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533, 1119], 'immunity.2': [417], 'Research': [418, 1489, 1736, 1771], 'seeking': [419], 'translate': [421], 'concept': [423, 1170], 'therapeutic': [426, 1374, 1397, 1460, 1582], 'approach': [427], 'based': [428, 1467], 'on': [429, 500, 1270, 1468], 'neuromodulating': [430], 'soon': [433], 'rapidly': [436, 757], 'evolving': [437], 'field': [438], 'exploring': [439], 'possibility': [441, 1371], 'treat': [443], 'seriously': [444], 'debilitating': [445], 'conditions': [446], 'abnormalities': [450], 'chronic': [452, 720], 'inflammation.Neural': [453], 'Modulation': [454], 'FunctionBefore': [457], 'discovery': [459], 'pathway,': [464], 'fight': [466], 'flight': [468], 'orchestrated': [470], 'autonomic': [473, 1316, 1898], '(ANS)': [476], 'sympathetic': [479, 510, 560, 574, 602, 617, 1005, 1110, 1361], 'parasympathetic': [481, 512, 619, 1112], 'reflexes': [482, 1362], 'were': [483], 'considered': [484, 542, 1105, 1193], 'domain': [486], 'cardiologists': [488, 605, 628], 'In': [492, 1431], 'fact,': [493], 'ANS': [495, 1092, 1160], 'significant': [498, 596, 727], 'influence': [499], 'function': [502, 546, 1368], 'at': [503, 784, 989, 1339, 1400], 'levels.': [505], 'Indeed,': [506], 'imbalance': [507, 1161], 'arms': [513, 620], 'accompanies': [514], 'diseases': [517], '(CVD)': [518], 'interacts': [520], 'with': [521, 590, 755, 805, 976, 1042, 1237, 1447, 1855], 'renin–angiotensin–aldosterone': [523], 'other': [526, 1156], 'main': [527], 'function.': [536, 1321], 'Blood': [537, 1946, 1949], 'always': [540], 'archetypal': [544], 'regulated': [547], 'reflexes.': [550], 'Thus,': [551], 'clinical': [552, 1164, 1394], 'scientists': [553], 'have': [554, 629, 1104], 'developed': [555], 'state-of-the-art': [556], 'techniques': [557], 'study': [559], 'activity': [563], 'patients': [565, 589, 599], 'CVD.': [568], 'Over': [569], 'decades,': [570], 'microneurography': [571, 1002], 'postganglionic': [573], 'efferents': [575], 'directed': [576], 'skeletal': [579], 'muscle': [580], 'vasculature': [581], 'norepinephrine': [583], 'spillover': [584], 'plasma': [587], 'essential': [591, 1033, 1174], 'hypertension': [592, 718, 737, 880, 1150, 1377, 1420, 1463, 1679], 'showed': [593, 821], 'proportion': [597], 'display': [600], 'activated': [601, 1018], 'outflow.': [603], 'Hence,': [604, 860], 'interested': [607, 763], 'developing': [609], 'devices': [610, 1239, 1449], 'balance': [614], 'ANS.Neuroimmune': [623], 'FunctionArguably,': [627], 'overlooked': [630], 'advances': [631, 1389], 'emerging': [632, 758, 1434], 'underlying': [637], 'neuromodulation': [638, 1263], 'immunity,': [640, 1029], 'fields': [644], 'pursued': [647], 'separate': [648], 'paths': [649], 'time.': [653], 'Moreover,': [654], 'was': [656, 1476], 'not': [657, 1500], 'included': [658], 'myriad': [661], 'implicated': [665], 'etiology': [669], 'hypertension.': [671, 1067, 1303, 1406], 'Although': [672], 'old': [673], 'observations': [674, 1280], 'suggested': [675], 'may': [680, 781, 1294], 'be': [681, 740, 782, 803, 877, 1192, 1209, 1275], 'onset': [685, 1642], 'hypertension,': [687, 769, 916], 'ideas': [689], 'remained': [690, 812], 'ignored': [691], 'decades': [693], 'until': [694], 'groundbreaking': [695], 'work': [696, 1475], 'David': [698], "Harrison's3": [699], 'laboratory': [700, 1229], 'elegantly': [701], 'demonstrated': [702], 'lymphocytes': [704], 'are': [705, 894, 1173, 1281, 1499], 'necessary': [706, 1265], 'increase': [708, 1267], 'blood': [709, 810, 899, 938, 995, 1117, 1268], 'widely': [713], 'used': [714], 'experimental': [715], 'model': [716], 'involving': [719, 1001], 'exposure': [721], 'angiotensin': [723, 845], 'II.': [724], 'Despite': [725], 'implications': [728], 'findings,': [731], 'continued': [738], 'regarded': [741], 'largely': [742, 813], 'part': [744], 'inflammatory': [747, 1453, 1565], 'reaction': [748], 'target': [750, 934, 2001], 'damage.': [752], 'all': [756, 1043], 'fields,': [759], 'groups': [761], 'immunologic': [766], 'basis': [767], 'increasing': [770], 'awareness': [771], 'inadequate': [773], 'incomplete': [775], 'efficacy': [776], 'current': [778], 'antihypertensive': [779], 'therapies': [780], 'explained,': [783], 'least': [785], 'part,': [787], 'lack': [790], 'appreciation': [792], 'mechanisms.': [796], 'Yet': [797], 'how': [798, 887, 981], 'novel': [800, 1044], 'concepts': [801], 'could': [802], 'integrated': [804, 1338], 'classical': [807, 1360], 'unexplored.It': [814], 'interesting': [816, 1210], 'note': [818], 'evidence': [820], 'lesions': [822], 'within': [823, 1140], 'specific': [824], 'brain': [825, 919, 1330], 'regions': [826], 'sensing': [829], 'peripheral': [830], 'circulating': [831], 'substances,': [832], 'such': [833], 'subfornical': [836], 'organ,': [837], 'prevent': [838], 'hypertensive': [842, 1020, 1083, 1271], 'effects': [843], 'II,': [846], 'thereby': [847], 'suggesting': [848], 'involvement': [849], 'integrating': [854], 'both': [855, 895], 'vascular': [858, 1367], 'responses.': [859], 'conceivable': [863], 'governing': [868], 'responses—identified': [870], 'so-called': [873], 'anti-inflammatory': [875], 'reflex—may': [876], 'well,': [882], 'would': [884, 1208], 'help': [885], 'elucidate': [886, 1062], 'twinned': [889], 'crucially': [896], 'regulation.': [901, 940], 'By': [902, 1714], 'pursuing': [903], 'hypothesis,': [905], 'we': [906, 1013, 1069, 1103, 1127, 1256], 'found': [907, 1230], 'spleen': [910, 965, 1026, 1333, 1638], 'unprecedented': [913], 'role': [914], 'whereby': [917], 'connected': [921], 'secondary': [924], 'lymphoid': [925], 'prime': [928, 1028], 'cells': [930], 'subsequently': [931], 'recruited': [932], 'organs': [935, 1134], 'crucial': [936], 'Mechanistic': [941], 'insights': [942], 'brain-spleen': [945], 'axis': [946, 1760], 'led': [947], 'us': [948], 'uncover': [950], 'new': [952, 1032, 1052, 1471], 'molecular': [953], 'pathway': [954, 986, 1034, 1301, 1327, 1675], 'mediating': [955], 'neuroimmune': [957, 1064, 1073, 1189, 1300, 1325, 1385, 1403, 1416, 1634], 'established': [959, 988], 'noradrenergic-mediated': [961], 'release': [962], 'placental': [967, 1410], 'growth': [968, 972, 1411], 'factor,': [969], 'angiogenic': [971, 1629], 'factor': [973, 1412, 1630], 'potentially': [974], 'targetable': [975], 'pharmacological': [977, 1426], 'approaches.4,5': [978], 'To': [979, 1101], 'determine': [980], 'newly': [983, 1323, 1380], 'recognized': [984, 1324], 'anatomic': [991], 'level': [992, 1341], 'regulate': [994], 'pressure,': [996], 'technological': [998], 'step': [999], 'forward': [1000], 'splenic': [1006, 1234, 1262], 'necessary.5': [1009], 'Using': [1010], 'approach,': [1012], 'mapped': [1014], 'vagus-splenic': [1016], 'challenges': [1021], 'conveyed': [1023], 'revealing': [1030], 'hypertension.Clinical': [1037], 'Perspectives': [1038], 'Future': [1040], 'DirectionsAs': [1041], 'concepts,': [1045], 'findings': [1047, 1144, 1167], 'propose': [1048], 'list': [1050], 'questions;': [1053], 'specifically,': [1054], 'opportunity': [1058], 'cardiology': [1060], 'path': [1065, 1392], 'First,': [1068], 'should': [1070, 1151, 1191, 1455], 'delineate': [1071], 'responsible': [1075], 'orchestrating': [1077], 'nondispensable': [1079], 'challenges,': [1084], 'opposed': [1086], 'traditional': [1089], 'view': [1090, 1309], 'hard-wired': [1093, 1311], 'circuits': [1095, 1139, 1313], 'modulating': [1096, 1319, 1354, 1401, 1452], '(Figure).': [1100], 'date,': [1102], 'vasculature,': [1122], 'kidneys,': [1123], 'heart,': [1125], 'but': [1126], 'ignore': [1129], 'presence': [1131], 'related': [1137, 1283, 1465], 'architecture.': [1142], 'Also,': [1143], 'obtained': [1145, 1221, 1441], 'context': [1148], 'encourage': [1152, 1456], 'researchers': [1153], 'examine': [1155], 'CVDs': [1157], 'critically': [1162], 'influences': [1163], 'outcome.': [1165], 'Numerous': [1166], 'supporting': [1168], 'leukocytes': [1172], 'participants': [1175], 'various': [1177], 'stages': [1178], 'CVD': [1180, 1466], 'progression': [1181], 'complication6': [1183], 'suggest': [1184], 'fact': [1186], '1': [1194], 'atherosclerosis,': [1200, 1697], 'myocardial': [1201, 1698], 'ischemia,': [1202], 'heart': [1204, 1701], 'failure.': [1205], 'Last,': [1206], 'reconsider,': [1212], 'perspective': [1215], 'cardiologists,': [1217], 'early': [1219, 2005], 'results': [1220, 1443], 'stimulation': [1225, 1561], 'endotoxemia.': [1227], "Tracey's1,2": [1228], 'activating': [1232, 1259], 'bioelectronic': [1238, 1436], 'protected': [1240], 'mice': [1241], 'one': [1243], 'most': [1246], 'lethal': [1247], 'consequences': [1248], 'septic': [1250], 'shock': [1251], 'dramatic': [1253], 'hypotension).': [1254], 'Now': [1255], 'know': [1257], 'same': [1261], 'challenges.': [1272], 'Might': [1273], 'possible': [1276], 'closely': [1282], 'finding': [1286], 'fine-tune': [1290], 'yield': [1295], 'benefit?Download': [1296], 'figureDownload': [1297], 'PowerPointFigure.': [1298], 'Schematic': [1304], 'representation': [1305], 'typical': [1308], "reflex's": [1326], 'connects': [1328], 'cholinergic-sympathetic': [1335, 1674], 'nerves': [1337], 'celiac': [1344], 'mesenteric': [1345], 'ganglion.': [1346], 'contextualization': [1348], 'cardiac,': [1364], 'renal,': [1365], 'prospects': [1369], 'identify': [1373], 'targets': [1375], 'identified': [1381], 'components': [1382], 'reflex.Overall,': [1386], 'provide': [1390], 'testing': [1395], 'strategies': [1398], 'aimed': [1399], 'identification': [1408], 'raises': [1421], 'prospect': [1423], 'harnessing': [1425], 'approaches': [1427, 1461], 'targeting': [1428], 'pathway.': [1430], 'addition,': [1432], 'progress': [1433], 'medicine,': [1437], 'recently': [1440], 'promising': [1442], 'autoimmune': [1445], 'disorders': [1446], 'implantable': [1448], 'capable': [1450], 'reflexes,2': [1454], 'investigators': [1457], 'design': [1459], 'exciting': [1470], 'concepts.Sources': [1472], 'FundingThis': [1474], 'supported': [1477], 'Italian': [1480], 'Ministry': [1481], 'Health': [1483], '"Ricerca': [1484], 'Corrente"': [1485], 'European': [1488], 'Council': [1490], '(ERC-StG-SymPAtHY-759921)': [1491], 'D.C.DisclosuresNone.FootnotesThe': [1493], 'opinions': [1494], 'expressed': [1495], 'article': [1498], 'necessarily': [1501], 'those': [1502], 'editors': [1505], 'American': [1509, 2028], 'Heart': [1510, 1786, 2029], 'Associationhttps://www.ahajournals.org/journal/circDaniela': [1511], 'daniela.[email': [1537], 'protected]itReferences1.': [1538], 'Borovikova': [1539], 'LV,': [1540], 'Ivanova': [1541], 'S,': [1542, 1616, 1661], 'Zhang': [1543, 1717], 'M,': [1544, 1620, 1625, 1653, 1668, 1815, 1826, 1828, 1832, 1872, 1874, 1916, 1934, 1936, 1981], 'Yang': [1545, 1723, 1726], 'H,': [1546, 1552], 'Botchkina': [1547], 'GI,': [1548], 'Watkins': [1549], 'LR,': [1550], 'Wang': [1551, 1747], 'Abumrad': [1553], 'N,': [1554, 1938], 'Eaton': [1555], 'JW,': [1556], 'KJ.': [1558, 1579], 'Vagus': [1559], 'attenuates': [1562], 'endotoxin.Nature.': [1568], '2000;': [1569], '405:458–462.': [1570], 'doi:': [1571, 1589, 1606, 1647, 1687, 1705], '10.1038/35013070CrossrefMedlineGoogle': [1572], 'Scholar2.': [1573], 'Chavan': [1574], 'SS,': [1575], 'Pavlov': [1576], 'VA,': [1577], 'Mechanisms': [1580], 'relevance': [1583], 'neuro-immune': [1585], 'communication.Immunity.': [1586], '2017;': [1587], '46:927–942.': [1588], '10.1016/j.immuni.2017.06.008CrossrefMedlineGoogle': [1590], 'Scholar3.': [1591], 'Norlander': [1592], 'AE,': [1593], 'Madhur': [1594], 'MS,': [1595], 'Harrison': [1596], 'DG.': [1597], 'hypertension.J': [1601], 'Exp': [1602], 'Med.': [1603], '2018;': [1604], '215:21–33.': [1605], '10.1084/jem.20171773CrossrefMedlineGoogle': [1607], 'Scholar4.': [1608], 'D,': [1610, 1651, 1817], 'Pallante': [1611, 1654], 'F,': [1612, 1655, 1882, 1983], 'Fardella': [1613, 1615, 1656, 1660], 'V,': [1614, 1657], 'Iacobucci': [1617, 1658], 'R,': [1618, 1659, 1665, 1813, 1838, 1884, 1926, 1989], 'Federici': [1619], 'Cifelli': [1621, 1669], 'G,': [1622, 1670, 1819], 'De': [1623, 1666, 1822], 'Lucia': [1624, 1667], 'G.': [1627, 1672], 'PlGF': [1631], 'mediates': [1632, 1681], 'allow': [1640], 'hypertension.Immunity.': [1644], '2014;': [1645], '41:737–752.': [1646], '10.1016/j.immuni.2014.11.002CrossrefMedlineGoogle': [1648], 'Scholar5.': [1649], 'Perrotta': [1652], 'L,': [1663, 1750], 'A': [1673, 1765, 1781, 1844, 1857, 1996], 'primes': [1676], 'brain-to-spleen': [1682], 'communication.Nat': [1683], 'Commun.': [1684], '2016;': [1685], '7:13035.': [1686], '10.1038/ncomms13035CrossrefMedlineGoogle': [1688], 'Scholar6.': [1689], 'Swirski': [1690], 'FK,': [1691], 'Nahrendorf': [1692], 'M.': [1693], 'Leukocyte': [1694], 'behavior': [1695], 'infarction,': [1699], 'failure.Science.': [1702], '2013;': [1703], '339:161–166.': [1704], '10.1126/science.1230719CrossrefMedlineGoogle': [1706], 'Scholar': [1707], 'Previous': [1708], 'Back': [1709], 'top': [1711], 'Next': [1712], 'FiguresReferencesRelatedDetailsCited': [1713], 'Liu': [1715], 'W,': [1716], 'X,': [1718, 1752, 1920, 1960], 'Wu': [1719], 'Z,': [1720], 'Huang': [1721], 'K,': [1722, 1830], 'C': [1724, 1889], 'L': [1727, 1754, 1886], '(2022)': [1728, 1758], 'Brain–heart': [1729], 'communication': [1730], 'health': [1732, 1762], 'diseases,': [1734], 'Bulletin,': [1737, 1772], '10.1016/j.brainresbull.2022.02.012,': [1738], '183,': [1739], '(27-37),': [1740], 'Online': [1741, 1776, 1867, 1911, 1954, 1976, 2013], 'publication': [1742, 1777, 1868, 1912, 1955, 1977, 2014], 'date:': [1743, 1778, 1869, 1913, 1956, 1978, 2015], '1-Jun-2022.': [1744], 'Wei': [1745], 'Y,': [1746], 'T,': [1748, 1807], 'Liao': [1749], 'Fan': [1751], 'Chang': [1753], 'Hashimoto': [1756], 'K': [1757], 'Brain-spleen': [1759], 'diseases:': [1764], 'review': [1766], 'future': [1768], 'perspective,': [1769], '10.1016/j.brainresbull.2022.02.008,': [1773], '182,': [1774], '(130-140),': [1775], '1-May-2022.': [1779], 'Filosa': [1780], 'Sawamiphak': [1783], 'S': [1784], '(2021)': [1785, 1848, 1890], 'development': [1787], 'regeneration—a': [1789], 'multi‐organ': [1790], 'effort,': [1791], 'FEBS': [1793], 'Journal,': [1794], '10.1111/febs.16319': [1795], 'Sanchez-Larsen': [1796], 'A,': [1797, 1801, 1809, 1811, 1821, 1836, 1878, 1922, 1958, 1991], 'Conde-Blanco': [1798], 'E,': [1799, 1876, 1918, 1924], 'Viloria-Alebesque': [1800], 'Sánchez-Vizcaíno': [1802], 'Buendía': [1803], 'C,': [1804, 1834], 'Espinosa': [1805], 'Oltra': [1806], 'Alvarez-Noval': [1808], 'Aledo-Serrano': [1810], 'Martin-Garcia': [1812], 'Ramos-Araque': [1814], 'Campos': [1816, 1883], 'Valle-Peñacoba': [1818], 'Sierra-Gómez': [1820], 'Ceballos-Cerrajería': [1823], 'P,': [1824, 1840, 1880, 1928, 1930], 'Agundez-Sarasola': [1825], 'Khawaja': [1827], 'Hampel': [1829], 'Serra-Martínez': [1831], 'Arbós-Barber': [1833], 'Gómez-Ibáñez': [1835], 'Villino-Boquete': [1837], 'Cabezudo-García': [1839], 'Rodríguez-Lavado': [1841], 'I,': [1842], 'Principe': [1843], 'Sopelana-Garay': [1846], 'D': [1847], 'COVID-19': [1849], 'prevalence': [1850], 'mortality': [1852], 'people': [1854], 'epilepsy:': [1856], 'nation-wide': [1858], 'multicenter': [1859], 'study,': [1860], 'Epilepsy': [1861], '&': [1862], 'Behavior,': [1863], '10.1016/j.yebeh.2021.108379,': [1864], '125,': [1865], '(108379),': [1866], '1-Dec-2021.': [1870], 'Garcia': [1871], 'Milanez': [1873], 'Nishi': [1875], 'Sato': [1877], 'Carvalho': [1879], 'Nogueira': [1881], 'Oyama': [1885], 'Bergamaschi': [1888], 'Retroperitoneal': [1891], 'adipose': [1892], 'denervation': [1894], 'improves': [1895], 'cardiometabolic': [1896], 'dysfunction': [1899], 'high': [1902], 'fat': [1903], 'diet': [1904], 'model,': [1905], 'Life': [1906], 'Sciences,': [1907], '10.1016/j.lfs.2021.119841,': [1908], '283,': [1909], '(119841),': [1910], '1-Oct-2021.': [1914], 'Siedlinski': [1915], 'Jozefczuk': [1917], 'Xu': [1919], 'Teumer': [1921], 'Evangelou': [1923], 'Schnabel': [1925], 'Welsh': [1927], 'Maffia': [1929], 'Erdmann': [1931], 'J,': [1932, 1987], 'Tomaszewski': [1933], 'Caulfield': [1935], 'Sattar': [1937], 'Holmes': [1939], 'M': [1940, 1962], 'Guzik': [1942], 'T': [1943], '(2020)': [1944, 1966], 'White': [1945], 'Cells': [1947], 'Pressure,': [1950], 'Circulation,': [1951], '141:16,': [1952], '(1307-1317),': [1953], '21-Apr-2020.Mouton': [1957], 'Li': [1959], 'Hall': [1961, 1964], 'J': [1965], 'Obesity,': [1967], 'Hypertension,': [1968], 'Cardiac': [1970], 'Dysfunction,': [1971], 'Circulation': [1972], 'Research,': [1973, 2009], '126:6,': [1974], '(789-806),': [1975], '13-Mar-2020.': [1979], 'Albaghdadi': [1980], 'Garcia-Polite': [1982], 'Zani': [1984], 'B,': [1985], 'Keating': [1986], 'Melidone': [1988], 'Spognardi': [1990], 'Markham': [1992], 'P': [1993], 'Tzafriri': [1995], '(2019)': [1997], 'Splenic': [1998], 'artery': [1999], 'denervation:': [2000], 'micro-anatomy,': [2002], 'feasibility,': [2003], 'experience,': [2007], '10.1016/j.trsl.2019.07.012,': [2010], '213,': [2011], '(100-111),': [2012], '1-Nov-2019.': [2016], 'October': [2017], '30,': [2018], '2018Vol': [2019], 'Issue': [2021], '18': [2022], 'Advertisement': [2023, 2043], 'Article': [2024], 'InformationMetrics': [2025], '©': [2026], '2018': [2027, 2036], 'Association,': [2030], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.118.035628PMID:': [2031], '30372133': [2032], 'publishedOctober': [2034], '29,': [2035], 'Keywordshypertensionimmune': [2037], 'systemautonomic': [2038], 'systemcardiovascular': [2040], 'diseasesneuroimmunomodulationPDF': [2041], 'download': [2042], 'SubjectsAutonomic': [2044], 'Nervous': [2045], 'SystemBasic': [2046], 'Science': [2047], 'ResearchPathophysiology': [2048]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2898965529', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-16T20:50:17.637136', 'created_date': '2018-11-09'}