Title: The Acute Toxic Effects of Cysteamine and Their Modification by X-irradiation
Abstract: SummaryThe toxic effects of cysteamine in mice are described. A dose of just over twice the usual radioprotective dose caused severe convulsions and killed about half the injected animals. The dangers of using this compound in man are discussed.When a toxic dose of cysteamine was followed by 100 rads of x-rays 2–15 min later, there was a statistically significant reduction in the number of deaths caused by the cysteamine. Doses of 500–5000 rads had no effect on cysteamine mortality. Possible mechanisms are discussed, and a radiation effect on the nervous system is thought to be more likely than a reversal of the protective effect of cysteamine.
Publication Year: 1963
Publication Date: 1963-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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