Publication Information

{'id': 'https://openalex.org/W2805516202', 'doi': None, 'title': 'p21 as a transcriptional regulator of Bmp2 gene: structural requirements and molecular partners', 'display_name': 'p21 as a transcriptional regulator of Bmp2 gene: structural requirements and molecular partners', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2805516202', 'mag': '2805516202'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://dialnet.unirioja.es/servlet/tesis?codigo=146978', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030005041', 'display_name': 'Esther Gómez Ibarlucea Traba', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Esther Gómez Ibarlucea Traba', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5030005041'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9516, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/polo-like-kinase', 'display_name': 'Polo-like kinase', 'score': 0.7779745}, {'id': 'https://openalex.org/keywords/restriction-point', 'display_name': 'Restriction point', 'score': 0.67513907}, {'id': 'https://openalex.org/keywords/cyclin-dependent-kinase-6', 'display_name': 'Cyclin-dependent kinase 6', 'score': 0.59070104}, {'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.588652}, {'id': 'https://openalex.org/keywords/e2f', 'display_name': 'E2F', 'score': 0.4696818}], 'concepts': [{'id': 'https://openalex.org/C124320809', 'wikidata': 'https://www.wikidata.org/wiki/Q46292', 'display_name': 'Cyclin-dependent kinase', 'level': 4, 'score': 0.8965436}, {'id': 'https://openalex.org/C84815855', 'wikidata': 'https://www.wikidata.org/wiki/Q7225885', 'display_name': 'Polo-like kinase', 'level': 4, 'score': 0.7779745}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.73645246}, {'id': 'https://openalex.org/C152857842', 'wikidata': 'https://www.wikidata.org/wiki/Q7316321', 'display_name': 'Restriction point', 'level': 5, 'score': 0.67513907}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.60939115}, {'id': 'https://openalex.org/C199649820', 'wikidata': 'https://www.wikidata.org/wiki/Q14911762', 'display_name': 'Cyclin-dependent kinase 6', 'level': 5, 'score': 0.59070104}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.588652}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5247907}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.5044819}, {'id': 'https://openalex.org/C83258922', 'wikidata': 'https://www.wikidata.org/wiki/Q24771933', 'display_name': 'E2F', 'level': 4, 'score': 0.4696818}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.43753505}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.26891667}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.26641726}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://dialnet.unirioja.es/servlet/tesis?codigo=146978', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3153896431', 'https://openalex.org/W2762642851', 'https://openalex.org/W2480172624', 'https://openalex.org/W2431819429', 'https://openalex.org/W2412923675', 'https://openalex.org/W2151762855', 'https://openalex.org/W2134900251', 'https://openalex.org/W2105738310', 'https://openalex.org/W2088355640', 'https://openalex.org/W2060990273', 'https://openalex.org/W2037736876', 'https://openalex.org/W2035932967', 'https://openalex.org/W2027711618', 'https://openalex.org/W2024144567', 'https://openalex.org/W2001775703', 'https://openalex.org/W1984188081', 'https://openalex.org/W1982397395', 'https://openalex.org/W1895935492', 'https://openalex.org/W1576704182', 'https://openalex.org/W152264431'], 'abstract_inverted_index': {'Cell': [0], 'proliferation': [1], 'occurs': [2], 'through': [3, 284], 'a': [4, 81, 97, 105, 132, 158, 327, 357, 382, 514, 526, 546, 551], 'series': [5], 'of': [6, 38, 45, 108, 128, 134, 151, 160, 185, 194, 210, 248, 257, 265, 297, 307, 310, 331, 371, 415, 438, 453, 485, 489, 498, 521, 535, 554, 567], 'stages': [7], 'that': [8, 25, 66, 245, 276, 348, 434, 466], 'are': [9, 26, 69, 131, 142, 177, 373], 'collectively': [10], 'termed': [11], 'the': [12, 17, 29, 39, 46, 67, 72, 89, 92, 113, 124, 183, 207, 215, 236, 249, 295, 304, 308, 369, 406, 413, 420, 439, 496, 499, 519, 531, 564], 'cell': [13, 18, 90, 93, 100, 114, 170, 261, 479], 'cycle.': [14], 'In': [15, 290], 'eukaryotes,': [16], 'cycle': [19, 94, 101, 171], 'is': [20, 79, 102, 154, 315, 351, 392, 469, 524], 'divided': [21, 178], 'into': [22, 179], 'four': [23], 'phases': [24, 44], 'organized': [27], 'around': [28], 'synthesis': [30], '(S': [31], 'phase)': [32, 37], 'and': [33, 49, 59, 74, 95, 116, 122, 188, 202, 212, 214, 225, 238, 263, 300, 360, 365, 404, 429, 493, 507, 533, 563], 'mitotic': [34], 'segregation': [35], '(M': [36], 'genome.': [40], 'The': [41, 148, 190, 482], 'two': [42, 180], 'other': [43], 'cycle,': [47, 262], 'G1': [48], 'G2,': [50], 'represent': [51], 'gap': [52], 'periods': [53], 'during': [54], 'which': [55, 88, 110, 141, 164, 227, 410, 538], 'cells': [56, 342], 'check': [57], 'cell-intrinsic': [58], 'extrinsic': [60], 'signals': [61, 118], 'in': [62, 87, 112, 312, 338, 476, 502, 518, 530, 570, 576], 'order': [63], 'to': [64, 168, 268, 287, 400, 495, 543], 'ensure': [65], 'conditions': [68], 'suitable': [70], 'for': [71, 423], 'S': [73], 'M': [75], 'phase,': [76], 'respectively.': [77], 'There': [78], 'also': [80, 280, 380, 525, 540], 'quiescent': [82], 'state,': [83], 'known': [84], 'as': [85, 166, 513, 545], 'G0,': [86], 'exits': [91], 'reaches': [96], 'non-proliferative': [98], 'state.\r\nThe': [99], 'regulated': [103, 156], 'by': [104, 144, 157, 222, 232, 354, 368, 375, 394, 409, 417, 471], 'molecular': [106, 407], 'network': [107], 'proteins': [109, 278], 'operates': [111], 'nucleus': [115, 520], 'integrates': [117], 'from': [119], 'both': [120, 235], 'outside': [121], 'inside': [123], 'cell.': [125], 'Core': [126], 'components': [127], 'this': [129], 'machinery': [130], 'family': [133, 192, 217, 251], 'serine/threonine': [135], 'kinases': [136, 139], 'named': [137], 'cyclin-dependent': [138], '(Cdk)': [140], 'activated': [143], 'their': [145, 186, 258], 'associated': [146], 'cyclins.': [147], 'kinase': [149], 'activity': [150, 484], 'cyclin-Cdk': [152, 230], 'complexes': [153, 231], 'tightly': [155], 'plethora': [159], 'Cdk': [161, 239, 246], 'inhibitors': [162, 247], '(CKIs),': [163], 'serve': [165], 'brakes': [167], 'halt': [169], 'progression': [172], 'under': [173], 'unfavorable': [174], 'conditions.': [175], 'CKIs': [176], 'families': [181], 'on': [182, 260, 363, 387, 426, 443, 458, 556], 'basis': [184], 'structure': [187], 'specificities:': [189], 'INK4': [191], '(Inhibitors': [193], 'Cdk4)': [195], 'containing': [196], 'p15INK4b,': [197], 'p16': [198], 'INK4a,': [199], 'p18': [200], 'INK4c': [201], 'p19': [203], 'INK4d': [204], 'only': [205], 'bind': [206], 'monomeric': [208], 'forms': [209], 'Cdk4': [211], 'Cdk6;': [213], 'Cip/Kip': [216, 250, 277], '(Cdk-interacting': [218], 'protein/Kinase-inhibitory': [219], 'protein)': [220], 'comprised': [221], 'p21Cip1,': [223], 'p27Kip1': [224], 'p57Kip2': [226], 'control': [228], 'multiple': [229], 'interacting': [233], 'with': [234, 320], 'cyclin': [237], 'subunits.\r\nHowever,': [240], 'recent': [241], 'data': [242], 'has': [243, 273, 539, 559], 'shown': [244, 347, 465], 'can': [252, 279, 293], 'impact': [253], 'biological': [254, 305, 565], 'processes': [255], 'independently': [256], 'roles': [259], 'some': [264], 'them': [266], 'seem': [267], 'be': [269, 436, 574], 'Cdk-independent.': [270], 'Thus,': [271], 'it': [272], 'been': [274, 541, 561], 'reported': [275], 'modulate': [281], 'gene': [282, 468], 'expression': [283, 350, 414, 428], 'direct': [285], 'binding': [286, 385, 532], 'transcription': [288], 'factors.': [289], 'particular,': [291], 'p21': [292, 311, 332, 355, 391, 411, 424, 432, 472, 486], 'inhibit': [294], 'activities': [296], 'E2F1,': [298], 'c-Myc': [299], 'STAT': [301], '3.': [302], 'However,': [303, 550], 'significance': [306, 566], 'role': [309, 330], 'transcriptional': [313, 358, 474, 547, 552], 'regulation': [314], 'still': [316], 'poorly': [317], 'understood.\r\nIn': [318], 'collaboration': [319], 'Isabel': [321], 'Farinas’': [322], 'group': [323], 'we': [324, 398, 449, 463, 509], 'have': [325, 346, 379, 464, 510], 'identified': [326, 381, 511], 'biologically': [328], 'relevant': [329], 'regulating': [333], 'bone': [334], 'morphogenetic': [335], '(BMP)': [336], 'pathway': [337], 'mouse': [339], 'neural': [340], 'stem': [341], '(NSCs).': [343], 'Previous': [344], 'results': [345], 'Bmp2': [349, 388, 427, 444, 459, 467, 557], 'normally': [352], 'repressed': [353, 470], 'at': [356, 473], 'level': [359, 475], 'deleterious': [361], 'effects': [362, 425], 'self-renewal': [364], 'multipotency,': [366], 'caused': [367], 'elimination': [370], 'p21,': [372], 'mediated': [374], 'secreted': [376], 'BMPs.': [377], 'We': [378], 'putative': [383], 'E2F': [384], 'site': [386], 'promoter': [389, 460, 558], 'where': [390], 'detected': [393], 'chromatin': [395], 'immunoprecipitation.': [396], 'Here': [397], 'plan': [399], 'further': [401], 'characterize': [402], 'genetically': [403], 'biochemically': [405], 'mechanism': [408], 'regulates': [412], 'BMPs': [416], 'first,': [418], 'identifying': [419, 431], 'structural': [421], 'requirements': [422], 'second,': [430], 'partners': [433], 'could': [435], 'part': [437], 'repressor': [440, 483], 'complex': [441], 'sitting': [442], 'promoter.\r\nFor': [445], 'our': [446], 'first': [447], 'goal': [448], 'generated': [450], 'different': [451], 'mutants': [452, 457], 'p21.': [454], 'Using': [455], 'these': [456], 'luciferase': [461], 'assays': [462], 'an': [477, 501], 'E2F-dependent,': [478], 'cycle-independent': [480], 'manner.': [481], 'was': [487], 'independent': [488], 'its': [490], 'cyclin-binding': [491], 'ability': [492], 'mapped': [494], 'N-terminus': [497], 'molecule.\r\nUsing': [500], 'vitro': [503], 'pull': [504], 'down': [505], 'assay': [506], 'proteomics,': [508], 'p54(nrb)/NonO': [512], 'new': [515], 'p21-interacting': [516], 'protein': [517, 528], 'NSCs.': [522], 'NonO': [523, 555], 'multifunctional': [527], 'involved': [529], 'processing': [534], 'nucleic': [536], 'acids': [537], 'described': [542], 'function': [544], 'regulator': [548], '.': [549], 'effect': [553], 'not': [560], 'addressed': [562], 'p21-NonO': [568], 'interaction': [569], 'NSCs': [571], 'cultures': [572], 'should': [573], 'investigated': [575], 'future': [577], 'research.': [578]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2805516202', 'counts_by_year': [], 'updated_date': '2024-12-12T21:00:13.114824', 'created_date': '2018-06-13'}