Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2751645603', 'doi': 'https://doi.org/10.1083/jcb.201702092', 'title': 'Karyopherins regulate nuclear pore complex barrier and transport function', 'display_name': 'Karyopherins regulate nuclear pore complex barrier and transport function', 'publication_year': 2017, 'publication_date': '2017-09-01', 'ids': {'openalex': 'https://openalex.org/W2751645603', 'doi': 'https://doi.org/10.1083/jcb.201702092', 'mag': '2751645603', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28864541', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5674887'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.201702092', 'pdf_url': 'https://rupress.org/jcb/article-pdf/216/11/3609/1373941/jcb_201702092.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://rupress.org/jcb/article-pdf/216/11/3609/1373941/jcb_201702092.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087770781', 'display_name': 'Larisa E. Kapinos', 'orcid': 'https://orcid.org/0000-0001-6101-0876'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Larisa E. Kapinos', 'raw_affiliation_strings': ['Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100821480', 'display_name': 'Binlu Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Binlu Huang', 'raw_affiliation_strings': ['Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034860044', 'display_name': 'Chantal Rencurel', 'orcid': 'https://orcid.org/0009-0008-8562-7211'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Chantal Rencurel', 'raw_affiliation_strings': ['Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024607246', 'display_name': 'Roderick Y. H. Lim', 'orcid': 'https://orcid.org/0000-0001-5015-6087'}, 'institutions': [{'id': 'https://openalex.org/I1850255', 'display_name': 'University of Basel', 'ror': 'https://ror.org/02s6k3f65', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I1850255']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Roderick Y.H. Lim', 'raw_affiliation_strings': ['Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland', 'institution_ids': ['https://openalex.org/I1850255']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5024607246'], 'corresponding_institution_ids': ['https://openalex.org/I1850255'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.157, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '216', 'issue': '11', 'first_page': '3609', 'last_page': '3624'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nucleoporin', 'display_name': 'Nucleoporin', 'score': 0.9328026}, {'id': 'https://openalex.org/keywords/ran', 'display_name': 'Ran', 'score': 0.9059087}, {'id': 'https://openalex.org/keywords/nuclear-pore', 'display_name': 'Nuclear pore', 'score': 0.89212203}, {'id': 'https://openalex.org/keywords/importin', 'display_name': 'Importin', 'score': 0.77267337}, {'id': 'https://openalex.org/keywords/nls', 'display_name': 'NLS', 'score': 0.70850515}, {'id': 'https://openalex.org/keywords/karyopherin', 'display_name': 'Karyopherin', 'score': 0.51908445}, {'id': 'https://openalex.org/keywords/barrier-function', 'display_name': 'Barrier function', 'score': 0.42850056}], 'concepts': [{'id': 'https://openalex.org/C68556195', 'wikidata': 'https://www.wikidata.org/wiki/Q3571630', 'display_name': 'Nucleoporin', 'level': 5, 'score': 0.9328026}, {'id': 'https://openalex.org/C160704184', 'wikidata': 'https://www.wikidata.org/wiki/Q18031028', 'display_name': 'Ran', 'level': 2, 'score': 0.9059087}, {'id': 'https://openalex.org/C126725582', 'wikidata': 'https://www.wikidata.org/wiki/Q30679', 'display_name': 'Nuclear pore', 'level': 3, 'score': 0.89212203}, {'id': 'https://openalex.org/C59157529', 'wikidata': 'https://www.wikidata.org/wiki/Q994741', 'display_name': 'Nuclear transport', 'level': 4, 'score': 0.88054836}, {'id': 'https://openalex.org/C133882971', 'wikidata': 'https://www.wikidata.org/wiki/Q24205524', 'display_name': 'Importin', 'level': 5, 'score': 0.77267337}, {'id': 'https://openalex.org/C186435350', 'wikidata': 'https://www.wikidata.org/wiki/Q1050365', 'display_name': 'NLS', 'level': 4, 'score': 0.70850515}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.62775755}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53120273}, {'id': 'https://openalex.org/C2777336224', 'wikidata': 'https://www.wikidata.org/wiki/Q3193641', 'display_name': 'Karyopherin', 'level': 5, 'score': 0.51908445}, {'id': 'https://openalex.org/C51911345', 'wikidata': 'https://www.wikidata.org/wiki/Q4863604', 'display_name': 'Barrier function', 'level': 2, 'score': 0.42850056}, {'id': 'https://openalex.org/C49805395', 'wikidata': 'https://www.wikidata.org/wiki/Q910966', 'display_name': 'Nuclear localization sequence', 'level': 3, 'score': 0.4037115}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.40060258}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.3509938}, {'id': 'https://openalex.org/C2780114586', 'wikidata': 'https://www.wikidata.org/wiki/Q40260', 'display_name': 'Cell nucleus', 'level': 3, 'score': 0.3487712}], 'mesh': [{'descriptor_ui': 'D022022', 'descriptor_name': 'Nuclear Pore', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D028901', 'descriptor_name': 'alpha Karyopherins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D028961', 'descriptor_name': 'beta Karyopherins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D021581', 'descriptor_name': 'Active Transport, Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022022', 'descriptor_name': 'Nuclear Pore', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D022022', 'descriptor_name': 'Nuclear Pore', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028861', 'descriptor_name': 'Nuclear Pore Complex Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D028861', 'descriptor_name': 'Nuclear Pore Complex Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D028861', 'descriptor_name': 'Nuclear Pore Complex Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028901', 'descriptor_name': 'alpha Karyopherins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D028901', 'descriptor_name': 'alpha Karyopherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028961', 'descriptor_name': 'beta Karyopherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028961', 'descriptor_name': 'beta Karyopherins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020931', 'descriptor_name': 'ran GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020931', 'descriptor_name': 'ran GTP-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.201702092', 'pdf_url': 'https://rupress.org/jcb/article-pdf/216/11/3609/1373941/jcb_201702092.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5674887', 'pdf_url': 'https://europepmc.org/articles/pmc5674887?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674887', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://edoc.unibas.ch/56012/3/3609.full.pdf', 'pdf_url': 'https://edoc.unibas.ch/56012/3/3609.full.pdf', 'source': {'id': 'https://openalex.org/S4306401836', 'display_name': 'edoc (University of Basel)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1850255', 'host_organization_name': 'University of Basel', 'host_organization_lineage': ['https://openalex.org/I1850255'], 'host_organization_lineage_names': ['University of Basel'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28864541', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.201702092', 'pdf_url': 'https://rupress.org/jcb/article-pdf/216/11/3609/1373941/jcb_201702092.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320310466', 'funder_display_name': 'Universität Basel', 'award_id': None}, {'funder': 'https://openalex.org/F4320320924', 'funder_display_name': 'Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung', 'award_id': '31003A_146612'}, {'funder': 'https://openalex.org/F4320333268', 'funder_display_name': 'Swiss Nanoscience Institute', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 79, 'referenced_works': ['https://openalex.org/W1503329918', 'https://openalex.org/W1589847606', 'https://openalex.org/W1729786173', 'https://openalex.org/W1911750425', 'https://openalex.org/W1968714309', 'https://openalex.org/W1968863167', 'https://openalex.org/W1975680667', 'https://openalex.org/W1982413468', 'https://openalex.org/W1983691941', 'https://openalex.org/W1984485152', 'https://openalex.org/W1991018390', 'https://openalex.org/W1991776028', 'https://openalex.org/W1995311028', 'https://openalex.org/W1996155262', 'https://openalex.org/W1996381709', 'https://openalex.org/W1996786959', 'https://openalex.org/W2001074096', 'https://openalex.org/W2002017977', 'https://openalex.org/W2003957660', 'https://openalex.org/W2005535845', 'https://openalex.org/W2009084328', 'https://openalex.org/W2009975411', 'https://openalex.org/W2013765041', 'https://openalex.org/W2020541498', 'https://openalex.org/W2021057156', 'https://openalex.org/W2022506021', 'https://openalex.org/W2026323590', 'https://openalex.org/W2028885314', 'https://openalex.org/W2038720967', 'https://openalex.org/W2047245819', 'https://openalex.org/W2047450338', 'https://openalex.org/W2048492672', 'https://openalex.org/W2059464647', 'https://openalex.org/W2059569036', 'https://openalex.org/W2061040254', 'https://openalex.org/W2063174199', 'https://openalex.org/W2063452741', 'https://openalex.org/W2063812024', 'https://openalex.org/W2071495839', 'https://openalex.org/W2073526608', 'https://openalex.org/W2081023618', 'https://openalex.org/W2098090751', 'https://openalex.org/W2098336767', 'https://openalex.org/W2104564852', 'https://openalex.org/W2105987719', 'https://openalex.org/W2106243159', 'https://openalex.org/W2108482921', 'https://openalex.org/W2110779567', 'https://openalex.org/W2115899882', 'https://openalex.org/W2124433428', 'https://openalex.org/W2126448555', 'https://openalex.org/W2129821375', 'https://openalex.org/W2133201628', 'https://openalex.org/W2134160801', 'https://openalex.org/W2137978942', 'https://openalex.org/W2143566830', 'https://openalex.org/W2146719608', 'https://openalex.org/W2148292198', 'https://openalex.org/W2149565486', 'https://openalex.org/W2156674577', 'https://openalex.org/W2158446517', 'https://openalex.org/W2162175822', 'https://openalex.org/W2165306451', 'https://openalex.org/W2191767682', 'https://openalex.org/W2193922719', 'https://openalex.org/W2220896177', 'https://openalex.org/W2264369621', 'https://openalex.org/W2311715732', 'https://openalex.org/W2322055506', 'https://openalex.org/W2323967330', 'https://openalex.org/W2342593775', 'https://openalex.org/W2395390247', 'https://openalex.org/W2403082327', 'https://openalex.org/W2403358826', 'https://openalex.org/W2439976878', 'https://openalex.org/W2529120786', 'https://openalex.org/W2581766311', 'https://openalex.org/W2804367574', 'https://openalex.org/W808997722'], 'related_works': ['https://openalex.org/W4244290910', 'https://openalex.org/W4210460713', 'https://openalex.org/W2891879415', 'https://openalex.org/W2172097982', 'https://openalex.org/W2166767358', 'https://openalex.org/W2125881857', 'https://openalex.org/W2125509876', 'https://openalex.org/W2105987719', 'https://openalex.org/W2065336404', 'https://openalex.org/W2051727992'], 'abstract_inverted_index': {'Nucleocytoplasmic': [0], 'transport': [1], 'is': [2, 66, 77, 91, 103], 'sustained': [3], 'by': [4, 79, 113], 'karyopherins': [5], '(Kaps)': [6], 'and': [7, 35, 41, 56, 72, 156], 'a': [8, 62, 161, 164], 'Ran': [9], 'guanosine': [10], 'triphosphate': [11], '(RanGTP)': [12], 'gradient': [13], 'that': [14, 51, 65, 145], 'imports': [15], 'nuclear': [16, 27], 'localization': [17], 'signal': [18], '(NLS)–specific': [19], 'cargoes': [20], '(NLS-cargoes)': [21], 'into': [22], 'the': [23, 59, 80, 132, 151], 'nucleus.': [24], 'However,': [25], 'how': [26], 'pore': [28], 'complex': [29], '(NPC)': [30], 'barrier': [31, 74, 118, 141], 'selectivity,': [32], 'Kap': [33], 'traffic,': [34], 'NLS-cargo': [36, 70], 'release': [37, 71, 158], 'are': [38, 135], 'systematically': [39], 'linked': [40], 'simultaneously': [42], 'regulated': [43], 'remains': [44], 'incoherent.': [45], 'In': [46], 'this': [47, 100], 'study,': [48], 'we': [49], 'show': [50], 'Kapα': [52], 'facilitates': [53], 'Kapβ1': [54, 84, 108, 123, 127], 'turnover': [55, 128], 'occupancy': [57], 'at': [58, 105], 'NPC': [60, 73, 117, 140, 152], 'in': [61], 'RanGTP-dependent': [63], 'manner': [64], 'directly': [67], 'coupled': [68], 'to': [69, 85], 'function.': [75, 142], 'This': [76], 'underpinned': [78], 'binding': [81], 'affinity': [82], 'of': [83, 150, 166], 'phenylalanine–glycine': [86], 'nucleoporins': [87], '(FG': [88], 'Nups),': [89], 'which': [90], 'comparable': [92], 'with': [93], 'RanGTP·Kapβ1,': [94], 'but': [95, 137], 'stronger': [96], 'for': [97, 139], 'Kapα·Kapβ1.': [98], 'On': [99], 'basis,': [101], 'RanGTP': [102, 114], 'ineffective': [104], 'releasing': [106], 'standalone': [107], 'from': [109], 'NPCs.': [110], 'Depleting': [111], 'Kapα·Kapβ1': [112], 'further': [115], 'abrogates': [116], 'function,': [119], 'whereas': [120], 'adding': [121], 'back': [122], 'rescues': [124], 'it': [125], 'while': [126], 'softens': [129], 'it.': [130], 'Therefore,': [131], 'FG': [133], 'Nups': [134], 'necessary': [136], 'insufficient': [138], 'We': [143], 'conclude': [144], 'Kaps': [146], 'constitute': [147], 'integral': [148], 'constituents': [149], 'whose': [153], 'barrier,': [154], 'transport,': [155], 'cargo': [157], 'functionalities': [159], 'establish': [160], 'continuum': [162], 'under': [163], 'mechanism': [165], 'Kap-centric': [167], 'control.': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2751645603', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-20T01:52:35.791862', 'created_date': '2017-09-15'}