Title: Effects of oxygen atomizing inhalation ambroxol on the inflammatory response to non-ventilatied lung undergoing one lung ventilation in rabbits
Abstract: Objective To investigate the effects of oxygen atomizing inhalation of low dose ambr- oxol on the inflammatory response to non-ventilatied lung undergoing one lung ventilation (OLV). Methods Fourty healthy rabbits were randomly divided into control group ( group C) receiving two-lung ventilation for two h, group OLV receiving right-lung ventilation for 2 h, group intravenous administration of ambroxol (IA) receiving intraveous injection of ambroxol 15 mg/kg, and group oxygen drive atomization inhalation of ambroxol (AIA) receiving oxygen atomizing inhalation of ambroxol 7.5 mg before right-lung ventilation for 2 h. The concentrations of tumor necrosis factor (TNF)-a, interleukin (IL)-113, IL-8, and IL-10 in left tracheal fluid were determined. Results TNF-oL, IL-113 and IL-8 concentrations in left tracheal fluid were (69. 88±18. 54), (61.54 ± 10. 92 ), and (49. 53 ± 8.28 ) ng/L respectively, which were significantly increased in group AIA as compared with those in group OLV [( 16.04 ± 1.41 ), ( 3.46±0. 27 ), and ( 16. 87 -± 1.73) ng/L] , while IL-10 concentration was ( 12. 60 ± 0. 98 ) ng/L, which was significantly higher in group AIA than in group OLV [( 16. 56 ± 1.36) rig/L] ( P 〈 0. O1 ). Conclusion Oxygen atom- izing inhalation of low dose ambroxol can inhibit the inflammatory response to non-ventilatied lung undergo- ing OLV in rabbits.
Key words:
Ambroxol; Respiratory, artificial; Inflammation; Rabbit
Publication Year: 2013
Publication Date: 2013-03-08
Language: en
Type: article
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