Publication Information

{'id': 'https://openalex.org/W2005182538', 'doi': 'https://doi.org/10.1161/circresaha.111.249235', 'title': 'Progress in the Reprogramming of Somatic Cells', 'display_name': 'Progress in the Reprogramming of Somatic Cells', 'publication_year': 2013, 'publication_date': '2013-01-31', 'ids': {'openalex': 'https://openalex.org/W2005182538', 'doi': 'https://doi.org/10.1161/circresaha.111.249235', 'mag': '2005182538', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23371904', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3790469'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.111.249235', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.249235', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.249235', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102217332', 'display_name': 'Tianhua Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tianhua Ma', 'raw_affiliation_strings': ['From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I1321430492', 'https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083685156', 'display_name': 'Min Xie', 'orcid': 'https://orcid.org/0000-0002-2967-3490'}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Min Xie', 'raw_affiliation_strings': ['From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I1321430492', 'https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103430755', 'display_name': 'Timothy Laurent', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy Laurent', 'raw_affiliation_strings': ['From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I1321430492', 'https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008419499', 'display_name': 'Sheng Ding', 'orcid': 'https://orcid.org/0000-0002-3354-1263'}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sheng Ding', 'raw_affiliation_strings': ['From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I1321430492', 'https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.058, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 118, 'citation_normalized_percentile': {'value': 0.999731, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '112', 'issue': '3', 'first_page': '562', 'last_page': '574'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12264', 'display_name': 'Tissue Engineering and Regenerative Medicine', 'score': 0.984, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transdifferentiation', 'display_name': 'Transdifferentiation', 'score': 0.9695144}, {'id': 'https://openalex.org/keywords/reprogramming', 'display_name': 'Reprogramming', 'score': 0.9587263}, {'id': 'https://openalex.org/keywords/regenerative-medicine', 'display_name': 'Regenerative Medicine', 'score': 0.55559325}, {'id': 'https://openalex.org/keywords/cell-type', 'display_name': 'Cell type', 'score': 0.50869495}], 'concepts': [{'id': 'https://openalex.org/C60870556', 'wikidata': 'https://www.wikidata.org/wiki/Q2300675', 'display_name': 'Transdifferentiation', 'level': 3, 'score': 0.9695144}, {'id': 'https://openalex.org/C77255625', 'wikidata': 'https://www.wikidata.org/wiki/Q402093', 'display_name': 'Reprogramming', 'level': 3, 'score': 0.9587263}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.9227827}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.7438169}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.64040637}, {'id': 'https://openalex.org/C10854531', 'wikidata': 'https://www.wikidata.org/wiki/Q1061415', 'display_name': 'Regenerative medicine', 'level': 3, 'score': 0.55559325}, {'id': 'https://openalex.org/C189014844', 'wikidata': 'https://www.wikidata.org/wiki/Q189118', 'display_name': 'Cell type', 'level': 3, 'score': 0.50869495}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.48625338}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.48589295}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.46697092}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.4370277}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.32072031}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.30532685}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.2872638}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21794793}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D065150', 'descriptor_name': 'Cellular Reprogramming', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D057026', 'descriptor_name': 'Induced Pluripotent Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054338', 'descriptor_name': 'Cell Transdifferentiation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D065150', 'descriptor_name': 'Cellular Reprogramming', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057026', 'descriptor_name': 'Induced Pluripotent Stem Cells', 'qualifier_ui': 'Q000637', 'qualifier_name': 'transplantation', 'is_major_topic': False}, {'descriptor_ui': 'D057026', 'descriptor_name': 'Induced Pluripotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057026', 'descriptor_name': 'Induced Pluripotent Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.111.249235', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.249235', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3790469', 'pdf_url': 'https://europepmc.org/articles/pmc3790469?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790469', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/27v3x9zd', 'pdf_url': 'https://escholarship.org/content/qt27v3x9zd/qt27v3x9zd.pdf?t=rst8wz', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23371904', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circresaha.111.249235', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.111.249235', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.66, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 96, 'referenced_works': ['https://openalex.org/W1587712169', 'https://openalex.org/W1965898965', 'https://openalex.org/W1966969776', 'https://openalex.org/W1967210596', 'https://openalex.org/W1967729506', 'https://openalex.org/W1969015262', 'https://openalex.org/W1971463847', 'https://openalex.org/W1972334415', 'https://openalex.org/W1974012180', 'https://openalex.org/W1974773432', 'https://openalex.org/W1983802599', 'https://openalex.org/W1986500594', 'https://openalex.org/W1986595047', 'https://openalex.org/W1987167495', 'https://openalex.org/W1987774343', 'https://openalex.org/W1988294855', 'https://openalex.org/W1991037959', 'https://openalex.org/W1994142477', 'https://openalex.org/W1996732700', 'https://openalex.org/W1999038855', 'https://openalex.org/W1999519607', 'https://openalex.org/W2001284661', 'https://openalex.org/W2002943691', 'https://openalex.org/W2008365696', 'https://openalex.org/W2010672807', 'https://openalex.org/W2017438799', 'https://openalex.org/W2025738240', 'https://openalex.org/W2027833338', 'https://openalex.org/W2031569048', 'https://openalex.org/W2032058920', 'https://openalex.org/W2032570745', 'https://openalex.org/W2039551265', 'https://openalex.org/W2043457504', 'https://openalex.org/W2045619208', 'https://openalex.org/W2046013132', 'https://openalex.org/W2047015004', 'https://openalex.org/W2050689355', 'https://openalex.org/W2055327776', 'https://openalex.org/W2057437339', 'https://openalex.org/W2057641653', 'https://openalex.org/W2058553784', 'https://openalex.org/W2059223857', 'https://openalex.org/W2061837158', 'https://openalex.org/W2067423804', 'https://openalex.org/W2070354412', 'https://openalex.org/W2070672434', 'https://openalex.org/W2072239613', 'https://openalex.org/W2076486071', 'https://openalex.org/W2077806591', 'https://openalex.org/W2081620485', 'https://openalex.org/W2081628067', 'https://openalex.org/W2081970735', 'https://openalex.org/W2083462941', 'https://openalex.org/W2084562248', 'https://openalex.org/W2086851461', 'https://openalex.org/W2093155802', 'https://openalex.org/W2093522429', 'https://openalex.org/W2093888082', 'https://openalex.org/W2095546080', 'https://openalex.org/W2097259163', 'https://openalex.org/W2098597036', 'https://openalex.org/W2102560467', 'https://openalex.org/W2104708641', 'https://openalex.org/W2105199381', 'https://openalex.org/W2106485710', 'https://openalex.org/W2106844301', 'https://openalex.org/W2111920812', 'https://openalex.org/W2112485709', 'https://openalex.org/W2114206069', 'https://openalex.org/W2123970448', 'https://openalex.org/W2125691342', 'https://openalex.org/W2125987139', 'https://openalex.org/W2126376889', 'https://openalex.org/W2126409708', 'https://openalex.org/W2126580353', 'https://openalex.org/W2126780067', 'https://openalex.org/W2128940002', 'https://openalex.org/W2130519358', 'https://openalex.org/W2134328115', 'https://openalex.org/W2136541538', 'https://openalex.org/W2138248682', 'https://openalex.org/W2138977668', 'https://openalex.org/W2141856502', 'https://openalex.org/W2142046859', 'https://openalex.org/W2142744987', 'https://openalex.org/W2145615770', 'https://openalex.org/W2151220680', 'https://openalex.org/W2152483372', 'https://openalex.org/W2155507705', 'https://openalex.org/W2158979552', 'https://openalex.org/W2164012688', 'https://openalex.org/W2166599552', 'https://openalex.org/W2166628699', 'https://openalex.org/W2167121336', 'https://openalex.org/W2167202160', 'https://openalex.org/W2168665601'], 'related_works': ['https://openalex.org/W4254937032', 'https://openalex.org/W3083924761', 'https://openalex.org/W3029540856', 'https://openalex.org/W2744405843', 'https://openalex.org/W2738441173', 'https://openalex.org/W2418603484', 'https://openalex.org/W2415743749', 'https://openalex.org/W2243107914', 'https://openalex.org/W2005182538', 'https://openalex.org/W1999800789'], 'abstract_inverted_index': {'Pluripotent': [0], 'stem': [1, 41, 53], 'cells': [2, 10], 'can': [3, 107], 'differentiate': [4], 'into': [5], 'nearly': [6], 'all': [7], 'types': [8], 'of': [9, 38, 57, 66, 100, 122, 140, 153, 173, 194, 206, 213, 222], 'in': [11, 73, 159, 210, 231], 'the': [12, 60, 96, 120, 180, 211, 219], 'body.': [13], 'This': [14, 171], 'unique': [15], 'potential': [16], 'provides': [17], 'significant': [18], 'promise': [19], 'for': [20, 133], 'cell-based': [21], 'therapies': [22], 'to': [23, 49, 92, 119, 145, 162], 'restore': [24], 'tissues': [25, 125], 'or': [26, 34, 70, 165], 'organs': [27, 127], 'destroyed': [28], 'by': [29], 'injuries,': [30], 'degenerative': [31], 'diseases,': [32], 'aging,': [33], 'cancer.': [35], 'The': [36], 'discovery': [37], 'induced': [39], 'pluripotent': [40, 52], 'cell': [42, 143], '(iPSC)': [43], 'technology': [44], 'offers': [45], 'a': [46, 89, 150, 191], 'possible': [47], 'strategy': [48, 91, 132], 'generate': [50], 'patient-specific': [51, 124], 'cells.': [54, 200, 238], 'However,': [55], 'because': [56], 'concerns': [58], 'about': [59], 'specificity,': [61], 'efficiency,': [62], 'kinetics,': [63], 'and': [64, 94, 112, 126, 178, 227], 'safety': [65], 'iPSC': [67, 97, 115, 160, 167, 186, 223], 'reprogramming,': [68], 'improvements': [69], 'fundamental': [71], 'changes': [72], 'this': [74], 'process': [75], 'are': [76], 'required': [77], 'before': [78], 'their': [79], 'effective': [80], 'clinical': [81], 'use.': [82], 'A': [83], 'chemical': [84], 'approach': [85], 'is': [86, 136], 'regarded': [87], 'as': [88], 'promising': [90], 'improve': [93, 114], 'change': [95], 'process.': [98], 'Dozens': [99], 'small': [101, 207], 'molecules': [102], 'have': [103], 'been': [104], 'identified': [105], 'that': [106], 'functionally': [108], 'replace': [109], 'reprogramming': [110, 187], 'factors': [111, 157], 'significantly': [113], 'reprogramming.': [116], 'In': [117, 215], 'addition': [118], 'prospect': [121], 'deriving': [123], 'from': [128], 'iPSCs,': [129], 'another': [130], 'attractive': [131], 'regenerative': [134], 'medicine': [135], 'transdifferentiation—the': [137], 'direct': [138], 'conversion': [139], 'one': [141], 'somatic': [142], 'type': [144, 172], 'another.': [146], 'Recent': [147], 'studies': [148], 'revealed': [149], 'new': [151, 220], 'paradigm': [152], 'transdifferentiation:': [154], 'using': [155], 'transcription': [156, 168, 224], 'used': [158], 'generation': [161, 212], 'induce': [163], 'transdifferentiation': [164, 174, 226], 'called': [166], 'factor–based': [169, 225], 'transdifferentiation.': [170], 'not': [175], 'only': [176], 'reveals': [177], 'uses': [179], 'developmentally': [181], 'plastic': [182], 'intermediates': [183], 'generated': [184], 'during': [185], 'but': [188], 'also': [189], 'produces': [190], 'wide': [192], 'range': [193], 'cells,': [195, 235], 'including': [196], 'expandable': [197], 'tissue-specific': [198], 'precursor': [199], 'Here,': [201], 'we': [202, 217], 'review': [203], 'recent': [204], 'progress': [205], 'molecule': [208], 'approaches': [209], 'iPSCs.': [214], 'addition,': [216], 'summarize': [218], 'concept': [221], 'discuss': [228], 'its': [229], 'application': [230], 'generating': [232], 'various': [233], 'lineage-specific': [234], 'especially': [236], 'cardiovascular': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2005182538', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 10}], 'updated_date': '2025-01-02T10:49:19.463109', 'created_date': '2016-06-24'}