Title: Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia
Abstract: Congenital cytomegalovirus infection (cCMV) is the most common congenital viral infection, present in 0.5% to 1.0% of live births, with up to 20% of infected children suffering from neurological impairments. 1 de Vries J.J.C. Korver A.M.H. Verkerk P.H. et al. Congenital cytomegalovirus infection in the Netherlands: birth prevalence and risk factors. J Med Virol. 2011; 83: 1777-1782https://doi.org/10.1002/jmv.22181 Crossref PubMed Scopus (28) Google Scholar A recent report found cCMV infections in 9.6% of children with cerebral palsy (CP). 2 Smithers-Sheedy H. Raynes-Greenow C. Badawi N. et al. Congenital cytomegalovirus among children with cerebral palsy. J Pediatr. 2017; 181 (e1): 267-271https://doi.org/10.1016/j.jpeds.2016.10.024 Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar CP is most commonly caused by cystic periventricular leukomalacia (c-PVL). The white matter lesions in PVL exhibited a similar pathologic appearance to those observed in cCMV infections in a small case control series. 3 Voorn J.P. van der Pouweis P.J. Vermeulen R.J. Barkhof F. Knaap M.S. van der Quantitative M.R. Imaging and spectroscopy in congenital Cytomegalovirus infection and periventricular leukomalacia suggests a comparable neuropathological substrate of the cerebral white matter lesions. Neuropediatrics. 2009; 40: 168-173https://doi.org/10.1055/s-0030-1249760 Crossref PubMed Scopus (1) Google Scholar Furthermore, the pathogenesis of PVL involves systemic hypoxic-ischemic injury and can be potentiated by infectious and inflammatory prenatal events, which are components of several major clinical risk factors such as preterm premature rupture of membranes (PPROM), chorioamnionitis, hypocapnia, and sepsis. 4 Resch B. Vollaard E. Maurer U. Haas J. Rosegger H. Müller W. Risk factors and determinants of neurodevelopmental outcome in cystic periventricular leucomalacia. Eur J Pediatr. 2000; 159: 663-670https://doi.org/10.1007/PL00008403 Crossref PubMed Scopus (99) Google Scholar , 5 Hatzidaki E. Giahnakis E. Maraka S. et al. Risk factors for periventricular leukomalacia. Acta Obstet Gynecol Scand. 2009; 88: 110-115https://doi.org/10.1080/00016340802503039 Crossref PubMed Scopus (39) Google Scholar
Publication Year: 2018
Publication Date: 2018-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 6
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