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'polyproline-based': [56], '(PGMs)': [59], 'can': [61, 92], 'be': [62, 93], 'facilely': [63], 'assembled': [64], 'via': [65], 'amide': [66], 'coupling': [67], 'chemistry.': [68], 'Molecular': [69], 'dynamics': [70], 'simulations': [71], 'show': [72], 'PGMs': [74, 108, 148, 170], 'recapitulate': [75], 'key': [76], 'structural': [78], 'features': [79], '(i.e.': [80], '∼9': [81], 'Å-sized': [82], 'repeating': [83], 'units,': [84], 'periodicity': [85], 'and': [86, 88, 102, 117, 119, 139, 154, 178, 186, 192], 'helicity)': [87], 'as': [89, 124], 'GAGs,': [91], 'tuned': [94], 'introduce': [96], 'systematic': [97], 'variations': [98], 'sulfate': [100], 'clustering': [101], 'spacing.': [103], 'Functionally,': [104], 'a': [105, 143], 'variety': [106], 'control': [109], 'various': [110], 'activities': [112, 138], '(concerning': [113], 'P-selectin,': [114], 'neurotrophic': [115], 'factors': [116], 'heparinase)': [118], 'exhibit': [120], 'GAG-like': [121], 'characteristics': [122], 'such': [123], 'progressive': [125], 'modulation,': [126], 'comparable': [127], 'effectiveness': [128], 'heparins,': [130], 'need': [131, 174], 'for': [132, 175], 'different': [133, 137], 'sequences': [134], 'suit': [136], 'the': [140, 172], 'presence': [141], '"minimal': [144], 'bioactive': [145], 'length".': [146], 'Furthermore,': [147], 'consistent': [150], 'effects': [151], 'vivo': [153], 'successfully': [155], 'provide': [156], 'therapeutic': [157], 'benefits': [158], 'over': [159], 'cancer': [160], 'metastasis.': [161], 'Taken': [162], 'together': [163], 'their': [165], 'high': [166], 'level': [167], 'biosafety,': [169], 'answer': [171], 'long-standing': [173], 'an': [176], 'effective': [177], 'practicable': [179], 'strategy': [180], 'manipulate': [182], 'GAG-appropriate': [183], 'medicine': [191], 'biotechnology.': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2888189623', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-13T15:35:33.493285', 'created_date': '2018-08-31'}