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'pathophysiological': [215, 497], 'chain': [216, 780, 1437], 'events': [218, 782, 1440, 1495], 'linking': [219, 362, 565], 'chronic': [220, 286, 325, 566, 625, 660, 716, 1454, 1535], 'with': [223, 298, 547, 569, 753, 788, 843, 1000, 1037, 1048, 1367, 1420, 2045, 2450, 2457, 2692], '(CVD)': [226], 'includes': [227], 'dysregulation': [228, 642], 'hypothalamic–pituitary–adrenal': [231, 1357], 'axis': [232], 'autonomic': [236, 1004, 1034], 'nervous': [237, 1005, 1035, 1809], 'system.': [238], 'Among': [239], 'physiological': [241, 420, 513, 641, 1707], 'changes': [242], 'are': [243, 437, 484, 528, 619, 807, 881, 916, 1149, 1311, 1345, 1525, 1558], 'increased': [244, 247, 674, 929, 1014], 'rate,': [246, 1019], 'blood': [248, 687, 1015, 1043], 'pressure,': [249], 'energy': [250], 'mobilization,': [251], 'decreased': [252], 'insulin': [253], 'sensitivity,': [254], 'endothelial': [256, 697, 3205], 'dysfunction.1': [257], 'These': [258], 'processes': [259, 618, 2140], 'ultimately': [261], 'result': [262], 'manifest': [264], 'CVD.': [265], 'terms': [267, 1202], 'population': [269], 'health,': [270, 3209], 'largest': [272], 'part': [273], 'burden': [276, 1533], 'CVD': [278, 1158, 1166, 1422, 1899], 'attributed': [280], 'CHD.': [282], 'Epidemiological': [283, 810], 'associations': [284, 741, 999, 1070], 'at': [289, 328, 416, 730, 882, 892, 904, 917, 1635], 'work,': [290, 329, 745], 'core': [292, 897], 'social': [293, 2238], 'stressor': [294, 630, 666, 1447], 'modern': [296], 'life,': [297], 'CHD': [299, 358, 754, 932, 1136, 1424], 'have': [300], 'been': [301, 954, 1111, 1171, 1428], 'repeatedly': [302], 'confirmed': [303], '(see': [304], 'below).': [305], 'For': [306, 585], 'instance,': [307], 'multicohort': [311], 'study': [312, 1644], '90': [314], '164': [315], 'individuals,': [316, 939], 'simultaneous': [318], 'exposure': [319, 626, 658, 714, 1412, 1443], 'major': [322, 376, 503, 1176, 1330], 'forms': [323, 1212], 'job': [330, 846, 912, 992, 1073, 2042], 'strain': [331, 847, 852, 993], 'effort–reward': [333, 849, 887, 995], 'imbalance,': [334, 888], 'revealed': [335], '1.4-fold': [337, 928], 'increase': [338, 1051], 'risk': [340, 930, 951, 1147, 2269, 2399], 'incident': [342, 570, 726, 1638], 'CHD.2': [343], 'Much': [344], 'needs': [345], 'be': [347, 476, 976, 1338, 1511], 'learned': [348], 'on': [349, 401, 740, 1127, 1165, 1174, 1207, 1335, 1435, 1514, 1517, 1608, 2011, 2199, 2274, 2613, 2776, 2961, 3015, 3075, 3165, 3313], 'signals': [352], 'involved.Role': [353], 'DevelopmentThere': [359], 'evidence': [361, 701, 739, 1124], 'mononuclear': [366, 1667], 'cell': [367, 1269, 1668, 2143], 'activation': [368], 'via': [369, 2737], 'nuclear': [370, 382, 386, 531, 1053, 1374, 1393], 'factor': [371, 383, 387, 389, 452, 532, 537, 539, 1054, 1375, 1394, 1396, 2696], 'κB.3': [372], 'Fine': [373], 'tuning': [374], 'redox': [378, 409, 597, 1279, 1703, 1921, 2162, 2204, 2290], 'switches,': [379], 'such': [380, 1063, 1520], 'κB': [384, 1055], 'E2–related': [388, 538, 1395], '2/Kelch-like': [390], 'ECH-associated': [391, 542, 1361], 'protein': [392, 543, 1362, 1371, 1383], '1,': [393, 1266, 1587], 'central': [396, 408, 1702], 'focus': [397], 'current': [399, 506, 1161, 1331, 1609], 'research': [400], 'oxidative': [402, 429, 440, 637, 680, 1040, 1099, 1168, 1198, 1486, 1708, 1710, 1841, 1884, 1901, 1923, 2014, 2046, 2139, 2231, 2275, 2295, 2451, 2575], 'stress.4': [403], 'H2O2': [404, 444, 483, 493, 1351, 2293], 'emerged': [405], 'signaling': [410, 1704], 'molecule,': [411], 'occurring': [412], 'normal': [414], 'metabolite': [415], 'nanomolar': [417], 'concentration': [418], 'under': [419, 2520], 'conditions': [421], '(1–10': [422], 'nmol/L': [423, 435], 'H2O2),': [424], 'which': [425], 'denoted': [427, 438], 'eustress,': [430], 'whereas': [431], 'higher': [432], 'concentrations': [433, 516], '(>100': [434], 'H2O2)': [436], 'distress': [441, 1199], '(Figure': [442], 'A).5': [443], 'now': [446], 'established': [447, 711, 949, 1113, 1151], 'endothelial-derived': [450], 'hyperpolarizing': [451, 1739], 'plays': [454, 1741], 'important': [456, 1743], 'role': [457, 1484, 1744, 2229, 2488], 'autoregulation.6': [460], 'Recently,': [461], 'Kv1.5': [462], 'were': [464], 'found': [465], 'contribute': [467, 632], 'H2O2-induced': [469, 1133], 'dilation': [470, 1780, 3199], 'human': [472, 1072, 1128, 1205, 1470, 1778], 'arteries': [473], 'modulated': [477, 620], 'CHD.7': [479], 'Major': [480, 525], 'sources': [481, 1178, 1332], 'NADPH': [486, 1097, 1181, 1390], 'oxidases': [487], 'mitochondrial': [490, 622, 635], 'sites': [491, 1270], 'generation.': [494], 'How': [495], 'link': [498, 1109], 'implemented': [500], 'task': [504, 880], 'research.Download': [507], 'figureDownload': [508], 'PowerPointFigure.': [509], 'A,': [510, 574, 1599, 1630, 1654, 1760, 1762, 1827, 1911, 1979, 1997, 2176, 2252, 2323, 2368, 2432, 2440, 2505, 2654, 2669, 2671, 2827, 2915, 2946, 3089, 3097, 3187, 3218, 3252, 3262, 3302], 'Relationship': [511, 2625], 'supraphysiological': [515], 'physiology': [522], 'pathophysiology.': [524], 'adaptive': [526], 'responses': [527, 611, 1960], 'mounted': [529], '(NF)-κB': [533], 'Nrf2': [535], '(nuclear': [536], '2)/Keap1': [540], '(Kelch-like': [541], '1)': [544], 'systems.': [545], 'Adapted': [546], 'permission': [548], 'graphical': [551, 772], 'abstract': [552], 'Sies.5': [554], 'Copyright': [555], '©': [556, 3342], '2017,': [557], 'Author.': [559], 'B,': [560, 577, 770, 2313, 2373, 2711], 'Conceptual': [561], 'scheme': [562], 'representing': [563], 'pathways': [564, 762, 776, 2578], 'disease.': [573], 'epidemiological': [575, 820, 1479], 'evidence1,2,8;': [576], 'responses3,9,10;': [579], 'C,': [580, 1684, 1941, 1943, 2509, 2646, 2648, 3185], 'clinical': [581, 1926], 'evidence.11,12': [584], 'comments,': [586], 'see': [587], 'text.Exposure': [588], 'intrinsic': [590], 'or': [591, 994, 1044, 1047, 1565], 'extrinsic': [592, 629, 665], 'stressors': [593], 'compromises': [594], 'cellular': [596], 'homeostasis': [598], 'organism,': [601], 'resulting': [602, 643], 'preponderance': [605], 'oxidants.': [607], 'Acute': [608, 2957], 'psychological': [609, 1963, 2404], 'neuroendocrine,': [613, 1955], 'metabolic,': [614, 1956], 'inflammatory,': [615, 1957], 'transcriptional': [617, 1959], 'functions.13': [623], 'Repeated,': [624], 'impaired': [634, 1138], 'function,': [636, 2013], 'distress,': [638, 2573], 'subsequent': [640], 'allostatic': [645], 'overload': [646, 2523], 'susceptibility': [648], 'CHD.1': [650], 'Recent': [651], 'results': [652], 'animal': [654, 1115], 'studies': [655, 821, 925, 973, 988, 1116, 1126, 1156, 1206, 2021], 'demonstrate': [656, 926], 'low-level': [661], 'noise': [662, 717, 2010], 'leads': [667], 'elevated': [669, 719, 883, 918, 1003, 1421], 'release': [670], 'hormones,': [673], 'levels': [675], 'surrogate': [677], 'markers': [678, 1038], 'vascular': [683, 693, 1045, 2012], 'tissue': [684, 1046], 'plasma,': [686], 'pressure': [688, 1016], 'increase,': [689], 'proinflammatory': [690, 1057], 'activity': [691, 1007, 1031, 1058, 1811], 'tissue,': [694], 'enhanced': [696, 1030, 1466], 'dysfunction.14': [698], 'Such': [699, 987, 1523], 'experimental': [700, 979], 'supports': [702], 'hypothesis': [704], 'stress-related': [706, 1453], 'mechanisms': [707], 'underlying': [708, 985], 'epidemiologically': [710], 'association': [712, 1419], 'between': [713, 2626], 'relative': [720], 'risks': [721], 'developing': [723], 'hypertension': [724], 'CHD.Chronic': [727], 'CHDHere,': [733], 'propose': [735], 'use': [737], 'available': [738], 'chronically': [743, 1414], 'stressful': [744, 834, 1415], 'prominent': [747], 'widely': [749], 'prevalent': [750], 'socioenvironmental': [751], 'stressor,': [752, 898], 'blueprint': [757], 'interdisciplinary': [759, 1467], 'inquiry,': [760], 'integrating': [761], 'mediate': [765], 'association.': [767], 'Figure': [769], 'representation': [773], 'displayed.': [778], 'represented': [784], 'here': [785], 'arrows,': [787], 'only': [789], 'few': [791], 'indicators': [792, 1001, 2044], 'given': [793], 'reduce': [795], 'complexity.': [796], 'To': [797], 'illustrate': [798, 1431], 'conceptual': [800], 'approach,': [801], 'arrows': [803], 'A': [804, 1661, 2186, 2570, 2605, 2767, 2877, 2922, 3010, 3162, 3224], 'C': [806, 2386, 2546, 2834], 'briefly': [808], 'discussed:A:': [809], 'Association': [811], 'Between': [812], 'CHDA': [816], 'series': [817], 'prospective': [819], 'has': [822, 953, 1110, 1170, 1427], 'identified': [823], 'distinct': [824, 1458, 1507], 'deleterious': [825, 2482], 'components': [826], 'within': [827], 'complexity': [829], 'diversity': [831], 'potentially': [833], 'environments': [837], 'applying': [839, 1472], 'stress-theoretical': [841], 'model,': [842], 'stressors,': [845], 'imbalance.': [850], 'Job': [851], 'considers': [853], 'threat': [854, 889], 'control': [856, 877], 'crucial': [859], 'element,': [860], 'maintaining': [861], 'individuals': [863, 900, 2486], 'working': [864], 'jobs': [866], 'defined': [867], 'high': [869, 902], 'demand': [870], '(eg,': [871, 1008, 1117], 'heavy': [872], 'pressure)': [874], 'low': [876], 'over': [878], 'their': [879, 2272], 'risk.': [885, 920], 'reward': [891], 'considered': [895, 1497], 'where': [899], 'spending': [901], 'efforts': [903], 'without': [906], 'receiving': [907], 'adequate': [908], 'rewards': [909], '(salary,': [910], 'promotion,': [911], 'security,': [913], 'recognition)': [915], 'Results': [921], '>20': [923], 'cohort': [924, 972], 'exposed': [936, 2682], 'versus': [937], 'nonexposed': [938], 'mentioned': [941, 1131, 1312], 'above.1,2': [942], 'estimates,': [945], 'influence': [947], 'factors': [952, 1148, 2270], 'adjusted': [955], 'multivariate': [958], 'statistical': [959], 'analysis.B:': [960], 'Biomarkers:': [965, 3009], 'Autonomic': [966, 1808], 'Nervous': [967, 1258], 'System': [968], 'StressEpidemiological': [971], 'need': [974], 'substantiated': [977], 'quasiexperimental': [981], 'investigations': [982, 1468], 'elucidate': [984], 'pathways.': [986], 'included': [989], 'measurement': [990], 'imbalance': [996, 1634, 2392], 'reported': [998], 'secretion': [1009], 'cortisol': [1011, 1080, 1846], 'noradrenaline,': [1013], 'diminished': [1021], 'rate': [1023], 'variability).8': [1024], 'addition,': [1026], 'concomitant': [1050], 'was': [1059, 1137], 'documented.3': [1060], 'biomarkers,': [1062], 'urinary': [1065], '8-hydroxy-2′-deoxyguanosine': [1066], 'H2O2,': [1068], 'showed': [1069], 'settings,15': [1075], 'well': [1077, 1112, 1150], 'anticipatory': [1079, 1845], 'reactivity.9': [1081], 'As': [1082, 1130], 'shown': [1083], 'rat': [1086, 1877], 'model': [1087, 1878], 'stress,': [1090, 1837, 2015, 2296], 'there': [1091, 1121], 'early': [1094], 'elevation': [1095], 'oxidase-2–derived': [1098], 'hypothalamus.10C:': [1103], 'CVDThis': [1108], 'Ref.': [1118], '14),': [1119], 'preliminary': [1123], 'subjects.': [1129], 'above,': [1132], 'vasodilation': [1134], 'because': [1139], 'switching': [1141], 'potassium': [1143], 'channels.7': [1144], 'Clinical': [1145], 'correlate': [1153], 'numerous': [1155], 'epidemiology.': [1159], 'state': [1162, 1196], 'knowledge': [1164, 1434, 1516], 'compiled,11,12': [1172], 'focusing': [1173], 'enzymatic': [1177], 'oxidants,': [1180], 'oxidases,': [1182], 'mitochondria,': [1183], 'xanthine': [1184], 'oxidase,': [1185, 2492], 'lipoxygenase,': [1186], 'myeloperoxidase.': [1188], 'challenge': [1190], 'closely': [1193], 'monitor': [1194], 'controlled': [1204], 'other': [1211], 'Table': [1216], 'provides': [1217], 'list': [1219], 'systems': [1222], 'molecules': [1225], 'deserve': [1227], 'further': [1228], 'scrutiny': [1229], 'identification': [1232], 'links': [1235], 'final': [1241], 'outcome,': [1242], 'CHD.Table.': [1243], 'Potential': [1244], 'Targets': [1245], 'Interest': [1247], 'Stress–Oxidative': [1251], 'Stress–Coronary': [1252], 'Disease': [1254, 2736, 2968], 'Chain': [1255], 'EventsCentral/Autonomic': [1257], 'SystemMessenger': [1259], 'Molecules/Assay': [1260], 'TargetsHPA': [1261], 'axisCortisolSAM': [1262], 'axisNoradrenalineNOX': [1263], 'enzymes': [1264], '(NOX': [1265], '2,': [1267], '4)H2O2Circulatory/cardiac': [1268], 'NOX': [1271], 'enzymesH2O2': [1272], 'NOS': [1273], 'enzymesNO': [1274], 'signalingThioredoxins,': [1276], 'peroxiredoxins': [1277], 'switchesNF-κB,': [1280], 'Nrf2/Keap1': [1281], 'Ion': [1282], 'channelsK+': [1283], '(Kv1.5)': [1285], 'ChromatinTelomere': [1286], 'shortening;': [1287], 'sirtuins': [1288], 'DNA': [1289], 'damage8-oxodG;': [1290], 'comet': [1291], 'assay': [1292], 'RNA': [1293], 'damage8-oxoG': [1294], 'Micro-RNAsmiR-200c': [1295], 'Protein': [1296], 'modification/damageNitrotyrosine/eg,': [1297], 'MICAL': [1298], 'Lipid': [1299, 3066], 'peroxidationF2-Isoprostanes': [1300], 'InflammationCytokines;': [1301], 'inflammasome,': [1302], 'NLRP3': [1303], 'MacrophageMKP1Some': [1304], 'targets': [1305], 'involved': [1308], 'species': [1310], 'examples': [1314], 'much': [1317], 'rich': [1319], 'panoply.': [1320], 'Because': [1321], 'restrictions': [1323], 'number': [1326], 'references,': [1328], 'information': [1334], 'cannot': [1337], 'spelled': [1339], 'out;': [1340], 'some': [1341, 2084], 'topics': [1344], 'treated': [1346], 'et': [1349, 1631, 1659], 'al.4': [1350], 'indicates': [1352], 'peroxide;': [1354], 'HPA': [1355], 'axis,': [1356, 1400], 'axis;': [1358], 'Keap1,': [1359], 'Kelch-like': [1360], '1;': [1363], 'MICAL,': [1364], 'molecule': [1365, 1705], 'interacting': [1366], 'CasL;': [1368], 'MKP1,': [1369], 'mitogen-activated': [1370], 'phosphatase-1;': [1372], 'NF-κB,': [1373], 'kB;': [1376], 'NLRP3,': [1377], 'NACHT,': [1378], 'LRR,': [1379], 'PYD': [1381], 'domains-containing': [1382], '3;': [1384], 'NOS,': [1385], 'nitric': [1386], 'oxide': [1387], 'synthase;': [1388], 'NOX,': [1389], 'oxidase;': [1391], 'Nrf2,': [1392], '2;': [1397], 'SAM': [1399], 'sympatho–adrenomedullary': [1401], 'axis.Outlook': [1402], 'Focus': [1404], 'Future': [1406], 'ResearchTo': [1407], 'summarize,': [1408], 'case': [1410], 'risk,': [1423], 'particular,': [1426], 'chosen': [1429], 'progress': [1432], 'leading': [1441], 'development': [1450, 1490], 'disease,': [1455, 1920, 3139], 'mediated': [1456], 'psychobiological': [1459], 'biochemical': [1461], 'mechanisms.': [1462], 'This': [1463], 'calls': [1464], 'among': [1469], 'populations': [1471], 'advanced': [1473], 'methods': [1474], 'molecular,': [1476], 'biomedical,': [1477], 'researches.': [1480], 'Elucidating': [1481], 'key': [1483], 'cascade': [1493], 'crucial.': [1498], 'Furthermore,': [1499], 'it': [1500], 'hoped': [1502], 'efficacy': [1505], 'preventive': [1508], 'measures': [1509, 1524], 'can': [1510], 'enhanced,': [1512], 'based': [1513], 'improved': [1515], 'pivotal': [1518], 'metabolites': [1519], 'H2O2.': [1522], 'urgently': [1526], 'needed': [1527], 'view': [1529], 'growing': [1532], 'diseases': [1536], 'aging': [1538], 'societies.AcknowledgmentsH.': [1539], 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