Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2784384431', 'doi': 'https://doi.org/10.2147/eb.s127812', 'title': 'Profile of tocilizumab and its potential in the treatment of giant cell arteritis', 'display_name': 'Profile of tocilizumab and its potential in the treatment of giant cell arteritis', 'publication_year': 2018, 'publication_date': '2018-01-01', 'ids': {'openalex': 'https://openalex.org/W2784384431', 'doi': 'https://doi.org/10.2147/eb.s127812', 'mag': '2784384431', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29416384', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5790065'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/eb.s127812', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=40238', 'source': {'id': 'https://openalex.org/S4210229303', 'display_name': 'Eye and Brain', 'issn_l': '1179-2744', 'issn': ['1179-2744'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=40238', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063268602', 'display_name': 'Susan P. Mollan', 'orcid': 'https://orcid.org/0000-0002-6314-4437'}, 'institutions': [{'id': 'https://openalex.org/I2799307867', 'display_name': 'Queen Elizabeth Hospital Birmingham', 'ror': 'https://ror.org/048emj907', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1308923049', 'https://openalex.org/I2799307867']}, {'id': 'https://openalex.org/I1308923049', 'display_name': 'University Hospitals Birmingham NHS Foundation Trust', 'ror': 'https://ror.org/014ja3n03', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1308923049']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Susan Mollan', 'raw_affiliation_strings': ['Birmingham Neuro-Ophthalmology Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham,', 'Institute of Metabolism and Systems Research, University of Birmingham,'], 'affiliations': [{'raw_affiliation_string': 'Birmingham Neuro-Ophthalmology Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham,', 'institution_ids': ['https://openalex.org/I2799307867', 'https://openalex.org/I1308923049']}, {'raw_affiliation_string': 'Institute of Metabolism and Systems Research, University of Birmingham,', 'institution_ids': ['https://openalex.org/I79619799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091485968', 'display_name': 'John Horsburgh', 'orcid': 'https://orcid.org/0000-0002-0642-7430'}, 'institutions': [{'id': 'https://openalex.org/I1308923049', 'display_name': 'University Hospitals Birmingham NHS Foundation Trust', 'ror': 'https://ror.org/014ja3n03', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1308923049']}, {'id': 'https://openalex.org/I2799307867', 'display_name': 'Queen Elizabeth Hospital Birmingham', 'ror': 'https://ror.org/048emj907', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1308923049', 'https://openalex.org/I2799307867']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John Horsburgh', 'raw_affiliation_strings': ['Birmingham Neuro-Ophthalmology Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham,'], 'affiliations': [{'raw_affiliation_string': 'Birmingham Neuro-Ophthalmology Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham,', 'institution_ids': ['https://openalex.org/I1308923049', 'https://openalex.org/I2799307867']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062360747', 'display_name': 'Bhaskar Dasgupta', 'orcid': 'https://orcid.org/0000-0002-5523-6534'}, 'institutions': [{'id': 'https://openalex.org/I2800288755', 'display_name': 'Southend University Hospital NHS Foundation Trust', 'ror': 'https://ror.org/05fa42p74', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800288755']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Bhaskar Dasgupta', 'raw_affiliation_strings': ['Department of Rheumatology, Southend University Hospital, Southend-on-Sea, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Rheumatology, Southend University Hospital, Southend-on-Sea, UK', 'institution_ids': ['https://openalex.org/I2800288755']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2320, 'currency': 'USD', 'value_usd': 2320, 'provenance': 'doaj'}, 'apc_paid': {'value': 2320, 'currency': 'USD', 'value_usd': 2320, 'provenance': 'doaj'}, 'fwci': 0.399, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.442511, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': 'Volume 10', 'issue': None, 'first_page': '1', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10697', 'display_name': 'Classification and Management of Vasculitides', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10697', 'display_name': 'Classification and Management of Vasculitides', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12438', 'display_name': 'Diagnosis and Management of Urticaria', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tocilizumab', 'display_name': 'Tocilizumab', 'score': 0.98459804}, {'id': 'https://openalex.org/keywords/giant-cell-arteritis', 'display_name': 'Giant Cell Arteritis', 'score': 0.577458}], 'concepts': [{'id': 'https://openalex.org/C2777178219', 'wikidata': 'https://www.wikidata.org/wiki/Q425154', 'display_name': 'Tocilizumab', 'level': 3, 'score': 0.98459804}, {'id': 'https://openalex.org/C2776712624', 'wikidata': 'https://www.wikidata.org/wiki/Q707816', 'display_name': 'Giant cell arteritis', 'level': 4, 'score': 0.9213314}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7751226}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.55006456}, {'id': 'https://openalex.org/C2776015282', 'wikidata': 'https://www.wikidata.org/wiki/Q644318', 'display_name': 'Vasculitis', 'level': 3, 'score': 0.52857524}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.51902354}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5038704}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.35370874}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.24186361}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.08181253}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/eb.s127812', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=40238', 'source': {'id': 'https://openalex.org/S4210229303', 'display_name': 'Eye and Brain', 'issn_l': '1179-2744', 'issn': ['1179-2744'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5790065', 'pdf_url': 'https://europepmc.org/articles/pmc5790065?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790065', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29416384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/eb.s127812', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=40238', 'source': {'id': 'https://openalex.org/S4210229303', 'display_name': 'Eye and Brain', 'issn_l': '1179-2744', 'issn': ['1179-2744'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 85, 'referenced_works': ['https://openalex.org/W1488642175', 'https://openalex.org/W1837022211', 'https://openalex.org/W1840567140', 'https://openalex.org/W1875891029', 'https://openalex.org/W1908449555', 'https://openalex.org/W1964525131', 'https://openalex.org/W1969421278', 'https://openalex.org/W1983310071', 'https://openalex.org/W1984510109', 'https://openalex.org/W1989068788', 'https://openalex.org/W1989745983', 'https://openalex.org/W1992126131', 'https://openalex.org/W1995278898', 'https://openalex.org/W1995328147', 'https://openalex.org/W1995928415', 'https://openalex.org/W1996291417', 'https://openalex.org/W2002076761', 'https://openalex.org/W2004589503', 'https://openalex.org/W2004923814', 'https://openalex.org/W2010568725', 'https://openalex.org/W2011487877', 'https://openalex.org/W2017223857', 'https://openalex.org/W2018118744', 'https://openalex.org/W2025492877', 'https://openalex.org/W2027647195', 'https://openalex.org/W2043298079', 'https://openalex.org/W2053328369', 'https://openalex.org/W2054059257', 'https://openalex.org/W2055026612', 'https://openalex.org/W2056768892', 'https://openalex.org/W2063485775', 'https://openalex.org/W2073838717', 'https://openalex.org/W2083407120', 'https://openalex.org/W2086583795', 'https://openalex.org/W2089566607', 'https://openalex.org/W2093961109', 'https://openalex.org/W2094111001', 'https://openalex.org/W2096493334', 'https://openalex.org/W2096862304', 'https://openalex.org/W2101528090', 'https://openalex.org/W2103495299', 'https://openalex.org/W2104030082', 'https://openalex.org/W2111894252', 'https://openalex.org/W2114308202', 'https://openalex.org/W2125212735', 'https://openalex.org/W2125398562', 'https://openalex.org/W2127445888', 'https://openalex.org/W2132810505', 'https://openalex.org/W2142907734', 'https://openalex.org/W2150186790', 'https://openalex.org/W2150952126', 'https://openalex.org/W2151858167', 'https://openalex.org/W2159685763', 'https://openalex.org/W2159897707', 'https://openalex.org/W2163480494', 'https://openalex.org/W2164921123', 'https://openalex.org/W2165958923', 'https://openalex.org/W2170001916', 'https://openalex.org/W2171355496', 'https://openalex.org/W2172108666', 'https://openalex.org/W2177530838', 'https://openalex.org/W2230391954', 'https://openalex.org/W2292169217', 'https://openalex.org/W2301051286', 'https://openalex.org/W2318380925', 'https://openalex.org/W2323838831', 'https://openalex.org/W2362038500', 'https://openalex.org/W2387687330', 'https://openalex.org/W2414416943', 'https://openalex.org/W2415640172', 'https://openalex.org/W2416094949', 'https://openalex.org/W2416485589', 'https://openalex.org/W2417793618', 'https://openalex.org/W2468787467', 'https://openalex.org/W2498871550', 'https://openalex.org/W2527887155', 'https://openalex.org/W2531581712', 'https://openalex.org/W2558363236', 'https://openalex.org/W2581891606', 'https://openalex.org/W2586880532', 'https://openalex.org/W2604543169', 'https://openalex.org/W2610358466', 'https://openalex.org/W2737436316', 'https://openalex.org/W4254038388', 'https://openalex.org/W4378195235'], 'related_works': ['https://openalex.org/W4205149088', 'https://openalex.org/W3096335653', 'https://openalex.org/W2792261031', 'https://openalex.org/W2784384431', 'https://openalex.org/W2737436316', 'https://openalex.org/W2550140927', 'https://openalex.org/W2307127799', 'https://openalex.org/W2275736852', 'https://openalex.org/W2093526042', 'https://openalex.org/W1968260519'], 'abstract_inverted_index': {'Abstract:': [0], 'Giant': [1], 'cell': [2, 122], 'arteritis': [3], '(GCA)': [4], 'remains': [5, 40], 'a': [6, 41, 59], 'medical': [7], 'emergency': [8], 'due': [9], 'to': [10, 62, 100], 'the': [11, 26, 64, 69, 72, 86, 108], 'threat': [12], 'of': [13, 28, 47, 58, 66, 71, 75, 88, 112], 'permanent': [14], 'sight': [15], 'loss.': [16], 'High-dose': [17], 'glucocorticoids': [18], '(GCs)': [19], 'are': [20, 32], 'effective': [21], 'in': [22, 25, 44, 114], 'inducing': [23], 'remission': [24], 'majority': [27], 'patients,': [29, 48], 'however,': [30], 'relapses': [31], 'common': [33], 'which': [34], 'lengthen': [35], 'GC': [36, 38], 'therapy.': [37], 'toxicity': [39], 'major': [42], 'morbidity': [43], 'this': [45], 'group': [46], 'and': [49, 110, 117], 'conventional': [50], 'steroid-sparing': [51], 'therapies': [52], 'have': [53, 82, 106], 'not': [54], 'yet': [55], 'shown': [56], 'enough': [57], 'clinical': [60, 80], 'benefit': [61], 'change': [63], 'standard': [65], 'care.': [67], 'As': [68], 'understanding': [70], 'underlying': [73], 'immunopathophysiology': [74], 'GCA': [76], 'has': [77, 98], 'increased,': [78], 'positive': [79], 'observations': [81], 'been': [83], 'made': [84], 'with': [85], 'use': [87], 'IL-6': [89], 'receptor': [90], 'inhibitor': [91], 'therapies,': [92], 'such': [93], 'as': [94], 'tocilizumab': [95], '(TCZ).': [96], 'This': [97], 'led': [99], 'prospective': [101], 'randomized': [102], 'control': [103], 'trials': [104], 'that': [105], 'highlighted': [107], 'safety': [109], 'efficacy': [111], 'TCZ': [113], 'both': [115], 'new-onset': [116], 'relapsing': [118], 'GCA.': [119], 'Keywords:': [120], 'giant': [121], 'arteritis,': [123, 125], 'temporal': [124], 'Horton': [126], 'disease,': [127], 'interleukin-6,': [128], 'tocilizumab,': [129], 'treatment': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2784384431', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-09-17T19:40:00.279560', 'created_date': '2018-02-02'}