [3915], '8': [3916], 'hours,': [3917], 'prudent': [3921], 'assess': [3923], 'another': [3926], 'day': [3927], 'counseling': [3929], 'avoid': [3933], 'meals.': [3935], 'Documentation': [3936], 'assessing': [3946], "patient's": [3948], 'undertaken.S2.2-1–S2.2-6': [3959], 'Similarly,': [3960], 'relatively': [3962], 'modest': [3963], 'differences': [3964], 'postprandial': [3971], 'state,': [3972], 'individuals': [3991], 'ASCVD.S2.2-1–S2.2-6': [3994], 'profile': [4010], 'eval': [4015]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2900034165', 'counts_by_year': [{'year': 2024, 'cited_by_count': 826}, {'year': 2023, 'cited_by_count': 992}, {'year': 2022, 'cited_by_count': 839}, {'year': 2021, 'cited_by_count': 1011}, {'year': 2020, 'cited_by_count': 902}, {'year': 2019, 'cited_by_count': 575}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-12-24T08:34:02.265713', 'created_date': '2018-11-16'}
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