Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin–Angiotensin System

Name: Work Video:
Duration: 3 min 30 s
Xinping Yue; Tyler Basting; Thomas W. Flanagan; Jiaxi Xu; Thomas D. Lobell; Nicholas W. Gilpin; Jason Gardner; Eric Lazartigues
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'playing': [79], 'pivotal': [81], 'role': [82], 'angiotensin-converting': [85, 111, 198, 221, 237, 249, 281, 343], '2/angiotensin-(1–7)': [87], 'compensatory': [88, 342], 'axis': [89], 'system.': [93], 'Angiotensin': [94], '(AT2R),': [98], 'another': [99], 'angiotensin-II,': [102], 'opposes': [103], 'deleterious': [105], 'effects': [106], 'AT1R': [108], 'activation,': [109], '2–formed': [113], 'angiotensin-(1–7)': [114], 'has': [115], 'been': [116], 'shown': [117], 'activate': [119], 'AT2R.Objectives:': [120], 'goal': [122], 'present': [125], 'study': [126, 185], 'was': [127, 150, 173, 302], 'examine': [129, 153], 'how': [130], 'nicotine,': [131], 'addictive': [133], 'component': [134], 'cigarette': [136, 164, 188, 210], 'smoke,': [137], 'alters': [138], 'homeostasis': [140, 350], 'system.Methods:': [144], 'Quantitative': [145], 'real-time': [146], 'polymerase': [147], 'chain': [148], 'reaction': [149], 'performed': [151], 'expression': [155, 196, 218, 252], 'components': [158], 'after': [163], 'smoke': [165, 189, 211], 'exposure': [166, 230], 'or': [167, 190], 'direct': [168, 191], 'nicotine': [169, 192, 229, 245, 272, 288, 319, 347], 'inhalation.': [170], 'Radio': [171], 'telemetry': [172], 'used': [174], 'continuous': [176], 'blood': [177, 299], 'pressure': [178], 'recording': [179], 'conscious,': [181], 'unrestrained': [182], 'mice.Results:': [183], 'Our': [184, 335], 'showed': [186, 273], 'that': [187], 'inhalation': [193, 247], 'inhibits': [194], '2/AT2R': [200, 345], 'multiple': [202, 356], 'organs': [203], 'cell': [205], 'types.': [206], 'In': [207, 226, 242, 265], 'lung,': [209], '(6': [212], 'cigarettes/d,': [213], '12': [214], 'wk)': [215, 293], 'inhibited': [216, 248], 'both': [220], 'AT2R.': [225, 241], 'cardiac': [227], 'fibroblasts,': [228], 'resulted': [231], 'near': [233], 'complete': [234], 'suppression': [235], 'brain,': [244], 'vapor': [246, 289], 'hypothalamus,': [255], 'region': [257], 'involved': [258], 'central': [260], 'regulation': [261], 'cardiopulmonary': [263], 'function.': [264], 'addition,': [266], 'cultured': [267], 'Neuro2A': [268], 'cells': [269], 'exposed': [270, 286], 'dose-dependent': [275], 'reduction': [276], 'enzymatic': [278], 'activity': [279], '2.': [283], 'Functionally,': [284], 'mice': [285, 321], '(12': [290], 'h/d,': [291], '4': [292], 'exhibited': [294], 'significantly': [295], 'mean': [297], 'arterial': [298], 'pressure,': [300], 'which': [301, 358], 'more': [303], 'pronounced': [304], 'during': [305], 'night': [307], 'active': [308], 'cycle': [309], '(mean': [310], '±': [311, 314, 324], 'SE,': [312], '124': [313], '0.6': [315], 'mm': [316, 326], 'Hg': [317, 327], 'vapor–exposed': [320], 'vs.': [322], '107': [323], '0.4': [325], 'air': [329], 'control': [330], 'mice;': [331], 'P': [332], '<': [333], '0.0001).Conclusions:': [334], 'findings': [336], 'suggest': [337], 'that,': [338], 'downregulating': [340], 'elements,': [346], 'disrupts': [348], 'organs,': [357], 'likely': [360], 'an': [361], 'important': [362], 'mechanism': [363], 'leading': [364], 'disease.': [372]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2802058961', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-24T08:58:32.825369', 'created_date': '2018-05-17'}
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