Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2785792383', 'doi': 'https://doi.org/10.1016/j.cell.2018.01.029', 'title': 'The Human Transcription Factors', 'display_name': 'The Human Transcription Factors', 'publication_year': 2018, 'publication_date': '2018-02-01', 'ids': {'openalex': 'https://openalex.org/W2785792383', 'doi': 'https://doi.org/10.1016/j.cell.2018.01.029', 'mag': '2785792383', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30290144'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2018.01.029', 'pdf_url': 'http://www.cell.com/article/S0092867418301065/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S0092867418301065/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045640909', 'display_name': 'Samuel A. Lambert', 'orcid': 'https://orcid.org/0000-0001-8222-008X'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Samuel A. Lambert', 'raw_affiliation_strings': ['Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038145078', 'display_name': 'Arttu Jolma', 'orcid': 'https://orcid.org/0000-0002-2543-7490'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Arttu Jolma', 'raw_affiliation_strings': ['Donnelly Centre, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Donnelly Centre, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061914082', 'display_name': 'Laura F. Campitelli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Laura F. Campitelli', 'raw_affiliation_strings': ['Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037037683', 'display_name': 'Pratyush Kumar Das', 'orcid': 'https://orcid.org/0000-0003-2822-9619'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Pratyush K. Das', 'raw_affiliation_strings': ['Genome-Scale Biology Program, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Genome-Scale Biology Program, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008875131', 'display_name': 'Yimeng Yin', 'orcid': 'https://orcid.org/0000-0002-5454-608X'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Yimeng Yin', 'raw_affiliation_strings': ['Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033054003', 'display_name': 'Mihai Albu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Mihai Albu', 'raw_affiliation_strings': ['Donnelly Centre, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Donnelly Centre, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100715042', 'display_name': 'Xiaoting Chen', 'orcid': 'https://orcid.org/0000-0002-3782-3962'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaoting Chen', 'raw_affiliation_strings': ['Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA', 'institution_ids': ['https://openalex.org/I1285204247']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031611528', 'display_name': 'Jussi Taipale', 'orcid': 'https://orcid.org/0000-0003-4204-0951'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI', 'GB', 'SE'], 'is_corresponding': False, 'raw_author_name': 'Jussi Taipale', 'raw_affiliation_strings': ['Department of Biochemistry, Cambridge University, Cambridge CB2 1GA, United Kingdom', 'Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden', 'Genome-Scale Biology Program, University of Helsinki, Helsinki, Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Cambridge University, Cambridge CB2 1GA, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}, {'raw_affiliation_string': 'Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Genome-Scale Biology Program, University of Helsinki, Helsinki, Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071531544', 'display_name': 'Timothy R. Hughes', 'orcid': 'https://orcid.org/0000-0002-8721-4719'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Timothy R. Hughes', 'raw_affiliation_strings': ['Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'Donnelly Centre, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Donnelly Centre, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073587598', 'display_name': 'Matthew T. Weirauch', 'orcid': 'https://orcid.org/0000-0001-7977-9122'}, 'institutions': [{'id': 'https://openalex.org/I1285204247', 'display_name': "Cincinnati Children's Hospital Medical Center", 'ror': 'https://ror.org/01hcyya48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1285204247']}, {'id': 'https://openalex.org/I92156820', 'display_name': 'University of Cincinnati Medical Center', 'ror': 'https://ror.org/02p72h367', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I92156820']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew T. Weirauch', 'raw_affiliation_strings': ['Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA', 'Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA', 'Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA', 'institution_ids': ['https://openalex.org/I1285204247']}, {'raw_affiliation_string': 'Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA', 'institution_ids': ['https://openalex.org/I92156820']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 27.717, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2469, 'citation_normalized_percentile': {'value': 0.999734, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '172', 'issue': '4', 'first_page': '650', 'last_page': '665'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transcription-factors', 'display_name': 'Transcription Factors', 'score': 0.652587}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.522863}, {'id': 'https://openalex.org/keywords/cis-regulatory-module', 'display_name': 'Cis-regulatory module', 'score': 0.46087912}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.90191364}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.7589287}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.59014964}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.56815326}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.56564087}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5228282}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.5131324}, {'id': 'https://openalex.org/C197077220', 'wikidata': 'https://www.wikidata.org/wiki/Q720988', 'display_name': 'Human genome', 'level': 4, 'score': 0.50745076}, {'id': 'https://openalex.org/C190796033', 'wikidata': 'https://www.wikidata.org/wiki/Q1093165', 'display_name': 'Cis-regulatory module', 'level': 5, 'score': 0.46087912}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.4227378}, {'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.37983185}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.35851666}], 'mesh': [{'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020218', 'descriptor_name': 'Response Elements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020816', 'descriptor_name': 'Amino Acid Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2018.01.029', 'pdf_url': 'http://www.cell.com/article/S0092867418301065/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29425488', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2018.01.029', 'pdf_url': 'http://www.cell.com/article/S0092867418301065/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320313227', 'funder_display_name': 'Lupus Research Alliance', 'award_id': None}, {'funder': 'https://openalex.org/F4320322581', 'funder_display_name': 'Vetenskapsrådet', 'award_id': '2016-00158'}], 'datasets': [], 'versions': [], 'referenced_works_count': 129, 'referenced_works': ['https://openalex.org/W110099204', 'https://openalex.org/W114066646', 'https://openalex.org/W151679603', 'https://openalex.org/W1601063618', 'https://openalex.org/W1636205509', 'https://openalex.org/W1900337607', 'https://openalex.org/W1928213240', 'https://openalex.org/W1971002293', 'https://openalex.org/W1971451591', 'https://openalex.org/W1971993554', 'https://openalex.org/W1976066719', 'https://openalex.org/W1980825481', 'https://openalex.org/W1984189354', 'https://openalex.org/W1987122345', 'https://openalex.org/W1987414043', 'https://openalex.org/W1987779112', 'https://openalex.org/W1989419347', 'https://openalex.org/W1993643818', 'https://openalex.org/W1998196230', 'https://openalex.org/W2001294950', 'https://openalex.org/W2004622806', 'https://openalex.org/W2005223383', 'https://openalex.org/W2005530496', 'https://openalex.org/W2007203150', 'https://openalex.org/W2012034410', 'https://openalex.org/W2012627860', 'https://openalex.org/W2014061560', 'https://openalex.org/W2018219462', 'https://openalex.org/W2021059897', 'https://openalex.org/W2022736304', 'https://openalex.org/W2025919590', 'https://openalex.org/W2026690931', 'https://openalex.org/W2028200156', 'https://openalex.org/W2029722028', 'https://openalex.org/W2033169664', 'https://openalex.org/W2033245528', 'https://openalex.org/W2034892963', 'https://openalex.org/W2036209857', 'https://openalex.org/W2041014047', 'https://openalex.org/W2041877620', 'https://openalex.org/W2042392223', 'https://openalex.org/W2045362835', 'https://openalex.org/W2047405437', 'https://openalex.org/W2048284172', 'https://openalex.org/W2053117901', 'https://openalex.org/W2059296675', 'https://openalex.org/W2059919630', 'https://openalex.org/W2064127422', 'https://openalex.org/W206414981', 'https://openalex.org/W2067899297', 'https://openalex.org/W2072391169', 'https://openalex.org/W2074964991', 'https://openalex.org/W2078059415', 'https://openalex.org/W2081212776', 'https://openalex.org/W2083590085', 'https://openalex.org/W2084831115', 'https://openalex.org/W2086038224', 'https://openalex.org/W2088204347', 'https://openalex.org/W2093594635', 'https://openalex.org/W2097228095', 'https://openalex.org/W2098412979', 'https://openalex.org/W2098513996', 'https://openalex.org/W2099061740', 'https://openalex.org/W2100990361', 'https://openalex.org/W2105389823', 'https://openalex.org/W2110251865', 'https://openalex.org/W2111634384', 'https://openalex.org/W2112019511', 'https://openalex.org/W2116467413', 'https://openalex.org/W2117446594', 'https://openalex.org/W2126888219', 'https://openalex.org/W2127996002', 'https://openalex.org/W2129795133', 'https://openalex.org/W2130479394', 'https://openalex.org/W2132781864', 'https://openalex.org/W2135030836', 'https://openalex.org/W2137465688', 'https://openalex.org/W2138069365', 'https://openalex.org/W2140754446', 'https://openalex.org/W2143539785', 'https://openalex.org/W2145010689', 'https://openalex.org/W2146393977', 'https://openalex.org/W2146808643', 'https://openalex.org/W2146890600', 'https://openalex.org/W2147339635', 'https://openalex.org/W2147710217', 'https://openalex.org/W2151754128', 'https://openalex.org/W2155304372', 'https://openalex.org/W2157505599', 'https://openalex.org/W2159324718', 'https://openalex.org/W2159942968', 'https://openalex.org/W2161633633', 'https://openalex.org/W2166496717', 'https://openalex.org/W2170282111', 'https://openalex.org/W2170964754', 'https://openalex.org/W2171193618', 'https://openalex.org/W2175853567', 'https://openalex.org/W2180291937', 'https://openalex.org/W2180845368', 'https://openalex.org/W2224056471', 'https://openalex.org/W2273958019', 'https://openalex.org/W2281531600', 'https://openalex.org/W2304402346', 'https://openalex.org/W2314176140', 'https://openalex.org/W2331147307', 'https://openalex.org/W2345512687', 'https://openalex.org/W2465336312', 'https://openalex.org/W2479952736', 'https://openalex.org/W2481378334', 'https://openalex.org/W2518972560', 'https://openalex.org/W2529467427', 'https://openalex.org/W2546872920', 'https://openalex.org/W2548430945', 'https://openalex.org/W2553676377', 'https://openalex.org/W2556063213', 'https://openalex.org/W2557496587', 'https://openalex.org/W2559482520', 'https://openalex.org/W2575110262', 'https://openalex.org/W2594086611', 'https://openalex.org/W2603617582', 'https://openalex.org/W2608458533', 'https://openalex.org/W2610903912', 'https://openalex.org/W2739782708', 'https://openalex.org/W2752092162', 'https://openalex.org/W2781533148', 'https://openalex.org/W4246359243', 'https://openalex.org/W4246645317', 'https://openalex.org/W4247412012', 'https://openalex.org/W42563142'], 'related_works': ['https://openalex.org/W4206937239', 'https://openalex.org/W3159317682', 'https://openalex.org/W3145419749', 'https://openalex.org/W3038565614', 'https://openalex.org/W2992086063', 'https://openalex.org/W2979343233', 'https://openalex.org/W2891762942', 'https://openalex.org/W2754901504', 'https://openalex.org/W2688223077', 'https://openalex.org/W2152611630'], 'abstract_inverted_index': {'Transcription': [0], 'factors': [1], '(TFs)': [2], 'recognize': [3], 'specific': [4], 'DNA': [5], 'sequences': [6], 'to': [7, 35, 53, 122], 'control': [8, 29], 'chromatin': [9], 'and': [10, 47, 64, 80, 98, 114], 'transcription,': [11], 'forming': [12], 'a': [13, 72], 'complex': [14], 'system': [15], 'that': [16], 'guides': [17], 'expression': [18, 99], 'of': [19, 43, 55, 71, 74, 85, 89, 110, 119], 'the': [20, 38, 69, 117], 'genome.': [21], 'Despite': [22], 'keen': [23], 'interest': [24], 'in': [25, 94], 'understanding': [26], 'how': [27, 37, 48, 60], 'TFs': [28, 44, 61, 79, 91, 104], 'gene': [30, 125], 'expression,': [31], 'it': [32], 'remains': [33], 'challenging': [34], 'determine': [36], 'precise': [39], 'genomic': [40], 'binding': [41, 50, 81], 'sites': [42], 'are': [45, 62], 'specified': [46], 'TF': [49], 'ultimately': [51], 'relates': [52], 'regulation': [54], 'transcription.': [56], 'This': [57], 'review': [58], 'considers': [59], 'identified': [63], 'functionally': [65], 'characterized,': [66], 'principally': [67], 'through': [68], 'lens': [70], 'catalog': [73], 'over': [75], '1,600': [76], 'likely': [77], 'human': [78, 90, 111], 'motifs': [82], 'for': [83], 'two-thirds': [84], 'them.': [86], 'Major': [87], 'classes': [88], 'differ': [92], 'markedly': [93], 'their': [95], 'evolutionary': [96], 'trajectories': [97], 'patterns,': [100], 'underscoring': [101], 'distinct': [102], 'functions.': [103], 'likewise': [105], 'underlie': [106], 'many': [107], 'different': [108], 'aspects': [109], 'physiology,': [112], 'disease,': [113], 'variation,': [115], 'highlighting': [116], 'importance': [118], 'continued': [120], 'effort': [121], 'understand': [123], 'TF-mediated': [124], 'regulation.': [126]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2785792383', 'counts_by_year': [{'year': 2024, 'cited_by_count': 388}, {'year': 2023, 'cited_by_count': 514}, {'year': 2022, 'cited_by_count': 506}, {'year': 2021, 'cited_by_count': 421}, {'year': 2020, 'cited_by_count': 318}, {'year': 2019, 'cited_by_count': 209}, {'year': 2018, 'cited_by_count': 77}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-18T17:23:57.004714', 'created_date': '2018-02-23'}