Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Name: Work Video:
Duration: 3 min 30 s
Leonardo Augusto; Jennifer Martynowicz; Kirk A. Staschke; Ronald C. Wek; William J. Sullivan
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'control': [53], 'through': [54], 'phosphorylation': [55, 160], 'α': [58], 'subunit': [59], 'T.': [61], 'eukaryotic': [63], 'initiation': [64], 'factor': [65], '2': [66], '(eIF2α)': [67], '(TgIF2α)': [68], 'critical': [71], 'component': [72], 'stress': [76, 128], 'response.': [77], 'Diverse': [78], 'stresses': [79], 'induce': [81], 'conversion': [83], 'to': [86, 108, 113, 126, 164, 195], 'bradyzoites,': [87], 'including': [88], 'those': [89], 'disrupting': [90], "parasite's": [92], 'endoplasmic': [93, 117], 'reticulum': [94, 118], '(ER)': [95], '(ER': [96], 'stress).': [97], 'possesses': [99], 'four': [100], 'eIF2α': [101, 122], 'kinases,': [102], 'one': [103], 'which': [105], '(TgIF2K-A)': [106], 'localizes': [107], 'ER': [111, 127, 165], 'analogously': [112], 'protein': [114], 'kinase': [115, 119, 123], 'R-like': [116], '(PERK),': [120], 'responds': [125], 'mammalian': [130], 'cells.': [131], 'Here,': [132], 'we': [133], 'investigated': [134], 'effects': [136], 'PERK': [139], 'inhibitor': [140], '(PERKi)': [141], 'on': [142], 'Our': [144, 225], 'results': [145], 'show': [146], 'PERKi': [149, 167, 193, 203, 215], 'GSK2606414': [150], 'blocks': [151], 'enzymatic': [153], 'activity': [154], 'TgIF2K-A': [156, 233], 'reduces': [158], 'TgIF2α': [159], 'specifically': [161], 'response': [163], 'stress.': [166], 'also': [168], 'significantly': [169], 'impeded': [170], 'multiple': [171], 'steps': [172], 'tachyzoite': [175], 'lytic': [176], 'cycle': [177], 'sharply': [179], 'lowered': [180], 'frequency': [182], 'bradyzoite': [184], 'differentiation': [185], 'vitro': [187], 'Pretreatment': [188], 'host': [190, 209], 'cells': [191, 210], 'with': [192], 'prior': [194], 'did': [197], 'not': [198], 'affect': [199], 'infectivity,': [201], 'still': [204], 'impaired': [205], 'replication': [207], 'lacking': [211], 'PERK.': [212], 'In': [213], 'mice,': [214], 'conferred': [216], 'modest': [217], 'protection': [218], 'from': [219], 'lethal': [221], 'dose': [222], 'findings': [226], 'represent': [227], 'first': [229], 'pharmacological': [230], 'evidence': [231], 'supporting': [232], 'as': [234], 'attractive': [236], 'new': [237], 'target': [238], 'for': [239], 'treatment': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2891119758', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2025-01-04T02:34:51.968350', 'created_date': '2018-09-27'}
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