Publication Information

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3013], 'failure': [171, 1939, 2115, 2185, 2230, 2263, 2300, 2339, 2693, 2797, 3014], '(HF)': [172], 'was': [173, 296, 301, 310, 517, 619], 'heralded.1': [174], 'Although': [175, 833], 'an': [176, 255, 312, 538, 637, 887, 917, 1660], 'in-depth': [177], 'review': [178], '2': [180, 1494], 'decades': [181], 'work': [183], 'HF': [186, 200, 225, 248, 295, 308, 333, 338, 350, 384, 460, 606, 643, 682, 720, 794, 797, 811, 926, 950, 992, 1008, 1018, 1036, 1054, 1128, 1139, 1297, 1322, 1402, 1421], 'cannot': [188, 791, 1457, 1556], 'be': [189, 879, 1185, 1237, 1435, 1498, 1589, 1669, 1728, 1733, 1765, 1776], 'conducted': [190], 'herein,': [191], 'several': [192], 'points': [193, 1074], 'important': [195, 436, 655, 687, 693, 955, 1076, 1167], 'contextualize': [197, 695], 'editorial.': [199], 'syndrome2': [203], 'classified': [204, 500, 554], 'according': [205, 387, 555], 'left': [208], 'ventricular': [209], 'ejection': [210, 2700], 'fraction': [211], '(EF)': [212], 'into': [213, 501, 1767], 'reduced': [214, 340, 645, 2699], 'or': [215, 262, 511, 521, 535, 542, 547, 1404, 1447, 1826], 'preserved': [216, 352, 608, 684, 1020, 1038, 2697], 'EF.': [217, 609, 646, 1039], 'As': [218, 762], 'chronic': [220, 506, 1937], 'condition': [221], 'frequent': [223, 229], 'exacerbations,': [224], 'cause': [230], 'hospitalizations': [232, 315, 475, 721, 795, 1129, 1133, 1316, 2223, 2264, 2361], 'United': [235, 2342, 2364, 2759], 'States.3': [236], 'To': [237], 'investigate': [238], 'epidemic,': [240], 'one': [241, 259], 'must': [242, 1727, 1732, 1764, 1775], 'accurately': [243], 'ascertain': [244, 1220], 'incidence': [246, 293, 331, 592, 604, 641, 809, 891, 1016, 1484, 1502, 2116, 2148, 2463, 2501], 'whether': [250, 1570], 'each': [251], 'episode': [252], 'truly': [254, 1398, 1489], 'incident': [256, 2298], '(the': [257], 'first': [258], 'occur)': [261], 'recurrence.': [264], 'Doing': [265], 'so': [266], 'requires': [267], 'comprehensive': [268], 'longitudinal': [269, 1654], 'data,': [270], 'which': [271, 368, 1022, 1059, 1065, 1183, 1288, 1465, 1576, 1774], 'seldom': [273], 'available,': [274], 'few': [276], 'studies': [277, 562, 785, 863, 1391, 1737], 'can': [278, 876, 1434, 1572, 1802], 'provide': [279, 1452], 'that': [280, 306, 329, 590, 715, 743, 784, 853, 933, 944, 958, 1143, 1180, 1200, 1215, 1315, 1482, 1500, 1666, 1797], 'information.': [281], 'Available': [282], 'data': [283, 414, 420, 438, 661, 770, 823, 905, 939, 1042, 1334, 1432, 1455, 1510, 1536, 1679, 1683, 1700, 1722, 1748, 1752, 1770, 1781, 1812, 2605], 'indicated': [284], 'that,': [285, 974, 1125], 'until': [286], 'turn': [288, 1861], 'century,': [291], 'mostly': [297], 'stable': [298, 507, 1141], 'while': [299], 'survival': [300, 2118, 2151, 2225], 'improving,': [302], 'leading': [303], 'conclude': [305], 'partly': [311], 'as': [316, 723, 814, 985, 1221, 1258, 1393, 1512, 2863], 'survivors': [317], 'became': [318], 'candidates': [319], 'recurrent': [321], 'hospitalizations.4,5': [322], 'Over': [323, 799], 'past': [325, 1493], 'decade,': [326], 'evidence': [327, 529, 1481], 'indicates': [328, 1124], 'declining,': [335], 'particularly': [336, 620, 667, 1246], 'EF,': [341, 1021], 'no': [343, 1068], 'change': [344], 'mortality.6': [346], 'proportion': [348], 'EF': [353, 558, 685], 'has': [354, 1488, 1647], 'been': [355, 1084], 'increasing.': [356], 'This': [357, 1586, 1657], 'phenotype': [358], 'incompletely': [360], 'understood,': [361], 'likely': [362], 'heterogeneous,': [363], 'lacks': [365], 'specific': [366, 1069], 'treatment,': [367], 'stalls': [369], 'progress': [370, 1409], 'against': [371, 1551], 'epidemic.': [373], 'These': [374, 822, 938, 1450, 1532, 1786], 'observations': [375], 'underscore': [376, 1335], 'importance': [378, 1337, 1372], 'surveillance': [380, 395, 413, 437, 473, 827, 1390, 1535, 1574, 1600, 1665, 1705], 'understand': [382], 'how': [383], 'manifests': [385], 'itself': [386], 'person,': [389], 'time,': [390, 597], 'place,': [392], 'precise': [394], 'prerequisite': [398], 'plan': [400], 'monitor': [402, 1385], 'interventions': [403, 1546], 'design': [405], 'policies.': [406], 'Because': [407, 1712], 'currently': [411], 'available': [412], 'were': [415, 476, 487, 552, 1140], 'generated': [416, 1749], 'among': [417, 611, 622, 753, 928, 1317, 2301], 'white': [418, 634], 'populations,': [419], 'diverse': [422, 1045], 'populations': [423], 'urgently': [425], 'needed.In': [426], 'present': [428, 883, 908, 966], 'issue': [429], 'Circulation,': [431], 'Chang': [432, 1516, 2201, 2742], 'colleagues7': [434], 'report': [435, 885, 910, 968, 1114, 1364, 1946, 2087, 2615], 'from': [439, 478, 796, 836, 976, 1026, 1044, 1115, 1152, 1720, 1750, 2088, 2547, 2616, 2957], 'ARIC': [441, 580, 884, 909, 967, 1010, 1041, 1333, 1363, 1394, 2236], 'study': [442, 849], '(Atherosclerosis': [443], 'Risk': [444], 'Communities)': [446], 'trends': [449, 2145, 2260, 2460, 2497], 'over': [450, 596, 742, 868, 936, 995, 1087, 1491], 'decade': [452], '4': [454], 'communities': [456, 1046, 2234], 'acute': [458, 539, 2227, 2467], 'decompensated': [459, 548, 2228], '(ADHF)': [461], 'events': [462], 'outcomes.': [464, 1711], 'Using': [465, 706, 2761], 'rigorous': [467, 575], 'approach': [468, 1348], 'characteristic': [469], 'manually': [471, 830], 'curated': [472, 831], 'studies,': [474], 'sampled': [477], 'International': [479], 'Classification': [480], 'Diseases-9': [482], 'codes': [483, 1157], 'candidate': [485], 'cases': [486, 578], 'reviewed': [488], 'adjudicated': [490], 'generate': [492], 'validated': [494, 1151, 1739], 'cohort': [495], 'individuals': [497], 'ADHF': [499, 527, 594, 1147, 1205], 'definite': [502], 'ADHF,': [503, 505, 1272], 'possible': [504], 'HF,': [508, 666, 1256, 1287], 'unlikely': [510], 'unclassifiable': [512], 'HF.': [513, 677, 1193, 1531], 'case': [515, 1033, 1098, 1149], 'status': [516, 2929], 'assigned': [518], 'by': [519, 764, 972, 1187, 1515, 1634, 1706, 1804, 2265], 'computer': [520], 'physician': [522], 'review.': [523], 'criteria': [525], 'required': [528], 'based': [530], 'symptoms,': [532, 546], 'signs,': [533], 'imaging,': [534], 'treatment': [536], 'exacerbation,': [540], 'worsening': [541, 994], 'circulatory': [549], 'state.': [550], 'Events': [551], 'further': [553, 689], 'relying': [559], 'echocardiographic': [561], 'using': [563, 786], 'cut': [565], 'point': [566, 864], '50%,': [568], 'consistent': [569, 912], 'guidelines.2': [572], 'Altogether': [573], 'ascertainment': [576], 'bestows': [581], 'critical': [582], 'validity': [583], 'data.': [586, 1449, 1743], 'findings': [588, 653, 878, 1025, 1107, 1214], 'indicate': [589], 'increased': [595], 'reflecting': [598], 'primarily': [599, 1299], 'rise': [601, 618, 1013], 'Observed': [610], 'all': [612, 1417], 'race': [613, 898], 'sex': [615, 2266], 'groups,': [616], 'prominent': [621], 'black': [623], 'women,': [624], 'striking': [627], 'annual': [628], 'yearly': [629], 'increase': [630, 638, 888], '12.8%.': [632], 'Only': [633], 'men': [635], 'experienced': [636, 1196], 'Case': [647], 'fatality': [648], 'did': [649], 'not': [650, 1233, 1379, 1478, 1521, 1668, 1820], 'change.': [651], 'given': [656], 'relative': [658], 'paucity': [659], 'epidemiology': [664, 1692, 2543], 'problematic': [668], 'blacks,': [670, 754], 'who': [671], 'experience': [672], 'disproportionate': [674], 'burden': [675, 752, 873, 927, 948, 990, 1285, 1440, 1529], 'Finally,': [678], 'transition': [680, 1809], 'toward': [681, 1035, 1055, 1410, 1810], 'document.These': [690], 'results': [691], 'light': [697], 'previous': [699, 970], 'reports': [700, 943, 1011], 'same': [703, 801, 1424], 'time': [704, 802, 869, 996, 1578], 'period.': [705], 'National': [708, 767, 788, 858, 1117, 2257, 2549, 2752], 'Inpatient': [709, 768, 789, 859, 1118], 'Sample,': [710], 'Ziaeian': [711, 960, 2245], 'et': [712, 961, 1517, 3086], 'al8': [713, 962], 'reported': [714, 854, 1514], 'national': [717, 1382], 'rates': [718, 1131], '(defined': [722], 'primary': [725, 1127], 'hospitalization': [726], 'HF)': [728], 'decreased': [729], 'steadily': [730], 'between': [731, 1120], '2002': [732], '2013,': [734], 'equating': [735], 'notable': [738], 'decline': [739, 844, 867], '≈31%': [741], 'decade.': [744], 'However,': [745, 1194], 'disparities': [746, 987, 1526], 'persisted,': [747], 'markedly': [750], 'higher': [751], 'calling': [755, 998], 'urgent': [757, 1000], 'measures': [758], 'address': [760], 'it.': [761], 'acknowledged': [763], 'authors,': [766], 'Sample': [769, 790, 1119], 'have': [771, 1083, 1380, 1479], 'intrinsic': [772], 'limitations': [773], 'and,': [774, 1608], 'particular,': [776], 'lack': [778], 'unique': [780, 793], 'patient': [781], 'identifiers,': [782], 'such': [783, 1257, 1314, 1392, 1511], 'distinguish': [792], 'readmissions.': [798], 'period': [803], 'Olmsted': [805, 847, 1027, 2188], 'County,': [806, 2189], 'MN,': [807], 'declined': [812, 1490], 'substantially': [813], 'well,': [815], 'rate': [818], 'reduction': [819], '37.5%.6': [821], 'rely': [824], 'robust': [826, 2687], 'methods': [828, 1601], 'cases.': [832], 'they': [834], 'emanate': [835, 1043], 'single': [838], 'community,': [839], 'magnitude': [841, 1524], 'County': [848, 1028], 'commensurate': [851], 'overall': [855, 872], 'Sample.': [860], 'Thus,': [861, 1554], 'both': [862, 902], 'HF.How': [875], 'these': [877, 1397], 'reconciled': [880], 'ADHF?': [893], 'First,': [894], 'regard': [896, 1003], 'ethnicity-specific': [900], 'findings,': [901], 'Ziaeian8': [904], 'their': [914, 1428], 'depiction': [915], 'alarming': [918], 'situation': [919], 'major': [922], 'disparity': [923], 'blacks': [929], 'gap': [932], 'widening': [935], 'time.': [937], 'resonate': [940], 'prior': [942], 'underscored': [945], 'excess': [947], 'blacks.9': [952], 'It': [953, 1231], 'note': [957], 'augment': [969, 1093], 'publications': [971], 'demonstrating': [973, 1639], 'far': [975], 'addressing': [977], 'inequalities,': [978], 'fact': [982], 'losing': [983], 'ground': [984], 'racial': [986], 'interventions.Second,': [1001], 'partitioning': [1006], 'phenotypes,': [1009], 'resonates': [1023], 'shift': [1031], 'mix': [1034], 'hence': [1048], 'demonstrate': [1049, 1796], 'ubiquitous': [1051], 'evolution': [1052], 'clinical': [1057, 1202, 1213, 1655], 'presentation,': [1058], 'poorly': [1061], 'understood': [1062], 'there': [1066], 'treatment.10': [1070], 'Third,': [1071, 1361], 'some': [1072], 'methodological': [1073, 1798], 'consider.': [1078], 'Shift': [1079], 'coding': [1081], 'practices': [1082], 'well': [1085], 'documented': [1086, 1778], 'HF11': [1091], 'complexity': [1095], 'finding': [1099], 'processes': [1100], 'interpretation': [1104], 'different': [1109], 'reports.': [1110], 'For': [1111], 'example,': [1112, 1709], 'another': [1113], '2001': [1121], '2009': [1123], 'although': [1126, 1273], 'declined,': [1130], 'secondary': [1136], 'diagnosis': [1137, 1203, 1270], 'decade.12ARIC': [1144], 'relies': [1145, 1210], 'definition': [1150], 'pool': [1154], 'diagnostic': [1156], 'any': [1159], 'position': [1160], '(not': [1161], 'only': [1162], 'primary).': [1163], 'decompensation': [1165], 'identify': [1169], 'because': [1170, 1208, 1247], 'it': [1171, 1209], 'cardinal': [1174], 'physiological': [1175], 'component': [1176], 'disease': [1179, 1330, 1340, 1375, 1463, 1472, 2081], 'causes': [1181], 'hospitalizations,': [1182], 'could': [1184, 1520], 'prevented': [1186], 'optimizing': [1188, 2921], 'outpatient': [1190], 'management': [1191, 1935, 2922], 'clinicians': [1197], 'would': [1198, 1477, 1497, 1667], 'agree': [1199], 'challenging': [1207, 1592], 'solely': [1211], 'increasingly': [1217], 'difficult': [1218], 'body': [1223], 'mass': [1224], 'index': [1225], 'population': [1229, 2535, 2545], 'increases.': [1230], 'uncommon': [1234], 'clinically': [1235], 'at': [1238, 1687, 1859], 'times': [1239], 'unsure': [1240], "patient's": [1243], 'volume': [1244], 'status,': [1245], 'other': [1248, 1293], 'comorbid': [1249, 1294], 'conditions': [1250], 'share': [1251], 'signs': [1252], 'symptoms': [1254], 'dyspnea,': [1259], 'orthopnea,': [1260], 'peripheral': [1262], 'edema.': [1263], 'Therefore,': [1264], 'quest': [1266], 'pure': [1269], 'mechanistically': [1274], 'important,': [1275], 'may': [1276], 'lead': [1277], 'restrictive': [1280], 'appraisal': [1281, 2181], 'global': [1284], 'frequently': [1290], 'interwoven': [1291], 'conditions.': [1295], 'Indeed,': [1296], 'occurs': [1298], 'elderly': [1302, 1318, 2800], 'integrated': [1305], 'context': [1308], 'multimorbidity': [1310], 'geriatric': [1312], 'conditions,': [1313], 'persons': [1319, 1418], 'living': [1320, 1419], 'often': [1323], 'reflect': [1324], 'combination': [1326], 'ailments': [1328], 'processes.13': [1331], 'addition': [1342], 'perhaps': [1345], 'more': [1346], 'holistic': [1347], 'disease.': [1354, 1553], 'Both': [1355], 'approaches': [1356, 1685], 'complementary': [1358], 'necessary.': [1360], 'constitutes': [1365, 1717], 'powerful': [1367], 'illustration': [1368], 'crucial': [1371], 'surveillance.Because': [1376], 'do': [1378, 1557], 'system': [1383], 'cardiovascular': [1386, 1857], 'need': [1389], 'answer': [1396], 'fundamental': [1399], 'questions:': [1400], 'Is': [1401], 'declining': [1403], 'increasing?': [1405], 'Are': [1406, 1416], 'making': [1408], 'control': [1412], 'risk': [1414], 'factors?': [1415], 'managed': [1422], 'way': [1425, 1615], 'outcomes': [1429, 2465, 2868], 'improving?': [1430], 'Other': [1431], 'sources': [1433, 1451], 'used': [1436], 'examine': [1438], 'including': [1444], 'voluntary': [1445], 'registries': [1446], 'claims': [1448], 'useful': [1453], 'hypothesis-generating': [1454], 'but': [1456], 'measure': [1458], 'occurrence': [1460], '(incidence),': [1464], 'core': [1468, 1689], 'metric': [1469], 'prevention.': [1473], 'Without': [1474], 'surveillance,': [1475], 'undisputable': [1480], 'myocardial': [1486, 2440, 2468], 'infarction': [1487], 'decades,14,15': [1495], 'unaware': [1499], 'atrial': [1504, 2499], 'fibrillation': [1505, 2500], 'stable,16': [1507], 'without': [1509], 'those': [1513, 1822], 'al,7': [1518], 'quantify': [1522], 'examples': [1533], 'constitute': [1537], 'cornerstone': [1539], 'evaluation': [1542, 1933], 'public': [1544, 1595], 'health': [1545, 1596, 1606, 1628, 1637, 1645, 1714], 'our': [1548, 1792], 'collective': [1549], 'fight': [1550], 'without.': [1558], 'With': [1559], 'ever': [1561], 'prevailing': [1562], 'considerations': [1563], 'cost': [1565], 'containment,': [1566], 'question': [1568, 1587], 'afford': [1573], 'research,': [1575], 'takes': [1577], 'thus': [1580], 'expensive,': [1582], 'recurrently': [1584], 'raised.': [1585], 'should': [1588], 'refocused': [1590], 'researchers': [1593], 'professionals': [1597], 'reengineer': [1599], 'fully': [1603], 'leverage': [1604], 'electronic': [1605, 1618, 1627, 1644, 1691, 1713, 1811], 'records': [1607], 'doing': [1610], 'so,': [1611], 'define': [1613], 'forward': [1616], 'epidemiology.17': [1619], 'rapid': [1621], 'growth': [1622, 1658], 'implementation': [1625], 'record': [1629], 'systems,': [1630], 'fueled': [1631], 'part': [1633, 1757], 'incentives': [1635], 'systems': [1638], 'meaningful': [1641], 'use': [1642], 'records,': [1646], 'considerably': [1648], 'expanded': [1649], 'availability': [1651], 'dense': [1653], 'datasets.18': [1656], 'presents': [1659], 'unparalleled': [1661], 'opportunity': [1662, 1696], 'conduct': [1664], 'feasible': [1670], 'conventional': [1672], 'methods.': [1673], 'increasing': [1675], 'accessibility': [1676], 'digital': [1678], 'combined': [1680], 'science': [1684], 'offers': [1694], 'enrich': [1698], 'collection': [1701, 1723, 1771], 'steps': [1702], 'customary': [1703], 'including,': [1707], 'patient-reported': [1710], 'records-based': [1715], 'research': [1716], 'departure': [1719], 'historical': [1721], 'methods,': [1724], 'challenges': [1726], 'addressed': [1729], 'deliberately.': [1730], 'Phenotypes': [1731], 'standardized': [1734], 'large-scale': [1736], 'capture': [1741], 'reliable': [1742], 'Voluminous,': [1744], 'complex,': [1745], 'dynamic': [1747], 'heterogeneous': [1751], 'sources,': [1753], 'large': [1756], 'information': [1759], 'embedded': [1760], 'narrative': [1762], 'form,': [1763], 'transformed': [1766], 'platforms': [1768], 'extraction,': [1773], 'rigorously': [1777], 'ensure': [1780], 'traceability,': [1782], 'validity,': [1783], 'reproducibility.': [1785], 'opportunities': [1788], 'exciting,': [1790], 'challenge': [1793], 'rigor': [1799], 'efficiency': [1801], 'coexist': [1803], 'managing': [1805], 'supporting': [1807], 'sources.19DisclosuresNone.Footnoteshttps://www.ahajournals.org/journal/circThe': [1813], 'opinions': [1814], 'expressed': [1815], 'necessarily': [1821], 'editors': [1825], 'American': [1829, 1923, 1949, 2071, 2090, 2773, 3101], 'Association.Véronique': [1831], 'roger.[email': [1851], 'protected]eduReferences1.': [1852], 'Braunwald': [1853], 'E.': [1854], 'Shattuck': [1855], 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