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[561, 4258, 4368], 'TourainePhilippe': [593], 'Touraine': [594, 4510], 'Lebrun-VignesBenedicte': [644], 'Lebrun-Vignes': [645, 3752, 4142, 4252, 4317, 4374, 4506], 'RodenDan': [686], 'Roden': [688, 2621, 2670, 4059, 4156, 4331, 4381, 4479, 4520], 'BachelotAnne': [702], 'Bachelot': [703, 2653, 2866, 3604, 4262, 4366, 4518], 'Funck-BrentanoChristian': [753], 'Funck-Brentano': [754, 2655, 2874, 3211, 3602, 3754, 4154, 4265, 4327, 4376, 4457, 4512], 'Originally': [792, 4566], 'published2': [793], 'Jul': [794], '2018https://doi.org/10.1161/CIRCULATIONAHA.118.034282Circulation.': [795], '2018;138:110–113Other': [796], 'version(s)': [797], 'this': [799, 808, 2228, 2524], 'articleYou': [800], 'are': [801, 1762, 2175, 2308], 'viewing': [802], 'the': [803, 832, 862, 918, 960, 963, 1060, 1066, 1129, 1242, 1419, 1802, 1853, 1917, 1969, 2018, 2101, 2115, 2140, 2179, 2222, 2283, 2319, 2328, 2337, 2344, 2373, 2376, 2380, 2386, 2393, 2397, 2404, 2423, 2429, 2464, 2548, 2552, 2633, 2716, 2948, 3077, 3292, 3443, 3549, 3645, 3734, 3798, 3875, 4029, 4080, 4113, 4344], 'most': [804], 'recent': [805], 'version': [806], 'article.': [809], 'Previous': [810, 815, 2769], 'versions:': [811], 'July': [812, 4550], '2,': [813, 4568], '2018:': [814], 'Version': [816], 'Record': [818], 'Long': [819, 3684], 'QT': [820, 2983, 3062, 3100, 3225, 3444, 3652, 3685, 4120, 4193, 4226, 4274, 4487, 4530], 'intervals': [821], 'corrected': [822, 3224], 'for': [823, 932, 939, 973, 1045, 1085, 1104, 1119, 1128, 1175, 1235, 1315, 1600, 1637, 1756, 1900, 1921, 1927, 1933, 1941, 1947, 1958, 1965, 2056, 2095, 2120, 2152, 2356, 2365, 2403, 2433, 2544, 2632, 3099, 3487, 3920, 4022, 4492], 'rate': [824, 1920], '(QTc)': [825], '>480': [826], '500': [828], 'milliseconds': [829], 'predispose': [830], 'polymorphic': [833], 'ventricular': [834, 858, 1121, 1580, 2639, 2662, 2790, 2884, 3479], 'tachycardia': [835], 'torsades': [836, 1723, 3104, 4277], 'pointes': [838, 3106, 4279, 4534], '(TdP).1': [839], 'Because': [840], 'QTc': [841, 872, 1018, 1146, 1219, 1224, 1279, 1307, 1356, 1387, 1404, 1469, 1522, 1625, 1660, 2785, 3371], 'is': [842, 846, 1788, 2144, 2183, 2201, 2333, 2384, 2521], 'shorter': [843], 'TdP': [845, 874, 888, 1010, 1024, 1070, 1115, 1201, 1227, 1294, 1310, 1334, 1385, 1393, 1414, 1496, 1577, 2083, 2106, 2131, 2153, 2298, 2415], 'less': [847], 'frequent': [848], 'men': [850, 980, 1726, 1758, 1821, 2030, 2062, 2135, 2273, 2793, 3482, 4271], 'than': [851], 'women': [853], 'because': [855, 2071], 'testosterone': [856, 878, 1016, 1043, 1516, 1654, 1848, 1899, 2076, 2241, 2287, 2303, 2317, 3738, 3864], 'shortens': [857], 'repolarization,': [859, 3494], 'we': [860, 954, 2239, 2409], 'examined': [861], 'effect': [863], 'hypogonadism': [865, 976, 1032, 1151, 1177, 1508, 1533, 1587, 1605, 1644, 1679, 1979, 2012, 2060, 2074, 2104, 2143, 2182, 2226, 2232, 2261, 2413], 'androgen': [867, 1876, 3484], 'deprivation': [868, 3485], 'therapy': [869, 2078, 3011, 3181, 3486, 3740, 3793, 3865, 4404, 4433], '(ADT)': [870], 'on': [871, 1091, 1156, 1212, 1319, 1333, 1412, 1551, 2661, 2758, 2786, 3442, 3539, 3874, 4073, 4169, 4386, 4536], 'risk.2We': [875], 'prospectively': [876], 'evaluated': [877], 'related': [880, 1178, 4231], 'plasma': [881], 'levels': [882, 1517, 1655, 2288], 'each': [884], 'man': [885], 'seen': [886], 'with': [887, 951, 1100, 1125, 1301, 1308, 1386, 1399, 1623, 1727, 1740, 1790, 1822, 1832, 1950, 1982, 2011, 2021, 2024, 2278, 2523, 2982, 3223, 3234, 3322, 3840, 4223, 4272, 4281, 4539], '(n=7)': [889], 'over': [890, 1221, 1241], '19': [891], 'months': [892], 'at': [893, 1203, 1298, 1312, 1395, 1796, 2526], 'single': [895], 'university': [896], 'hospital': [897], '(Hôpital': [898], 'Pitié-Salpétrière,': [899], 'France,': [901], 'Commission': [902], 'nationale': [903], "l'informatique": [905], 'libertés': [908], '1491960v0,': [910], "patients'": [911], 'informed': [912], 'consent': [913], 'obtained).': [914], 'We': [915], 'then': [916], 'analyzed': [917], 'European': [919, 1806, 2850], 'pharmacovigilance': [920, 1807, 2377, 3762, 4172, 4286], 'database': [921, 1808, 2378], '(up': [922, 988, 1793], 'June': [924], '2017,': [925, 991], 'URL:': [926], 'https://clinicaltrials.gov,': [927], 'Unique': [928], 'identifier:': [929], 'NCT03193138)': [930], 'searching': [931], 'QTc/TdP': [933], 'adverse': [934, 3872], 'drug': [935, 3655, 4105, 4107, 4123], 'reactions': [936], '(Medical': [937], 'Dictionary': [938], 'Regulatory': [940], 'Activities': [941], 'terms:': [942], 'long-QT': [943], 'syndrome': [944, 1318, 2268, 4194, 4275], '[LQT],': [945], 'ECG': [946], 'QT-prolonged,': [947], 'TdP)': [949], 'associated': [950, 1981, 2277, 2981, 3178, 3799, 4222, 4280], 'ADT,': [952], 'performed': [955], 'cross-sectional': [957], 'analysis': [958, 1810, 1889, 3643, 4111], 'association': [961, 2020, 2058, 2066], 'between': [962, 1291, 2059, 2224, 2411], 'International': [964, 3015, 3617, 4081], 'Classification': [965], 'Diseases': [967], 'revisions': [968], '9': [969], '10': [971, 1473, 1844], 'codes': [972], 'LQT/TdP': [974, 1983, 2022], '1.1': [978], 'million': [979], 'US': [983], 'electronic': [984, 1970, 2381, 2446], 'health': [985, 1971, 2382], 'record': [986, 1972, 2383, 2448], 'cohort': [987, 3230, 4236], 'November': [990], 'Institutional': [996], 'Review': [997, 4438], 'Board': [998], 'approval': [999], 'no.': [1000], '171796).3Hypogonadism': [1001], 'was': [1002, 1022, 1055, 2420], 'diagnosed': [1003], '7': [1005, 1007, 1067, 2247], 'cases': [1008, 1988], '(Table).': [1011], 'After': [1012], 'correction': [1013, 2072, 2128], 'low': [1015, 1744, 2286], 'levels,': [1017], 'shortened': [1019], 'there': [1021], 'no': [1023, 1126, 1200, 1253, 1309, 1352, 1392, 1592, 1649, 2501], 'recurrence.': [1025], 'Three': [1026], 'patients': [1027, 1041, 2244, 2290, 3233, 3796, 3868], 'had': [1028], 'spontaneous': [1029, 2255], 'reversal': [1030], 'after': [1033, 1144, 1169, 1231, 1284, 1337, 1361, 1384, 1527, 1598, 2208, 2302], 'resolution': [1034], 'severe': [1037, 1536, 1609, 1683], 'critical': [1038, 2205], 'illness;': [1039], '3': [1040, 1299, 1396], 'needed': [1042, 2364], 'supplementation': [1044, 2242], 'chronic': [1046, 1427], 'hypogonadism;': [1047, 1446], '1': [1049, 1313, 1359, 1382, 1525, 1777, 1992, 2044, 4555], 'patient': [1050], 'died.': [1051], 'LQT': [1052, 1825], 'genetic': [1053], 'screening': [1054], 'negative': [1056], '6': [1058, 1061, 1117, 1596], 'tested': [1062], 'patients.Table.': [1063], 'Details': [1064], 'Cases': [1068], 'Identified': [1071], 'With': [1072, 3059, 3377, 3544, 3925, 4340], 'HypogonadismPatient': [1073], 'No.Patient': [1074], 'Age,': [1075], 'yMedical': [1076], 'HistoryClinical': [1077], 'PresentationCharacterization': [1078], 'Hypogonadism*Other': [1080], 'Liable': [1081], 'Drugs': [1082], 'Conditions': [1084], 'TdP†Outcome172Hypertension,': [1086], 'normal': [1087, 1216, 1401, 1488, 1490, 1570, 1572, 1624, 1629, 1631, 1742, 1786], 'EF,': [1088, 1217, 1402, 1491, 1571, 1630, 1707], 'ischemic': [1089, 1326], 'cardiomyopathy': [1090], 'β-blockers,': [1092], 'Non-Langerhans,': [1093], 'Langerhans': [1094], 'cell': [1095], 'histiocytosis': [1096], 'infiltrating': [1097], 'multiple': [1098, 1563], 'organs': [1099], 'BRAF': [1101], 'mutation': [1102], '(ECD)': [1103], '2': [1105, 1229, 1282, 2291, 3236], 'y': [1106, 1205], 'treated': [1107, 1165, 1398, 1456], 'by': [1108, 1166, 1248, 1347, 1457, 1535, 1566, 1576, 1607, 1681, 2075, 2422, 2452, 3491, 4063], 'interferon-αRespiratory': [1109], 'distress': [1110], 'recurrent': [1112], 'episodes': [1113, 1228, 1415, 1497, 3173], 'requiring': [1116, 1416, 1553, 1626], 'cardioversions': [1118, 1417], 'post-TdP': [1120], 'fibrillationNo': [1122], 'sexual': [1123, 1239, 1304, 2275], 'activity': [1124, 2714], 'erection': [1127], 'past': [1130, 1243], '6–8': [1131], 'moPlasma': [1132], 'electrolytes': [1133, 1251, 1350, 1590, 1647], 'troponins': [1135], 'normalICD': [1136], 'implantedQTc': [1137], '≈440': [1138], 'ms': [1139, 1148, 1154, 1281, 1358, 1674], 'before': [1140, 1287, 1377, 1509, 1588, 1645], 'ECD;': [1141], 'progressive': [1142, 1218, 1782], 'prolongation': [1143, 1220, 2788, 3102, 4488], 'ECD:': [1145], '≈550': [1147, 1357], 'concomitant': [1149], 'onsetQTc': [1152], '>550': [1153], 'while': [1155, 1635, 1698], 'long-term': [1157, 1379], 'β-blockerClinical': [1158], 'examination:': [1159], 'bilateral': [1160], 'hypotrophic': [1161], 'testes,': [1162], 'gynecomastiaLung': [1163], 'infection': [1164], 'spiramycin': [1167], '(but': [1168], 'first': [1170], 'episode': [1171], 'syncope)Testosterone': [1173], 'started': [1174], 'sustained': [1176], 'his': [1180], 'histiocytosisMixed': [1181], 'central': [1182, 1262, 1443, 1752], 'peripheral': [1184, 1264, 1445, 1736], 'hypogonadism,': [1185, 1344, 1737], 'Bio-T:': [1186, 1447, 1464, 1611], '0.5': [1187, 1689], 'ng/mL,': [1188, 1268, 1370, 1449, 1466, 1541, 1613, 1687], 'FSH:': [1189, 1269, 1371, 1450, 1542, 1614, 1688], '9.5': [1190], 'IU/L,': [1191, 1271, 1373, 1452, 1544, 1616, 1690], 'LH:': [1192, 1272, 1374, 1453, 1545, 1617, 1691], '11.6': [1193], 'IU/LQTc': [1194], 'normalization': [1195, 1302, 1514, 1652, 2256], 'within': [1196, 1472, 1663], '4': [1197, 1222, 2245], 'd': [1198, 1230, 1597], 'recurrence': [1202, 1311, 1394], '1.5': [1204, 1657, 1766], 'despite': [1206], 'vemurafenib': [1207], 'introduction': [1208], '(ECD)278Paroxysmal': [1209], 'atrial': [1210, 1423, 1493, 1556, 4167], 'fibrillation': [1211, 1424, 1581], 'sotalol': [1213], 'digoxin,': [1215], 'y:': [1223], '≈460–480': [1225], 'msSyncopal': [1226], 'mitral': [1232], 'valve': [1233], 'replacement': [1234, 1849, 2077, 3010, 3739, 4403], 'endocarditisProgressive': [1236], 'apparition': [1237], 'symptoms': [1240, 1305, 2165, 2276], '5': [1244], 'y,': [1245], 'probably': [1246, 1345], 'caused': [1247, 1346, 1575], 'late-onset': [1249, 1348], 'hypogonadismNormal': [1250, 1349], 'acute': [1254, 1353, 1537, 1593, 1608, 1650, 1666, 1682], 'ischemiaTemporary': [1255], 'pacingQTc': [1256], '>600': [1257, 1441], 'ms,': [1258], 'paroxysmal': [1259, 1275, 1316, 1422, 1492, 1555], 'atrioventricular': [1260, 1276], 'blocksMixed': [1261], 'hypogonadism:': [1265, 1367, 2753, 3729, 4282], 'Bio-T': [1266, 1368, 1539, 1685, 1785], '<0.1': [1267, 1369, 1540, 1686], '16.6': [1270], '10.6': [1273], 'IU/LBradycardia,': [1274], 'blocksPersistence': [1277], '≈500': [1280], 'mo': [1283, 1300, 1526], 'surgerySotalol': [1285], 'withdrawn': [1286], 'surgery;': [1288], 'time': [1289], 'lag': [1290], 'withdrawal': [1292, 1437], '>5': [1295], 'dTestosterone': [1296, 1474], 'administration': [1297, 1381], 'y375Pacemaker': [1314], 'bradycardia-tachycardia': [1317], 'amiodarone': [1320, 1362], 'bisoprolol': [1322], '(QTc': [1323], '≈530': [1324], 'ms),': [1325, 1406], 'cardiomyopathy,': [1327], 'EF=35%–45%,': [1328], 'moderate': [1329], 'renal': [1330], 'failureCardiac': [1331], 'arrest': [1332, 1574], '12': [1335, 3384], 'h': [1336], 'elective': [1338], 'pacemaker': [1339], 'replacementChronic': [1340], 'clinical': [1341, 1428, 2097], 'signs': [1342, 1429, 1506, 1585, 1642], 'ischemiaPersistence': [1354], 'wk': [1360, 1383], 'hydroxyzine': [1364], 'withdrawalQTc=660': [1365], 'msPeripheral': [1366], '44.9': [1372], '51.3': [1375], 'IU/LHydroxyzine': [1376], 'surgery,': [1378, 2249], 'amiodaroneTestosterone': [1380], 'shortening': [1388, 1467], '(≈480': [1389], 'ms)': [1390, 1471, 1524, 1634, 1662], 'mo490Hypertension': [1397], 'diuretics,': [1400], 'borderline': [1403], '(≈460': [1405], 'cured': [1407], 'prostate': [1408, 1479, 1481, 2340, 3138, 3488, 4023], 'cancer,': [1409, 3489], 'temporal': [1410], 'arteritis': [1411], 'corticosteroidsSyncopal': [1413], 'context': [1420, 1499, 1676], 'sepsisMild': [1426], 'hypogonadismSevere': [1431], 'hypokalemia': [1432], '(2': [1433], 'mmol/L)Correction': [1434], 'hypokalemia,': [1436], 'liable': [1439], 'drugsQTc': [1440], 'msMixed': [1442], '0.2': [1448], '17.5': [1451], '20': [1454, 3638, 4104], 'IU/LSepsis': [1455], 'ciprofloxacin': [1458], 'fluconazoleSpontaneous': [1460], 'incomplete': [1461], 'reversion': [1462], '0.7': [1465], '(486': [1470], 'not': [1475, 2300, 2309, 2537], 'given': [1476], '(history': [1477], 'cancer)563Hypertension,': [1480], 'adenoma,': [1482], 'familial': [1483], 'history': [1484], 'sudden': [1486, 2722], 'death,': [1487], 'QTc,': [1489], 'fibrillationMultiple': [1494], 'self-terminating': [1495], 'septic': [1501], 'hemorrhagic': [1503], 'shocksNo': [1504], 'preexisting': [1505, 1584, 1641], 'shockShocks,': [1510], 'extracorporeal': [1511], 'membrane': [1512], 'oxygenationSpontaneous': [1513], '(Bio-T:': [1518, 1656], '0.9': [1519], 'ng/mL)': [1520, 1658], '(440': [1523], 'recovery': [1528], 'from': [1529, 2389, 4028], 'shockQTc:': [1530], '508': [1531], 'msCentral': [1532, 1604], 'triggered': [1534, 1606, 1680], 'conditions;': [1538, 1610, 1684], '6.9': [1543], '10.7': [1546], 'IU/LVentricular': [1547], 'arrhythmias': [1548, 2720, 4429], 'ischemia': [1550], 'inotropes': [1552], 'amiodarone663Hypertension,': [1554], 'fibrillation,': [1557], 'systemic': [1558], 'aneurysmal': [1559], 'vasculopathy': [1560], 'leading': [1561, 1578, 1977], 'strokes': [1564], 'complicated': [1565], 'epilepsy': [1567], 'hemiplegia,': [1569], 'QTcCardiac': [1573], '(>15': [1582], 'cardioversions)No': [1583], 'TdPNormal': [1589, 1646], 'ischemiaSeptic': [1594], 'death': [1595], 'admission': [1599], 'cardiac': [1601], 'arrestQTc': [1602], '≈560': [1603], '0.3': [1612], '6.4': [1615], '4.4': [1618], 'IU/L772Syncopal': [1619], 'sinus': [1620], 'node': [1621], 'dysfunction': [1622, 2843, 3480], 'pacemaker,': [1627], 'hypertension,': [1628], 'QTcTdP': [1632], '(QTc=470': [1633], 'hospitalized': [1636], 'transient': [1638, 2218, 2225], 'cerebral': [1639], 'ischemiaNo': [1640], 'ischemiaSpontaneous': [1651], '(430': [1661], 'weeks': [1664], 'event': [1667], 'resolutionRecurrence': [1668], 'acquired': [1670], 'prolonged': [1671], 'QTc:': [1672], '480': [1673], 'endocarditisCentral': [1678], '1.4': [1692], 'IU/L': [1693], '(for': [1694], 'endocarditis': [1695], 'event)ICD': [1696], 'upgrading': [1697], 'changing': [1699], 'pacemakerBio-T': [1700], 'indicates': [1701], 'bioavailable': [1702], 'testosterone;': [1703], 'ECD,': [1704], 'Erdheim-Chester': [1705], 'disease;': [1706], 'ejection': [1708], 'fraction': [1709], '(left': [1710], 'ventricle);': [1711], 'FSH,': [1712, 1765], 'follicle-stimulating': [1713], 'hormone;': [1714, 1720], 'ICD,': [1715], 'implantable': [1716], 'cardioverter-defibrillator;': [1717], 'LH,': [1718, 1770], 'luteinizing': [1719], 'TdP,': [1722, 2121, 2357], 'pointes.*Hypogonadic': [1725], 'high': [1728, 2160, 2187], 'FSH': [1729, 1745], 'LH': [1731, 1747], 'were': [1732, 1748, 1980], 'classified': [1733], 'having': [1735], 'whereas': [1738], 'those': [1739], 'inappropriately': [1741], 'considered': [1749], 'have': [1751], 'hypogonadism.': [1753], 'Normal': [1754], 'values': [1755, 1787], 'adult': [1757], 'our': [1760, 2295], 'laboratory': [1761], 'follows:': [1764], '12.4': [1768], 'IU/L;': [1769, 1774], '1.7': [1771], '8.6': [1773], 'Bio-T,': [1776], '3.2': [1779], 'ng/mL.': [1780], 'A': [1781, 2888, 2904, 2908, 2969, 3228, 3258, 3311, 3411, 3436, 3446, 3605, 3726, 4015, 4026, 4076, 4171, 4189, 4263, 4283, 4379, 4423, 4426, 4482], 'decrease': [1783], 'expected': [1789, 2184], 'increasing': [1791], 'age': [1792], '40%': [1795], '90': [1797], 'years': [1798], 'age).†According': [1800], 'CredibleMeds': [1803], 'website': [1804, 2345], '(https://crediblemeds.org/).The': [1805], '(http://www.adrreports.eu/fr/search.html)': [1809], 'identified': [1811], '43': [1812], '34': [1814, 1830], '221': [1815, 1831], 'individual': [1816], 'case': [1817, 2296, 2394, 2889, 3184], 'safety': [1818], 'reports': [1819], 'drug-induced': [1823, 2719, 4486], '(di)': [1824], '(diLQT)': [1826], '15': [1828], 'diTdP': [1833, 1903, 1936], 'suspected': [1834], 'be': [1836, 2069, 2112, 2158, 2186, 2234, 2363, 2538], 'attributable': [1837], 'ADT': [1839, 1851, 1897, 2025, 2085], 'versus': [1840, 1989, 2035, 2041], 'none': [1841], '(0': [1842], '847)': [1845], 'reported': [1846], 'during': [1847, 2204], 'therapy.': [1850], 'included': [1852], 'following': [1854], 'pharmacological': [1855], 'classes': [1856], 'drugs:': [1858], 'gonadotrophin-releasing': [1859, 1867], 'hormone': [1860, 1868, 3222, 4432, 4467], 'receptor': [1861, 1869, 1877], 'agonists': [1862], '(leuprolide,': [1863], 'buserelin,': [1864], 'goserelin,': [1865], 'triptorelin),': [1866], 'antagonist': [1870], '(degarelix),': [1871], 'cytochrome-17': [1872], 'inhibitor': [1873], '(abiraterone),': [1874], 'nonsteroidal': [1875], 'antagonists': [1878], '(bicalutamide,': [1879], 'flutamide,': [1880], 'nilutamide,': [1881], 'enzalutamide),': [1882], '5α-reductase': [1884], 'inhibitors': [1885], '(finasteride,': [1886], 'dutasteride).': [1887], 'Disproportionality': [1888], 'showed': [1890], 'higher': [1891, 2279], 'reporting': [1892, 1908, 1919, 2274, 4535], 'odds': [1893], 'ratios': [1894], '(ORs)4': [1895], 'comparing': [1896], 'diLQT': [1901, 1922], '(reporting': [1904], 'OR,': [1905, 1909, 1997, 2004], '3.75–∞,': [1906], 'P<0.0001;': [1907], '1.3–∞,': [1910], 'P=0.03;': [1911], 'respectively).': [1912], 'Degarelix': [1913], 'abiraterone': [1915], 'carried': [1916, 2017], 'highest': [1918, 2019], '(n=4': [1923], '769': [1925, 1939], '[0.52%]': [1926], 'degarelix;': [1928, 1942], 'n=7': [1929], '4723': [1931, 1945], '[0.15%]': [1932], 'abiraterone)': [1934, 1948], '(n=2': [1937], '[0.26%]': [1940], 'n=5': [1943], '[0.11%]': [1946, 1957], 'compared': [1949, 2023, 4538], 'other': [1951, 2029, 2130, 2498, 2542], 'ADTs': [1952], '(n=32': [1953], '28': [1955, 1962, 2038], '729': [1956, 1963], 'diLQT;': [1959], 'n=8': [1960], '[0.03%]': [1964], 'diTdP;': [1966], 'both': [1967], 'P<0.05).In': [1968], 'cohort,': [1973], 'conditions': [1974, 2016], 'drugs': [1976, 2367], '(86': [1984], '38': [1986], '041': [1987], '649': [1990, 2042], '082': [1993, 2045], '891': [1994, 2046], 'controls;': [1995], 'crude': [1996], '3.8': [1998], '[95%': [1999, 2006], 'confidence': [2000, 2007], 'interval,': [2001, 2008], '3–4.7];': [2002], 'age-adjusted': [2003], '4.8': [2005], '3.8–6.1]).': [2009], 'secondary': [2013, 4430], 'endocrine': [2015, 2761], 'users': [2026], 'all': [2028], '(30': [2031], '9202': [2033], '[0.33%]': [2034], '56': [2036], '839': [2039], '[0.19%]': [2040], '[0.06%],': [2047], 'respectively,': [2048], 'P<0.0001).Taken': [2049], 'together,': [2050], 'these': [2051, 2237], 'data': [2052, 2387], 'provide': [2053, 2092, 2400], 'consistent': [2054], 'support': [2055, 2139], 'an': [2057, 2123, 2754], 'LQT/TdP.': [2064, 2089], 'The': [2065, 2305, 2443, 2497, 2529, 2627, 3363, 3438, 3572], 'appears': [2067], 'causal': [2070], 'can': [2079, 2086, 2215], 'treat': [2080], 'prevent': [2082], 'lead': [2087, 2216], 'These': [2090, 2462], 'results': [2091, 2549], 'strong': [2093], 'justification': [2094], 'recommendation': [2098], 'investigate': [2100], 'possibility': [2102], 'when': [2105, 2164, 2178], 'occurs': [2107], 'men.': [2109, 2155, 2192], 'Hypogonadism': [2110, 3056, 3316, 3700], 'should': [2111, 2126, 2157], 'added': [2113], 'list': [2116], 'risk': [2118, 2132, 2150, 2717, 2847, 2979, 3097, 3648, 4116, 4220], 'factors': [2119, 2133, 2980, 3098, 3649, 4117, 4221], 'increased': [2124, 2845], 'awareness': [2125], 'prompt': [2127], 'receiving': [2136], 'ADT.Our': [2137], 'findings': [2138], 'hypothesis': [2141], 'that': [2142, 2197, 2316, 2385], 'correctable': [2146], 'readily': [2148], 'identifiable': [2149], 'factor': [2151], 'There': [2156], 'index': [2161], 'suspicion': [2163], 'such': [2166, 2188, 2368], 'erectile': [2168], 'dysfunction,': [2169], 'testicular': [2170], 'hypotrophy,': [2171], 'hot': [2173], 'flashes': [2174], 'present,': [2176], 'particularly': [2177], 'prevalence': [2180, 2977], 'elderly': [2191, 2272, 3663, 4126], 'It': [2193], 'has': [2194, 2262, 2449, 2485], 'been': [2195, 2264, 2450, 2486], 'shown': [2196], 'hypothalamic-pituitary-gonadal': [2198], 'axis': [2199], 'physiology': [2200], 'dramatically': [2202], 'altered': [2203], 'illnesses': [2206], 'major': [2209], 'surgery': [2210], 'brain': [2212], 'injury': [2213, 3497], 'functional': [2219], 'hypogonadism5;': [2220], 'therefore,': [2221], 'distinction': [2223], 'setting': [2229], 'preexistent': [2231], 'may': [2233, 2362], 'difficult.': [2235], 'For': [2236], 'reasons,': [2238], 'postponed': [2240], 'through': [2246], '(sepsis,': [2248], 'stroke;': [2251], 'Table),': [2252], 'awaiting': [2253], 'pituitary': [2258], 'function.': [2259], 'Late-onset': [2260], 'recently': [2263], 'defined': [2265], 'middle-aged': [2270], 'cardiovascular': [2280, 2846, 3013, 3142, 3703, 3735, 3802, 3876, 4406], 'mortality': [2281], 'presence': [2284], '(eg,': [2289], '3).5': [2293], 'In': [2294], 'series,': [2297, 2890], 'did': [2299], 'recur': [2301], 'supplementation.': [2304], 'basic': [2306], 'mechanisms': [2307], 'completely': [2310], 'defined,': [2311], 'but': [2312], 'preclinical': [2313], 'studies': [2314], 'show': [2315], 'increases': [2318], 'repolarizing': [2320], 'potassium': [2321], 'currents': [2322], 'IKr': [2323], 'IKs': [2325], 'decreases': [2327], 'depolarizing': [2329], 'L-type': [2330], 'calcium': [2331], 'current.2ADT': [2332], 'cornerstone': [2335], 'treatment': [2338], 'cancer.': [2341], 'Among': [2342], 'ADTs,': [2343], 'crediblemeds.org': [2346], 'currently': [2347], 'lists': [2348], 'only': [2349], 'degarelix': [2350], 'leuprolide': [2352], 'possible': [2354], 'risks': [2355, 3800], 'so': [2358], 'further': [2359], 'guideline': [2360], 'updates': [2361], 'newer': [2366], 'abiraterone.A': [2370], 'limitation': [2371], 'analyses': [2374, 2399], 'come': [2388], 'uncontrolled': [2390], 'sources.': [2391], 'Nevertheless,': [2392], 'series': [2395], 'population': [2398], 'orthogonal': [2401], 'validation': [2402], 'causal,': [2405], 'treatable,': [2407], 'relationship': [2408], 'postulate': [2410], 'male': [2412], 'risk.Sources': [2416], 'FundingThis': [2418], 'study': [2419, 2534, 2634, 3231], 'supported': [2421, 2451], 'Cancer': [2424, 2439, 3842, 3922, 4034], 'Thématique': [2426], 'Multi-Organisme': [2427], 'French': [2430], 'Alliance': [2432], 'Life': [2434], 'Health': [2436], 'Sciences:': [2437], 'Plan': [2438], '2014': [2440], '2019.': [2442], 'deidentified': [2445], 'medical': [2447], 'numerous': [2453], 'sources:': [2454], 'institutional': [2455], 'funding,': [2456], 'private': [2457], 'agencies,': [2458], 'federal': [2460], 'grants.': [2461], 'include': [2463], 'Institutes': [2466], 'Health–funded': [2468], 'Shared': [2469], 'Instrumentation': [2470], 'Grant': [2471], 'S10RR025141': [2472], 'Clinical': [2474, 2799, 3368, 3586, 4268], 'Translational': [2476, 4077], 'Science': [2477], 'Awards': [2478], 'grants': [2479], 'UL1TR002243,': [2480], 'UL1TR000445,': [2481], 'UL1RR024975.DisclosuresDr': [2483], 'consultant': [2488], 'Novartis,': [2490], 'Pfizer,': [2491], 'Bristol': [2492], 'Myers': [2493], 'Squibb,': [2494], 'Takeda.': [2496], 'authors': [2499], 'report': [2500], 'conflicts.AppendixInvestigatorsMarie': [2502], 'Bretagne,': [2503], 'Pauline': [2504], 'Dureau,': [2505], 'Valentin': [2506], 'Saqué,': [2507], 'Aida': [2508], 'Zarhrate-Ghoul,': [2509], 'Clément': [2510], 'Bourguignon,': [2511], 'Monique': [2512], 'Leban,': [2513], 'Virginie': [2514], 'Grouthier,': [2515], 'Martino': [2516], 'Vaglio.Footnoteshttps://www.ahajournals.org/journal/circThe': [2517], 'online-only': [2518], 'Data': [2519], 'Supplement': [2520], 'available': [2522, 2540], 'article': [2525], 'https://www.ahajournals.org/journal/circ/doi/suppl/10.1161/CIRCULATIONAHA.118.034282.Data': [2527], 'sharing:': [2528], 'data,': [2530], 'analytical': [2531], 'methods,': [2532], 'materials': [2535], 'will': [2536], 'made': [2539], 'researchers': [2543], 'purposes': [2545], 'reproducing': [2547], 'replicating': [2551], 'procedure.Joe-Elie': [2553], 'joe-elie.[email': [2592, 2595], 'protected]fr': [2593], 'protected]eduReferences1.': [2596], 'Curtis': [2597], 'MJ,': [2598, 2616], 'Hancox': [2599], 'JC,': [2600], 'Farkas': [2601], 'A,': [2602, 2654, 2809, 2811, 2867, 2928, 3032, 3034, 3120, 3122, 3198, 3208, 3256, 3304, 3306, 3386, 3388, 3398, 3402, 3460, 3462, 3464, 3470, 3561, 3563, 3630, 3785, 3815, 3817, 3819, 3902, 3939, 4001, 4145, 4314, 4367, 4509, 4515, 4519], 'Wainwright': [2603], 'CL,': [2604, 2606], 'Stables': [2605], 'Saint': [2607], 'DA,': [2608], 'Clements-Jewery': [2609], 'H,': [2610, 3332, 3510, 3520, 3524, 3783, 3981, 3997, 3999, 4013], 'Lambiase': [2611], 'PD,': [2612], 'Billman': [2613], 'GE,': [2614], 'Janse': [2615], 'Pugsley': [2617], 'MK,': [2618], 'Ng': [2619], 'GA,': [2620], 'DM,': [2622, 2671], 'Camm': [2623], 'AJ,': [2624], 'Walker': [2625], 'MJ.': [2626], 'Lambeth': [2628], 'Conventions': [2629], '(II):': [2630], 'guidelines': [2631], 'animal': [2636], 'human': [2638], 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'Between': [3574], 'Sex': [3575, 4198], 'Hormones': [3576], 'Susceptibility': [3578], 'Arrhythmias:': [3581], 'Molecular': [3583, 3620], 'Basis': [3584], 'Implications,': [3587], '10.3389/fcvm.2021.644279,': [3592], 'Grouthier': [3594, 4504], 'Sexual': [3610], 'Dimorphisms,': [3611], 'Anti-Hormonal': [3612], 'Therapy': [3613, 3837, 3919, 3959], 'Arrhythmias,': [3616], 'Sciences,': [3621], '10.3390/ijms22031464,': [3622], '22:3,': [3623], '(1464)': [3624], 'V': [3635, 4101], 'drug–drug': [3639], 'interactions,': [3640, 4108], 'polypharmacy,': [3641], 'nature': [3646, 4114, 4218], 'potentially': [3658], 'inappropriate': [3659], 'psychiatry': [3664, 4127, 4238], 'outpatients,': [3665, 4128], 'Therapeutic': [3666], 'Advances': [3667], 'Disease,': [3670], '10.1177/17539447211058892,': [3671], '15,': [3672], '(175394472110588),': [3673], '1-Jan-2021.': [3677], 'Important': [3681], 'Developments': [3682], '142:25,': [3688], '(2416-2419),': [3689], '22-Dec-2020.': [3693], 'health,': [3704], 'Postgraduate': [3705], '10.1080/00325481.2020.1805917,': [3707], '132:sup4,': [3708], '(35-41),': [3709], '16-Dec-2020.': [3713], 'Sesti': [3714], 'Pofi': [3716], 'Minnetti': [3718], 'Tenuta': [3720], 'Gianfrilli': [3722], 'D': [3723, 4060, 4332, 4382, 4480], 'Isidori': [3725], 'Late‐onset': [3728], 'Reductio': [3730], 'ad': [3731], 'absurdum': [3732], 'risk‐benefit': [3736], 'Andrology,': [3742], '10.1111/andr.12876,': [3743], '8:6,': [3744], '(1614-1627),': [3745], '1-Nov-2020.': [3749, 3773], 'Bihan': [3750], 'Uses': [3760], 'databases:': [3763], 'An': [3764], 'overview,': [3765], '10.1016/j.therap.2020.02.022,': [3767], '75:6,': [3768], '(591-598),': [3769], 'Kharaba': [3774, 3854], 'Buabeid': [3776, 3856], 'Ibrahim': [3778], 'Jirjees': [3780], 'Obaidi': [3782], 'Kaddaha': [3784], 'Khajehkarimoddini': [3786], 'Alfoteih': [3789, 3859], 'Y': [3790, 3860], 'hypogonadal': [3795, 3867], 'events,': [3803], 'Biomedicine': [3804], '&': [3805], 'Pharmacotherapy,': [3806], 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