Publication Information

{'id': 'https://openalex.org/W2752626458', 'doi': 'https://doi.org/10.2147/jaa.s144100', 'title': 'Innovative treatments for severe refractory asthma: how to choose the right option for the right patient?', 'display_name': 'Innovative treatments for severe refractory asthma: how to choose the right option for the right patient?', 'publication_year': 2017, 'publication_date': '2017-08-01', 'ids': {'openalex': 'https://openalex.org/W2752626458', 'doi': 'https://doi.org/10.2147/jaa.s144100', 'mag': '2752626458', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28919788', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5587160'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/jaa.s144100', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=38197', 'source': {'id': 'https://openalex.org/S164068349', 'display_name': 'Journal of Asthma and Allergy', 'issn_l': '1178-6965', 'issn': ['1178-6965'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=38197', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070079416', 'display_name': 'Francesco Menzella', 'orcid': 'https://orcid.org/0000-0003-3950-5789'}, 'institutions': [{'id': 'https://openalex.org/I4210115422', 'display_name': 'Ospedale Santa Maria', 'ror': 'https://ror.org/02b68mf79', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115422']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Menzella', 'raw_affiliation_strings': ['Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy', 'institution_ids': ['https://openalex.org/I4210115422', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059138269', 'display_name': 'Carla Galeone', 'orcid': 'https://orcid.org/0000-0001-8102-9814'}, 'institutions': [{'id': 'https://openalex.org/I4210115422', 'display_name': 'Ospedale Santa Maria', 'ror': 'https://ror.org/02b68mf79', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115422']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Carla Galeone', 'raw_affiliation_strings': ['Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy', 'institution_ids': ['https://openalex.org/I4210115422', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072984614', 'display_name': 'Francesca Bertolini', 'orcid': 'https://orcid.org/0000-0003-4181-3895'}, 'institutions': [{'id': 'https://openalex.org/I173911158', 'display_name': 'Iowa State University', 'ror': 'https://ror.org/04rswrd78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I173911158']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Francesca Bertolini', 'raw_affiliation_strings': ['Department of Animal Science, Iowa State University, Ames, IA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Animal Science, Iowa State University, Ames, IA, USA', 'institution_ids': ['https://openalex.org/I173911158']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007333769', 'display_name': 'Claudia Castagnetti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115422', 'display_name': 'Ospedale Santa Maria', 'ror': 'https://ror.org/02b68mf79', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115422']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Claudia Castagnetti', 'raw_affiliation_strings': ['Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy', 'institution_ids': ['https://openalex.org/I4210115422', 'https://openalex.org/I4210153126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029476886', 'display_name': 'Nicola Facciolongo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210115422', 'display_name': 'Ospedale Santa Maria', 'ror': 'https://ror.org/02b68mf79', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115422']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Nicola Facciolongo', 'raw_affiliation_strings': ['Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy', 'institution_ids': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210115422']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 0.754, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.536709, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': 'Volume10', 'issue': None, 'first_page': '237', 'last_page': '247'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Respiratory and Cough-Related Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13770', 'display_name': 'Pediatric health and respiratory diseases', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/3604', 'display_name': 'Emergency Medical Services'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dupilumab', 'display_name': 'Dupilumab', 'score': 0.93277764}, {'id': 'https://openalex.org/keywords/bronchial-thermoplasty', 'display_name': 'Bronchial thermoplasty', 'score': 0.8905754}, {'id': 'https://openalex.org/keywords/omalizumab', 'display_name': 'Omalizumab', 'score': 0.8188847}, {'id': 'https://openalex.org/keywords/benralizumab', 'display_name': 'Benralizumab', 'score': 0.79908824}], 'concepts': [{'id': 'https://openalex.org/C2777832160', 'wikidata': 'https://www.wikidata.org/wiki/Q3306175', 'display_name': 'Mepolizumab', 'level': 4, 'score': 0.96320915}, {'id': 'https://openalex.org/C2779824493', 'wikidata': 'https://www.wikidata.org/wiki/Q5315925', 'display_name': 'Dupilumab', 'level': 3, 'score': 0.93277764}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9123668}, {'id': 'https://openalex.org/C2776550738', 'wikidata': 'https://www.wikidata.org/wiki/Q4973817', 'display_name': 'Bronchial thermoplasty', 'level': 4, 'score': 0.8905754}, {'id': 'https://openalex.org/C2778564945', 'wikidata': 'https://www.wikidata.org/wiki/Q415392', 'display_name': 'Omalizumab', 'level': 4, 'score': 0.8188847}, {'id': 'https://openalex.org/C2779185760', 'wikidata': 'https://www.wikidata.org/wiki/Q3638304', 'display_name': 'Benralizumab', 'level': 5, 'score': 0.79908824}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.65515614}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.6227387}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.22878319}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.099969774}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.09868023}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.08206013}, {'id': 'https://openalex.org/C2780769369', 'wikidata': 'https://www.wikidata.org/wiki/Q4375', 'display_name': 'Bronchoconstriction', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/jaa.s144100', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=38197', 'source': {'id': 'https://openalex.org/S164068349', 'display_name': 'Journal of Asthma and Allergy', 'issn_l': '1178-6965', 'issn': ['1178-6965'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/d4dcc82c34e74604b5d8ff97dd3e6a97', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5587160', 'pdf_url': 'https://europepmc.org/articles/pmc5587160?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587160', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28919788', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/jaa.s144100', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=38197', 'source': {'id': 'https://openalex.org/S164068349', 'display_name': 'Journal of Asthma and Allergy', 'issn_l': '1178-6965', 'issn': ['1178-6965'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 98, 'referenced_works': ['https://openalex.org/W1506450640', 'https://openalex.org/W1684695949', 'https://openalex.org/W1822329757', 'https://openalex.org/W1876031798', 'https://openalex.org/W1895198892', 'https://openalex.org/W1916962812', 'https://openalex.org/W1935628316', 'https://openalex.org/W1970648068', 'https://openalex.org/W1972336030', 'https://openalex.org/W1973755667', 'https://openalex.org/W1982723165', 'https://openalex.org/W1991886932', 'https://openalex.org/W1992096079', 'https://openalex.org/W1997864710', 'https://openalex.org/W2013105339', 'https://openalex.org/W2020991883', 'https://openalex.org/W2028190708', 'https://openalex.org/W2029319906', 'https://openalex.org/W2038556027', 'https://openalex.org/W2038883847', 'https://openalex.org/W2046396976', 'https://openalex.org/W2057883586', 'https://openalex.org/W2065797637', 'https://openalex.org/W2067324660', 'https://openalex.org/W2068464930', 'https://openalex.org/W2070763554', 'https://openalex.org/W2075699130', 'https://openalex.org/W2095754126', 'https://openalex.org/W2096018298', 'https://openalex.org/W2096421443', 'https://openalex.org/W2098276532', 'https://openalex.org/W2102629488', 'https://openalex.org/W2102751976', 'https://openalex.org/W2105020714', 'https://openalex.org/W2110534370', 'https://openalex.org/W2110882251', 'https://openalex.org/W2111115925', 'https://openalex.org/W2118291917', 'https://openalex.org/W2120018683', 'https://openalex.org/W2121469814', 'https://openalex.org/W2121954044', 'https://openalex.org/W2127482775', 'https://openalex.org/W2128472414', 'https://openalex.org/W2129649074', 'https://openalex.org/W2132166755', 'https://openalex.org/W2137025442', 'https://openalex.org/W2138355864', 'https://openalex.org/W2146852572', 'https://openalex.org/W2150035260', 'https://openalex.org/W2153395214', 'https://openalex.org/W2154323789', 'https://openalex.org/W2157860317', 'https://openalex.org/W2158472936', 'https://openalex.org/W2160134481', 'https://openalex.org/W2164367822', 'https://openalex.org/W2167829087', 'https://openalex.org/W2171522161', 'https://openalex.org/W2171524064', 'https://openalex.org/W2171776700', 'https://openalex.org/W2183689150', 'https://openalex.org/W2185031583', 'https://openalex.org/W2192072888', 'https://openalex.org/W2289369304', 'https://openalex.org/W2289995419', 'https://openalex.org/W2299467455', 'https://openalex.org/W2319946384', 'https://openalex.org/W2326738494', 'https://openalex.org/W2332563436', 'https://openalex.org/W2339358422', 'https://openalex.org/W2342693354', 'https://openalex.org/W2397684683', 'https://openalex.org/W2414878351', 'https://openalex.org/W2416385748', 'https://openalex.org/W2475158269', 'https://openalex.org/W2475880293', 'https://openalex.org/W2486626743', 'https://openalex.org/W2501022427', 'https://openalex.org/W2507725704', 'https://openalex.org/W2511120040', 'https://openalex.org/W2513258422', 'https://openalex.org/W2515900781', 'https://openalex.org/W2548196387', 'https://openalex.org/W2594033175', 'https://openalex.org/W2599638337', 'https://openalex.org/W2604291894', 'https://openalex.org/W2611110414', 'https://openalex.org/W2613362962', 'https://openalex.org/W2616060585', 'https://openalex.org/W2619633721', 'https://openalex.org/W2897571949', 'https://openalex.org/W2899000161', 'https://openalex.org/W2956481022', 'https://openalex.org/W3092449484', 'https://openalex.org/W3166421311', 'https://openalex.org/W4230835938', 'https://openalex.org/W4230991751', 'https://openalex.org/W4237026384', 'https://openalex.org/W4300846665'], 'related_works': ['https://openalex.org/W4367721016', 'https://openalex.org/W4309047244', 'https://openalex.org/W3212805450', 'https://openalex.org/W3142314375', 'https://openalex.org/W2996693098', 'https://openalex.org/W2982816949', 'https://openalex.org/W2972937804', 'https://openalex.org/W2757822157', 'https://openalex.org/W2752626458', 'https://openalex.org/W2507725704'], 'abstract_inverted_index': {'Abstract:': [0], 'The': [1, 195], 'increasing': [2, 128], 'understanding': [3], 'of': [4, 12, 17, 40, 44, 61, 103, 130, 134, 138, 145, 153, 192, 197, 209, 212], 'the': [5, 9, 30, 37, 80, 127, 135, 143, 146, 163, 172, 176, 184, 204, 207, 210, 229, 239], 'molecular': [6], 'biology': [7], 'and': [8, 20, 63, 88, 180, 236], 'etiopathogenetic': [10], 'mechanisms': [11, 60], 'asthma': [13, 50, 217], 'helps': [14], 'in': [15, 79, 174, 188], 'identification': [16, 144], 'numerous': [18], 'phenotypes': [19], 'endotypes,': [21], 'particularly': [22], 'for': [23, 68, 99, 215], 'severe': [24, 47, 246], 'refractory': [25, 216], 'asthma.': [26], 'For': [27], 'a': [28, 41, 100, 107, 114], 'decade,': [29], 'only': [31], 'available': [32, 78, 214], 'biologic': [33, 56], 'therapy': [34], 'that': [35, 225, 232, 242], 'met': [36], 'unmet': [38], 'needs': [39], 'specific': [42], 'group': [43], 'patients': [45, 179], 'with': [46, 58, 159], 'uncontrolled': [48], 'allergic': [49], 'has': [51, 95], 'been': [52, 66, 96], 'omalizumab.': [53], 'Recently,': [54], 'new': [55, 131, 167, 193], 'therapies': [57, 213], 'different': [59, 230], 'action': [62], 'targets': [64], 'have': [65], 'approved': [67], 'marketing,': [69], 'such': [70, 83], 'as': [71, 84], 'mepolizumab.': [72], 'Other': [73], 'promising': [74, 115], 'drugs': [75], 'will': [76, 226], 'be': [77, 124], 'coming': [81], 'years,': [82], 'reslizumab,': [85], 'benralizumab,': [86], 'dupilumab': [87], 'lebrikizumab.': [89], 'Moreover,': [90], 'since': [91], '2010,': [92], 'bronchial': [93, 252], 'thermoplasty': [94], 'successfully': [97], 'introduced': [98], 'limited': [101], 'number': [102], 'patients.': [104, 149], 'This': [105, 150], 'is': [106, 112, 141], 'nonpharmacologic': [108], 'endoscopic': [109], 'procedure': [110], 'which': [111], 'considered': [113], 'therapy,': [116], 'even': [117], 'though': [118], 'several': [119], 'aspects': [120, 186], 'still': [121, 142, 243], 'need': [122], 'to': [123, 165, 170, 202, 221, 237], 'clarified.': [125], 'Despite': [126], 'availability': [129], 'therapies,': [132], 'one': [133], 'major': [136], 'problems': [137], 'each': [139, 160], 'treatment': [140], 'most': [147, 177], 'suitable': [148], 'sudden': [151], 'abundance': [152], 'therapeutic': [154], 'options,': [155], 'sometimes': [156, 233], 'partially': [157, 234], 'overlapping': [158], 'other,': [161], 'increases': [162], 'importance': [164], 'identify': [166], 'biomarkers': [168, 254], 'useful': [169, 223], 'guide': [171], 'clinician': [173, 205], 'selecting': [175], 'appropriate': [178], 'treatments,': [181], 'without': [182], 'forgetting': [183], 'drug-economic': [185], 'seen': [187], 'elevated': [189], 'direct': [190], 'cost': [191], 'therapies.': [194], 'aim': [196], 'this': [198], 'review': [199], 'is,': [200], 'therefore,': [201], 'update': [203], 'on': [206], 'state': [208], 'art': [211], 'and,': [218], 'above': [219], 'all,': [220], 'give': [222], 'directions': [224], 'help': [227], 'understand': [228], 'choices': [231], 'overlap': [235], 'dispel': [238], 'possible': [240], 'doubts': [241], 'exist.': [244], 'Keywords:': [245], 'asthma,': [247], 'phenotypes,': [248], 'monoclonal': [249], 'antibodies,': [250], 'IL-5,': [251], 'thermoplasty,': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2752626458', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-12T00:54:14.835421', 'created_date': '2017-09-15'}