Publication Information

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'abstract_inverted_index': {'要約：血友病は当該因子活性レベルが臨床的重症度と相関を示すため，活性レベル<1': [0], 'IU/dL': [1, 3, 5], 'は重症，1～5': [2], 'は中等症，>5～<40': [4], 'は軽症と分類される．一方，活性レベルと臨床症状が相関しない症例もしばしば経験する．この乖離の要因の1': [6], 'つに，凝固1': [7], '段法による因子活性が生体内全体の止血凝固能を十分には反映しないことが考えられる．現在では細胞基盤型凝固モデルで生体内凝固機序が説明されており，この概念を反映するような，包括的な血液凝固機能評価の測定法が発展している．トロンボエラストグラフィー，凝固波形解析，トロンビン生成試験がその代表である．コンピューター化され，凝固過程の定性的評価，さらに算出したパラメータによる定量的評価も可能である．包括的凝固評価により，患者本来の凝血学的止血能を把握し，また出血の重症度予測や止血管理の方針や，長期にわたる止血方針も立案することも可能と考えられている．さらに先天性血友病のみならず，重篤な出血症状を呈する後天性血友病A': [8], 'および他の凝固障害症の診断や治療効果判定などにも多く応用されている．今後，止血関連研究や治療止血効果の評価法の中心的役割としてますます発展していくことが期待される．': [9]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2742663113', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-13T20:43:15.916015', 'created_date': '2017-08-17'}