Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2789844784', 'doi': 'https://doi.org/10.1016/j.devcel.2018.02.010', 'title': 'PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis', 'display_name': 'PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis', 'publication_year': 2018, 'publication_date': '2018-03-01', 'ids': {'openalex': 'https://openalex.org/W2789844784', 'doi': 'https://doi.org/10.1016/j.devcel.2018.02.010', 'mag': '2789844784', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29533773', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5854208'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2018.02.010', 'pdf_url': 'http://www.cell.com/article/S1534580718301059/pdf', 'source': {'id': 'https://openalex.org/S83804233', 'display_name': 'Developmental Cell', 'issn_l': '1534-5807', 'issn': ['1534-5807', '1878-1551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S1534580718301059/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042592485', 'display_name': 'Moon Jong Kim', 'orcid': 'https://orcid.org/0000-0002-7876-4639'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Moon Jong Kim', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101760010', 'display_name': 'Bo Xia', 'orcid': 'https://orcid.org/0000-0003-1983-0015'}, 'institutions': [{'id': 'https://openalex.org/I1295876152', 'display_name': 'Houston Methodist', 'ror': 'https://ror.org/027zt9171', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1295876152']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bo Xia', 'raw_affiliation_strings': ['Center for Cardiovascular Regeneration, Houston Methodist Hospital Research Institute, Houston, TX, USA', 'Department of Cardiothoracic Surgery, Weill Cornell Medical College, Cornell University, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Cardiovascular Regeneration, Houston Methodist Hospital Research Institute, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1295876152']}, {'raw_affiliation_string': 'Department of Cardiothoracic Surgery, Weill Cornell Medical College, Cornell University, New York, NY, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067887857', 'display_name': 'Han Na Suh', 'orcid': 'https://orcid.org/0000-0002-7647-7249'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Han Na Suh', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100698688', 'display_name': 'Sung Ho Lee', 'orcid': 'https://orcid.org/0000-0002-4654-384X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sung Ho Lee', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083736833', 'display_name': 'Suckjoon Jun', 'orcid': 'https://orcid.org/0000-0002-0139-4297'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sohee Jun', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036305757', 'display_name': 'Esther M. Lien', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Esther M. Lien', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100436849', 'display_name': 'Jie Zhang', 'orcid': 'https://orcid.org/0000-0003-1180-5819'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jie Zhang', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023457020', 'display_name': 'Kaifu Chen', 'orcid': 'https://orcid.org/0000-0003-1009-4357'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I1295876152', 'display_name': 'Houston Methodist', 'ror': 'https://ror.org/027zt9171', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1295876152']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kaifu Chen', 'raw_affiliation_strings': ['Center for Cardiovascular Regeneration, Houston Methodist Hospital Research Institute, Houston, TX, USA', 'Department of Cardiothoracic Surgery, Weill Cornell Medical College, Cornell University, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiothoracic Surgery, Weill Cornell Medical College, Cornell University, New York, NY, USA', 'institution_ids': ['https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Center for Cardiovascular Regeneration, Houston Methodist Hospital Research Institute, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1295876152']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029966999', 'display_name': 'Jae‐Il Park', 'orcid': 'https://orcid.org/0000-0002-0737-2654'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jae-Il Park', 'raw_affiliation_strings': ['Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center and Health Science Center, Houston, TX 77030, USA', 'Program in Genetics and Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center and Health Science Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Program in Genetics and Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5029966999'], 'corresponding_institution_ids': ['https://openalex.org/I1343551460'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.227, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.861407, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '44', 'issue': '5', 'first_page': '582', 'last_page': '596.e4'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Stem Cells and Tumor Metastasis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Stem Cells and Tumor Metastasis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Engineering Bacteria for Cancer Treatment', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13199', 'display_name': 'Genetic Adaptation of Lactase Persistence in Humans', 'score': 0.9834, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancer-metabolism', 'display_name': 'Cancer Metabolism', 'score': 0.520252}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8968493}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.84177953}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.7714205}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6847344}, {'id': 'https://openalex.org/C171056886', 'wikidata': 'https://www.wikidata.org/wiki/Q193119', 'display_name': 'Regeneration (biology)', 'level': 2, 'score': 0.5721588}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.5617981}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.53449076}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.49379596}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.49189115}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45773697}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.42204446}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.16624814}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14954048}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06647959}], 'mesh': [{'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012038', 'descriptor_name': 'Regeneration', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012038', 'descriptor_name': 'Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060449', 'descriptor_name': 'Wnt Signaling Pathway', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2018.02.010', 'pdf_url': 'http://www.cell.com/article/S1534580718301059/pdf', 'source': {'id': 'https://openalex.org/S83804233', 'display_name': 'Developmental Cell', 'issn_l': '1534-5807', 'issn': ['1534-5807', '1878-1551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5854208', 'pdf_url': 'https://europepmc.org/articles/pmc5854208?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854208', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29533773', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2018.02.010', 'pdf_url': 'http://www.cell.com/article/S1534580718301059/pdf', 'source': {'id': 'https://openalex.org/S83804233', 'display_name': 'Developmental Cell', 'issn_l': '1534-5807', 'issn': ['1534-5807', '1878-1551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320306078', 'funder_display_name': 'U.S. Department of Defense', 'award_id': 'CA140572'}, {'funder': 'https://openalex.org/F4320308129', 'funder_display_name': 'Cancer Prevention and Research Institute of Texas', 'award_id': 'RP140563'}, {'funder': 'https://openalex.org/F4320309682', 'funder_display_name': 'Duncan Family Institute for Cancer Prevention and Risk Assessment', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01 CA193297-01'}, {'funder': 'https://openalex.org/F4320332521', 'funder_display_name': 'University of Texas MD Anderson Cancer Center', 'award_id': 'CA016672'}, {'funder': 'https://openalex.org/F4320337351', 'funder_display_name': 'National Cancer Institute', 'award_id': 'P50 CA098258'}], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1483496013', 'https://openalex.org/W1791828066', 'https://openalex.org/W1965157206', 'https://openalex.org/W1970291858', 'https://openalex.org/W1973245460', 'https://openalex.org/W1982603620', 'https://openalex.org/W1985886021', 'https://openalex.org/W1987584325', 'https://openalex.org/W1989940296', 'https://openalex.org/W1990606472', 'https://openalex.org/W1994216131', 'https://openalex.org/W1997360704', 'https://openalex.org/W2002513358', 'https://openalex.org/W2003299661', 'https://openalex.org/W2004878973', 'https://openalex.org/W2006419043', 'https://openalex.org/W2017828716', 'https://openalex.org/W2024204178', 'https://openalex.org/W2026644829', 'https://openalex.org/W2029231546', 'https://openalex.org/W2029556699', 'https://openalex.org/W2036988662', 'https://openalex.org/W2040498703', 'https://openalex.org/W2041165380', 'https://openalex.org/W2044022855', 'https://openalex.org/W2044531485', 'https://openalex.org/W2047151533', 'https://openalex.org/W2048768497', 'https://openalex.org/W2051055358', 'https://openalex.org/W2058569154', 'https://openalex.org/W2061495325', 'https://openalex.org/W2062069198', 'https://openalex.org/W2066277278', 'https://openalex.org/W2066362124', 'https://openalex.org/W2066925975', 'https://openalex.org/W2069970995', 'https://openalex.org/W2070845123', 'https://openalex.org/W2071588736', 'https://openalex.org/W2074178149', 'https://openalex.org/W2077498174', 'https://openalex.org/W2084745919', 'https://openalex.org/W2094252236', 'https://openalex.org/W2105241495', 'https://openalex.org/W2106299774', 'https://openalex.org/W2111130664', 'https://openalex.org/W2116315632', 'https://openalex.org/W2119059014', 'https://openalex.org/W2120381403', 'https://openalex.org/W2126271976', 'https://openalex.org/W2128378918', 'https://openalex.org/W2134359750', 'https://openalex.org/W2138977668', 'https://openalex.org/W2140754284', 'https://openalex.org/W2141437534', 'https://openalex.org/W2145955680', 'https://openalex.org/W2153679407', 'https://openalex.org/W2157010562', 'https://openalex.org/W2164479709', 'https://openalex.org/W2167869412', 'https://openalex.org/W2168649383', 'https://openalex.org/W2170039745', 'https://openalex.org/W2171262765', 'https://openalex.org/W2171507631', 'https://openalex.org/W2262448048', 'https://openalex.org/W2304950752', 'https://openalex.org/W2338910578', 'https://openalex.org/W2769478432', 'https://openalex.org/W4245282491'], 'related_works': ['https://openalex.org/W582905479', 'https://openalex.org/W3148046299', 'https://openalex.org/W2937181318', 'https://openalex.org/W2592007767', 'https://openalex.org/W2543202296', 'https://openalex.org/W2507081987', 'https://openalex.org/W2165132828', 'https://openalex.org/W2080599553', 'https://openalex.org/W2055808176', 'https://openalex.org/W2026862129'], 'abstract_inverted_index': {'The': [0], 'underlying': [1], 'mechanisms': [2], 'of': [3, 30, 68, 78, 96], 'how': [4], 'self-renewing': [5, 144], 'cells': [6, 44], 'are': [7], 'controlled': [8], 'in': [9, 39], 'regenerating': [10], 'tissues': [11], 'and': [12, 42, 46, 48, 54, 80, 87, 116, 139], 'cancer': [13], 'remain': [14], 'ambiguous.': [15], 'PCNA-associated': [16], 'factor': [17], '(PAF)': [18], 'modulates': [19], 'DNA': [20], 'repair': [21], 'via': [22], 'PCNA.': [23], 'Also,': [24], 'PAF': [25, 36, 57, 69, 84, 104], 'hyperactivates': [26], 'Wnt/β-catenin': [27, 118], 'signaling': [28, 119, 132], 'independently': [29], 'PCNA': [31], 'interaction.': [32], 'We': [33], 'found': [34], 'that': [35, 129], 'is': [37, 58, 134], 'expressed': [38], 'intestinal': [40, 52, 61, 71, 99, 109, 137], 'stem': [41], 'progenitor': [43], '(ISCs': [45], 'IPCs)': [47], 'markedly': [49], 'upregulated': [50], 'during': [51, 98], 'regeneration': [53, 72, 138], 'tumorigenesis.': [55], 'Whereas': [56], 'dispensable': [59], 'for': [60, 136], 'homeostasis,': [62], 'upon': [63], 'radiation': [64], 'injury,': [65], 'genetic': [66], 'ablation': [67], 'impairs': [70], 'along': [73], 'with': [74, 111], 'the': [75, 89, 94, 130], 'severe': [76], 'loss': [77], 'ISCs': [79], 'Myc': [81], 'expression.': [82], 'Mechanistically,': [83], 'conditionally': [85], 'occupies': [86], 'transactivates': [88], 'c-Myc': [90], 'promoter,': [91], 'which': [92], 'induces': [93], 'expansion': [95], 'ISCs/IPCs': [97], 'regeneration.': [100], 'In': [101], 'mouse': [102], 'models,': [103], 'knockout': [105], 'inhibits': [106], 'Apc': [107], 'inactivation-driven': [108], 'tumorigenesis': [110, 140], 'reduced': [112], 'tumor': [113], 'cell': [114], 'stemness': [115], 'suppressed': [117], 'activity,': [120], 'supported': [121], 'by': [122, 141], 'transcriptome': [123], 'profiling.': [124], 'Collectively,': [125], 'our': [126], 'results': [127], 'unveil': [128], 'PAF-Myc': [131], 'axis': [133], 'indispensable': [135], 'positively': [142], 'regulating': [143], 'cells.': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2789844784', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-08-21T20:04:53.606214', 'created_date': '2018-03-29'}