Publication Information

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{'Background:\xa0Methotrexate': [0], '(MXT)': [1], 'is': [2, 13, 37, 213], 'the': [3, 38, 50, 56, 81, 110, 235], 'corner': [4], 'stone': [5], 'in': [6, 16, 20, 63, 76, 256], 'treatment': [7], 'of': [8, 47, 49, 59, 68, 83, 203, 218, 224, 238, 246, 254, 260], 'rheumatoid': [9, 23, 71, 130, 135, 145, 261], 'arthritis.': [10, 170, 262], 'Although': [11], 'methotrexate': [12, 69, 87, 101, 239, 255], 'usually': [14], 'administrated': [15], 'low': [17], 'weakly': [18], 'dose': [19, 132, 154, 160, 166, 209, 223, 237], 'patients': [21], 'with': [22, 65, 86, 207], 'arthritis': [24, 72, 136, 146], 'discontinuation': [25], 'rates': [26], 'are': [27], 'as': [28, 30, 103, 109], 'high': [29, 153, 208], '16%': [31], 'due': [32], 'to': [33, 54, 199, 230, 234], 'adverse': [34], 'effects.': [35], 'Hepatotoxicity': [36], 'most': [39], 'common': [40], 'side': [41], 'effect': [42, 58, 250], 'after': [43], 'long': [44], 'term': [45], 'course': [46], 'methotrexate.\xa0Aim': [48], 'study:\xa0This': [51], 'work': [52], 'aimed': [53], 'investigate': [55], 'potential': [57], 'sitagliptin': [60, 156, 162, 168, 247], 'alone': [61, 102, 240], 'and': [62, 186, 193, 251], 'combination': [64, 227], 'different': [66], 'doses': [67], 'on': [70, 90, 95, 99], '(RA)': [73], 'induced': [74, 129], 'experimentally': [75], 'rats.': [77], 'Moreover,': [78], 'we': [79], 'investigated': [80], 'benefits': [82], 'sitaglipitn': [84], 'co-administration': [85], 'not': [88], 'only': [89], 'RA': [91], 'progression,': [92], 'but': [93], 'also': [94], 'organs': [96], 'commonly': [97], 'injured': [98], 'using': [100], 'a': [104], 'disease-modifying': [105], 'anti-rheumatic': [106], 'drug': [107, 220], 'such': [108], 'liver.\xa0Methods:\xa042': [111], 'male': [112], 'adult': [113], 'Sprague': [114], 'Dawley': [115], 'rats': [116], 'divided': [117], 'into': [118], 'seven': [119], 'equal': [120], 'groups:': [121], 'Normal': [122], 'control': [123], 'group,': [124], 'None': [125], 'treated': [126, 134, 144, 157, 163, 169], 'Freund,s': [127, 257], 'adjuvant': [128, 258], 'arthritis,High': [131], 'MXT': [133, 225], '(1': [137], 'mg/kg/3': [138], 'days': [139], 'i.p.)': [140], 'over': [141], '4': [142, 151], 'weeks,Sitagliptin': [143], '(10': [147], 'mg/kg/day': [148], 'p.o)': [149], 'for': [150], 'weeks,': [152], 'MXT+': [155, 161, 167, 210], 'arthritis,': [158, 164], '1/2': [159], '1/4': [165], 'Serological': [171], 'parameters': [172], 'namely,': [173], 'cyclic': [174], 'citrullinated': [175], 'peptide': [176], 'antibodies': [177], '(Anti-CCP),': [178], 'matrix': [179, 183], 'metalloproteinase-3(MMP-3),': [180], 'cartilage': [181], 'oligometric': [182], 'protein': [184], '(COMP)': [185], 'TNF-α': [187], 'level': [188], 'were': [189, 197], 'measured.': [190], 'Liver': [191], 'tissue': [192], 'hind': [194], 'paw': [195], 'joint': [196], 'subjected': [198], 'histopathological': [200], 'examination.\xa0Results:\xa0Best': [201], 'degree': [202], 'improvement': [204], 'was': [205, 228], 'obtained': [206], 'sitagliptin.': [211], 'It': [212], 'significantly': [214], 'better': [215], 'than': [216], 'that': [217], 'either': [219], 'alone.': [221], 'Half': [222], '/sitagliptin': [226], 'proved': [229], 'be': [231], 'equally': [232], 'effective': [233], 'full': [236], 'regarding': [241], 'all': [242], 'tested': [243], 'parameters.\xa0Conclusion:\xa0concomitant': [244], 'administration': [245], 'augmented': [248], 'immunosuppressive': [249], 'ameliorated': [252], 'hepatotoxicity': [253], 'model': [259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2804909636', 'counts_by_year': [], 'updated_date': '2024-12-07T09:38:59.580382', 'created_date': '2018-06-01'}