Title: Management of clinical and subclinical actinic keratoses with histological and immunohistochemical assessments by confocal microscopy
Abstract: Dermatologic TherapyVolume 31, Issue 5 e12672 Letter to the Editor Management of clinical and subclinical actinic keratoses with histological and immunohistochemical assessments by confocal microscopy Caterina Mazzella, Corresponding Author Caterina Mazzella [email protected] orcid.org/0000-0002-8915-0798 Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy Correspondence Caterina Mazzella, MD, Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, via S. Pansini n.5, Naples 80131, Italy. Email: [email protected] for more papers by this authorVincenzo Greco, Vincenzo Greco Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this authorClaudia Costa, Claudia Costa Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this authorMassimiliano Scalvenzi, Massimiliano Scalvenzi Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this authorDaniela Russo, Daniela Russo Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, ItalySearch for more papers by this authorRiccardo Savastano, Riccardo Savastano Department of Medicine and Surgery, University of Salerno, Fisciano (Sa), ItalySearch for more papers by this authorStefania Staibano, Stefania Staibano Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, ItalySearch for more papers by this authorGabriella Fabbrocini, Gabriella Fabbrocini orcid.org/0000-0002-0064-1874 Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this author Caterina Mazzella, Corresponding Author Caterina Mazzella [email protected] orcid.org/0000-0002-8915-0798 Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy Correspondence Caterina Mazzella, MD, Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, via S. Pansini n.5, Naples 80131, Italy. Email: [email protected] for more papers by this authorVincenzo Greco, Vincenzo Greco Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this authorClaudia Costa, Claudia Costa Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this authorMassimiliano Scalvenzi, Massimiliano Scalvenzi Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this authorDaniela Russo, Daniela Russo Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, ItalySearch for more papers by this authorRiccardo Savastano, Riccardo Savastano Department of Medicine and Surgery, University of Salerno, Fisciano (Sa), ItalySearch for more papers by this authorStefania Staibano, Stefania Staibano Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, ItalySearch for more papers by this authorGabriella Fabbrocini, Gabriella Fabbrocini orcid.org/0000-0002-0064-1874 Dermatology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, ItalySearch for more papers by this author First published: 11 September 2018 https://doi.org/10.1111/dth.12672Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Reflectance confocal microscopy has been used to monitor treatment efficacy in non-melanoma skin cancer, but few studies have compared different therapies using the same confocal criteria. We compare a single score designed in previous study to evaluate confocal, histological, and immunohistochemical results obtained before and after two treatments of actinic keratosis (AK) and in field cancerisation area. Thirty volunteer male patients, aged >50-year old, with at least three clinically visible AKs on the bald scalp, were included in this study: 15 patients were submitted to 3% diclofenac therapy and 15 to 5% fluorouracil therapy. Confocal imaging was performed on a 5 × 5 cm skin area. In five patients of each group we performed cutaneous biopsies. Scaling, upper nucleated cells, and inflammatory cells showed a higher percentage reduction in field cancerisation, especially in diclofenac treatment group, while in AK inflammatory cells showed a greater percentage reduction in 5-fluorouracil treatment group. Both therapies are efficacious, but their effectiveness is different on the single parameters of the confocal, histology, immunohistochemically. CONFLICT OF INTEREST None. Citing Literature Volume31, Issue5September/October 2018e12672 RelatedInformation