Publication Information

{'id': 'https://openalex.org/W2729207723', 'doi': 'https://doi.org/10.18632/oncotarget.18688', 'title': 'ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways', 'display_name': 'ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways', 'publication_year': 2017, 'publication_date': '2017-06-27', 'ids': {'openalex': 'https://openalex.org/W2729207723', 'doi': 'https://doi.org/10.18632/oncotarget.18688', 'mag': '2729207723', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28977902', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5617462'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18688', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18688&path%5B%5D=60033', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18688&path%5B%5D=60033', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102001041', 'display_name': 'Xiao Ni', 'orcid': 'https://orcid.org/0000-0002-0154-446X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Xiao Ni', 'raw_affiliation_strings': ['Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045522133', 'display_name': 'Xiang Zhang', 'orcid': 'https://orcid.org/0000-0002-5891-3668'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiang Zhang', 'raw_affiliation_strings': ['Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100852149', 'display_name': 'Cheng-Hui Hu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheng-Hui Hu', 'raw_affiliation_strings': ['Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061029843', 'display_name': 'Timothy Langridge', 'orcid': 'https://orcid.org/0000-0002-4247-8147'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy Langridge', 'raw_affiliation_strings': ['Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045679809', 'display_name': 'Rohinton S. Tarapore', 'orcid': 'https://orcid.org/0000-0002-8070-5646'}, 'institutions': [{'id': 'https://openalex.org/I4210128844', 'display_name': 'Oncoceutics (United States)', 'ror': 'https://ror.org/032rwz169', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210128844']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rohinton S. Tarapore', 'raw_affiliation_strings': ['Oncoceutics, Inc., Philadelphia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Oncoceutics, Inc., Philadelphia, PA, USA', 'institution_ids': ['https://openalex.org/I4210128844']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008547275', 'display_name': 'Joshua E. Allen', 'orcid': 'https://orcid.org/0000-0002-6835-1128'}, 'institutions': [{'id': 'https://openalex.org/I4210128844', 'display_name': 'Oncoceutics (United States)', 'ror': 'https://ror.org/032rwz169', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210128844']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joshua E. Allen', 'raw_affiliation_strings': ['Oncoceutics, Inc., Philadelphia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Oncoceutics, Inc., Philadelphia, PA, USA', 'institution_ids': ['https://openalex.org/I4210128844']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036916387', 'display_name': 'Wolfgang Oster', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128844', 'display_name': 'Oncoceutics (United States)', 'ror': 'https://ror.org/032rwz169', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210128844']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wolfgang Oster', 'raw_affiliation_strings': ['Oncoceutics, Inc., Philadelphia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Oncoceutics, Inc., Philadelphia, PA, USA', 'institution_ids': ['https://openalex.org/I4210128844']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030460763', 'display_name': 'Madeleine Duvic', 'orcid': 'https://orcid.org/0000-0002-8971-4565'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Madeleine Duvic', 'raw_affiliation_strings': ['Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5102001041'], 'corresponding_institution_ids': ['https://openalex.org/I1343551460'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.302, 'has_fulltext': False, 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.918768, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '37', 'first_page': '61761', 'last_page': '61776'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11811', 'display_name': 'Cutaneous lymphoproliferative disorders research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11811', 'display_name': 'Cutaneous lymphoproliferative disorders research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12685', 'display_name': 'Phytochemical compounds biological activities', 'score': 0.9741, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12159', 'display_name': 'T-cell and Retrovirus Studies', 'score': 0.9713, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/integrated-stress-response', 'display_name': 'Integrated stress response', 'score': 0.42115608}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.68735665}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6242895}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5846248}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4807658}, {'id': 'https://openalex.org/C88634738', 'wikidata': 'https://www.wikidata.org/wiki/Q24769543', 'display_name': 'Annexin', 'level': 3, 'score': 0.45908633}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.43294}, {'id': 'https://openalex.org/C2779638656', 'wikidata': 'https://www.wikidata.org/wiki/Q6043166', 'display_name': 'Integrated stress response', 'level': 5, 'score': 0.42115608}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34919566}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3367418}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2860409}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.17622676}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.066812634}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18688', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18688&path%5B%5D=60033', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5617462', 'pdf_url': 'https://europepmc.org/articles/pmc5617462?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617462', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28977902', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18688', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18688&path%5B%5D=60033', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1487834525', 'https://openalex.org/W1584223654', 'https://openalex.org/W1700177965', 'https://openalex.org/W1877715550', 'https://openalex.org/W1973596639', 'https://openalex.org/W1974164594', 'https://openalex.org/W1976261196', 'https://openalex.org/W1986553267', 'https://openalex.org/W2001267569', 'https://openalex.org/W2006379003', 'https://openalex.org/W2010646651', 'https://openalex.org/W2015046794', 'https://openalex.org/W2019249970', 'https://openalex.org/W2023561138', 'https://openalex.org/W2028270160', 'https://openalex.org/W2029275361', 'https://openalex.org/W2030822086', 'https://openalex.org/W2050102194', 'https://openalex.org/W2061352751', 'https://openalex.org/W2069290710', 'https://openalex.org/W2069294265', 'https://openalex.org/W2071115015', 'https://openalex.org/W2072552734', 'https://openalex.org/W2076046722', 'https://openalex.org/W2080425028', 'https://openalex.org/W2081107312', 'https://openalex.org/W2083631019', 'https://openalex.org/W2094869832', 'https://openalex.org/W2098536205', 'https://openalex.org/W2123586017', 'https://openalex.org/W2130292549', 'https://openalex.org/W2131748990', 'https://openalex.org/W2133447682', 'https://openalex.org/W2134062610', 'https://openalex.org/W2149379768', 'https://openalex.org/W2153294454', 'https://openalex.org/W2159042224', 'https://openalex.org/W2160374852', 'https://openalex.org/W2162357150', 'https://openalex.org/W2162606162', 'https://openalex.org/W2168462144', 'https://openalex.org/W2195886524', 'https://openalex.org/W2202793491', 'https://openalex.org/W2227783113', 'https://openalex.org/W2248954893', 'https://openalex.org/W2277096689', 'https://openalex.org/W2278250712', 'https://openalex.org/W2283948643', 'https://openalex.org/W2406617174', 'https://openalex.org/W2414320071', 'https://openalex.org/W2489728460', 'https://openalex.org/W2506357836', 'https://openalex.org/W2508405730', 'https://openalex.org/W2508581601', 'https://openalex.org/W2514974106', 'https://openalex.org/W2524605863', 'https://openalex.org/W2600944061', 'https://openalex.org/W980720098'], 'related_works': ['https://openalex.org/W3146516931', 'https://openalex.org/W2379687242', 'https://openalex.org/W2378294407', 'https://openalex.org/W2369438163', 'https://openalex.org/W2363554473', 'https://openalex.org/W2360124056', 'https://openalex.org/W2351990639', 'https://openalex.org/W2351725030', 'https://openalex.org/W2348668550', 'https://openalex.org/W2036918052'], 'abstract_inverted_index': {'//': [0], 'Xiao': [1, 57], 'Ni': [2], '1': [3, 7, 11, 15, 33, 34], ',': [4, 8, 12, 16, 21, 26], 'Xiang': [5], 'Zhang': [6], 'Cheng-Hui': [9], 'Hu': [10], 'Timothy': [13], 'Langridge': [14], 'Rohinton': [17], 'S.': [18], 'Tarapore': [19], '2': [20, 25, 29, 49], 'Joshua': [22], 'E.': [23], 'Allen': [24], 'Wolfgang': [27], 'Oster': [28], 'and': [30, 87, 90, 93, 135, 144, 246, 263, 280, 283], 'Madeleine': [31], 'Duvic': [32], 'Department': [35], 'of': [36, 40, 122, 129, 172, 187, 227], 'Dermatology,': [37], 'The': [38, 127, 219], 'University': [39], 'Texas': [41], 'MD': [42], 'Anderson': [43], 'Cancer': [44], 'Center,': [45], 'Houston,': [46], 'TX,': [47], 'USA': [48, 54], 'Oncoceutics,': [50], 'Inc.,': [51], 'Philadelphia,': [52], 'PA,': [53], 'Correspondence': [55], 'to:': [56], 'Ni,': [58], 'email:': [59], '[email protected]': [60], 'Keywords:': [61], 'NHL,': [62], 'ONC201,': [63, 100], 'TIC10,': [64], 'TRAIL,': [65], 'cancer': [66], 'Received:': [67], 'December': [68], '22,': [69, 73], '2016': [70], 'Accepted:': [71], 'May': [72], '2017': [74, 78], 'Published:': [75], 'June': [76], '27,': [77], 'ABSTRACT': [79], 'Cutaneous': [80], 'T-cell': [81], 'lymphomas': [82], '(CTCLs)': [83], 'are': [84, 97], 'extremely': [85], 'symptomatic': [86], 'still': [88], 'incurable,': [89], 'more': [91], 'effective': [92], 'less': [94], 'toxic': [95], 'therapies': [96], 'urgently': [98], 'needed.': [99], 'an': [101], 'imipridone': [102], 'compound,': [103], 'has': [104], 'shown': [105], 'efficacy': [106, 271], 'in': [107, 110, 139, 163, 179, 206, 213, 233, 244], 'pre-clinical': [108], 'studies': [109], 'multiple': [111], 'advanced': [112], 'cancers.': [113], 'This': [114], 'study': [115], 'was': [116, 231, 239], 'to': [117, 235], 'evaluate': [118], 'the': [119, 132], 'anti-tumor': [120, 265], 'activity': [121], 'ONC201': [123, 130, 156, 175, 202, 236, 256, 259], 'on': [124, 131, 267], 'CTCL': [125, 140, 153, 268], 'cells.': [126, 218, 269], 'effect': [128, 266], 'cell': [133, 141, 160, 166], 'growth': [134, 161], 'apoptosis': [136, 178, 205], 'were': [137, 253], 'evaluated': [138], 'lines': [142, 167], '(n=8)': [143], 'primary': [145], 'CD4': [146, 207, 215], '+': [147, 195, 208, 216], 'malignant': [148, 209], 'T': [149, 210, 217], 'cells': [150, 181], 'isolated': [151], 'from': [152], 'patients': [154], '(n=5).': [155], 'showed': [157], 'a': [158, 169, 183, 225, 261], 'time-dependent': [159], 'inhibition': [162], 'all': [164], 'treated': [165], 'with': [168, 182], 'concentration': [170, 185], 'range': [171, 186], '1.25-10.0': [173], 'μM.': [174], 'also': [176], 'induced': [177, 204], 'tested': [180], 'narrow': [184], '2.5-10.0': [188], 'μM,': [189], 'evidenced': [190], 'by': [191, 198], 'increased': [192], 'Annexin': [193], 'V': [194], 'cells,': [196, 211], 'accompanied': [197], 'accumulated': [199], 'sub-G1': [200], 'portions.': [201], 'only': [203], 'not': [212], 'normal': [214], 'activating': [220, 274], 'transcription': [221], 'factor': [222], '4': [223], '(ATF4),': [224], 'hallmark': [226], 'integrated': [228, 275], 'stress': [229, 276], 'response,': [230], 'upregulated': [232], 'response': [234, 277], 'whereas': [237], 'Akt': [238], 'downregulated.': [240], 'In': [241], 'addition,': [242], 'molecules': [243], 'JAK/STAT': [245, 282], 'NF-κB': [247, 284], 'pathways,': [248], 'as': [249, 251], 'well': [250], 'IL-32β,': [252], 'downregulated': [254], 'following': [255], 'treatment.': [257], 'Thus,': [258], 'exerts': [260], 'potent': [262], 'selective': [264], 'Its': [270], 'may': [272], 'involve': [273], 'through': [278], 'ATF4': [279], 'inactivating': [281], 'pathways.': [285]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2729207723', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-12-16T19:43:09.806798', 'created_date': '2017-07-14'}