Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W277899686', 'doi': 'https://doi.org/10.1007/bf02788565', 'title': 'The inhibitory effect of an EGF receptor-specific tyrosine kinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF I', 'display_name': 'The inhibitory effect of an EGF receptor-specific tyrosine kinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF I', 'publication_year': 1998, 'publication_date': '1998-10-01', 'ids': {'openalex': 'https://openalex.org/W277899686', 'doi': 'https://doi.org/10.1007/bf02788565', 'mag': '277899686', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9816541'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf02788565', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103923857', 'display_name': 'International Journal of Pancreatology', 'issn_l': '0169-4197', 'issn': ['0169-4197', '2363-5134'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310315801', 'host_organization_name': 'Humana Press', 'host_organization_lineage': ['https://openalex.org/P4310315801'], 'host_organization_lineage_names': ['Humana Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108513909', 'display_name': 'Masao Kobari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masao Kobari', 'raw_affiliation_strings': ['First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070435265', 'display_name': 'Björn Kullenberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Björn Kullenberg', 'raw_affiliation_strings': ['Department of Surgery, University Hospital, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, University Hospital, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021905552', 'display_name': 'Anders Björkman', 'orcid': 'https://orcid.org/0000-0003-0600-1365'}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Anders Björkman', 'raw_affiliation_strings': ['Department of Surgery, University Hospital, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, University Hospital, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112641883', 'display_name': 'Seiki Matsuno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Seiki Matsuno', 'raw_affiliation_strings': ['Department of Surgery, University Hospital, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, University Hospital, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037166555', 'display_name': 'Ingemar Ihse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ingemar Ihse', 'raw_affiliation_strings': ['Department of Surgery, University Hospital, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, University Hospital, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111623304', 'display_name': 'Jan Axelson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jan Axelson', 'raw_affiliation_strings': ['First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.415, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.514413, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 73}, 'biblio': {'volume': '24', 'issue': '2', 'first_page': '85', 'last_page': '95'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.7516314}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6080642}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5607516}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.5282133}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5230354}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.50534445}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.49670106}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.4538504}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4511664}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3970319}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3952502}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.1423406}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13450032}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12529892}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D020032', 'descriptor_name': 'Tyrphostins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007334', 'descriptor_name': 'Insulin-Like Growth Factor I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007334', 'descriptor_name': 'Insulin-Like Growth Factor I', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020032', 'descriptor_name': 'Tyrphostins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf02788565', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103923857', 'display_name': 'International Journal of Pancreatology', 'issn_l': '0169-4197', 'issn': ['0169-4197', '2363-5134'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310315801', 'host_organization_name': 'Humana Press', 'host_organization_lineage': ['https://openalex.org/P4310315801'], 'host_organization_lineage_names': ['Humana Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9816541', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.64}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W118213103', 'https://openalex.org/W1483755415', 'https://openalex.org/W1549590989', 'https://openalex.org/W1570334509', 'https://openalex.org/W1608647261', 'https://openalex.org/W1668194762', 'https://openalex.org/W1678579765', 'https://openalex.org/W1758076702', 'https://openalex.org/W1827870815', 'https://openalex.org/W1966112698', 'https://openalex.org/W1966867506', 'https://openalex.org/W1976570855', 'https://openalex.org/W1985466280', 'https://openalex.org/W1985832060', 'https://openalex.org/W1992401642', 'https://openalex.org/W2010979311', 'https://openalex.org/W2015083350', 'https://openalex.org/W2016842677', 'https://openalex.org/W2036417334', 'https://openalex.org/W2043132693', 'https://openalex.org/W2049613194', 'https://openalex.org/W2054507311', 'https://openalex.org/W2062863047', 'https://openalex.org/W2070126659', 'https://openalex.org/W2072031500', 'https://openalex.org/W2083354235', 'https://openalex.org/W2083369675', 'https://openalex.org/W2088054041', 'https://openalex.org/W2100932174', 'https://openalex.org/W2104379671', 'https://openalex.org/W2125292670', 'https://openalex.org/W2148251849', 'https://openalex.org/W2163958696', 'https://openalex.org/W2166091439', 'https://openalex.org/W2169434055', 'https://openalex.org/W2731594918', 'https://openalex.org/W96205076'], 'related_works': ['https://openalex.org/W4386496024', 'https://openalex.org/W4385899916', 'https://openalex.org/W4307860292', 'https://openalex.org/W3011987339', 'https://openalex.org/W2512058705', 'https://openalex.org/W2347992620', 'https://openalex.org/W2075312788', 'https://openalex.org/W2072481810', 'https://openalex.org/W1985998670', 'https://openalex.org/W1967360913'], 'abstract_inverted_index': {'Epidermal': [0], 'growth': [1, 73, 212, 291], 'factor': [2], '(EGF)': [3], 'increased': [4, 42, 161, 209, 234, 286, 316], 'the': [5, 9, 23, 34, 43, 49, 53, 85, 91, 98, 118, 133, 186, 203, 210, 220, 248, 267, 271, 277, 299, 304], 'cell': [6, 13, 35, 44, 54, 99, 105, 128, 162, 187, 199, 204, 211, 221, 227, 235, 249, 278, 287, 300, 317], 'number': [7, 36, 55, 100, 129, 163, 188, 205, 222, 236, 250, 301], 'of': [8, 22, 48, 69, 84, 93, 138, 181, 206], 'two': [10, 102], 'pancreatic': [11, 79, 103], 'cancer': [12, 80, 104], 'lines,': [14], 'MiaPaCa-2': [15, 107, 158, 184, 207], 'and': [16, 46, 67, 71, 95, 117, 140, 150, 168, 208, 302, 311], 'LN-36,': [17], 'in': [18, 32, 63, 78, 101, 111, 123, 144, 198, 270], 'vitro.': [19], 'A': [20], 'blockade': [21, 47], 'EGF-R': [24], 'tyrosine': [25, 153], 'kinase': [26, 154], 'with': [27, 132, 146, 160, 166, 232, 237, 256, 261, 284], 'tyrphostin': [28, 156], 'was': [29, 58, 88, 130, 178, 292], 'more': [30], 'efficient': [31], 'reducing': [33], 'than': [37], 'inhibiting': [38, 147, 192, 217, 268, 296], 'receptor': [39, 148], 'antibodies.': [40], 'IGF-1': [41, 96, 141, 201, 283, 305], 'number,': [45, 288], 'IGF-1-R': [50], 'initially': [51], 'decreased': [52, 185], 'that': [56], 'later': [57, 312], 'followed': [59], 'by': [60, 189, 214, 223, 251], 'an': [61, 151, 233, 285, 315], 'increase': [62, 197, 307], 'LN-36.': [64], 'The': [65, 82, 127, 136, 191, 216, 225, 295], 'receptors': [66], 'ligands': [68], 'EGF': [70, 94, 139, 231], 'insulin-like': [72], 'factor-1': [74], '(IGF-1)': [75], 'are': [76], 'overexpressed': [77], 'tissue.': [81], 'aim': [83], 'present': [86], 'experiments': [87], 'to': [89, 164, 183, 230, 265, 282], 'study': [90], 'effects': [92, 137], 'on': [97], 'lines.': [106], 'cells': [108, 122], 'were': [109, 142], 'grown': [110], '0.2%': [112], 'fetal': [113], 'calf': [114], 'serum': [115], '(FCS)': [116], 'newly': [119], 'established': [120], 'LN-36': [121, 226, 280], 'serum-free': [124], 'medium': [125], '(SFM).': [126], 'measured': [131], 'XTT': [134], 'method.': [135], 'studied': [143], 'combination': [145], 'antibodies': [149], 'EGF-R-specific': [152], 'inhibitor,': [155], 'B56.': [157], 'responded': [159, 229, 281], 'stimulation': [165, 260], 'EGF,': [167], 'at': [169, 240, 253], '10−8': [170], 'M': [171, 242], 'or': [172], 'higher': [173], 'concentrations': [174], 'a': [175, 238], 'dose-response': [176], 'pattern': [177], 'seen.': [179], 'Administration': [180], 'B56': [182, 246], '87%.': [190], 'EGF-R-Ab': [193, 269], 'only': [194], 'inhibited': [195], 'EGF-induced': [196], 'number.': [200, 279, 318], 'doubled': [202], 'induced': [213, 314], 'EGF.': [215, 262], 'IGF-1-R-Ab': [218, 297], 'reduced': [219, 247, 298], '10%.': [224], 'line': [228], 'maximum': [239], '5×10−9': [241], 'after': [243, 308], '96': [244], 'h.': [245], '90%': [252], '10−5': [254], 'M,': [255], 'less': [257], 'effect': [258], 'during': [259], 'In': [263], 'contrast': [264], 'B56,': [266], 'same': [272], 'experiment': [273], 'did': [274], 'not': [275, 293], 'reduce': [276], 'but': [289], 'EGF-stimulated': [290], 'influenced.': [294], 'suppressed': [303], 'stimulated': [306], '24': [309], 'h': [310], 'it': [313]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W277899686', 'counts_by_year': [], 'updated_date': '2024-12-14T16:56:36.496993', 'created_date': '2016-06-24'}