Evaluation of a Novel Rule-Out Myocardial Infarction Protocol Incorporating High-Sensitivity Troponin T in a US Hospital

Name: Work Video:
Duration: 3 min 30 s
Rebecca Vigen; Patricia Kutscher; Fernabelle Fernandez; Amy Yu; Bryan Bertulfo; Ibrahim A. Hashim; Kyle Molberg; Deborah B. Diercks; Jeffery C. Metzger; José Constancio Ruiz Soto; Dergham Alzubaidy; Lorie Thibodeaux; José A. Joglar; James A. de Lemos; Sandeep R. Das
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'improvement': [835], 'waiver': [839], 'informed': [841], 'consent.Download': [842], 'figureDownload': [843], 'PowerPointFigure.': [844], 'High-sensitivity': [845, 2417], 'T(cTnT)': [848], 'comparisons': [851], 'algorithm.A,': [863], 'Hospital/UT': [865], 'assay.': [876], 'B,': [877, 1536, 1544, 1611, 1755, 1867, 2233, 2247, 2286, 2398, 2446, 2456, 2542, 2898], 'Proportions': [878], 'acute': [884, 1575, 1639, 1723, 1806, 2424, 2430, 3026], 'algorithm.': [896, 906, 1187], 'C,': [897, 1490, 1498, 1534, 1542, 1559, 1563, 1593, 1597, 1607, 1753, 1759, 1765, 1902, 1941, 1976, 2177, 2249, 2269, 2296, 2320, 2365, 2470, 2759, 2761], 'Comparison': [898, 2590], 'NPV': [907], 'indicates': [908], 'value;': [911], 'PPV,': [913], 'positive': [914, 1023, 1052, 1204], 'value.In': [916], 'cohort': [918], '(N=536,': [919], 'mean': [920], 'age': [921], '55': [922], 'years,': [923], '44%': [924], 'women),': [925], '2.1%,': [933], 'unstable': [934], 'angina': [935], '0.4%,': [937], 'nonischemic': [939], 'injury': [941], '17.0%.': [943], 'With': [944, 958, 1917, 1996, 2929], '80.4%': [948], 'hours.': [957, 981], 'protocol,': [962], '83.8%': [963], 'hours,': [968], '30.0%': [970], 'baseline,': [972], '24.8%': [973], 'hour,': [976], '28.9%': [978], 'Compared': [982], '19.6%': [984], 'considered': [987], '16.2%': [993], 'under': [998, 1357], '(P=0.03;': [1002], "McNemar's": [1003], 'test;': [1004], 'Figure': [1005], '[B]).': [1006], 'had': [1010], '100%,': [1018], 'specificity': [1019, 1224], '86%,': [1021], '13%': [1027], 'After': [1035], 'readjudication': [1036], 'gold': [1041], 'standard,': [1042], 'operating': [1043], 'characteristics': [1044], 'identical': [1046], 'except': [1047], 'slightly': [1050], 'lower': [1051, 1214, 1231], '12%.': [1056], 'Of': [1057], 'out,': [1062], 'recurrent': [1064], 'events': [1066], 'detected': [1068], 'over': [1069], '30': [1070], 'days': [1071], 'follow-up.': [1073], 'When': [1074], 'algorithm,': [1081], 'higher': [1083, 1180], '(83.8': [1091], 'versus': [1092], '55.4%,': [1093], 'P<0.0001),': [1094], 'resulting': [1095], 'movement': [1097], '152/154': [1099], 'assigned': [1101], 'observation': [1103], 'status': [1104], 'group': [1114], '[C]).In': [1120], 'summary,': [1121], 'applied': [1134, 1225], 'contemporary': [1137], 'population,': [1141], 'did': [1155], 'so': [1156], 'sooner,': [1157], 'half': [1161], 'This': [1172, 1188, 1309], 'also': [1174], 'appropriately': [1175], 'much': [1179, 1230], 'appears': [1192], 'safe,': [1193], '100%.': [1202], 'an': [1208, 1299, 2527], 'notably': [1213], 'population': [1217, 1228], 'prior': [1220], 'studies,1': [1221], 'reflecting': [1222], 'similar': [1223, 1293], 'prevalence.': [1233], 'Thus,': [1234], 'judgment': [1236], 'remains': [1237], 'essential': [1238], 'interpretation': [1241], 'becomes': [1250], 'adopted': [1251], 'States,': [1255], 'where': [1256], 'is': [1258, 1280, 1311, 1362], 'indiscriminately': [1261], 'many': [1264], 'countries.': [1266], 'subtle': [1268], 'distinction': [1271], 'classification': [1282], 'individuals': [1284], '"abnormal"': [1286], 'rather': [1287], '"rule-in."': [1289], 'We': [1290, 2658], 'recommend': [1291], 'approach': [1294], 'centers': [1297], 'anticipated': [1300], 'low': [1301], 'prevalence': [1303], 'among': [1304], 'those': [1305], 'measurement.': [1308], 'limited': [1312], 'small': [1315], 'size': [1316], 'lack': [1318], 'external': [1320], 'validation;': [1321], 'thus,': [1322], 'future': [1323], 'studies': [1324], 'needed': [1326], 'externally': [1328], 'validate': [1329], 'determine': [1334], 'resource': [1336], 'implications.Sources': [1337], 'FundingDr': [1339], 'supported': [1342], 'National': [1345, 1353, 1379], 'Advancing': [1348], 'Translational': [1349], 'Sciences': [1350], 'Institutes': [1354, 1380], 'award': [1358], 'UL1TR001105.': [1359], 'content': [1361], 'solely': [1363], 'responsibility': [1365], 'authors': [1368, 1442], 'does': [1370], 'necessarily': [1372], 'represent': [1373], 'official': [1375], 'views': [1376], 'Health.DisclosuresDr': [1382], 'reports': [1384, 1402, 1434], 'consulting': [1385, 1391, 1412, 1435], 'income': [1386, 1392, 1413, 1436], 'Roche': [1388, 1406, 1415, 1438], 'Diagnostics,': [1389, 1416, 1418, 1421], 'research': [1394], 'support': [1395, 1404], 'Siemens': [1397], 'Diagnostics.': [1398, 1431, 1439], 'Dr': [1399, 1432], 'grant': [1403], 'Diagnostics': [1407, 1410], 'Abbott': [1409, 1417], 'Ortho': [1419], 'Endpoint': [1423], 'Committees': [1424], 'Radiometer': [1426], "Siemen's": [1428], 'Care': [1430, 2375], 'report': [1443], 'conflicts.Footnoteshttps://www.ahajournals.org/journal/circData': [1445], 'sharing:': [1446], 'data': [1448], 'materials': [1451], 'will': [1452], 'be': [1454], 'made': [1455], 'researchers.Guest': [1459], 'Editor': [1460], 'article': [1463], 'Evangelos': [1465], 'Giannitsis,': [1466], 'MD.Rebecca': [1467], 'Rebecca.[email': [1479], 'protected]eduReferences1.': [1480], 'Reichlin': [1481, 1531, 1737, 2258], 'T,': [1482, 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[2311], 'Mccord': [2313], 'Nowak': [2315, 2451, 2806], 'deFilippi': [2319, 2823, 3045], 'Christenson': [2321, 2447, 2629, 2808], 'Panteghini': [2323], 'Plebani': [2325], 'Verschuren': [2327], 'French': [2329], 'Weiser': [2331], 'Jernberg': [2334], 'Criteria': [2338], 'Observe-Zone': [2341], '0/1h-hs-cTnT': [2345], 'Algorithm,': [2346], '144:10,': [2348], '(773-787),': [2349], '7-Sep-2021.': [2353], 'Ganguli': [2354], 'Cui': [2356], 'Thakore': [2358], 'Orav': [2360], 'Januzzi': [2362, 2644], 'Baugh': [2364], 'Sequist': [2366], 'Wasfy': [2369], 'Downstream': [2372], 'Cascades': [2373], 'Following': [2376], 'Test': [2379], 'Implementation,': [2380], 'American': [2384, 2747, 3101], 'College': [2385, 2748], '10.1016/j.jacc.2021.04.049,': [2388], '77:25,': [2389], '(3171-3179),': [2390], '1-Jun-2021.': [2394], 'Westwood': [2395], 'Ramaekers': [2397], 'Grimm': [2399], 'Worthy': [2401], 'Fayter': [2403], 'Armstrong': [2405], 'Buksnys': [2407], 'Ross': [2409], 'Joore': [2411], 'Kleijnen': [2414], 'assays': [2419], 'people': [2428], 'pain:': [2432], 'systematic': [2434, 2794], 'economic': [2437], 'evaluation,': [2438], 'Technology': [2440], 'Assessment,': [2441], '10.3310/hta25330,': [2442], '25:33,': [2443], '(1-276)': [2444], 'Allen': [2445], 'Cohen': [2449], 'Wilkerson': [2453], 'Mumma': [2455, 2541], 'Madsen': [2457], 'McCord': [2459, 2812, 3040, 3050], 'Huis': [2461], "in't": [2462], 'Veld': [2463], 'Massoomi': [2465], 'Stopyra': [2467], 'Montero': [2469], 'Weaver': [2471], 'K': [2474], 'Diagnostic': [2479, 2563, 2988], 'Strategies': [2486], 'Variables': [2489], 'Multisite': [2492], 'Cohort,': [2494], '143:17,': [2496], '(1659-1672),': [2497], '27-Apr-2021.': [2501], 'Furmaga': [2502], 'McDonald': [2504], 'Hall': [2506], 'Muthukumar': [2508], 'Willett': [2510], 'Basit': [2512], 'D': [2516, 2588], 'Impact': [2518], 'High‐sensitivity': [2520], 'Testing': [2522], 'Operational': [2524], 'Characteristics': [2525], 'Urban': [2528], 'Academic': [2531], 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'66:3,': [2968], '(403-405),': [2969], '1-Mar-2020.': [2973], 'Agusala': [2974], 'Khera': [2976], 'Cheeran': [2978], 'Mody': [2980], 'Reddy': [2982], 'Link': [2985], '(2019)': [2987, 3047], 'prognostic': [2990], 'utility': [2991], 'post-cardiac': [2996], 'arrest': [2997], 'care,': [2998], 'Resuscitation,': [2999], '10.1016/j.resuscitation.2019.06.004,': [3000], '141,': [3001], '(69-72),': [3002], '1-Aug-2019.': [3006], 'Sharain': [3009], 'Smith': [3013], 'F': [3016], 'care': [3028], 'emerging': [3030], 'opportunities': [3031], 'outpatient': [3034], 'setting,': [3035], 'Minerva': [3036], 'Medica,': [3037], '10.23736/S0026-4806.18.05874-3,': [3038], '110:2': [3039], 'L': [3043], 'et': [3051], 'al': [3052], 'Letter': [3054], 'Regarding': [3055], 'Article,': [3056], '"Designing': [3057], 'Better': [3059], 'Mousetrap:': [3060], 'Reflections': [3061], 'November': [3064], '28,': [3065], '2017,': [3066], 'Meeting': [3072], 'Next-Generation': [3074], '"High-Sensitivity"': [3075], 'Diagnose': 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