Publication Information

{'id': 'https://openalex.org/W2809395715', 'doi': 'https://doi.org/10.1007/s13555-018-0247-0', 'title': 'Efficacy Endpoints in Clinical Trials in Actinic Keratosis', 'display_name': 'Efficacy Endpoints in Clinical Trials in Actinic Keratosis', 'publication_year': 2018, 'publication_date': '2018-06-18', 'ids': {'openalex': 'https://openalex.org/W2809395715', 'doi': 'https://doi.org/10.1007/s13555-018-0247-0', 'mag': '2809395715', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29916197', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6109027'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13555-018-0247-0', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s13555-018-0247-0.pdf', 'source': {'id': 'https://openalex.org/S4210222097', 'display_name': 'Dermatology and Therapy', 'issn_l': '2190-9172', 'issn': ['2190-9172', '2193-8210'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s13555-018-0247-0.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103128793', 'display_name': 'Torsten Skov', 'orcid': 'https://orcid.org/0000-0002-1918-3340'}, 'institutions': [{'id': 'https://openalex.org/I4210165112', 'display_name': 'Leo Pharma (Denmark)', 'ror': 'https://ror.org/05tzrdd39', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I4210165112']}], 'countries': ['DK'], 'is_corresponding': True, 'raw_author_name': 'Torsten Skov', 'raw_affiliation_strings': ['LEO Pharma A/S, Ballerup, Denmark'], 'affiliations': [{'raw_affiliation_string': 'LEO Pharma A/S, Ballerup, Denmark', 'institution_ids': ['https://openalex.org/I4210165112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004655672', 'display_name': 'Eggert Stockfleth', 'orcid': 'https://orcid.org/0000-0002-1922-9062'}, 'institutions': [{'id': 'https://openalex.org/I904495901', 'display_name': 'Ruhr University Bochum', 'ror': 'https://ror.org/04tsk2644', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I904495901']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Eggert Stockfleth', 'raw_affiliation_strings': ['Department of Dermatology, Ruhr-University, Bochum, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Ruhr-University, Bochum, Germany', 'institution_ids': ['https://openalex.org/I904495901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073877780', 'display_name': 'Rolf‐Markus Szeimies', 'orcid': 'https://orcid.org/0000-0002-8452-0737'}, 'institutions': [{'id': 'https://openalex.org/I4210094099', 'display_name': 'Klinikum Vest', 'ror': 'https://ror.org/00nrggp23', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094099']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rolf-Markus Szeimies', 'raw_affiliation_strings': ['Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany', 'institution_ids': ['https://openalex.org/I4210094099']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037610321', 'display_name': 'Brian Berman', 'orcid': 'https://orcid.org/0000-0001-9872-5402'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian Berman', 'raw_affiliation_strings': ['Department of Dermatology, University of Miami Miller School of Medicine, Miami, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, University of Miami Miller School of Medicine, Miami, USA', 'institution_ids': ['https://openalex.org/I145608581']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5103128793'], 'corresponding_institution_ids': ['https://openalex.org/I4210165112'], 'apc_list': {'value': 4700, 'currency': 'GBP', 'value_usd': 6850, 'provenance': 'doaj'}, 'apc_paid': {'value': 4700, 'currency': 'GBP', 'value_usd': 6850, 'provenance': 'doaj'}, 'fwci': 1.263, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.784851, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '8', 'issue': '3', 'first_page': '425', 'last_page': '433'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11306', 'display_name': 'Nonmelanoma Skin Cancer Studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11306', 'display_name': 'Nonmelanoma Skin Cancer Studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11811', 'display_name': 'Cutaneous lymphoproliferative disorders research', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10392', 'display_name': 'Cutaneous Melanoma Detection and Management', 'score': 0.984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/actinic-keratosis', 'display_name': 'Actinic keratosis', 'score': 0.96433485}, {'id': 'https://openalex.org/keywords/clearance', 'display_name': 'Clearance', 'score': 0.81430876}, {'id': 'https://openalex.org/keywords/keratosis', 'display_name': 'Keratosis', 'score': 0.8055885}, {'id': 'https://openalex.org/keywords/actinic-keratoses', 'display_name': 'Actinic Keratoses', 'score': 0.5499274}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.50500494}, {'id': 'https://openalex.org/keywords/photodermatosis', 'display_name': 'Photodermatosis', 'score': 0.4323707}], 'concepts': [{'id': 'https://openalex.org/C2777873816', 'wikidata': 'https://www.wikidata.org/wiki/Q422225', 'display_name': 'Actinic keratosis', 'level': 3, 'score': 0.96433485}, {'id': 'https://openalex.org/C138944611', 'wikidata': 'https://www.wikidata.org/wiki/Q1163287', 'display_name': 'Clearance', 'level': 2, 'score': 0.81430876}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.80970985}, {'id': 'https://openalex.org/C2778648961', 'wikidata': 'https://www.wikidata.org/wiki/Q3667186', 'display_name': 'Keratosis', 'level': 2, 'score': 0.8055885}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.769194}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.58667964}, {'id': 'https://openalex.org/C2910086692', 'wikidata': 'https://www.wikidata.org/wiki/Q422225', 'display_name': 'Actinic keratoses', 'level': 3, 'score': 0.5499274}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.50500494}, {'id': 'https://openalex.org/C2778341440', 'wikidata': 'https://www.wikidata.org/wiki/Q2986815', 'display_name': 'Photodermatosis', 'level': 5, 'score': 0.4323707}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.147163}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.0808765}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778378917', 'wikidata': 'https://www.wikidata.org/wiki/Q612693', 'display_name': 'Xeroderma pigmentosum', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C3019992690', 'wikidata': 'https://www.wikidata.org/wiki/Q92767510', 'display_name': 'Basal cell', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13555-018-0247-0', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s13555-018-0247-0.pdf', 'source': {'id': 'https://openalex.org/S4210222097', 'display_name': 'Dermatology and Therapy', 'issn_l': '2190-9172', 'issn': ['2190-9172', '2193-8210'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13555-018-0247-0', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s13555-018-0247-0.pdf', 'source': {'id': 'https://openalex.org/S4210222097', 'display_name': 'Dermatology and Therapy', 'issn_l': '2190-9172', 'issn': ['2190-9172', '2193-8210'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332071', 'funder_display_name': 'LEO Pharma', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1842567347', 'https://openalex.org/W1937563855', 'https://openalex.org/W1980038941', 'https://openalex.org/W2007233628', 'https://openalex.org/W2044030923', 'https://openalex.org/W2053558823', 'https://openalex.org/W2076061140', 'https://openalex.org/W2132174517', 'https://openalex.org/W2417964320', 'https://openalex.org/W2521785556', 'https://openalex.org/W2542432275', 'https://openalex.org/W2792419658'], 'related_works': ['https://openalex.org/W4242386261', 'https://openalex.org/W4200223857', 'https://openalex.org/W2322868828', 'https://openalex.org/W2105808906', 'https://openalex.org/W2030847199', 'https://openalex.org/W2024034796', 'https://openalex.org/W2017154835', 'https://openalex.org/W1973121679', 'https://openalex.org/W1837735082', 'https://openalex.org/W1514357538'], 'abstract_inverted_index': {'Actinic': [0], 'keratosis': [1, 26, 145, 166, 172], 'is': [2, 14], 'regarded': [3], 'as': [4, 108], 'a': [5, 31, 46, 50, 88], 'chronic': [6], 'disease': [7], 'of': [8, 18, 24, 30, 41, 57, 62, 70, 90, 111, 125, 138, 143], 'the': [9, 22, 28, 55, 94, 109, 123, 136, 161, 169], 'skin': [10], 'and,': [11], 'although': [12], 'fluctuating,': [13], 'chronically': [15], 'progressive.': [16], 'Approval': [17], 'new': [19], 'products': [20], 'for': [21, 135], 'treatment': [23, 47], 'actinic': [25, 43, 81, 127, 144, 165, 171], 'requires': [27], 'use': [29, 134], 'standard': [32], 'methodology': [33], 'in': [34, 45, 49, 60, 78, 93, 100, 104, 133, 164], 'clinical': [35, 76], 'trials': [36, 77], 'which': [37], 'emphasize': [38], 'complete': [39, 95, 115, 149], 'clearance': [40, 96, 116, 150], 'all': [42], 'keratoses': [44], 'field': [48], 'defined': [51], 'time': [52], 'span': [53], 'and': [54, 140, 151, 156], 'evaluation': [56], 'long-term': [58, 112, 141], 'efficacy': [59, 142], 'terms': [61], 'recurrence': [63, 103, 152], 'rate': [64], 'among': [65], 'completely': [66], 'cleared': [67, 105], 'patients.': [68], 'Analysis': [69], 'data': [71], 'from': [72], 'six': [73], 'previously': [74], 'published': [75], 'patients': [79, 106], 'with': [80], 'keratosis.': [82], 'There': [83], 'was': [84, 117], 'poor': [85], 'agreement': [86], 'over': [87], 'period': [89], '1': [91], 'month': [92], 'endpoint.': [97], 'This': [98], 'variation': [99], 'assessment': [101, 137], 'renders': [102], 'invalid': [107], 'estimate': [110], 'efficacy.': [113], 'Furthermore,': [114], 'shown': [118], 'to': [119], 'depend': [120], 'heavily': [121], 'on': [122], 'number': [124], 'baseline': [126], 'keratoses.': [128], 'The': [129], 'main': [130], 'endpoints': [131], 'presently': [132], 'short-': [139], 'field-directed': [146], 'therapy,': [147], 'namely,': [148], 'rate,': [153], 'are': [154], 'obsolete': [155], 'should': [157], 'be': [158], 'replaced': [159], 'by': [160], 'percentage': [162], 'reduction': [163], 'count': [167], 'or': [168], 'absolute': [170], 'count.': [173], 'LEO': [174], 'Pharma': [175], 'A/S.': [176]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2809395715', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-12-08T09:37:54.019574', 'created_date': '2018-06-29'}