Title: Biochemical characterization of scleroderma-inducing glycosaminoglycan.
Abstract:The scleroderma-inducing N-sulfated glycosaminoglycan previously isolated by us from the urine of patients with systemic scleroderma was further purified: it was biochemically characterized by low O-s...The scleroderma-inducing N-sulfated glycosaminoglycan previously isolated by us from the urine of patients with systemic scleroderma was further purified: it was biochemically characterized by low O-sulfation and relative high N-sulfation. Consistent with this finding, desulfated and N-resulfated heparin, which had a similar composition to the urine-derived scleroderma-inducing glycosaminoglycan, induced a significant degree of sclerotic fibrosis in the skin of mice which had received intraperitoneal injections of it, whereas N-desulfated heparin with contrasting sulfation to it failed to cause any significant change in the skin.Read More
Publication Year: 1988
Publication Date: 1988-01-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 2
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