Title: Metal inhibition of human alkylpurine-DNA-N-glycosylase activity in base excision repair
Abstract: Metal Inhibition of Human Alkylpurine-DNA-N-glycosylase Activity in Base Excision Repair Ping Wang † , Anton B. Guliaev † , and Bo Hang* Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720 Running title: Inhibition of Human APNG by Metals *To whom correspondence should be addressed: Tel: 510-495-2537. Fax: 510-486- 6488. E-mail: [email protected]. Both authors contributed equally. Abbreviations: Cd 2+ , cadmium; Ni 2+ , nickel; Zn 2+ , zinc; APNG, alkylpurine-DNA-N- glycosylase; Fpg, formamidopyrimidine-DNA glycosylase; OGG1, 8-oxoG-DNA glycosylase; AP, apurinic/apyrimidinic; APE1, AP endonuclease 1; BER, base excision repair; NER, nucleotide excision repair; MMR, mismatch repair; eA, 1,N 6 - ethenoadenine; THF, tetrahydrofuran; MD, molecular dynamics
Publication Year: 2006
Publication Date: 2006-02-28
Language: en
Type: article
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Cited By Count: 1
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