Publication Information

{'id': 'https://openalex.org/W2321507356', 'doi': 'https://doi.org/10.1097/00005344-200211000-00007', 'title': 'Angiotensin-(1-7) Inhibits Angiotensin II–Induced Signal Transduction', 'display_name': 'Angiotensin-(1-7) Inhibits Angiotensin II–Induced Signal Transduction', 'publication_year': 2002, 'publication_date': '2002-11-01', 'ids': {'openalex': 'https://openalex.org/W2321507356', 'doi': 'https://doi.org/10.1097/00005344-200211000-00007', 'mag': '2321507356', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12409978'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/00005344-200211000-00007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61167191', 'display_name': 'Journal of Cardiovascular Pharmacology', 'issn_l': '0160-2446', 'issn': ['0160-2446', '1533-4023'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1097/00005344-200211000-00007', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087745821', 'display_name': 'Zhiming Zhu', 'orcid': 'https://orcid.org/0000-0003-1035-5588'}, 'institutions': [], 'countries': ['CN', 'DE'], 'is_corresponding': True, 'raw_author_name': 'Zhiming Zhu', 'raw_affiliation_strings': ['China', 'Germany'], 'affiliations': [{'raw_affiliation_string': 'China', 'institution_ids': []}, {'raw_affiliation_string': 'Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103469198', 'display_name': 'Jian Zhong', 'orcid': None}, 'institutions': [], 'countries': ['CN', 'DE'], 'is_corresponding': False, 'raw_author_name': 'Jian Zhong', 'raw_affiliation_strings': ['China', 'Germany'], 'affiliations': [{'raw_affiliation_string': 'China', 'institution_ids': []}, {'raw_affiliation_string': 'Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101657877', 'display_name': 'Zhu Shan-jun', 'orcid': None}, 'institutions': [], 'countries': ['CN', 'DE'], 'is_corresponding': True, 'raw_author_name': 'Shanjun Zhu', 'raw_affiliation_strings': ['China', 'Germany'], 'affiliations': [{'raw_affiliation_string': 'China', 'institution_ids': []}, {'raw_affiliation_string': 'Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103205028', 'display_name': 'Daoyan Liu', 'orcid': 'https://orcid.org/0009-0005-1192-1440'}, 'institutions': [], 'countries': ['CN', 'DE'], 'is_corresponding': False, 'raw_author_name': 'Daoyan Liu', 'raw_affiliation_strings': ['China', 'Germany'], 'affiliations': [{'raw_affiliation_string': 'China', 'institution_ids': []}, {'raw_affiliation_string': 'Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015274001', 'display_name': 'Markus van der Giet', 'orcid': 'https://orcid.org/0000-0003-3590-5451'}, 'institutions': [], 'countries': ['CN', 'DE'], 'is_corresponding': False, 'raw_author_name': 'Markus van der Giet', 'raw_affiliation_strings': ['China', 'Germany'], 'affiliations': [{'raw_affiliation_string': 'Germany', 'institution_ids': []}, {'raw_affiliation_string': 'China', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067580450', 'display_name': 'Martin Tepel', 'orcid': 'https://orcid.org/0000-0002-0086-0997'}, 'institutions': [], 'countries': ['CN', 'DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Tepel', 'raw_affiliation_strings': ['China', 'Germany'], 'affiliations': [{'raw_affiliation_string': 'China', 'institution_ids': []}, {'raw_affiliation_string': 'Germany', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5087745821', 'https://openalex.org/A5101657877'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.728, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.894802, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '40', 'issue': '5', 'first_page': '693', 'last_page': '700'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9878, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.8970282}, {'id': 'https://openalex.org/C123915805', 'wikidata': 'https://www.wikidata.org/wiki/Q15332826', 'display_name': 'Angiotensin II receptor type 1', 'level': 4, 'score': 0.8289318}, {'id': 'https://openalex.org/C104849204', 'wikidata': 'https://www.wikidata.org/wiki/Q24778533', 'display_name': 'Angiotensin receptor', 'level': 4, 'score': 0.7548008}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.56482106}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.502839}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.48502535}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43110746}, {'id': 'https://openalex.org/C27016395', 'wikidata': 'https://www.wikidata.org/wiki/Q128861', 'display_name': 'Angiotensin-converting enzyme', 'level': 3, 'score': 0.4288605}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37273863}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.33749348}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1382393}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.044656754}], 'mesh': [{'descriptor_ui': 'D000803', 'descriptor_name': 'Angiotensin I', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000803', 'descriptor_name': 'Angiotensin I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057911', 'descriptor_name': 'Angiotensin Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011945', 'descriptor_name': 'Receptors, Angiotensin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/00005344-200211000-00007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61167191', 'display_name': 'Journal of Cardiovascular Pharmacology', 'issn_l': '0160-2446', 'issn': ['0160-2446', '1533-4023'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://journals.lww.com/cardiovascularpharm/Fulltext/2002/11000/Angiotensin__1_7__Inhibits_Angiotensin_II_Induced.7.aspx', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12409978', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/00005344-200211000-00007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61167191', 'display_name': 'Journal of Cardiovascular Pharmacology', 'issn_l': '0160-2446', 'issn': ['0160-2446', '1533-4023'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1513202942', 'https://openalex.org/W1854667691', 'https://openalex.org/W1909552007', 'https://openalex.org/W1991854388', 'https://openalex.org/W1997691216', 'https://openalex.org/W2024086991', 'https://openalex.org/W2034963012', 'https://openalex.org/W2045136560', 'https://openalex.org/W2051185167', 'https://openalex.org/W2053846349', 'https://openalex.org/W2058535498', 'https://openalex.org/W2067157370', 'https://openalex.org/W2071174074', 'https://openalex.org/W2071216374', 'https://openalex.org/W2093449144', 'https://openalex.org/W2096150812', 'https://openalex.org/W2097869282', 'https://openalex.org/W2103417517', 'https://openalex.org/W2116658326', 'https://openalex.org/W2134812217', 'https://openalex.org/W2137248091', 'https://openalex.org/W2147748270', 'https://openalex.org/W2151166210', 'https://openalex.org/W2151879019', 'https://openalex.org/W2157060282', 'https://openalex.org/W2157517728', 'https://openalex.org/W2181774693', 'https://openalex.org/W2302185736', 'https://openalex.org/W2317678845', 'https://openalex.org/W2327767845', 'https://openalex.org/W2413276389', 'https://openalex.org/W4294216491'], 'related_works': ['https://openalex.org/W2418445678', 'https://openalex.org/W2321507356', 'https://openalex.org/W2093949391', 'https://openalex.org/W2092435511', 'https://openalex.org/W2090731568', 'https://openalex.org/W2048982602', 'https://openalex.org/W2022842708', 'https://openalex.org/W2020125834', 'https://openalex.org/W1991157605', 'https://openalex.org/W1977216511'], 'abstract_inverted_index': {'The': [0, 39, 170], 'inhibitory': [1], 'effects': [2, 41, 123], 'of': [3, 10, 16, 42, 112, 119, 141, 164, 172, 181, 213, 219], 'angiotensin-(1–7)': [4, 43, 120, 173], 'on': [5, 124, 137, 148, 160, 177, 197], 'angiotensin': [6, 25, 113, 138, 149, 161, 178, 198, 220], 'II–induced': [7, 139, 150, 162, 179, 199], 'vasoconstriction,': [8], 'growth': [9], 'vascular': [11, 64], 'smooth': [12, 65], 'muscle': [13, 66], 'cells,': [14], 'stimulation': [15, 218], 'protein': [17, 58, 79, 92, 154, 165], 'kinase': [18, 80, 93, 166], 'C,': [19], 'extracellular': [20], 'signal-regulated': [21], 'kinases': [22], '(ERK),': [23], 'and': [24, 30, 82, 95, 99, 153, 168, 203], 'subtype': [26, 31], '1': [27], 'receptor': [28, 33, 101, 183, 188], '(AT1)': [29], '2': [32], '(AT2)': [34], 'mRNA': [35, 102, 184, 189], 'expression': [36, 103, 190], 'were': [37, 44, 84], 'investigated.': [38], 'hemodynamic': [40], 'measured': [45, 51, 61, 85, 105], 'in': [46, 62, 129, 209], 'Wistar': [47, 130], 'rats.': [48, 131], 'Vasoconstriction': [49], 'was': [50, 60, 104, 191], 'using': [52, 68, 90, 106], 'aortic': [53, 142], 'rings.': [54, 143], 'DNA': [55, 151], 'synthesis': [56, 59, 152], 'or': [57, 71], 'cultured': [63], 'cells': [67], '[3H]': [69, 72], 'thymidine': [70], 'leucine': [73], 'incorporation,': [74], 'respectively.': [75], 'Angiotensin': [76], 'II': [77, 114], 'stimulated': [78], 'C': [81, 94, 167], 'ERK1/2': [83, 96], 'by': [86], 'Western': [87], 'blot': [88], 'analysis': [89], 'phosphospecific': [91], 'antibodies.': [97], 'AT1': [98, 182, 214], 'AT2': [100, 187], 'reverse-transcription': [107], 'polymerase': [108], 'chain': [109], 'reaction.': [110], 'Infusion': [111], 'significantly': [115], 'increased': [116], 'whereas': [117, 186], 'infusion': [118], 'had': [121], 'no': [122], 'mean': [125], 'arterial': [126], 'blood': [127], 'pressure': [128], 'Angiotensin-(1–7)': [132, 144, 156, 193], 'dose-dependently': [133], 'showed': [134, 145, 157, 174, 194], 'partial': [135, 146, 158, 175, 195], 'antagonism': [136, 147, 159, 176, 196], 'contraction': [140], 'synthesis.': [155], 'activation': [163], 'ERK1/2.': [169], 'administration': [171], 'downregulation': [180], 'expression,': [185], 'unchanged.': [192], 'intracellular': [200], 'signal': [201], 'transduction': [202], 'may': [204], 'play': [205], 'a': [206], 'crucial': [207], 'role': [208], 'the': [210], 'adaptation': [211], 'process': [212], 'receptors': [215], 'to': [216], 'sustained': [217], 'II.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2321507356', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-27T11:13:43.874208', 'created_date': '2016-06-24'}