Publication Information

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[399, 1971], 'Imaging': [400, 1972], 'Study': [401, 1973], 'Evaluation': [403, 1975], 'Chest': [405, 1977], 'Pain)': [406], 'SCOT-HEART': [408, 1405, 1444, 2303], '(Scottish': [409], 'Computed': [410], 'Tomography': [411], 'Heart)': [414], 'trials,': [415], 'well': [417], 'registry': [420], '>86': [422], '000': [423], 'patients,': [424, 743], 'reveal': [425], 'an': [426, 978], '≈30%': [427], 'reduction': [429], 'infarction': [432], 'chest': [437, 2005, 2078, 2451], 'pain': [438, 2006, 2079], 'whose': [439], 'management': [440, 550, 685, 705, 765, 787, 967, 1048, 1113, 1418, 1813, 2313], 'was': [441, 923, 1474], 'guided': [442], 'versus': [445, 1671, 2012], 'traditional': [446, 570, 850], 'care': [447], 'testing.7,8Importantly,': [450], 'identifying': [456, 883, 1107, 1188, 1497], 'early': [459], 'manifestations': [460], 'thus': [465], 'allows': [466], 'timelier': [468], 'implementation': [469], 'effective': [471, 635, 1335, 1487], 'preventive': [472, 2397], 'measures.': [473], 'In': [474, 853, 1096], 'trial,': [477], 'two': [480], 'thirds': [481], 'infarctions': [484, 1250], 'deaths': [486, 1252], 'occurred': [487], 'who': [490, 828, 1365], 'had': [491], 'normal': [492], 'results,': [495], 'highlighting': [496], 'significance': [498, 986], 'nonobstructive': [500, 1159, 1204, 1257, 1272, 1286, 1415, 1423], 'atherosclerosis.6': [502], 'Accordingly,': [503], 'our': [504, 643, 692, 703, 1047], 'moving': [507], 'toward': [508], 'establishing': [509], 'evaluation': [518, 571, 2002], 'CHD—a': [523], 'reality': [524], 'already': [525], 'United': [528], 'Kingdom.9Although': [529], 'it': [530, 555, 983, 1259, 1509], 'clear': [532], 'presence,': [535], 'extent,': [536], 'are': [543, 711, 1537], 'critical': [544], 'factors': [545, 651, 989], 'prognosis': [548], 'remains': [556, 1309], 'unclear': [557], 'what': [558, 626, 1523], 'level': [559], 'detail': [561], 'needed': [563], 'optimally': [565], 'guiding': [566, 1486], 'treatment.': [568], 'Our': [569], 'using': [576, 862, 941], 'number': [578], 'stenosed': [580], 'vessels': [581], 'consideration': [583, 1060], 'high-risk': [585, 622, 742, 844, 898, 952, 1066, 1300, 1347, 1382], 'locations,': [586], 'main': [590, 1073], 'crude': [599], 'atheroma': [604, 614, 903, 1001, 1297], 'burden.10': [605], 'With': [606, 785], 'deriving': [611], 'total': [612, 1296], 'volume': [615], 'differentiated': [617], 'plaque': [618, 841, 845, 859, 886, 899, 950, 957, 1004, 1301, 1343, 1348], 'characteristics—including': [619], 'so': [620], 'called': [621], 'features—the': [623], 'question': [624], 'arises': [625], 'information': [627, 1484], 'may': [629, 768, 791, 1045, 1425], 'add': [630, 1522], 'achieving': [632], 'most': [634, 1248], 'CHD.In': [642], 'quest': [644], 'optimal': [647], 'assessment,': [649, 861, 1293, 1302], 'several': [650], 'should': [652], 'be': [653, 1238, 1399, 1435, 1527], 'considered:': [654], 'cost': [656], 'efforts': [658], 'exchange': [660], 'benefit,': [662], 'ease': [664], 'clarity': [666], 'effectively': [668, 678, 1106, 1133], 'communicating': [669], 'among': [672, 1503], 'providers,': [673], '(3)': [675, 737], 'ability': [676], 'apply': [679], 'available': [684], 'options.': [686, 1506], 'It': [687, 1176], 'seems': [688, 1510], 'prudent': [689, 1511], 'use': [691], 'present': [693, 764, 1366], 'grading': [695], 'system': [696], 'benchmark': [698], 'improvement.': [700], 'Of': [701], 'note,': [702], 'current': [704, 806, 1194], 'options': [706], 'improving': [708], 'infinite': [713], 'largely': [715], 'confined': [716], 'factor': [720, 1118], 'modification': [721, 1119], 'at': [725, 734, 757, 824, 892], 'low': [726, 1141, 1216], 'risk,': [727, 736, 1142, 1144, 1146, 1150], 'moderate': [729, 735, 1121, 1409], 'medical': [730, 739, 753, 1122, 1126, 1361, 1410, 1429], 'therapy': [731, 740, 754, 1362, 1411], 'intensive': [738, 752, 1125], '(4)': [745], 'addition': [750, 848, 1097], 'highest': [759], 'risk.': [760], 'Given': [761, 1246], 'few': [763], 'options,': [766, 788, 1114], 'need': [770], 'highly': [771], 'sophisticated': [772, 1342], 'tools': [773, 1502], 'categorize': [775, 1134], 'which': [776, 1014], 'will': [778, 1494], 'one': [781], 'these': [783, 789], 'strategies.': [784], 'requirements': [790], 'change': [792, 901, 927, 955], 'future.In': [795], 'context,': [797], 'Chang': [801, 974, 1314, 2182], 'al': [803, 976, 1316], 'issue': [807], 'journal': [810], 'great': [813], 'interest.': [814], 'The': [815, 916, 1006, 1311, 1492, 2206, 2389], 'authors': [816], 'studied': [817], '1345': [821], 'enrolled': [823], '13': [825], 'international': [826], 'centers': [827], 'underwent': [829], 'baseline': [830], 'follow-up': [832], 'burden': [842, 860, 904, 1002, 1298, 1344], 'features': [846], 'stenosis': [851], 'evaluation.11': [852], 'study,': [855], 'adding': [856, 895, 1290], 'dedicated': [863], 'vessel': [864], 'contour': [865], 'detection': [866], 'software,': [867], 'simple': [870, 1181], 'account': [871, 1321], 'segments': [875, 1324], 'stenoses': [877], 'increased': [878], 'performance': [881], 'progression': [887], 'adverse': [889, 914], 'events': [891], 'follow-up.': [893], 'Furthermore,': [894], 'over': [905, 1021], 'time': [906], 'model': [909, 1518], 'further': [910, 1280], 'improves': [911, 1459], 'prediction': [912], 'events.': [915], 'magnitude': [917], 'incremental': [919, 1530], 'prediction,': [921], 'small.': [924], 'Whether': [925], 'area': [930], 'under': [931], 'receiver': [933], 'operating': [934], 'characteristic': [935], 'curve': [936], '0.75': [938], '(model': [939, 947], 'just': [940], 'segment': [942], 'involvement': [943], 'score)': [944], '0.76': [946], 'also': [948], 'including': [949], 'burden,': [951], 'plaque,': [953], 'burden)': [958], 'clinically': [962], 'meaningful': [963], 'impact': [964], 'appears': [968], 'doubtful.': [969], 'Nevertheless,': [970], 'study': [972, 1007], 'important': [979], 'step': [980], 'forward': [981], 'recognizes': [984], 'key': [988], 'affecting': [990], 'progression.': [1005], 'limited': [1009], 'low-risk': [1012], 'population,': [1013], 'allow': [1017], 'stratification': [1020], 'whole': [1023], 'spectrum': [1024], 'CHD.': [1026], 'By': [1027, 2333], 'same': [1029], 'token,': [1030], 'results': [1032, 1607], 'do': [1033, 1353], 'give': [1035], 'insights': [1036], 'how': [1038], 'advanced': [1039, 1291], 'imaging': [1042, 1456, 1483], 'guide': [1046, 2312], 'CHD.Current': [1052], 'suggest': [1055, 1202], 'reserving': [1056], 'catheterization': [1058], 'revascularization)': [1062], 'features,': [1067], 'defined': [1068], 'multivessel': [1070, 1167, 1375], 'calcification,': [1077], 'ventricular': [1079, 1733], 'dysfunction,': [1080], 'ischemia.4': [1084], 'As': [1085, 1507], 'such,': [1086], 'they': [1087], 'represent': [1088], 'standard': [1090, 1469], 'comparison': [1092], 'context.': [1095], 'deciding': [1099], 'revascularization,': [1101], 'require': [1103], 'guidance': [1104, 1356], 'other': [1111, 1381], '3': [1112, 1230], 'only,': [1120], 'therapy,': [1123, 1390, 1430], 'therapy.': [1127], 'shown': [1131, 1236, 1525], 'suspected,': [1137], 'into': [1140], 'mild-moderate': [1143, 1283], 'high': [1145, 1149, 1218], 'very': [1148], 'based': [1151], '4': [1153, 1193], 'categories:': [1154], 'absence': [1155], 'atherosclerosis,': [1158], 'single-vessel': [1163, 1243], 'obstructive': [1164, 1244], 'main/left': [1171], 'disease.6': [1175], 'likely': [1178, 1261], 'such': [1180], 'categorization': [1182, 1308], 'sufficient': [1186], 'suited': [1190], 'treatment': [1195], 'options—with': [1196], '1': [1197], 'possible': [1198], 'exception:': [1199], 'recent': [1200], 'encompasses': [1208], 'rather': [1210], 'spectrum,': [1213], 'ranging': [1214], 'depending': [1219], 'atherosclerosis.12': [1224], 'Indeed,': [1225], 'all': [1229], 'major': [1231, 1401], 'arteries': [1233], 'equivalent': [1241], 'CHD.13': [1245], 'occur': [1253], 'CHD,6': [1258], 'nuanced': [1265, 1277], 'stratifying': [1269, 1338], 'necessary.': [1275], 'Such': [1276], 'could': [1279], 'differentiate': [1281], 'between': [1282], 'extensive': [1285, 1422], 'disease.12The': [1287], 'value': [1288, 1961], 'straightforward,': [1305], '4-stage': [1306], 'unclear.': [1310], 'demonstrates': [1317], 'mere': [1320], 'stenoses,': [1326], 'Segment': [1330], 'Involvement': [1331], 'Score,': [1332], 'similarly': [1334], 'evaluation.': [1349], 'Current': [1350, 2405], 'provide': [1355], 'intensity': [1359], 'but': [1370, 1431], 'no': [1372], 'evidence': [1373, 1453], 'reduced': [1377], 'ejection': [1378], 'fraction,': [1379], 'features.': [1383], 'Establishing': [1384], 'detailed': [1385], 'prescriptions': [1386], 'antilipid,': [1388], 'antiplatelet': [1389], 'etc,': [1391], 'large': [1394], 'group': [1395], 'would': [1398], 'advance.': [1402], 'revealed': [1406], 'effectiveness': [1407], 'disease.': [1416], 'Intuitively,': [1417], 'intensified': [1428], 'needs': [1433], 'proven': [1436], 'prospective': [1438], 'studies.12A': [1439], 'analysis': [1441], 'trial': [1445, 1660], 'hailed': [1448], 'first': [1451, 1477], 'ever': [1452], '(CT': [1457], 'angiography)': [1458], 'hard': [1460], 'outcomes': [1461, 2000], 'compared': [1466], 'care.14': [1471], 'Likely,': [1472], 'many': [1479], 'steps': [1480], 'implementing': [1482], 'efficient': [1489], 'care.': [1491], 'challenge': [1493], 'persist': [1495], 'right': [1499], 'combination': [1500], 'plenty': [1504], 'always,': [1508], 'start': [1513], 'basic,': [1516], 'straightforward': [1517], 'meaningful,': [1529], 'benefit.DisclosuresNone.Footnoteshttps://www.ahajournals.org/journal/circimagingThe': [1531], 'opinions': [1532], 'expressed': [1533], 'necessarily': [1539], 'editors': [1543], 'American': [1547, 1797, 1825, 1839, 1843, 2487], 'Association.Armin': [1549], 'protected]eduReferences1.': [1574], 'Yusuf': [1575], 'S,': [1576, 1697, 2158, 2279, 2293], 'Zucker': [1577], 'D,': [1578, 1703, 2138, 2343], 'Peduzzi': [1579], 'P,': [1580, 1707, 1713], 'Fisher': [1581], 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