Publication Information

{'id': 'https://openalex.org/W3159317682', 'doi': 'https://doi.org/10.1146/annurev-genom-122220-093818', 'title': 'Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms', 'display_name': 'Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms', 'publication_year': 2021, 'publication_date': '2021-05-05', 'ids': {'openalex': 'https://openalex.org/W3159317682', 'doi': 'https://doi.org/10.1146/annurev-genom-122220-093818', 'mag': '3159317682', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33951408'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-genom-122220-093818', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-genom-122220-093818', 'source': {'id': 'https://openalex.org/S8095556', 'display_name': 'Annual Review of Genomics and Human Genetics', 'issn_l': '1527-8204', 'issn': ['1527-8204', '1545-293X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-genom-122220-093818', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056347519', 'display_name': 'Frank Grosveld', 'orcid': 'https://orcid.org/0000-0002-7051-4715'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Frank Grosveld', 'raw_affiliation_strings': ['Department of Cell Biology, Erasmus MC, 3000 CA Rotterdam, The Netherlands;,'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Erasmus MC, 3000 CA Rotterdam, The Netherlands;,', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053210668', 'display_name': 'Jente van Staalduinen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}, {'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jente van Staalduinen', 'raw_affiliation_strings': ['Department of Cell Biology, Erasmus MC, 3000 CA Rotterdam, The Netherlands;,'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Erasmus MC, 3000 CA Rotterdam, The Netherlands;,', 'institution_ids': ['https://openalex.org/I2801952686', 'https://openalex.org/I913958620']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016167138', 'display_name': 'Ralph Stadhouders', 'orcid': 'https://orcid.org/0000-0002-1060-5607'}, 'institutions': [{'id': 'https://openalex.org/I913958620', 'display_name': 'Erasmus University Rotterdam', 'ror': 'https://ror.org/057w15z03', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I913958620']}, {'id': 'https://openalex.org/I2801952686', 'display_name': 'Erasmus MC', 'ror': 'https://ror.org/018906e22', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801952686']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ralph Stadhouders', 'raw_affiliation_strings': ['Department of Cell Biology, Erasmus MC, 3000 CA Rotterdam, The Netherlands;,', 'Department of Pulmonary Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Pulmonary Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}, {'raw_affiliation_string': 'Department of Cell Biology, Erasmus MC, 3000 CA Rotterdam, The Netherlands;,', 'institution_ids': ['https://openalex.org/I913958620', 'https://openalex.org/I2801952686']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.435, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 84, 'citation_normalized_percentile': {'value': 0.999788, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '22', 'issue': '1', 'first_page': '127', 'last_page': '146'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10184', 'display_name': 'Plant Molecular Biology Research', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/locus-control-region', 'display_name': 'Locus control region', 'score': 0.4544996}, {'id': 'https://openalex.org/keywords/enhancer-rnas', 'display_name': 'Enhancer RNAs', 'score': 0.4308135}], 'concepts': [{'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.9464161}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7040558}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.5993539}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5873674}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.58391184}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.549253}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.48725453}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.45929164}, {'id': 'https://openalex.org/C39981086', 'wikidata': 'https://www.wikidata.org/wiki/Q3455568', 'display_name': 'Locus control region', 'level': 5, 'score': 0.4544996}, {'id': 'https://openalex.org/C21784809', 'wikidata': 'https://www.wikidata.org/wiki/Q17119097', 'display_name': 'Enhancer RNAs', 'level': 5, 'score': 0.4308135}, {'id': 'https://openalex.org/C21592294', 'wikidata': 'https://www.wikidata.org/wiki/Q3238407', 'display_name': 'Regulatory sequence', 'level': 4, 'score': 0.42492926}, {'id': 'https://openalex.org/C27153228', 'wikidata': 'https://www.wikidata.org/wiki/Q3787274', 'display_name': 'Transcriptional regulation', 'level': 4, 'score': 0.42270896}], 'mesh': [{'descriptor_ui': 'D004742', 'descriptor_name': 'Enhancer Elements, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-genom-122220-093818', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-genom-122220-093818', 'source': {'id': 'https://openalex.org/S8095556', 'display_name': 'Annual Review of Genomics and Human Genetics', 'issn_l': '1527-8204', 'issn': ['1527-8204', '1545-293X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.eur.nl/en/publications/848eae34-3417-4078-b6e1-3c35c1f138bd', 'pdf_url': 'https://pure.eur.nl/files/56372252/Transcriptional_Regulation_by_Super_Enhancers_From_Discovery_to_Mechanisms.pdf', 'source': {'id': 'https://openalex.org/S4306401266', 'display_name': 'EUR Research Repository (Erasmus University Rotterdam)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I913958620', 'host_organization_name': 'Erasmus University Rotterdam', 'host_organization_lineage': ['https://openalex.org/I913958620'], 'host_organization_lineage_names': ['Erasmus University Rotterdam'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.eur.nl/ws/files/56372252/Transcriptional_Regulation_by_Super_Enhancers_From_Discovery_to_Mechanisms.pdf', 'pdf_url': 'https://pure.eur.nl/ws/files/56372252/Transcriptional_Regulation_by_Super_Enhancers_From_Discovery_to_Mechanisms.pdf', 'source': {'id': 'https://openalex.org/S4306401266', 'display_name': 'EUR Research Repository (Erasmus University Rotterdam)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I913958620', 'host_organization_name': 'Erasmus University Rotterdam', 'host_organization_lineage': ['https://openalex.org/I913958620'], 'host_organization_lineage_names': ['Erasmus University Rotterdam'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33951408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-genom-122220-093818', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-genom-122220-093818', 'source': {'id': 'https://openalex.org/S8095556', 'display_name': 'Annual Review of Genomics and Human Genetics', 'issn_l': '1527-8204', 'issn': ['1527-8204', '1545-293X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 145, 'referenced_works': ['https://openalex.org/W1484529414', 'https://openalex.org/W1529048149', 'https://openalex.org/W1606413960', 'https://openalex.org/W1625001989', 'https://openalex.org/W1832829702', 'https://openalex.org/W1964283168', 'https://openalex.org/W1968283357', 'https://openalex.org/W1969466735', 'https://openalex.org/W1970831058', 'https://openalex.org/W1971420993', 'https://openalex.org/W1971578941', 'https://openalex.org/W1971615450', 'https://openalex.org/W1972013835', 'https://openalex.org/W1975742243', 'https://openalex.org/W1978942031', 'https://openalex.org/W1986586739', 'https://openalex.org/W1991740019', 'https://openalex.org/W2000626262', 'https://openalex.org/W2002395443', 'https://openalex.org/W2002397775', 'https://openalex.org/W2004966039', 'https://openalex.org/W2006761445', 'https://openalex.org/W20086128', 'https://openalex.org/W2022465811', 'https://openalex.org/W2024841357', 'https://openalex.org/W2027703497', 'https://openalex.org/W2031013042', 'https://openalex.org/W2032619610', 'https://openalex.org/W2037164528', 'https://openalex.org/W2038218774', 'https://openalex.org/W2041171293', 'https://openalex.org/W2041611886', 'https://openalex.org/W2042358820', 'https://openalex.org/W2043187797', 'https://openalex.org/W2049395473', 'https://openalex.org/W2050579225', 'https://openalex.org/W2051784499', 'https://openalex.org/W2053572117', 'https://openalex.org/W2055643269', 'https://openalex.org/W2057087360', 'https://openalex.org/W2057893650', 'https://openalex.org/W2060484997', 'https://openalex.org/W2061555550', 'https://openalex.org/W2062408930', 'https://openalex.org/W2063815548', 'https://openalex.org/W2067956561', 'https://openalex.org/W2075024289', 'https://openalex.org/W2077122170', 'https://openalex.org/W2079407198', 'https://openalex.org/W2080567269', 'https://openalex.org/W2080670274', 'https://openalex.org/W2082414039', 'https://openalex.org/W2082793267', 'https://openalex.org/W2083073732', 'https://openalex.org/W2088135095', 'https://openalex.org/W2091775431', 'https://openalex.org/W2092941260', 'https://openalex.org/W2096998693', 'https://openalex.org/W2098412979', 'https://openalex.org/W2102707713', 'https://openalex.org/W2118299921', 'https://openalex.org/W2128151873', 'https://openalex.org/W2128355851', 'https://openalex.org/W2129842408', 'https://openalex.org/W2131511000', 'https://openalex.org/W2133484520', 'https://openalex.org/W2137310453', 'https://openalex.org/W2137465688', 'https://openalex.org/W2139066576', 'https://openalex.org/W2141340108', 'https://openalex.org/W2142071465', 'https://openalex.org/W2145144631', 'https://openalex.org/W2148486026', 'https://openalex.org/W2148966035', 'https://openalex.org/W2149454526', 'https://openalex.org/W2150013979', 'https://openalex.org/W2152531901', 'https://openalex.org/W2153145187', 'https://openalex.org/W2156066129', 'https://openalex.org/W2158053354', 'https://openalex.org/W2158919523', 'https://openalex.org/W2160856280', 'https://openalex.org/W2161671616', 'https://openalex.org/W2163353298', 'https://openalex.org/W2163884419', 'https://openalex.org/W2167732604', 'https://openalex.org/W2171442811', 'https://openalex.org/W2239249333', 'https://openalex.org/W2402820423', 'https://openalex.org/W2464000940', 'https://openalex.org/W2469912802', 'https://openalex.org/W2494187022', 'https://openalex.org/W2524507363', 'https://openalex.org/W2556513628', 'https://openalex.org/W2561961480', 'https://openalex.org/W2594764564', 'https://openalex.org/W2603000633', 'https://openalex.org/W2607363971', 'https://openalex.org/W2621774891', 'https://openalex.org/W267085019', 'https://openalex.org/W2725576187', 'https://openalex.org/W2761461280', 'https://openalex.org/W2782562502', 'https://openalex.org/W2783692764', 'https://openalex.org/W2785060777', 'https://openalex.org/W2785792383', 'https://openalex.org/W2786174959', 'https://openalex.org/W2787865536', 'https://openalex.org/W2790193774', 'https://openalex.org/W2790938332', 'https://openalex.org/W2793769859', 'https://openalex.org/W2802087233', 'https://openalex.org/W2808847099', 'https://openalex.org/W2809057270', 'https://openalex.org/W2809265915', 'https://openalex.org/W2812344549', 'https://openalex.org/W2894289085', 'https://openalex.org/W2897970825', 'https://openalex.org/W2901209536', 'https://openalex.org/W2906884244', 'https://openalex.org/W2942748350', 'https://openalex.org/W2945038365', 'https://openalex.org/W2945220048', 'https://openalex.org/W2949107687', 'https://openalex.org/W2949213644', 'https://openalex.org/W2952336494', 'https://openalex.org/W2956457862', 'https://openalex.org/W2963908148', 'https://openalex.org/W2964149073', 'https://openalex.org/W2971821708', 'https://openalex.org/W2974980872', 'https://openalex.org/W2984395420', 'https://openalex.org/W2990380375', 'https://openalex.org/W2994756760', 'https://openalex.org/W3000384293', 'https://openalex.org/W3007150393', 'https://openalex.org/W3008725968', 'https://openalex.org/W3008828407', 'https://openalex.org/W3012720150', 'https://openalex.org/W3045910546', 'https://openalex.org/W3087012180', 'https://openalex.org/W3109356327', 'https://openalex.org/W3109650778', 'https://openalex.org/W3112289427', 'https://openalex.org/W4234408131'], 'related_works': ['https://openalex.org/W4233294463', 'https://openalex.org/W2995519052', 'https://openalex.org/W2903161951', 'https://openalex.org/W2899714688', 'https://openalex.org/W2137310453', 'https://openalex.org/W2129874120', 'https://openalex.org/W2122113079', 'https://openalex.org/W2087652779', 'https://openalex.org/W2057105811', 'https://openalex.org/W1837809385'], 'abstract_inverted_index': {'Accurate': [0], 'control': [1, 61], 'of': [2, 14, 25, 33, 42, 71, 77, 80], 'gene': [3, 26, 34, 43, 93], 'expression': [4], 'in': [5, 55], 'the': [6, 10, 23, 29, 78, 81, 86], 'right': [7, 11], 'cell': [8], 'at': [9], 'moment': [12], 'is': [13], 'fundamental': [15], 'importance': [16], 'to': [17, 90], 'animal': [18], 'development': [19], 'and': [20, 63, 85], 'homeostasis.': [21], 'At': [22], 'heart': [24], 'regulation': [27], 'lie': [28], 'enhancers,': [30, 50], 'a': [31], 'class': [32], 'regulatory': [35, 94], 'elements': [36], 'that': [37], 'ensures': [38], 'precise': [39], 'spatiotemporal': [40], 'activation': [41], 'transcription.': [44], 'Mammalian': [45], 'genomes': [46], 'are': [47, 52], 'littered': [48], 'with': [49], 'which': [51], 'frequently': [53], 'organized': [54], 'cooperative': [56], 'clusters': [57], 'such': [58], 'as': [59], 'locus': [60], 'regions': [62], 'superenhancers.': [64], 'Here,': [65], 'we': [66], 'discuss': [67], 'our': [68], 'current': [69], 'knowledge': [70], 'enhancer': [72, 83], 'biology,': [73], 'including': [74], 'an': [75], 'overview': [76], 'discovery': [79], 'various': [82], 'subsets': [84], 'mechanistic': [87], 'models': [88], 'used': [89], 'explain': [91], 'their': [92], 'function.': [95]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3159317682', 'counts_by_year': [{'year': 2024, 'cited_by_count': 28}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 33}, {'year': 2021, 'cited_by_count': 6}], 'updated_date': '2025-01-06T17:34:23.481666', 'created_date': '2021-05-10'}