Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2897072461', 'doi': 'https://doi.org/10.1016/j.canlet.2018.10.006', 'title': 'Progression from low- to high-grade in a glioblastoma model reveals the pivotal role of immunoediting', 'display_name': 'Progression from low- to high-grade in a glioblastoma model reveals the pivotal role of immunoediting', 'publication_year': 2019, 'publication_date': '2019-02-01', 'ids': {'openalex': 'https://openalex.org/W2897072461', 'doi': 'https://doi.org/10.1016/j.canlet.2018.10.006', 'mag': '2897072461', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30312732'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.canlet.2018.10.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106234763', 'display_name': 'Cancer Letters', 'issn_l': '0304-3835', 'issn': ['0304-3835', '1872-7980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063466765', 'display_name': 'Irene Appolloni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Irene Appolloni', 'raw_affiliation_strings': ['Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035322239', 'display_name': 'Francesco Alessandrini', 'orcid': 'https://orcid.org/0000-0002-8450-848X'}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Alessandrini', 'raw_affiliation_strings': ['Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073018080', 'display_name': 'Davide Ceresa', 'orcid': 'https://orcid.org/0000-0002-2833-4024'}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Davide Ceresa', 'raw_affiliation_strings': ['Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031366173', 'display_name': 'Daniela Marubbi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}, {'id': 'https://openalex.org/I4210146472', 'display_name': 'Ospedale Policlinico San Martino', 'ror': 'https://ror.org/04d7es448', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146472', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniela Marubbi', 'raw_affiliation_strings': ['Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}, {'raw_affiliation_string': 'IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I4210146472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004860598', 'display_name': 'Eleonora Gambini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Eleonora Gambini', 'raw_affiliation_strings': ['Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056322405', 'display_name': 'Daniele Reverberi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146472', 'display_name': 'Ospedale Policlinico San Martino', 'ror': 'https://ror.org/04d7es448', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146472', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniele Reverberi', 'raw_affiliation_strings': ['IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I4210146472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009548645', 'display_name': 'Fabrizio Loiacono', 'orcid': 'https://orcid.org/0000-0001-9370-8910'}, 'institutions': [{'id': 'https://openalex.org/I4210146472', 'display_name': 'Ospedale Policlinico San Martino', 'ror': 'https://ror.org/04d7es448', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146472', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Fabrizio Loiacono', 'raw_affiliation_strings': ['IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I4210146472']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000567770', 'display_name': 'Paolo Malatesta', 'orcid': 'https://orcid.org/0000-0003-3045-3361'}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}, {'id': 'https://openalex.org/I4210146472', 'display_name': 'Ospedale Policlinico San Martino', 'ror': 'https://ror.org/04d7es448', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146472', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Paolo Malatesta', 'raw_affiliation_strings': ['Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Medicine (DIMES), University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I83816512']}, {'raw_affiliation_string': 'IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy', 'institution_ids': ['https://openalex.org/I4210146472']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5000567770'], 'corresponding_institution_ids': ['https://openalex.org/I83816512', 'https://openalex.org/I4210146472'], 'apc_list': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.378, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.999922, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '442', 'issue': None, 'first_page': '213', 'last_page': '221'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11313', 'display_name': 'Macrophage Activation and Polarization', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11313', 'display_name': 'Macrophage Activation and Polarization', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Gliomas', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/immunoediting', 'display_name': 'Immunoediting', 'score': 0.8977833}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.7819402}, {'id': 'https://openalex.org/keywords/glioblastoma', 'display_name': 'Glioblastoma', 'score': 0.511115}], 'concepts': [{'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.91473734}, {'id': 'https://openalex.org/C2780480104', 'wikidata': 'https://www.wikidata.org/wiki/Q18351145', 'display_name': 'Immunoediting', 'level': 4, 'score': 0.8977833}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.78816044}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.7819402}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6549415}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6042479}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.44705313}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.41505492}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34910226}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.31219774}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.24178353}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2207003}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07994416}], 'mesh': [{'descriptor_ui': 'D056704', 'descriptor_name': 'Adaptive Immunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016246', 'descriptor_name': 'Lymphocytes, Tumor-Infiltrating', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019139', 'descriptor_name': 'Tumor Escape', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D056704', 'descriptor_name': 'Adaptive Immunity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007121', 'descriptor_name': 'Immunocompetence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016867', 'descriptor_name': 'Immunocompromised Host', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016246', 'descriptor_name': 'Lymphocytes, Tumor-Infiltrating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016246', 'descriptor_name': 'Lymphocytes, Tumor-Infiltrating', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016246', 'descriptor_name': 'Lymphocytes, Tumor-Infiltrating', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060787', 'descriptor_name': 'Neoplasm Grading', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019139', 'descriptor_name': 'Tumor Escape', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.canlet.2018.10.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106234763', 'display_name': 'Cancer Letters', 'issn_l': '0304-3835', 'issn': ['0304-3835', '1872-7980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30312732', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1596020061', 'https://openalex.org/W1642873092', 'https://openalex.org/W1931031804', 'https://openalex.org/W1973094248', 'https://openalex.org/W1974616755', 'https://openalex.org/W1985228085', 'https://openalex.org/W1990791836', 'https://openalex.org/W1993189113', 'https://openalex.org/W1993525891', 'https://openalex.org/W1996145004', 'https://openalex.org/W1996398553', 'https://openalex.org/W2002786512', 'https://openalex.org/W2010258962', 'https://openalex.org/W2024576444', 'https://openalex.org/W2031749466', 'https://openalex.org/W2035421116', 'https://openalex.org/W2040473792', 'https://openalex.org/W2044685551', 'https://openalex.org/W2046972425', 'https://openalex.org/W2051672365', 'https://openalex.org/W2053725511', 'https://openalex.org/W2060813234', 'https://openalex.org/W2062889582', 'https://openalex.org/W2079320514', 'https://openalex.org/W2080631077', 'https://openalex.org/W2093455511', 'https://openalex.org/W2105085901', 'https://openalex.org/W2119482835', 'https://openalex.org/W2120865735', 'https://openalex.org/W2133465414', 'https://openalex.org/W2138550913', 'https://openalex.org/W2143169250', 'https://openalex.org/W2153452662', 'https://openalex.org/W2156389657', 'https://openalex.org/W2158217645', 'https://openalex.org/W2159675211', 'https://openalex.org/W2169589032', 'https://openalex.org/W2293520315', 'https://openalex.org/W2509656165', 'https://openalex.org/W2522122785', 'https://openalex.org/W2605830629'], 'related_works': ['https://openalex.org/W4322720888', 'https://openalex.org/W4296613612', 'https://openalex.org/W4200022043', 'https://openalex.org/W3193904228', 'https://openalex.org/W3179581056', 'https://openalex.org/W3032348021', 'https://openalex.org/W2897072461', 'https://openalex.org/W2884525857', 'https://openalex.org/W2166784282', 'https://openalex.org/W2112727616'], 'abstract_inverted_index': {'The': [0, 22], 'mutual': [1], 'reshape': [2], 'of': [3, 24, 43, 54, 61, 67, 77, 93, 136, 170], 'tumor': [4, 10, 108], 'and': [5, 31, 63, 99, 115], 'immune': [6, 117, 139, 176], 'system': [7, 69, 140, 177], 'cells': [8, 56, 80, 111], 'during': [9, 107], 'progression': [11, 30, 62, 109, 150], 'is': [12, 158], 'a': [13, 44, 101, 121, 163, 171], 'widely': [14], 'accepted': [15], 'notion': [16], 'in': [17, 27, 46, 84, 96, 141, 154, 178], 'different': [18, 59], 'cancers': [19], 'including': [20], 'gliomas.': [21], 'importance': [23], 'this': [25], 'phenomenon': [26], 'shaping': [28], 'glioma': [29, 48, 55, 79, 110, 143, 180], 'the': [32, 65, 75, 91, 116, 133, 137, 168, 175], 'mechanisms': [33], 'governing': [34], 'it,': [35], 'however,': [36], 'are': [37], 'not': [38], 'fully': [39], 'elucidated.': [40], 'Taking': [41], 'advantage': [42], 'well-characterized': [45], 'vivo': [47], 'model': [49], 'we': [50, 72, 146], 'performed': [51], 'an': [52], 'analysis': [53], 'transcriptomes': [57], 'at': [58], 'stages': [60], 'unveiled': [64], 'reorganization': [66], 'glioma-immune': [68], 'interactions.': [70], 'Specifically,': [71], 'show': [73], 'that': [74, 148], 'inability': [76], 'low-grade': [78, 125], 'to': [81, 162], 'orthotopically': [82], 'graft': [83], 'syngeneic': [85], 'immunocompetent': [86], 'mice,': [87, 156], 'positively': [88], 'correlates': [89], 'with': [90, 100], 'abundance': [92], 'infiltrating': [94], 'lymphocytes': [95], 'donor': [97], 'tumors': [98], 'highly': [102], 'immunostimulatory': [103], 'transcriptional': [104], 'profile.': [105], 'Notably,': [106], 'downregulate': [112], 'these': [113], 'genes': [114], 'infiltrate': [118], 'shifts': [119], 'towards': [120], 'pro-tumorigenic': [122], 'phenotype.': [123], 'Challenging': [124], 'gliomas': [126], 'by': [127], 'grafting': [128], 'into': [129], 'immunodeficient': [130, 155], 'hosts': [131], 'revealed': [132], 'crucial': [134], 'role': [135, 173], 'adaptive': [138], 'constraining': [142], 'progression.': [144, 181], 'Finally,': [145], 'observed': [147], 'although': [149], 'still': [151], 'takes': [152], 'place': [153], 'it': [157], 'slower,': [159], 'likely': [160], 'due': [161], 'milder': [164], 'selection': [165], 'thus': [166], 'reinforcing': [167], 'view': [169], 'pivotal': [172], 'for': [174], 'regulating': [179]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2897072461', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-09-13T14:03:46.989335', 'created_date': '2018-10-26'}