Publication Information

{'id': 'https://openalex.org/W2738441173', 'doi': 'https://doi.org/10.1016/j.gde.2017.07.003', 'title': 'Chemical reprogramming and transdifferentiation', 'display_name': 'Chemical reprogramming and transdifferentiation', 'publication_year': 2017, 'publication_date': '2017-07-26', 'ids': {'openalex': 'https://openalex.org/W2738441173', 'doi': 'https://doi.org/10.1016/j.gde.2017.07.003', 'mag': '2738441173', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28755566'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.gde.2017.07.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116174365', 'display_name': 'Current Opinion in Genetics & Development', 'issn_l': '0959-437X', 'issn': ['0959-437X', '1879-0380'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.gde.2017.07.003', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075580925', 'display_name': 'Xin Xie', 'orcid': 'https://orcid.org/0000-0003-2314-4800'}, 'institutions': [{'id': 'https://openalex.org/I4210126186', 'display_name': 'National Center for Drug Screening', 'ror': 'https://ror.org/0384ghs60', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126186']}, {'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xin Xie', 'raw_affiliation_strings': ['CAS Key Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China', 'Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China'], 'affiliations': [{'raw_affiliation_string': 'CAS Key Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China', 'institution_ids': ['https://openalex.org/I4210126186', 'https://openalex.org/I4210112820']}, {'raw_affiliation_string': 'Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100560640', 'display_name': 'Yanbin Fu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanbin Fu', 'raw_affiliation_strings': ['Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100414648', 'display_name': 'Jian Liu', 'orcid': 'https://orcid.org/0000-0002-0095-8978'}, 'institutions': [{'id': 'https://openalex.org/I4210126186', 'display_name': 'National Center for Drug Screening', 'ror': 'https://ror.org/0384ghs60', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126186']}, {'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Liu', 'raw_affiliation_strings': ['CAS Key Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China'], 'affiliations': [{'raw_affiliation_string': 'CAS Key Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China', 'institution_ids': ['https://openalex.org/I4210126186', 'https://openalex.org/I4210112820']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5075580925'], 'corresponding_institution_ids': ['https://openalex.org/I4210126186', 'https://openalex.org/I4210112820', 'https://openalex.org/I116953780'], 'apc_list': {'value': 4050, 'currency': 'USD', 'value_usd': 4050, 'provenance': 'doaj'}, 'apc_paid': {'value': 4050, 'currency': 'USD', 'value_usd': 4050, 'provenance': 'doaj'}, 'fwci': 1.076, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 83, 'citation_normalized_percentile': {'value': 0.999737, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '46', 'issue': None, 'first_page': '104', 'last_page': '113'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transdifferentiation', 'display_name': 'Transdifferentiation', 'score': 0.97880125}, {'id': 'https://openalex.org/keywords/reprogramming', 'display_name': 'Reprogramming', 'score': 0.9691522}], 'concepts': [{'id': 'https://openalex.org/C60870556', 'wikidata': 'https://www.wikidata.org/wiki/Q2300675', 'display_name': 'Transdifferentiation', 'level': 3, 'score': 0.97880125}, {'id': 'https://openalex.org/C77255625', 'wikidata': 'https://www.wikidata.org/wiki/Q402093', 'display_name': 'Reprogramming', 'level': 3, 'score': 0.9691522}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.78193855}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.7440934}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.67403203}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5269576}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.42409706}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.41784692}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38868397}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.38235337}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31263965}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.27939782}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.12909481}], 'mesh': [{'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D065150', 'descriptor_name': 'Cellular Reprogramming', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065150', 'descriptor_name': 'Cellular Reprogramming', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D065150', 'descriptor_name': 'Cellular Reprogramming', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054852', 'descriptor_name': 'Small Molecule Libraries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054852', 'descriptor_name': 'Small Molecule Libraries', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.gde.2017.07.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116174365', 'display_name': 'Current Opinion in Genetics & Development', 'issn_l': '0959-437X', 'issn': ['0959-437X', '1879-0380'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28755566', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.gde.2017.07.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116174365', 'display_name': 'Current Opinion in Genetics & Development', 'issn_l': '0959-437X', 'issn': ['0959-437X', '1879-0380'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.71, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31371511'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81425024'}], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1819927554', 'https://openalex.org/W1866852956', 'https://openalex.org/W1932303130', 'https://openalex.org/W1950098865', 'https://openalex.org/W1954039280', 'https://openalex.org/W1968310639', 'https://openalex.org/W1972298775', 'https://openalex.org/W1985147449', 'https://openalex.org/W1986595047', 'https://openalex.org/W2001419937', 'https://openalex.org/W2003315801', 'https://openalex.org/W2023238436', 'https://openalex.org/W2025696225', 'https://openalex.org/W2030406325', 'https://openalex.org/W2033500695', 'https://openalex.org/W2047015004', 'https://openalex.org/W2052726917', 'https://openalex.org/W2059223857', 'https://openalex.org/W2061632247', 'https://openalex.org/W2068897625', 'https://openalex.org/W2080914918', 'https://openalex.org/W2082714048', 'https://openalex.org/W2090362288', 'https://openalex.org/W2098511833', 'https://openalex.org/W2101569447', 'https://openalex.org/W2102020781', 'https://openalex.org/W2118430622', 'https://openalex.org/W2125987139', 'https://openalex.org/W2126780067', 'https://openalex.org/W2128128123', 'https://openalex.org/W2128940002', 'https://openalex.org/W2136541538', 'https://openalex.org/W2138977668', 'https://openalex.org/W2139697647', 'https://openalex.org/W2142046859', 'https://openalex.org/W2146939258', 'https://openalex.org/W2151220680', 'https://openalex.org/W2157546854', 'https://openalex.org/W2158258345', 'https://openalex.org/W2189937132', 'https://openalex.org/W2196955637', 'https://openalex.org/W2256191215', 'https://openalex.org/W2303476553', 'https://openalex.org/W2344920256', 'https://openalex.org/W2345033668', 'https://openalex.org/W2345071900', 'https://openalex.org/W2474671240', 'https://openalex.org/W2479215566', 'https://openalex.org/W2501155544', 'https://openalex.org/W2551571706', 'https://openalex.org/W2553349418', 'https://openalex.org/W2565566948', 'https://openalex.org/W590480505'], 'related_works': ['https://openalex.org/W4254937032', 'https://openalex.org/W3169544955', 'https://openalex.org/W3083924761', 'https://openalex.org/W3029540856', 'https://openalex.org/W2744405843', 'https://openalex.org/W2738441173', 'https://openalex.org/W2418603484', 'https://openalex.org/W2243107914', 'https://openalex.org/W2005182538', 'https://openalex.org/W1999800789'], 'abstract_inverted_index': {'The': [0, 17], 'revolutionizing': [1], 'somatic': [2, 49, 142], 'cell': [3, 11, 50, 58], 'reprogramming/transdifferentiation': [4, 51, 152], 'technologies': [5], 'provide': [6], 'a': [7, 86], 'new': [8], 'path': [9], 'for': [10, 20, 104], 'replacement': [12], 'therapies': [13], 'and': [14, 62, 80, 88, 153, 157], 'drug': [15], 'screening.': [16], 'original': [18], 'method': [19], 'reprogramming': [21, 114], 'involves': [22], 'the': [23, 31, 35, 109, 123, 147, 155], 'delivery': [24, 56], 'of': [25, 106, 150], 'exogenous': [26], 'transcription': [27], 'factors,': [28], 'leading': [29], 'to': [30, 44, 67, 83, 100, 113], 'safety': [32], 'concerns': [33], 'about': [34], 'possible': [36], 'genome': [37], 'integration.': [38], 'Many': [39], 'efforts': [40], 'have': [41, 72, 95, 130], 'been': [42, 96], 'taken': [43], 'avoid': [45], 'genetic': [46], 'alteration': [47], 'in': [48, 85, 119, 134, 162], 'by': [52], 'using': [53], 'non-integrating': [54], 'gene': [55], 'approaches,': [57], 'membrane': [59], 'permeable': [60], 'proteins,': [61], 'small': [63, 93, 110, 127], 'molecule': [64, 111, 128], 'compounds.': [65], 'Compared': [66], 'other': [68], 'methods,': [69], 'small-molecule': [70], 'compounds': [71], 'several': [73], 'unique': [74], 'advantages,': [75], 'such': [76], 'as': [77, 98], 'structural': [78], 'versatility': [79], 'being': [81], 'easy': [82], 'control': [84], 'time-dependent': [87], 'concentration-dependent': [89], 'way.': [90], 'More': [91], 'importantly,': [92], 'molecules': [94], 'used': [97], 'drugs': [99], 'treat': [101], 'human': [102], 'diseases': [103], 'thousands': [105], 'years.': [107], 'So': [108], 'approach': [112], 'might': [115], 'be': [116], 'more': [117], 'acceptable': [118], 'clinical-related': [120], 'uses.': [121], 'In': [122], 'past': [124], 'few': [125], 'years,': [126], 'approaches': [129], 'made': [131], 'significant': [132], 'progresses': [133], 'inducing': [135], 'pluripotent': [136], 'or': [137], 'functional': [138], 'differentiated': [139], 'cells': [140], 'from': [141], 'cells.': [143], 'Here': [144], 'we': [145], 'review': [146], 'recent': [148], 'achievements': [149], 'chemical': [151], 'discuss': [154], 'advantages': [156], 'challenges': [158], 'facing': [159], 'this': [160], 'strategy': [161], 'future': [163], 'applications.': [164]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2738441173', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-02T13:19:52.177530', 'created_date': '2017-07-31'}