Title: The Influence of inositol hexaphosphate on proliferation and differentiation of human pancreatic adenocarcinoma cell line PC-3 and human pancreatic primary culture cell
Abstract: Objective To observe the effects of IP6 on human pancreatic adenocarcinoma cell line PC-3 and human pancreatic primary culture cell proliferation and differentiation in vitro.Methods Direct counting cells for cell growth curve,MTT test,flow cytometry test cell apoptosis were used to observe cell proliferation and differentiation.Results IP6 inhibited the growth of human pancreatic adenocarcinoma cell line PC-3 in a time and dose dependent manner.The effect was biggest when the level was 10mmol/L,but little difference with 5mmol/L and 10mmol/L.When less than 5mmol/L,IP6 almost can not effect the growth of human pancreatic primary culture cell;only little inhibition in 5mmol/L,and it was obviously inhibited in 10mmol/L.Conclusion When 5mmol/L,IP6 is the best inhibited density,which could kill tumor cell utmost and interfere normal cell in the lowest level.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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